RO88201B - Procedeu pentru prepararea unor piridazine substituite bazic - Google Patents

Procedeu pentru prepararea unor piridazine substituite bazic

Info

Publication number
RO88201B
RO88201B RO113112A RO11311281A RO88201B RO 88201 B RO88201 B RO 88201B RO 113112 A RO113112 A RO 113112A RO 11311281 A RO11311281 A RO 11311281A RO 88201 B RO88201 B RO 88201B
Authority
RO
Romania
Prior art keywords
alkoxy
preparing
basically
substituted pyridazines
substituted
Prior art date
Application number
RO113112A
Other languages
English (en)
Other versions
RO88201A (ro
Inventor
Thomas Raabe
Helmut Bohn
A. Pierro Nartorana
Rolf Eberhard Nitz
Original Assignee
Cassella Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella Aktiengesellschaft filed Critical Cassella Aktiengesellschaft
Publication of RO88201A publication Critical patent/RO88201A/ro
Publication of RO88201B publication Critical patent/RO88201B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

Inventia se refera la un procedeu de obtinere a piridazinelor substituite bazic cu formula generala I: (vezi formula) în care R1, R2 si R3 independent unul de altul reprezinta un atom de hidrogen, alchil cu 1...8 atomi de carbon, alcoxi cu 1...8 atomi de carbon, alcoxi cu 1...8 atomi de carbon, alcheniloxi cu pîna la 6 atomi de carbon. Procedeul consta în aceea ca o piridazina bazic substituita cu formula generala II: (vezi formula) în care R1, R2 si R3 sunt ca mai sus si Q este clor sau brom si Y hidrogen sau eventual un radical benzil, eventual substituit, se hidrogeneaza cu hidrogen în mediu de alcanoli inferiori, apa sau amestec alcanol-apa în prezenta unui catalizator de paladiu pe carbune sau oxid de platina, la temperatura camerei.
RO113112A 1980-12-22 1981-12-21 Procedeu pentru prepararea unor piridazine substituite bazic RO88201B (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803048487 DE3048487A1 (de) 1980-12-22 1980-12-22 Basisch substituierte pyridazine, ihre herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
RO88201A RO88201A (ro) 1985-12-30
RO88201B true RO88201B (ro) 1985-12-31

Family

ID=6119960

Family Applications (3)

Application Number Title Priority Date Filing Date
RO113112A RO88201B (ro) 1980-12-22 1981-12-21 Procedeu pentru prepararea unor piridazine substituite bazic
RO106060A RO84277B (ro) 1980-12-22 1981-12-21 Procedeu pentru prepararea unor piridazine substituite bazic
RO113111A RO88190B (ro) 1980-12-22 1981-12-21 Procedeu pentru prepararea unor piridazine substituite bazic

Family Applications After (2)

Application Number Title Priority Date Filing Date
RO106060A RO84277B (ro) 1980-12-22 1981-12-21 Procedeu pentru prepararea unor piridazine substituite bazic
RO113111A RO88190B (ro) 1980-12-22 1981-12-21 Procedeu pentru prepararea unor piridazine substituite bazic

Country Status (26)

