RO88201B - Procedeu pentru prepararea unor piridazine substituite bazic - Google Patents
Procedeu pentru prepararea unor piridazine substituite bazicInfo
- Publication number
- RO88201B RO88201B RO113112A RO11311281A RO88201B RO 88201 B RO88201 B RO 88201B RO 113112 A RO113112 A RO 113112A RO 11311281 A RO11311281 A RO 11311281A RO 88201 B RO88201 B RO 88201B
- Authority
- RO
- Romania
- Prior art keywords
- alkoxy
- preparing
- basically
- substituted pyridazines
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Inventia se refera la un procedeu de obtinere a piridazinelor substituite bazic cu formula generala I: (vezi formula) în care R1, R2 si R3 independent unul de altul reprezinta un atom de hidrogen, alchil cu 1...8 atomi de carbon, alcoxi cu 1...8 atomi de carbon, alcoxi cu 1...8 atomi de carbon, alcheniloxi cu pîna la 6 atomi de carbon. Procedeul consta în aceea ca o piridazina bazic substituita cu formula generala II: (vezi formula) în care R1, R2 si R3 sunt ca mai sus si Q este clor sau brom si Y hidrogen sau eventual un radical benzil, eventual substituit, se hidrogeneaza cu hidrogen în mediu de alcanoli inferiori, apa sau amestec alcanol-apa în prezenta unui catalizator de paladiu pe carbune sau oxid de platina, la temperatura camerei.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19803048487 DE3048487A1 (de) | 1980-12-22 | 1980-12-22 | Basisch substituierte pyridazine, ihre herstellung und ihre verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
RO88201A RO88201A (ro) | 1985-12-30 |
RO88201B true RO88201B (ro) | 1985-12-31 |
Family
ID=6119960
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO113112A RO88201B (ro) | 1980-12-22 | 1981-12-21 | Procedeu pentru prepararea unor piridazine substituite bazic |
RO106060A RO84277B (ro) | 1980-12-22 | 1981-12-21 | Procedeu pentru prepararea unor piridazine substituite bazic |
RO113111A RO88190B (ro) | 1980-12-22 | 1981-12-21 | Procedeu pentru prepararea unor piridazine substituite bazic |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO106060A RO84277B (ro) | 1980-12-22 | 1981-12-21 | Procedeu pentru prepararea unor piridazine substituite bazic |
RO113111A RO88190B (ro) | 1980-12-22 | 1981-12-21 | Procedeu pentru prepararea unor piridazine substituite bazic |
Country Status (26)
Country | Link |
---|---|
US (1) | US4532239A (ro) |
EP (1) | EP0054946B1 (ro) |
JP (1) | JPS57128677A (ro) |
KR (1) | KR880002233B1 (ro) |
AT (1) | ATE8991T1 (ro) |
AU (1) | AU544386B2 (ro) |
CA (1) | CA1173033A (ro) |
CS (1) | CS236665B2 (ro) |
DD (1) | DD202013A5 (ro) |
DE (2) | DE3048487A1 (ro) |
DK (1) | DK149810C (ro) |
ES (3) | ES8304941A1 (ro) |
FI (1) | FI73418C (ro) |
GR (1) | GR81382B (ro) |
HK (1) | HK51485A (ro) |
IE (1) | IE51985B1 (ro) |
IL (1) | IL64605A (ro) |
NO (1) | NO814182L (ro) |
NZ (1) | NZ198919A (ro) |
PH (1) | PH17529A (ro) |
PL (3) | PL137150B1 (ro) |
PT (1) | PT74185B (ro) |
RO (3) | RO88201B (ro) |
SG (1) | SG7585G (ro) |
SU (2) | SU1170970A3 (ro) |
ZA (1) | ZA818806B (ro) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3023369A1 (de) * | 1980-06-23 | 1982-01-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
JPH0641454B2 (ja) * | 1985-02-27 | 1994-06-01 | 日産化学工業株式会社 | ピリダジノン誘導体 |
US4892947A (en) * | 1985-04-27 | 1990-01-09 | Nissan Chemical Industries Ltd. | 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it |
JPS61282194A (ja) * | 1985-06-06 | 1986-12-12 | Yukio Nakamura | ジエツト推進式舟艇の推進軸とその製造法 |
JPH0629254B2 (ja) * | 1986-09-08 | 1994-04-20 | 帝国臓器製薬株式会社 | ピリダジノン誘導体 |
DE3902316A1 (de) * | 1989-01-26 | 1990-08-02 | Lentia Gmbh | Neue piperazinylalkyl-3(2h)-pyridazinone, verfahren zu ihrer herstellung und ihre verwendung als blutdrucksenkende mittel |
NZ234087A (en) * | 1989-06-19 | 1991-08-27 | Teikoku Hormone Mfg Co Ltd | 2-(3-aryloxy(2-hydroxy-propylamino))-2-methylpropyl- aminophenyl pyridazine derivatives |
