PT99400A - Processo para a preparacao de derivados de 3-amido- e 3-sulfamido-indolilo e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de derivados de 3-amido- e 3-sulfamido-indolilo e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT99400A PT99400A PT99400A PT9940091A PT99400A PT 99400 A PT99400 A PT 99400A PT 99400 A PT99400 A PT 99400A PT 9940091 A PT9940091 A PT 9940091A PT 99400 A PT99400 A PT 99400A
- Authority
- PT
- Portugal
- Prior art keywords
- amido
- sulfamide
- contain
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Paints Or Removers (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60845790A | 1990-11-02 | 1990-11-02 | |
| US76753191A | 1991-10-02 | 1991-10-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT99400A true PT99400A (pt) | 1992-09-30 |
| PT99400B PT99400B (pt) | 1999-04-30 |
Family
ID=27085774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99400A PT99400B (pt) | 1990-11-02 | 1991-10-31 | Processo para a preparacao de derivados de 3-amido- e 3-sulfamido-indolilo e de composicoes farmaceuticas que os contem |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0483881B1 (pt) |
| JP (1) | JP3168565B2 (pt) |
| KR (1) | KR100220882B1 (pt) |
| AT (1) | ATE162519T1 (pt) |
| AU (1) | AU641052B2 (pt) |
| CA (1) | CA2054339C (pt) |
| DE (1) | DE69128764T2 (pt) |
| DK (1) | DK0483881T3 (pt) |
| ES (1) | ES2113359T3 (pt) |
| FI (1) | FI102676B (pt) |
| GR (1) | GR3026349T3 (pt) |
| HU (1) | HU214597B (pt) |
| IE (1) | IE913834A1 (pt) |
| IL (1) | IL99908A (pt) |
| NO (1) | NO177139C (pt) |
| NZ (1) | NZ240380A (pt) |
| PT (1) | PT99400B (pt) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4242675A1 (de) * | 1992-12-17 | 1994-06-23 | Basf Ag | Neue Hydroxyiminoalkylindolcarbonsäure-Derivate, ihre Herstellung und Verwendung |
| GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
| TW280819B (pt) * | 1993-11-17 | 1996-07-11 | Sumitomo Pharma | |
| US5801168A (en) * | 1994-06-09 | 1998-09-01 | Zeneca Limited | Substituted nitrogen heterocycles |
| CN101849953B (zh) | 2000-12-18 | 2012-04-25 | 株式会社医药分子设计研究所 | 炎症性细胞因子产生游离抑制剂 |
| DK1470102T3 (da) | 2002-01-29 | 2011-06-20 | Merck Serono Sa | Substituerede methylenamidderivater som modulatorer af proteintyrosinphosphataser (PTPS) |
| GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| CN1658872B (zh) | 2002-06-06 | 2010-09-22 | 株式会社医药分子设计研究所 | 抗过敏药 |
| AU2003242118B2 (en) | 2002-06-06 | 2008-09-11 | Institute Of Medicinal Molecular Design, Inc | O-substituted hydroxyaryl derivatives |
| EP1555018A4 (en) * | 2002-06-11 | 2009-01-07 | Inst Med Molecular Design Inc | MEANS FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES |
| MY147767A (en) | 2004-06-16 | 2013-01-31 | Janssen Pharmaceutica Nv | Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders |
| CA2570363A1 (en) | 2004-06-18 | 2005-12-29 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| MX2007002309A (es) * | 2004-08-24 | 2007-10-08 | Johnson & Johnson | Novedosos derivados de heteroarilsulfamida benzofusionados utiles como agentes anticonvulsivos. |
| AU2005325497A1 (en) | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| MX2007014613A (es) | 2005-05-20 | 2008-04-02 | Johnson & Johnson | Procedimiento para la preparacion de derivados de sulfamida. |
| US7973025B2 (en) | 2005-05-26 | 2011-07-05 | Neuron Systems, Inc. | Compositions and methods of treating retinal disease |
| US8716231B2 (en) | 2005-12-19 | 2014-05-06 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain |
| US8497298B2 (en) | 2005-12-19 | 2013-07-30 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels |
| AR058389A1 (es) | 2005-12-19 | 2008-01-30 | Janssen Pharmaceutica Nv | Uso de derivados heterociclicos benzo-fusionados de sulfamida para el tratamiento de la obesidad |
| US8937096B2 (en) | 2005-12-19 | 2015-01-20 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder |
| US8691867B2 (en) | 2005-12-19 | 2014-04-08 | Janssen Pharmaceutica Nv | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction |
