GB2111997A - Composition and method for inhibiting terminal deoxyribonucleotidyl transferase activity - Google Patents

Composition and method for inhibiting terminal deoxyribonucleotidyl transferase activity

Info

Publication number
GB2111997A
GB2111997A GB08302241A GB8302241A GB2111997A GB 2111997 A GB2111997 A GB 2111997A GB 08302241 A GB08302241 A GB 08302241A GB 8302241 A GB8302241 A GB 8302241A GB 2111997 A GB2111997 A GB 2111997A
Authority
GB
United Kingdom
Prior art keywords
composition
transferase activity
deoxyribonucleotidyl transferase
terminal deoxyribonucleotidyl
inhibiting terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08302241A
Other versions
GB2111997B (en
GB8302241D0 (en
Inventor
Ronald Mccaffrey
George Wright
Earl Baril
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB8302241D0 publication Critical patent/GB8302241D0/en
Publication of GB2111997A publication Critical patent/GB2111997A/en
Application granted granted Critical
Publication of GB2111997B publication Critical patent/GB2111997B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New uracil compounds having the formula: <IMAGE> wherein X is C1 - C10 alkoxy or amino. These compounds are useful in treating patients having leukemia, the cells of which express terminal deoxynucleotidyl transferase.
GB08302241A 1981-05-29 1981-05-29 Composition and method for inhibiting terminal deoxyribonucleotidyl transferase activity Expired GB2111997B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1981/000721 WO1982004192A1 (en) 1981-05-29 1981-05-29 Composition and method for inhibiting terminal deoxyribonucleotidyl transferase activity

Publications (3)

Publication Number Publication Date
GB8302241D0 GB8302241D0 (en) 1983-03-02
GB2111997A true GB2111997A (en) 1983-07-13
GB2111997B GB2111997B (en) 1986-01-22

Family

ID=22161257

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08302241A Expired GB2111997B (en) 1981-05-29 1981-05-29 Composition and method for inhibiting terminal deoxyribonucleotidyl transferase activity

Country Status (4)

Country Link
JP (1) JPS58500947A (en)
DE (1) DE3152869A1 (en)
GB (1) GB2111997B (en)
WO (1) WO1982004192A1 (en)

Also Published As

Publication number Publication date
JPS58500947A (en) 1983-06-09
DE3152869A1 (en) 1983-06-30
GB2111997B (en) 1986-01-22
GB8302241D0 (en) 1983-03-02
WO1982004192A1 (en) 1982-12-09

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee