PT948630E - Clonagem e caracterização da napsina, uma protease aspártica - Google Patents

Clonagem e caracterização da napsina, uma protease aspártica Download PDF

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Publication number
PT948630E
PT948630E PT97948546T PT97948546T PT948630E PT 948630 E PT948630 E PT 948630E PT 97948546 T PT97948546 T PT 97948546T PT 97948546 T PT97948546 T PT 97948546T PT 948630 E PT948630 E PT 948630E
Authority
PT
Portugal
Prior art keywords
lisboa
leu
gly
napsin
pro
Prior art date
Application number
PT97948546T
Other languages
English (en)
Portuguese (pt)
Inventor
Xinli Lin
Gerald Koelsch
Jordan J N Tang
Original Assignee
Oklahoma Med Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found filed Critical Oklahoma Med Res Found
Publication of PT948630E publication Critical patent/PT948630E/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478Aspartic endopeptidases (3.4.23)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PT97948546T 1996-11-20 1997-11-20 Clonagem e caracterização da napsina, uma protease aspártica PT948630E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3119696P 1996-11-20 1996-11-20
US4612697P 1997-05-09 1997-05-09

Publications (1)

Publication Number Publication Date
PT948630E true PT948630E (pt) 2008-06-11

Family

ID=26706937

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97948546T PT948630E (pt) 1996-11-20 1997-11-20 Clonagem e caracterização da napsina, uma protease aspártica

Country Status (11)