| WO2007137167A2 (en) | 2006-05-19 | 2007-11-29 | Janssen Pharmaceutica N.V. | Co-therapy for the treatment of epilepsy |
| AU2009271362B2 (en) | 2008-06-23 | 2014-03-13 | Janssen Pharmaceutica Nv | Crystalline form of (2s)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide |
| US8815939B2 (en) | 2008-07-22 | 2014-08-26 | Janssen Pharmaceutica Nv | Substituted sulfamide derivatives |
| WO2011072141A1 (en) | 2009-12-11 | 2011-06-16 | Neuron Systems, Inc. | Compositions and methods for the treatment of macular degeneration |
| HK1217325A1 (zh) | 2012-12-20 | 2017-01-06 | 奥尔德拉医疗公司 | 迫位原醇 |
| SG11201505587YA (en) | 2013-01-23 | 2015-08-28 | Aldeyra Therapeutics Inc | Toxic aldehyde related diseases and treatment |
| CA2898869A1 (en) | 2013-01-25 | 2014-07-31 | Aldeyra Therapeutics, Inc. | Novel traps in the treatment of macular degeneration |
| AU2016311158A1 (en) | 2015-08-21 | 2018-04-05 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| WO2017196881A1 (en) | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| CA3054811A1 (en) | 2017-03-16 | 2018-09-20 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| MX2020003425A (es) | 2017-10-10 | 2020-07-29 | Aldeyra Therapeutics Inc | Tratamiento de trastornos inflamatorios. |
| EP3833660A4 (en) | 2018-08-06 | 2022-05-11 | Aldeyra Therapeutics, Inc. | POLYMORPHIC COMPOUNDS AND THEIR USES |
| JP2022530967A (ja) | 2019-05-02 | 2022-07-05 | アルデイラ セラピューティクス， インコーポレイテッド | 多形化合物およびその使用 |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| CA3175856A1 (en) | 2020-05-13 | 2021-11-18 | Todd Brady | Pharmaceutical formulations and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60123485A (ja) * | 1983-12-08 | 1985-07-02 | Yoshitomi Pharmaceut Ind Ltd | インド−ル−３−カルボキサミド誘導体 |
| US4675332A (en) * | 1984-12-10 | 1987-06-23 | Warner-Lambert Company | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| IL84796A (en) * | 1986-12-17 | 1992-03-29 | Merck Frosst Canada Inc | Substituted n-benzyl-indoles and pharmaceutical compositions containing them |
-
1991
- 1991-10-28 CA CA002054339A patent/CA2054339C/en not_active Expired - Lifetime
- 1991-10-28 AU AU86760/91A patent/AU641052B2/en not_active Expired
- 1991-10-29 NZ NZ240380A patent/NZ240380A/en not_active IP Right Cessation
- 1991-10-30 IL IL9990891A patent/IL99908A/en not_active IP Right Cessation
- 1991-10-31 PT PT99400A patent/PT99400B/pt not_active IP Right Cessation
- 1991-10-31 FI FI915146A patent/FI102676B/fi not_active IP Right Cessation
- 1991-10-31 JP JP32157391A patent/JP3168565B2/ja not_active Expired - Lifetime
- 1991-11-01 KR KR1019910019414A patent/KR100220882B1/ko not_active Expired - Lifetime
- 1991-11-01 IE IE383491A patent/IE913834A1/en not_active IP Right Cessation
- 1991-11-01 NO NO914300A patent/NO177139C/no not_active IP Right Cessation
- 1991-11-01 HU HU913454A patent/HU214597B/hu unknown
- 1991-11-04 AT AT91118738T patent/ATE162519T1/de not_active IP Right Cessation
- 1991-11-04 ES ES91118738T patent/ES2113359T3/es not_active Expired - Lifetime
- 1991-11-04 DK DK91118738.3T patent/DK0483881T3/da active
- 1991-11-04 DE DE69128764T patent/DE69128764T2/de not_active Expired - Lifetime
- 1991-11-04 EP EP91118738A patent/EP0483881B1/en not_active Expired - Lifetime
-
1998
- 1998-03-13 GR GR980400534T patent/GR3026349T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100220882B1 (ko) | 1999-09-15 |
| ATE162519T1 (de) | 1998-02-15 |
| FI915146L (fi) | 1992-05-03 |
| DE69128764T2 (de) | 1998-06-04 |
| IL99908A0 (en) | 1992-08-18 |
| ES2113359T3 (es) | 1998-05-01 |
| CA2054339A1 (en) | 1992-05-03 |
| IE913834A1 (en) | 1992-05-22 |
| NO914300D0 (no) | 1991-11-01 |
| NO177139B (no) | 1995-04-18 |
| JPH0733737A (ja) | 1995-02-03 |
| DE69128764D1 (de) | 1998-02-26 |
| FI102676B1 (fi) | 1999-01-29 |
| EP0483881A1 (en) | 1992-05-06 |
| NZ240380A (en) | 1994-05-26 |
| AU8676091A (en) | 1992-05-07 |
| CA2054339C (en) | 2002-12-24 |
| EP0483881B1 (en) | 1998-01-21 |
| HUT59668A (en) | 1992-06-29 |
| NO177139C (no) | 1995-07-26 |
| IL99908A (en) | 1995-10-31 |
