ATE198335T1 - Cc-1065-analoge mit zwei cpi-subeinheiten - Google Patents

Cc-1065-analoge mit zwei cpi-subeinheiten

Info

Publication number
ATE198335T1
ATE198335T1 AT89308920T AT89308920T ATE198335T1 AT E198335 T1 ATE198335 T1 AT E198335T1 AT 89308920 T AT89308920 T AT 89308920T AT 89308920 T AT89308920 T AT 89308920T AT E198335 T1 ATE198335 T1 AT E198335T1
Authority
AT
Austria
Prior art keywords
pct
formula
date mar
compounds
cpi
Prior art date
Application number
AT89308920T
Other languages
English (en)
Inventor
Robert C Kelly
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE198335T1 publication Critical patent/ATE198335T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Amplifiers (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Stereophonic System (AREA)
  • Television Systems (AREA)
  • Television Receiver Circuits (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT89308920T 1988-09-12 1989-09-04 Cc-1065-analoge mit zwei cpi-subeinheiten ATE198335T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (1)

Publication Number Publication Date
ATE198335T1 true ATE198335T1 (de) 2001-01-15

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89308920T ATE198335T1 (de) 1988-09-12 1989-09-04 Cc-1065-analoge mit zwei cpi-subeinheiten

Country Status (14)

Country Link
US (1) US5541339A (de)
JP (1) JP3380237B2 (de)
KR (1) KR0137959B1 (de)
AT (1) ATE198335T1 (de)
AU (1) AU632288B2 (de)
CA (1) CA1340215C (de)
DE (1) DE68929275T2 (de)
DK (1) DK175458B1 (de)
FI (1) FI103668B1 (de)
GR (1) GR3035589T3 (de)
LV (1) LV12806B (de)
NO (1) NO303498B1 (de)
TW (1) TW217383B (de)
WO (1) WO1990002746A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2149768T3 (es) * 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
US7589180B2 (en) 2001-05-11 2009-09-15 Abbott Laboratories Inc. Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
KR20040063144A (ko) 2001-11-09 2004-07-12 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 단백질 키나제 억제제로서 유용한 벤즈이미다졸
CA2494942A1 (en) * 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
US20050215614A1 (en) * 2002-10-15 2005-09-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
EP1641759B1 (de) * 2003-07-07 2014-03-12 Merck Patent GmbH Malonamidderivate
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
MX2008002364A (es) * 2005-08-17 2008-03-18 Schering Corp Ligandos novedosos de cinasa basados en tiofeno y en furano de alta afinidad.
MX338185B (es) 2007-01-25 2016-04-05 Dana Farber Cancer Inst Inc Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante.
WO2008115404A1 (en) 2007-03-15 2008-09-25 Ludwing Institute For Cancer Research Treatment method using egfr antibodies and src inhibitors and related formulations
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
EP2188311B1 (de) 2007-08-14 2016-10-05 Ludwig Institute for Cancer Research Ltd. Auf den egf-rezeptor zielender, monoklonaler antikörper 175 und derivate und anwendungen davon
PL2344478T3 (pl) 2008-11-03 2018-02-28 Syntarga B.V. Analogi CC-1065 oraz ich koniugaty
LT2560645T (lt) 2010-04-21 2016-10-10 Syntarga B.V. Cc-1065 analogų ir bifunkcinių linkerių konjugatai
US20150265641A1 (en) 2012-10-22 2015-09-24 Arnold Glazier Methods for the Effective Treatment of Metastatic Cancer
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
KR102323301B1 (ko) 2014-01-10 2021-11-09 비온디스 비.브이. Cys 연결된 항체-약물 접합체의 정제 방법
CA2937731C (en) * 2014-01-27 2019-09-24 Pfizer Inc. Bifunctional cytotoxic agents
ES2785551T3 (es) 2014-06-30 2020-10-07 Glykos Finland Oy Derivado de sacárido de una carga útil tóxica y sus conjugados con anticuerpos
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
SG11201706991YA (en) * 2015-03-20 2017-10-30 Pfizer Bifunctional cytotoxic agents containing the cti pharmacophore

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
DE3750612T2 (de) * 1986-12-19 1995-03-02 Upjohn Co Cc-1065 analoge.

Also Published As

Publication number Publication date
DK41791A (da) 1991-03-08
DE68929275D1 (de) 2001-02-01
NO910958D0 (no) 1991-03-11
TW217383B (de) 1993-12-11
JP3380237B2 (ja) 2003-02-24
LV12806A (en) 2002-03-20
LV12806B (lv) 2002-05-20
FI911193A0 (fi) 1991-03-11
AU632288B2 (en) 1992-12-24
NO910958L (no) 1991-05-10
DK175458B1 (da) 2004-11-01
DK41791D0 (da) 1991-03-08
KR0137959B1 (ko) 1998-05-15
WO1990002746A1 (en) 1990-03-22
JPH04500664A (ja) 1992-02-06
FI103668B (fi) 1999-08-13
NO303498B1 (no) 1998-07-20
US5541339A (en) 1996-07-30
GR3035589T3 (en) 2001-06-29
KR900701801A (ko) 1990-12-04
CA1340215C (en) 1998-12-15
AU4192289A (en) 1990-04-02
FI103668B1 (fi) 1999-08-13
DE68929275T2 (de) 2001-05-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee