NO910958D0 - Nye cc-1065-analoger med to cpi-underenheter. - Google Patents

Nye cc-1065-analoger med to cpi-underenheter.

Info

Publication number
NO910958D0
NO910958D0 NO1991910958A NO910958A NO910958D0 NO 910958 D0 NO910958 D0 NO 910958D0 NO 1991910958 A NO1991910958 A NO 1991910958A NO 910958 A NO910958 A NO 910958A NO 910958 D0 NO910958 D0 NO 910958D0
Authority
NO
Norway
Prior art keywords
pct
formula
date mar
compounds
analogs
Prior art date
Application number
NO1991910958A
Other languages
English (en)
Other versions
NO910958L (no
NO303498B1 (no
Inventor
Robert C Kelly
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of NO910958D0 publication Critical patent/NO910958D0/no
Publication of NO910958L publication Critical patent/NO910958L/no
Publication of NO303498B1 publication Critical patent/NO303498B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Amplifiers (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Television Systems (AREA)
  • Television Receiver Circuits (AREA)
  • Stereophonic System (AREA)
NO910958A 1988-09-12 1991-03-11 AnalogifremgangsmÕte for fremstilling av terapeutisk aktive forbindelser NO303498B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (3)

Publication Number Publication Date
NO910958D0 true NO910958D0 (no) 1991-03-11
NO910958L NO910958L (no) 1991-05-10
NO303498B1 NO303498B1 (no) 1998-07-20

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
NO910958A NO303498B1 (no) 1988-09-12 1991-03-11 AnalogifremgangsmÕte for fremstilling av terapeutisk aktive forbindelser

Country Status (14)

Country Link
US (1) US5541339A (no)
JP (1) JP3380237B2 (no)
KR (1) KR0137959B1 (no)
AT (1) ATE198335T1 (no)
AU (1) AU632288B2 (no)
CA (1) CA1340215C (no)
DE (1) DE68929275T2 (no)
DK (1) DK175458B1 (no)
FI (1) FI103668B1 (no)
GR (1) GR3035589T3 (no)
LV (1) LV12806B (no)
NO (1) NO303498B1 (no)
TW (1) TW217383B (no)
WO (1) WO1990002746A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0563475B1 (en) * 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
PT2163256E (pt) 2001-05-11 2015-11-20 Ludwig Inst For Cancer Res Ltd Proteínas de ligação específica e suas utilizações
WO2003041708A1 (en) 2001-11-09 2003-05-22 Boehringer Ingelheim Pharmaceuticals, Inc. Benzimidazoles useful as protein kinase inhibitors
WO2004014905A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
EP1554271A1 (en) * 2002-10-15 2005-07-20 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
AU2004255566B2 (en) * 2003-07-07 2010-07-08 Merk Patent Gmbh Malonamide derivatives
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
MX2008002364A (es) * 2005-08-17 2008-03-18 Schering Corp Ligandos novedosos de cinasa basados en tiofeno y en furano de alta afinidad.
CN110613845A (zh) 2007-01-25 2019-12-27 达娜-法勃肿瘤研究所公司 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
CA2680854C (en) 2007-03-15 2017-02-14 Ludwig Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
US9283276B2 (en) 2007-08-14 2016-03-15 Ludwig Institute For Cancer Research Ltd. Monoclonal antibody 175 targeting the EGF receptor and derivatives and uses thereof
PT2344478T (pt) 2008-11-03 2017-11-28 Syntarga Bv Análogos de cc-1065 e seus conjugados
DK3056203T3 (da) 2010-04-21 2018-01-29 Syntarga Bv Konjugater af cc-1065-analoger og bifunktionelle linkere.
EP3721878A1 (en) 2012-10-22 2020-10-14 Arnold Glazier Methods for the effective treatment of metastatic cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
PL3092010T3 (pl) 2014-01-10 2019-01-31 Synthon Biopharmaceuticals B.V. Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek
HUE043427T2 (hu) * 2014-01-27 2019-08-28 Pfizer Bifunkciós citotoxikus szerek
US10973920B2 (en) 2014-06-30 2021-04-13 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
TWI712605B (zh) * 2015-03-20 2020-12-11 美商輝瑞股份有限公司 含有ｃｔｉ藥效基團之雙功能性細胞毒性劑

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
JP2598819B2 (ja) * 1986-12-19 1997-04-09 ジ・アップジョン・カンパニー 新規なｃｃ‐１０６５同族体

Also Published As

Publication number Publication date
FI911193A0 (fi) 1991-03-11
ATE198335T1 (de) 2001-01-15
DK175458B1 (da) 2004-11-01
FI103668B (fi) 1999-08-13
JPH04500664A (ja) 1992-02-06
DE68929275D1 (de) 2001-02-01
LV12806B (lv) 2002-05-20
AU632288B2 (en) 1992-12-24
AU4192289A (en) 1990-04-02
LV12806A (en) 2002-03-20
FI103668B1 (fi) 1999-08-13
DK41791D0 (da) 1991-03-08
KR900701801A (ko) 1990-12-04
WO1990002746A1 (en) 1990-03-22
NO910958L (no) 1991-05-10
KR0137959B1 (ko) 1998-05-15
US5541339A (en) 1996-07-30
JP3380237B2 (ja) 2003-02-24
NO303498B1 (no) 1998-07-20
DE68929275T2 (de) 2001-05-23
CA1340215C (en) 1998-12-15
DK41791A (da) 1991-03-08
GR3035589T3 (en) 2001-06-29
TW217383B (no) 1993-12-11

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