Country Link
US (1) US4532239A (ro)
EP (1) EP0054946B1 (ro)
JP (1) JPS57128677A (ro)
KR (1) KR880002233B1 (ro)
AT (1) ATE8991T1 (ro)
AU (1) AU544386B2 (ro)
CA (1) CA1173033A (ro)
CS (1) CS236665B2 (ro)
DD (1) DD202013A5 (ro)
DE (2) DE3048487A1 (ro)
DK (1) DK149810C (ro)
ES (3) ES8304941A1 (ro)
FI (1) FI73418C (ro)
GR (1) GR81382B (ro)
HK (1) HK51485A (ro)
IE (1) IE51985B1 (ro)
IL (1) IL64605A (ro)
NO (1) NO814182L (ro)
NZ (1) NZ198919A (ro)
PH (1) PH17529A (ro)
PL (3) PL137150B1 (ro)
PT (1) PT74185B (ro)
RO (3) RO88201B (ro)
SG (1) SG7585G (ro)
SU (2) SU1170970A3 (ro)
ZA (1) ZA818806B (ro)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3023369A1 (de) * 1980-06-23 1982-01-14 Boehringer Mannheim Gmbh, 6800 Mannheim Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPH0641454B2 (ja) * 1985-02-27 1994-06-01 日産化学工業株式会社 ピリダジノン誘導体
US4892947A (en) * 1985-04-27 1990-01-09 Nissan Chemical Industries Ltd. 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it
JPS61282194A (ja) * 1985-06-06 1986-12-12 Yukio Nakamura ジエツト推進式舟艇の推進軸とその製造法
JPH0629254B2 (ja) * 1986-09-08 1994-04-20 帝国臓器製薬株式会社 ピリダジノン誘導体
DE3902316A1 (de) * 1989-01-26 1990-08-02 Lentia Gmbh Neue piperazinylalkyl-3(2h)-pyridazinone, verfahren zu ihrer herstellung und ihre verwendung als blutdrucksenkende mittel
NZ234087A (en) * 1989-06-19 1991-08-27 Teikoku Hormone Mfg Co Ltd 2-(3-aryloxy(2-hydroxy-propylamino))-2-methylpropyl- aminophenyl pyridazine derivatives
US5221674A (en) * 1989-06-19 1993-06-22 Teikoku Hormone Mfg. Co., Ltd. Pyridazinone derivatives
HU214320B (hu) * 1991-12-20 1998-03-02 EGIS Gyógyszergyár Rt. Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
EP1082309B1 (en) * 1998-06-05 2005-09-14 Egis Gyogyszergyar Process for the preparation of a 3(2h)-pyridazinone- 4-substituted amino- 5-chloro- derivative
MX2009009948A (es) * 2007-03-15 2009-09-24 Schering Corp Derivados de piridazinona utiles como inhibidores de glucano sintasa.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1957706C3 (de) * 1968-11-18 1978-06-29 Pfizer Corp., Colon (Panama) Kernsubstituierte 3-Phenoxy-l-phenoxyalkylamino-propan-2-ole und Arzneimittel auf deren Basis
GB1421999A (en) * 1973-02-08 1976-01-21 Smith Kline French Lab Heterocyclic containing sulphoxides
US4115575A (en) * 1973-02-20 1978-09-19 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)-pyrazines
GB1488330A (en) * 1973-12-19 1977-10-12 Smith Kline French Lab Dihydropyridazinones
US4088764A (en) * 1973-12-27 1978-05-09 Cassella Farbwerke Mainkur Aktiengesellschaft Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol
CH591448A5 (ro) * 1974-05-14 1977-09-15 Ciba Geigy Ag
LU77339A1 (ro) * 1977-05-16 1979-01-19
DD146749A3 (de) * 1977-12-01 1981-03-04 Dieter Lehmann Verfahren zur herstellung von phenoxyalkanolamin-derivaten
DE3023369A1 (de) * 1980-06-23 1982-01-14 Boehringer Mannheim Gmbh, 6800 Mannheim Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
PL137106B1 (en) 1986-04-30
DK149810C (da) 1987-03-23
RO88201A (ro) 1985-12-30
FI73418C (fi) 1987-10-09
DK542881A (da) 1982-06-23
FI813941L (fi) 1982-06-23
KR830007577A (ko) 1983-11-04
EP0054946A1 (de) 1982-06-30
US4532239A (en) 1985-07-30
CS236665B2 (en) 1985-05-15
PL234312A1 (en) 1983-02-14
CA1173033A (en) 1984-08-21
ES518139A0 (es) 1983-10-01
IE813014L (en) 1982-06-22
PL238538A1 (en) 1983-04-25
GR81382B (ro) 1984-12-11
EP0054946B1 (de) 1984-08-15
ES8308859A1 (es) 1983-10-01
AU544386B2 (en) 1985-05-23
DE3165595D1 (en) 1984-09-20
ATE8991T1 (de) 1984-09-15
JPS57128677A (en) 1982-08-10
PL137150B1 (en) 1986-05-31
SG7585G (en) 1985-08-08
HK51485A (en) 1985-07-12
ES518138A0 (es) 1983-10-16
RO84277A (ro) 1984-05-23
IL64605A0 (en) 1982-03-31
SU1151204A3 (ru) 1985-04-15
SU1170970A3 (ru) 1985-07-30
DE3048487A1 (de) 1982-07-29
NZ198919A (en) 1985-05-31
ES508274A0 (es) 1983-03-16
PH17529A (en) 1984-09-13
RO88190B (ro) 1985-12-31
PL238537A1 (en) 1983-06-20
IL64605A (en) 1985-11-29
ES8400096A1 (es) 1983-10-16
PL136127B1 (en) 1986-01-31
DK149810B (da) 1986-10-06
KR880002233B1 (ko) 1988-10-20
FI73418B (fi) 1987-06-30
AU7870481A (en) 1982-07-01
ES8304941A1 (es) 1983-03-16
PT74185B (de) 1987-03-24
NO814182L (no) 1982-06-23
RO88190A (ro) 1985-12-30
PT74185A (de) 1982-01-01
ZA818806B (en) 1982-11-24
RO84277B (ro) 1984-07-30
IE51985B1 (en) 1987-05-13
DD202013A5 (de) 1983-08-24

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