Country Link
US (1) US6225103B1 (https=)
EP (1) EP0948630B1 (https=)
JP (2) JP2001503643A (https=)
AT (1) ATE393227T1 (https=)
AU (1) AU734220B2 (https=)
CA (1) CA2271294A1 (https=)
DE (1) DE69738653T2 (https=)
DK (1) DK0948630T3 (https=)
ES (1) ES2308791T3 (https=)
PT (1) PT948630E (https=)
WO (1) WO1998022597A2 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0897986A3 (en) * 1997-08-21 2000-07-05 Smithkline Beecham Corporation Aspartic proteinase 5 (ASP5)
US6432690B1 (en) * 1998-01-16 2002-08-13 Incyte Genomics, Inc. Human aspartic proteases
US6203979B1 (en) 1998-01-16 2001-03-20 Incyte Pharmaceuticals, Inc. Human protease molecules
US7045333B1 (en) 1998-01-16 2006-05-16 Incyte Corporation Human protease molecules
US7160679B1 (en) 1998-05-21 2007-01-09 Diadexus, Inc. Method of diagnosing, monitoring, and staging lung cancer
JP2002520048A (ja) * 1998-07-16 2002-07-09 インサイト・ファーマスーティカルズ・インコーポレイテッド ヒト・アスパラギン酸プロテアーゼ
EP1939297A1 (en) 1998-09-24 2008-07-02 Pharmacia & Upjohn Company LLC Alzheimer's disease secretase
US7456007B1 (en) 1998-12-31 2008-11-25 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
US7115410B1 (en) * 1999-02-10 2006-10-03 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
CN1390232A (zh) 1999-02-10 2003-01-08 艾兰制药公司 人β分泌酶、抑制剂、其组合物和用途
US7514408B1 (en) 1999-12-02 2009-04-07 Elan Pharmaceuticals, Inc. β-secretase enzyme compositions and methods
JP2001172200A (ja) * 1999-12-17 2001-06-26 Meneki Seibutsu Kenkyusho:Kk ヒトナプシンaに対する抗体およびこれを用いる医薬
DE60124080T2 (de) 2000-03-23 2007-03-01 Elan Pharmaceuticals, Inc., San Francisco Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
WO2002000891A2 (en) * 2000-06-26 2002-01-03 Bayer Aktiengesellschaft Human napsin-like aspartyl protease
EP1299352B1 (en) 2000-06-30 2005-12-28 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
EP1666452A2 (en) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
EP1500663A1 (en) * 2000-09-28 2005-01-26 Eli Lilly And Company Secreted proteins and their uses
US7217556B1 (en) 2000-12-23 2007-05-15 Pfizer Inc Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease
US7806980B2 (en) * 2000-12-23 2010-10-05 Elan Pharmaceuticals, Inc. Method for crystallizing human beta secretase in complex with an inhibitor
US7601528B1 (en) 2000-12-23 2009-10-13 Elan Pharmaceuticals, Inc. Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
US7384773B1 (en) 2001-05-10 2008-06-10 Pfizer Inc Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof
US7524668B1 (en) 2001-05-10 2009-04-28 Elan Pharmaceuticals, Inc. Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof
BR0210122A (pt) 2001-06-01 2004-06-15 Elan Pharm Inc Composto ou um sal farmaceuticamente aceitável do mesmo, método para o tratamento ou prevenção de uma doença, uso do composto ou de seu sal, e, método para preparar o mesmo
CA2450205A1 (en) 2001-06-13 2002-12-19 Elan Pharmaceuticals, Inc. Aminediols for the treatment of alzheimer's disease
EP1401452A1 (en) 2001-06-27 2004-03-31 Elan Pharmaceuticals, Inc. Beta-hydroxyamine derivatives useful in the treatment of alzheimer's disease
MXPA04000338A (es) 2001-07-10 2004-07-23 Upjohn Co Diamindioles para tratamiento de enfermedad de alzheimer.
MXPA04000337A (es) 2001-07-10 2004-07-23 Upjohn Co Amindioles para tratamiento de enfermedad de alzheimer.
US7186539B1 (en) 2001-08-31 2007-03-06 Pharmacia & Upjohn Company Method for refolding enzymes
CA2462851A1 (en) 2001-10-04 2003-04-10 Elan Pharmaceuticals, Inc. Hydroxypropylamines
NZ533107A (en) 2001-11-08 2007-04-27 Upjohn Co N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives
AU2003213252A1 (en) 2002-02-21 2003-09-09 Pharmacia And Upjohn Company Modified bace
WO2004058686A1 (en) 2002-04-30 2004-07-15 Elan Pharmaceuticals, Inc. Hydroxypropyl amides for the treatment of alzheimer’s disease
US7442537B1 (en) 2002-05-10 2008-10-28 Elan Pharmaceuticals, Inc. Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof
AU2003268023A1 (en) * 2002-07-23 2004-02-09 Incyte Corporation Protein modification and maintenance molecules
US7351738B2 (en) 2002-11-27 2008-04-01 Elan Pharmaceuticals, Inc. Substituted ureas and carbamates
UY28280A1 (es) 2003-04-21 2004-11-30 Pharmacia & Amp 2- hidroxi - 3- diaminoalcanos de benzamida
EP1473362A1 (en) 2003-05-02 2004-11-03 Elan Pharmaceuticals, Inc. Glycosylation variants of BACE
WO2005044977A2 (en) * 2003-06-25 2005-05-19 Diadexus, Inc. Compositions, splice variants and methods relating to lung specific genes and proteins
US20050239836A1 (en) 2004-03-09 2005-10-27 Varghese John Substituted hydroxyethylamine aspartyl protease inhibitors
US20070292346A1 (en) * 2004-03-25 2007-12-20 Rong Fan Lng105 Antibody Composition and Methods of Use, and Use of Lng105 to Assess Lung Cancer Risk
EP1773756A2 (en) 2004-07-09 2007-04-18 Elan Pharmaceuticals, Inc. Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
WO2007047305A1 (en) 2005-10-12 2007-04-26 Elan Pharmaceuticals, Inc. Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
CA2687750C (en) 2007-07-06 2016-10-18 Boehringer Ingelheim International Gmbh Substituted amino-quinazolinones, medicaments comprising said compound, their use and their method of manufacture

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107250A (en) * 1993-10-12 2001-08-08 Yeda Res & Dev Dna molecules involved in programmed cell death, proteins encoded thereby and methods and compositions using said dna molecules and proteins
GB9618966D0 (en) * 1996-09-11 1996-10-23 Smithkline Beecham Plc Novel compounds
US5776759A (en) * 1996-09-26 1998-07-07 Incyte Pharmaceuticals, Inc. Two novel human cathepsin proteins

Also Published As

Publication number Publication date
DE69738653T2 (de) 2009-06-04
EP0948630A2 (en) 1999-10-13
WO1998022597A3 (en) 1998-07-09
DK0948630T3 (da) 2008-08-11
US6225103B1 (en) 2001-05-01
AU734220B2 (en) 2001-06-07
JP2001503643A (ja) 2001-03-21
EP0948630B1 (en) 2008-04-23
JP2008118996A (ja) 2008-05-29
CA2271294A1 (en) 1998-05-28
AU5459298A (en) 1998-06-10
ES2308791T3 (es) 2008-12-01
ATE393227T1 (de) 2008-05-15
DE69738653D1 (de) 2008-06-05
WO1998022597A2 (en) 1998-05-28

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