ATE112279T1 - Cc-1065 analoge. - Google Patents

Cc-1065 analoge.

Info

Publication number
ATE112279T1
ATE112279T1 AT88901185T AT88901185T ATE112279T1 AT E112279 T1 ATE112279 T1 AT E112279T1 AT 88901185 T AT88901185 T AT 88901185T AT 88901185 T AT88901185 T AT 88901185T AT E112279 T1 ATE112279 T1 AT E112279T1
Authority
AT
Austria
Prior art keywords
formula
compounds
useful
analogue
spirocyclopropylpyrroloindole
Prior art date
Application number
AT88901185T
Other languages
English (en)
Inventor
Robert C Kelly
David G Martin
Paul A Aristoff
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE112279T1 publication Critical patent/ATE112279T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fire Alarms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Silicon Polymers (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Bidet-Like Cleaning Device And Other Flush Toilet Accessories (AREA)
  • Design And Manufacture Of Integrated Circuits (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
  • Forms Removed On Construction Sites Or Auxiliary Members Thereof (AREA)
  • Control Of Driving Devices And Active Controlling Of Vehicle (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT88901185T 1986-12-19 1987-12-11 Cc-1065 analoge. ATE112279T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94463386A 1986-12-19 1986-12-19

Publications (1)

Publication Number Publication Date
ATE112279T1 true ATE112279T1 (de) 1994-10-15

Family

ID=25481770

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88901185T ATE112279T1 (de) 1986-12-19 1987-12-11 Cc-1065 analoge.

Country Status (9)

Country Link
EP (1) EP0340243B1 (de)
JP (1) JP2598819B2 (de)
KR (1) KR960009264B1 (de)
AT (1) ATE112279T1 (de)
AU (1) AU617304B2 (de)
DE (1) DE3750612T2 (de)
HK (1) HK1000510A1 (de)
MX (1) MX9203200A (de)
WO (1) WO1988004659A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0684377B2 (ja) * 1986-04-17 1994-10-26 協和醗酵工業株式会社 新規化合物ｄｃ―８８ａ及びｄｃ―８９ａ１
US4994578A (en) * 1987-11-27 1991-02-19 Meiji Seika Kaisha, Ltd. Certain anti-tumor duocarmycin antibiotics from streptomyces
JP2562935B2 (ja) * 1988-04-28 1996-12-11 明治製菓株式会社 抗腫瘍性物質ｓｆ２５８２誘導体
JP2642165B2 (ja) * 1988-07-22 1997-08-20 協和醗酵工業株式会社 新規ｄｃ−８９化合物およびその製造法
US5084468A (en) * 1988-08-11 1992-01-28 Kyowa Hakko Kogyo Co., Ltd. Dc-88a derivatives
AU632288B2 (en) * 1988-09-12 1992-12-24 Pharmacia & Upjohn Company Novel cc-1065 analogs having two cpi subunits
US5008271A (en) * 1988-10-21 1991-04-16 Kyowa Hakko Kogyo Co., Ltd. DC-88A derivatives
JP2510335B2 (ja) * 1989-07-03 1996-06-26 協和醗酵工業株式会社 Ｄｃ―８８ａ誘導体
US5187186A (en) * 1989-07-03 1993-02-16 Kyowa Hakko Kogyo Co., Ltd. Pyrroloindole derivatives
KR100208957B1 (ko) * 1990-04-25 1999-07-15 로렌스 티. 마이젠헬더 신규한 cc-1065 유사체
US5248692A (en) * 1990-06-11 1993-09-28 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives as anti-tumor agents
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
US5258383A (en) * 1991-06-28 1993-11-02 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives
DK0563475T3 (da) * 1992-03-25 2000-09-18 Immunogen Inc Konjugater af cellebindende midler og derivater af CC-1065
US5248691A (en) * 1992-09-03 1993-09-28 Eli Lilly And Company Furanoindolines
US5670492A (en) * 1994-04-01 1997-09-23 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives
US5641780A (en) * 1994-04-22 1997-06-24 Kyowa Hakko Kogyo Co., Ltd. Pyrrolo-indole derivatives
KR100395083B1 (ko) * 1994-11-29 2004-02-05 자이단호오징 사가미 츄오 카가쿠겡큐쇼 아크릴아미드유도체및그제조방법
GB9516943D0 (en) * 1995-08-18 1995-10-18 Cancer Soc Auckland Div Nz Inc Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
AU721037B2 (en) * 1996-09-12 2000-06-22 Auckland Uniservices Limited Condensed N-acylindoles as antitumor agents
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
CA2341471C (en) 1998-08-27 2009-04-07 Spirogen Limited Pyrrolbenzodiazepines
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
US7129261B2 (en) * 2001-05-31 2006-10-31 Medarex, Inc. Cytotoxic agents
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
WO2005112919A2 (en) 2004-05-19 2005-12-01 Medarex, Inc. Self-immolative linkers and drug conjugates
CA2678514A1 (en) 2007-02-21 2008-08-28 Medarex, Inc. Chemical linkers with single amino acids and conjugates thereof
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CA2742568C (en) 2008-11-03 2017-09-26 Syntarga B.V. Novel cc-1065 analogs and their conjugates
EP3108886B1 (de) 2010-04-21 2020-06-17 Syntarga B.V. Konjugate von cc-1065 analogen und bifunktionelle linker
TR201810856T4 (tr) 2014-01-10 2018-08-27 Synthon Biopharmaceuticals Bv CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds

Also Published As

Publication number Publication date
DE3750612T2 (de) 1995-03-02
EP0340243B1 (de) 1994-09-28
JPH02502005A (ja) 1990-07-05
EP0340243A1 (de) 1989-11-08
DE3750612D1 (de) 1994-11-03
AU1229088A (en) 1988-07-15
MX9203200A (es) 1992-09-01
WO1988004659A3 (en) 1988-08-11
KR960009264B1 (en) 1996-07-16
AU617304B2 (en) 1991-11-28
JP2598819B2 (ja) 1997-04-09
HK1000510A1 (en) 1998-04-03
KR890700127A (ko) 1989-03-02
WO1988004659A2 (en) 1988-06-30

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Legal Events

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REN Ceased due to non-payment of the annual fee