US5221674A (en) * | 1989-06-19 | 1993-06-22 | Teikoku Hormone Mfg. Co., Ltd. | Pyridazinone derivatives |
HU214320B (hu) * | 1991-12-20 | 1998-03-02 | EGIS Gyógyszergyár Rt. | Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
EP1082309B1 (en) * | 1998-06-05 | 2005-09-14 | Egis Gyogyszergyar | Process for the preparation of a 3(2h)-pyridazinone- 4-substituted amino- 5-chloro- derivative |
MX2009009948A (es) * | 2007-03-15 | 2009-09-24 | Schering Corp | Derivados de piridazinona utiles como inhibidores de glucano sintasa. |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1957706C3 (de) * | 1968-11-18 | 1978-06-29 | Pfizer Corp., Colon (Panama) | Kernsubstituierte 3-Phenoxy-l-phenoxyalkylamino-propan-2-ole und Arzneimittel auf deren Basis |
GB1421999A (en) * | 1973-02-08 | 1976-01-21 | Smith Kline French Lab | Heterocyclic containing sulphoxides |
US4115575A (en) * | 1973-02-20 | 1978-09-19 | Ciba-Geigy Corporation | 2-(3-Amino-2-hydroxy-propoxy)-pyrazines |
GB1488330A (en) * | 1973-12-19 | 1977-10-12 | Smith Kline French Lab | Dihydropyridazinones |
US4088764A (en) * | 1973-12-27 | 1978-05-09 | Cassella Farbwerke Mainkur Aktiengesellschaft | Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol |
CH591448A5 (ro) * | 1974-05-14 | 1977-09-15 | Ciba Geigy Ag | |
LU77339A1 (ro) * | 1977-05-16 | 1979-01-19 | ||
DD146749A3 (de) * | 1977-12-01 | 1981-03-04 | Dieter Lehmann | Verfahren zur herstellung von phenoxyalkanolamin-derivaten |
DE3023369A1 (de) * | 1980-06-23 | 1982-01-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Aryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1980
- 1980-12-22 DE DE19803048487 patent/DE3048487A1/de not_active Withdrawn
-
1981
- 1981-11-10 NZ NZ198919A patent/NZ198919A/xx unknown
- 1981-12-07 CA CA000391595A patent/CA1173033A/en not_active Expired
- 1981-12-08 DK DK542881A patent/DK149810C/da not_active IP Right Cessation
- 1981-12-08 NO NO814182A patent/NO814182L/no unknown
- 1981-12-08 FI FI813941A patent/FI73418C/fi not_active IP Right Cessation
- 1981-12-17 DD DD81235901A patent/DD202013A5/de unknown
- 1981-12-17 CS CS819455A patent/CS236665B2/cs unknown
- 1981-12-18 PL PL1981238537A patent/PL137150B1/pl unknown
- 1981-12-18 PL PL1981234312A patent/PL136127B1/pl unknown
- 1981-12-18 PL PL1981238538A patent/PL137106B1/pl unknown
- 1981-12-19 EP EP81110620A patent/EP0054946B1/de not_active Expired
- 1981-12-19 DE DE8181110620T patent/DE3165595D1/de not_active Expired
- 1981-12-19 AT AT81110620T patent/ATE8991T1/de not_active IP Right Cessation
- 1981-12-21 KR KR1019810005043A patent/KR880002233B1/ko active
- 1981-12-21 JP JP56205363A patent/JPS57128677A/ja active Pending
- 1981-12-21 IE IE3014/81A patent/IE51985B1/en unknown
- 1981-12-21 IL IL64605A patent/IL64605A/xx unknown
- 1981-12-21 AU AU78704/81A patent/AU544386B2/en not_active Ceased
- 1981-12-21 PH PH26659A patent/PH17529A/en unknown
- 1981-12-21 ZA ZA818806A patent/ZA818806B/xx unknown
- 1981-12-21 RO RO113112A patent/RO88201B/ro unknown
- 1981-12-21 GR GR66860A patent/GR81382B/el unknown
- 1981-12-21 RO RO106060A patent/RO84277B/ro unknown
- 1981-12-21 RO RO113111A patent/RO88190B/ro unknown
- 1981-12-21 SU SU813367148A patent/SU1170970A3/ru active
- 1981-12-22 ES ES508274A patent/ES8304941A1/es not_active Expired
- 1981-12-22 PT PT74185A patent/PT74185B/pt unknown
-
1982
- 1982-08-20 SU SU823478901A patent/SU1151204A3/ru active
- 1982-12-13 ES ES518138A patent/ES8400096A1/es not_active Expired
- 1982-12-13 ES ES518139A patent/ES8308859A1/es not_active Expired
-
1983
- 1983-12-20 US US06/563,538 patent/US4532239A/en not_active Expired - Fee Related
-
1985
- 1985-01-26 SG SG75/85A patent/SG7585G/en unknown
- 1985-07-04 HK HK514/85A patent/HK51485A/xx unknown
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