| FI102676B (fi) | 1999-01-29 |
| HU913454D0 (en) | 1992-01-28 |
| HU214597B (hu) | 1998-04-28 |
| KR920009796A (ko) | 1992-06-25 |
| GR3026349T3 (en) | 1998-06-30 |
| FI915146A0 (fi) | 1991-10-31 |
| JP3168565B2 (ja) | 2001-05-21 |
| NO914300L (no) | 1992-05-04 |
| PT99400B (pt) | 1999-04-30 |
| DK0483881T3 (da) | 1998-03-16 |
| AU641052B2 (en) | 1993-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT99400A (pt) | Processo para a preparacao de derivados de 3-amido- e 3-sulfamido-indolilo e de composicoes farmaceuticas que os contem | |
| PT93094A (pt) | Processo para a preparacao de 1,3-oxatiolanos substituidos e de composicoes farmaceuticas que os contem | |
| PT98369A (pt) | Processo para a preparacao de azois substituidos e de composicoes farmaceuticas que os contem | |
| PT99227A (pt) | Processo para a preparacao de derivados da quinazolina e de composicoes farmaceuticas que os contem | |
| PT99671A (pt) | Processo para a preparacao de heparosanos-n,o-sulfatados e de composicoes farmaceuticas que os contem | |
| PT94645A (pt) | Processo para a preparacao de derivados de aminopirimidina com actividade fungicida e de composicoes fungicidas que os contem | |
| PT91465A (pt) | Processo para a preparacao de derivados de benzo-triazol substituido e de composicoes herbicidas que os contem | |
| PT96438A (pt) | Processo para preparacao de anti-oxidante lipideo-selectivos e de composicoes farmaceuticas que os contem | |
| PT91968A (pt) | Processo para a preparacao de novos piperidinil-benzimidazois e de composicoes farmaceuticas que os contem | |
| PT89497A (pt) | Processo para a preparacao de compostos piperidinilicos 1,4-dissubstituidos e de composicoes farmaceuticas que os contem | |
| PT97114A (pt) | Processo para a preparacao de derivados de hidantoina e de composicoes farmaceuticas que os contem | |
| PT84460B (pt) | Processo para a preparacao de derivados de ciclopropano 1,1-dissubstituidos e de composicoes farmaceuticas que os contem | |
| PT99795A (pt) | Processo para a preparacao e novos derivados de piperidinil-benzimidazol e de composicoes farmaceuticas que os contem | |
| PT93067A (pt) | Processo para a preparacao de derivados de 2-hidroxiacidos alifaticos e de eteres de 1-benzil-3-hidroximetilindazol, e de composicoes farmaceuticas que os contem | |
| PT82307B (pt) | Processo para a preparacao de derivados da 4'-demetil-4-epipodofilotoxina e de composicoes farmaceuticas que os contem | |
| PT89486A (pt) | Processo para a preparacao de derivados 16-de-hidro de vitamina d3 e de composicoes farmaceuticas que os contem | |
| PT89311A (pt) | Processo para a preparacao de novos aminoalcoxi-p-benzonitrilos substituidos utilizaveis como agentes antiarritmicos e de composicoes farmaceuticas que os contem | |
| PT89659A (pt) | Processo para a preparacao de {(5(6) (1h-azole-1-ilmetil)benzimidazole}-carbamatos e de composicoes farmaceuticas que os contem | |
| PT89145A (pt) | Processo para a preparacao de derivados da manumicina e de composicoes farmaceuticas que os contem | |
| PT88335A (pt) | Processo para a preparacao de derivados do acido 1,4-dihidro-4-oxo-3-quinolinocarboxilico e de composicoes farmaceuticas que os contem | |
| PT88351A (pt) | Processo para a preparacao de derivados de isoxazol-beta-carbolina e de composicoes farmaceuticas que os contem | |
| PT89214A (pt) | Processo para a preparacao de novos derivados de aminoacidos ciclicos e de composicoes farmaceuticas que os contem | |
| PT91215A (pt) | Processo para a preparacao de antagonistas de bombesina e de composicoes farmaceuticas que os contem | |
| PT91787A (pt) | Processo para a preparacao de tienopiranos substituidos e de composicoes farmaceuticas que os contem | |
| PT88370A (pt) | Processo para a preparacao de derivados da pirimidina fundidos triciclicos e de composicoes farmaceuticas que os contem |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19920504 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19990113 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20140113 |