ATE86994T1 - Ornithin-derivate und deren verwendung als inhibitoren von methothrexat resistenten zellen. - Google Patents
Ornithin-derivate und deren verwendung als inhibitoren von methothrexat resistenten zellen.Info
- Publication number
- ATE86994T1 ATE86994T1 AT88909452T AT88909452T ATE86994T1 AT E86994 T1 ATE86994 T1 AT E86994T1 AT 88909452 T AT88909452 T AT 88909452T AT 88909452 T AT88909452 T AT 88909452T AT E86994 T1 ATE86994 T1 AT E86994T1
- Authority
- AT
- Austria
- Prior art keywords
- resistant cells
- methothrexate
- inhibitors
- ornithine derivatives
- ornithine
- Prior art date
Links
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229960000485 methotrexate Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/117,212 US4767761A (en) | 1987-11-04 | 1987-11-04 | Ornithine derivatives and their use as methotrexate-resistant cell inhibitors |
| EP88909452A EP0345308B1 (de) | 1987-11-04 | 1988-10-12 | Ornithin-derivate und deren verwendung als inhibitoren von methothrexat resistenten zellen |
| PCT/US1988/003545 WO1989004312A1 (en) | 1987-11-04 | 1988-10-12 | Ornithine derivatives and their use as inhibitors of methotrexate resistant cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE86994T1 true ATE86994T1 (de) | 1993-04-15 |
Family
ID=22371547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88909452T ATE86994T1 (de) | 1987-11-04 | 1988-10-12 | Ornithin-derivate und deren verwendung als inhibitoren von methothrexat resistenten zellen. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4767761A (de) |
| EP (1) | EP0345308B1 (de) |
| JP (1) | JPH02502095A (de) |
| AT (1) | ATE86994T1 (de) |
| CA (1) | CA1316533C (de) |
| DE (1) | DE3879478T2 (de) |
| WO (1) | WO1989004312A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8727737D0 (en) * | 1987-11-26 | 1987-12-31 | Ici Plc | Antitumour agents |
| DE3833393A1 (de) * | 1988-10-01 | 1990-04-05 | Thomae Gmbh Dr K | Verwendung von pteridinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel |
| US4956461A (en) * | 1988-10-19 | 1990-09-11 | Dana Farber Cancer Institute, Inc. | Desamino-aminopterin and -methotrexate |
| GB9105771D0 (en) * | 1991-03-19 | 1991-05-01 | Cancer Res Inst Royal | Anti-cancer compounds |
| ATE147386T1 (de) * | 1991-08-12 | 1997-01-15 | Takeda Chemical Industries Ltd | Kondensierte pyrimidinderivate, ihre herstellung und ihre verwendung als antitumormittel |
| GB9205907D0 (en) * | 1992-03-18 | 1992-04-29 | Cancer Res Inst Royal | Anti-cancer compounds |
| US6989386B2 (en) * | 2002-04-30 | 2006-01-24 | Dana-Farber Cancer Institute | Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same |
| US20050032807A1 (en) * | 2003-08-06 | 2005-02-10 | Rosenwald Lindsay A. | Methods of treating inflammatory diseases with ammonium salts of ornitihine derivatives |
| WO2006113536A2 (en) * | 2005-04-14 | 2006-10-26 | Hana Biosciences, Inc. | Use of pt523 for treating cancers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4393064A (en) * | 1976-03-05 | 1983-07-12 | Sri International | Process and composition for treatment of leukemia and process for preparing the same |
| US4374987A (en) * | 1980-08-14 | 1983-02-22 | American Cyanamid Company | Process for the preparation of high purity methotrexate and derivatives thereof |
| US4490529A (en) * | 1983-09-06 | 1984-12-25 | Dana-Farber Cancer Institute, Inc. | Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin |
| US4628090A (en) * | 1984-08-21 | 1986-12-09 | Rensselaer Polytechnic Institute | Fluorine-containing antifolates incapable of polyglutanayte formation related compounds |
-
1987
- 1987-11-04 US US07/117,212 patent/US4767761A/en not_active Expired - Lifetime
-
1988
- 1988-10-12 EP EP88909452A patent/EP0345308B1/de not_active Expired - Lifetime
- 1988-10-12 DE DE8888909452T patent/DE3879478T2/de not_active Expired - Fee Related
- 1988-10-12 JP JP63508714A patent/JPH02502095A/ja active Granted
- 1988-10-12 WO PCT/US1988/003545 patent/WO1989004312A1/en not_active Ceased
- 1988-10-12 AT AT88909452T patent/ATE86994T1/de active
- 1988-10-18 CA CA000580412A patent/CA1316533C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0450314B2 (de) | 1992-08-13 |
| DE3879478D1 (de) | 1993-04-22 |
| CA1316533C (en) | 1993-04-20 |
| JPH02502095A (ja) | 1990-07-12 |
| EP0345308A1 (de) | 1989-12-13 |
| US4767761A (en) | 1988-08-30 |
| EP0345308B1 (de) | 1993-03-17 |
| EP0345308A4 (de) | 1990-05-14 |
| DE3879478T2 (de) | 1993-06-24 |
| WO1989004312A1 (en) | 1989-05-18 |
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