ATE198335T1 - Cc-1065-analoge mit zwei cpi-subeinheiten - Google Patents

Cc-1065-analoge mit zwei cpi-subeinheiten

Info

Publication number
ATE198335T1
ATE198335T1 AT89308920T AT89308920T ATE198335T1 AT E198335 T1 ATE198335 T1 AT E198335T1 AT 89308920 T AT89308920 T AT 89308920T AT 89308920 T AT89308920 T AT 89308920T AT E198335 T1 ATE198335 T1 AT E198335T1
Authority
AT
Austria
Prior art keywords
pct
formula
date mar
compounds
cpi
Prior art date
Application number
AT89308920T
Other languages
English (en)
Inventor
Robert C Kelly
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE198335T1 publication Critical patent/ATE198335T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Error Detection And Correction (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Semiconductor Integrated Circuits (AREA)
  • Amplifiers (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Television Receiver Circuits (AREA)
  • Stereophonic System (AREA)
  • Television Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT89308920T 1988-09-12 1989-09-04 Cc-1065-analoge mit zwei cpi-subeinheiten ATE198335T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24335088A 1988-09-12 1988-09-12
PCT/US1989/003329 WO1990002746A1 (en) 1988-09-12 1989-08-07 Novel cc-1065 analogs having two cpi subunits

Publications (1)

Publication Number Publication Date
ATE198335T1 true ATE198335T1 (de) 2001-01-15

Family

ID=22918400

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89308920T ATE198335T1 (de) 1988-09-12 1989-09-04 Cc-1065-analoge mit zwei cpi-subeinheiten

Country Status (14)

Country Link
US (1) US5541339A (de)
JP (1) JP3380237B2 (de)
KR (1) KR0137959B1 (de)
AT (1) ATE198335T1 (de)
AU (1) AU632288B2 (de)
CA (1) CA1340215C (de)
DE (1) DE68929275T2 (de)
DK (1) DK175458B1 (de)
FI (1) FI103668B1 (de)
GR (1) GR3035589T3 (de)
LV (1) LV12806B (de)
NO (1) NO303498B1 (de)
TW (1) TW217383B (de)
WO (1) WO1990002746A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69231123T2 (de) * 1992-03-25 2001-02-15 Immunogen Inc Konjugaten von Zell-bindender Mittel und Derivaten von CC-1065
US5502068A (en) * 1995-01-31 1996-03-26 Synphar Laboratories, Inc. Cyclopropylpyrroloindole-oligopeptide anticancer agents
EP2163256B1 (de) 2001-05-11 2015-09-02 Ludwig Institute for Cancer Research Ltd. Spezifische Bindeproteine und deren Verwendungen
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
YU37904A (sh) 2001-11-09 2006-08-17 Boehringer Ingelheim Pharmaceuticals Inc. Benzimidazoli kao korisni inhibitori proteinske kinaze
AU2003257094A1 (en) * 2002-08-08 2004-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
US20050215614A1 (en) * 2002-10-15 2005-09-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
CA2531485C (en) * 2003-07-07 2013-03-26 Merck Patent Gmbh Malonamide derivatives
WO2005079791A1 (en) * 2004-02-12 2005-09-01 Boehringer Ingelheim Pharmaceuticals, Inc. Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders
JP2009504756A (ja) * 2005-08-17 2009-02-05 シェーリング コーポレイション 新規な高親和性のチオフェンベースおよびフランベースのキナーゼリガンド
CN101711284A (zh) 2007-01-25 2010-05-19 达娜-法勃肿瘤研究所 抗egfr抗体在治疗egfr突变体介导的疾病中的用途
CN101688229B (zh) 2007-03-15 2013-06-12 路德维格癌症研究所 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CN108424454B (zh) 2007-08-14 2022-05-31 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
NO2344478T3 (de) 2008-11-03 2018-02-24
ES2815678T3 (es) 2010-04-21 2021-03-30 Syntarga Bv Conjugados de análogos de CC-1065 y conectores bifuncionales
EP2908809A2 (de) 2012-10-22 2015-08-26 Arnold Glazier Verfahren zur effektiven behandlung von metastasierendem tumor
DE102013012622A1 (de) * 2013-07-30 2015-02-05 Clariant lnternational Ltd Neue sterisch gehinderte cyclische Amine
CA2935456C (en) 2014-01-10 2018-09-18 Synthon Biopharmaceuticals B.V. Method for purifying cys-linked antibody-drug conjugates
SG11201605437YA (en) * 2014-01-27 2016-08-30 Pfizer Bifunctional cytotoxic agents
EP3160513B1 (de) 2014-06-30 2020-02-12 Glykos Finland Oy Saccharidderivat einer toxischen nutzlast und antikörperkonjugate davon
DE102015000124A1 (de) * 2015-01-07 2016-07-07 Clariant International Ltd. Verfahren zur Stabilisierung von Polyamiden
CA2923862C (en) * 2015-03-20 2024-02-13 Pfizer Inc. Bifunctional cytotoxic agents containing the cti pharmacophore

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169888A (en) * 1977-10-17 1979-10-02 The Upjohn Company Composition of matter and process
US4301248A (en) * 1979-12-21 1981-11-17 Bristol-Myers Company Fermentation process for making rachelmycin
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4912227A (en) * 1984-02-21 1990-03-27 The Upjohn Company 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
GB8528848D0 (en) * 1985-11-22 1985-12-24 Davy Mckee Poole Rolling mills
AU617304B2 (en) * 1986-12-19 1991-11-28 Pharmacia & Upjohn Company Novel cc-1065 analogs

Also Published As

Publication number Publication date
FI103668B (fi) 1999-08-13
LV12806B (lv) 2002-05-20
AU632288B2 (en) 1992-12-24
LV12806A (en) 2002-03-20
CA1340215C (en) 1998-12-15
DK41791A (da) 1991-03-08
JP3380237B2 (ja) 2003-02-24
NO303498B1 (no) 1998-07-20
NO910958L (no) 1991-05-10
US5541339A (en) 1996-07-30
AU4192289A (en) 1990-04-02
FI103668B1 (fi) 1999-08-13
DE68929275T2 (de) 2001-05-23
TW217383B (de) 1993-12-11
KR900701801A (ko) 1990-12-04
DE68929275D1 (de) 2001-02-01
DK41791D0 (da) 1991-03-08
GR3035589T3 (en) 2001-06-29
WO1990002746A1 (en) 1990-03-22
FI911193A0 (fi) 1991-03-11
NO910958D0 (no) 1991-03-11
JPH04500664A (ja) 1992-02-06
KR0137959B1 (ko) 1998-05-15
DK175458B1 (da) 2004-11-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee