PT866720E - Proteina ob para aumentar a massa do tecido mole - Google Patents

Proteina ob para aumentar a massa do tecido mole

Info

Publication number
PT866720E
PT866720E PT96938773T PT96938773T PT866720E PT 866720 E PT866720 E PT 866720E PT 96938773 T PT96938773 T PT 96938773T PT 96938773 T PT96938773 T PT 96938773T PT 866720 E PT866720 E PT 866720E
Authority
PT
Portugal
Prior art keywords
protein
increase mass
mole
increasing
tissue
Prior art date
Application number
PT96938773T
Other languages
English (en)
Portuguese (pt)
Inventor
Christopher Francis Toombs
Michael Benjamin Mann
Mary Ann Pelleymounter
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of PT866720E publication Critical patent/PT866720E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT96938773T 1995-11-22 1996-11-04 Proteina ob para aumentar a massa do tecido mole PT866720E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56173295A 1995-11-22 1995-11-22

Publications (1)

Publication Number Publication Date
PT866720E true PT866720E (pt) 2004-06-30

Family

ID=24243198

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96938773T PT866720E (pt) 1995-11-22 1996-11-04 Proteina ob para aumentar a massa do tecido mole

Country Status (15)

Country Link
EP (3) EP1285664B1 (OSRAM)
JP (2) JP4173914B2 (OSRAM)
AT (2) ATE259243T1 (OSRAM)
AU (3) AU7607496A (OSRAM)
CA (2) CA2358862A1 (OSRAM)
DE (2) DE69638119D1 (OSRAM)
DK (1) DK0866720T3 (OSRAM)
ES (2) ES2217327T3 (OSRAM)
IL (2) IL124442A0 (OSRAM)
MX (1) MX9803992A (OSRAM)
NZ (3) NZ527007A (OSRAM)
PT (1) PT866720E (OSRAM)
SI (1) SI0866720T1 (OSRAM)
WO (1) WO1997018833A1 (OSRAM)
ZA (1) ZA969605B (OSRAM)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001968A (en) * 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US20030040467A1 (en) 1998-06-15 2003-02-27 Mary Ann Pelleymounter Ig/ob fusions and uses thereof.
US6936439B2 (en) 1995-11-22 2005-08-30 Amgen Inc. OB fusion protein compositions and methods
NZ527007A (en) * 1995-11-22 2005-01-28 Amgen Inc Methods of increasing lean tissue mass using OB protein compositions
US6620413B1 (en) 1995-12-27 2003-09-16 Genentech, Inc. OB protein-polymer chimeras
US7074397B1 (en) 1996-01-08 2006-07-11 Genentech, Inc. Method for enhancing proliferation or differentiation of a cell using ob protein
US20050019325A1 (en) 1996-01-08 2005-01-27 Carter Paul J. WSX receptor agonist antibodies
US6541604B1 (en) 1996-01-08 2003-04-01 Genentech, Inc. Leptin receptor having a WSX motif
EP0877627A1 (en) * 1996-01-25 1998-11-18 Eli Lilly And Company Obesity protein analog compounds and formulations thereof
AU2810497A (en) * 1996-04-19 1997-11-12 University Of Washington Methods for inducing bone formation
EP1007648A4 (en) * 1996-12-20 2003-01-15 Lilly Co Eli ANTI-OBESITY PROTEINS
ATE351910T1 (de) * 1996-12-20 2007-02-15 Amgen Inc Ob-fusionsprotein enthaltende zusammensetzungen und verfahren
US20020019352A1 (en) * 1997-04-17 2002-02-14 David N. Brems Stable, active, human ob protein compositions and methods
EP0950417A3 (en) 1998-02-23 2000-02-23 Pfizer Products Inc. Treatment of skeletal disorders
WO1999053939A1 (en) * 1998-04-20 1999-10-28 Mayo Foundation For Medical Education And Research Treatment of osteoporosis with leptin
US6210924B1 (en) 1998-08-11 2001-04-03 Amgen Inc. Overexpressing cyclin D 1 in a eukaryotic cell line
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
AU1134000A (en) * 1998-10-27 2000-05-15 Eli Lilly And Company Prevention of muscle mass loss with leptin receptor ligands
CA2359840C (en) * 1999-02-12 2012-10-23 Amgen Inc. Glycosylated leptin compositions and related methods
US8106098B2 (en) 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
EP1444516B1 (en) 2001-10-22 2010-07-21 Amgen, Inc. Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment
WO2003077847A2 (en) 2002-03-12 2003-09-25 Merck & Co., Inc. Substituted amides
ES2390082T5 (es) * 2004-06-30 2018-01-19 Nektar Therapeutics Conjugados de resto de Factor IX y polímeros
EP1814590B2 (en) 2004-11-01 2013-12-11 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
US8394765B2 (en) 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
WO2008048691A2 (en) * 2006-10-18 2008-04-24 Amylin Pharmaceuticals, Inc. Use of leptin for treating post-lipectomy ectopic fat deposition and other post-lipectomy associated disorders
WO2009149379A2 (en) 2008-06-05 2009-12-10 Regents Of The University Of Michigan Use of leptin for the treatment of fatty liver diseases and conditions
MX351128B (es) 2010-09-28 2017-10-03 Aegerion Pharmaceuticals Inc Polipeptidos manipulados que tienen duracion de accion incrementada.
US9968575B2 (en) 2012-09-27 2018-05-15 The Children's Medical Center Corporation Compounds for the treatment of obesity and methods of use thereof
LT3074033T (lt) 2013-11-26 2019-02-25 The Children`S Medical Center Corporation Junginiai, skirti nutukimo gydymui ir jų panaudojimo būdai
US20170209408A1 (en) 2014-04-03 2017-07-27 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
DK3509624T3 (da) 2016-09-12 2023-11-13 Amryt Pharmaceuticals Inc Fremgangsmåder til detektering af anti-leptin-neutraliserende antistoffer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1228925B (it) * 1987-08-07 1991-07-10 Eniricerche Spa Procedimento per la preparazione dell'ormone della crescita umano
DK173142B1 (da) * 1988-08-24 2000-02-07 Natinco Nv Fremgangsmåde til forbedring af kødkvaliteten og foderomsætningseffektiviteten for grise
US5028440A (en) * 1990-01-30 1991-07-02 Iowa State University Research Foundation, Inc. Method of raising meat producing animals to increase lean tissue development
JPH09503973A (ja) * 1993-08-13 1997-04-22 プッツマイスター・ヴェルク マシーネンファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング 大型対象物の表面を処理する方法および装置
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
GB9511935D0 (en) * 1995-06-13 1995-08-09 Smithkline Beecham Plc Novel compound
NZ527007A (en) * 1995-11-22 2005-01-28 Amgen Inc Methods of increasing lean tissue mass using OB protein compositions
WO1997024440A1 (en) * 1995-12-27 1997-07-10 Genentech, Inc. Ob protein derivatives having prolonged half-life
ATE351910T1 (de) * 1996-12-20 2007-02-15 Amgen Inc Ob-fusionsprotein enthaltende zusammensetzungen und verfahren
ES2183351T3 (es) * 1997-04-17 2003-03-16 Amgen Inc Composicones que comprenden conjugados de proteina ob humana activa estable con una cadena fc de inmunoglobulinas y metodos.

Also Published As

Publication number Publication date
AU4265200A (en) 2000-09-21
IL124442A0 (en) 1998-12-06
AU7607496A (en) 1997-06-11
AU4265300A (en) 2000-09-07
ES2217327T3 (es) 2004-11-01
EP0956862A1 (en) 1999-11-17
JP4227325B2 (ja) 2009-02-18
DK0866720T3 (da) 2004-06-14
JP2002206000A (ja) 2002-07-23
CA2358862A1 (en) 1997-05-29
EP0866720B1 (en) 2004-02-11
EP1285664B1 (en) 2010-01-20
ZA969605B (en) 1997-06-02
DE69631544D1 (de) 2004-03-18
CA2236163A1 (en) 1997-05-29
SI0866720T1 (en) 2004-10-31
ATE455554T1 (de) 2010-02-15
MX9803992A (es) 1998-09-30
EP0866720A1 (en) 1998-09-30
DE69638119D1 (de) 2010-03-11
JP2000500492A (ja) 2000-01-18
NZ511617A (en) 2003-08-29
DE69631544T2 (de) 2004-12-23
IL127926A (en) 2006-08-20
NZ512083A (en) 2003-02-28
WO1997018833A1 (en) 1997-05-29
IL127926A0 (en) 1999-11-30
JP4173914B2 (ja) 2008-10-29
ATE259243T1 (de) 2004-02-15
AU763769B2 (en) 2003-07-31
ES2339846T3 (es) 2010-05-26
NZ527007A (en) 2005-01-28
EP1285664A2 (en) 2003-02-26
AU763755B2 (en) 2003-07-31
EP1285664A3 (en) 2003-07-30

Similar Documents

Publication Publication Date Title
PT866720E (pt) Proteina ob para aumentar a massa do tecido mole
ATE178907T1 (de) Rezeptorbindende region des diphtherietoxius
EA200100053A1 (ru) Кальций (3s)тетрагидро-3-фуранил(1s,2r)-3-[[(4-аминофенил)сульфонил](изобутил)амино]-1-бензил-2-(фосфоноокси)пропилкарбамат
FR12C0004I2 (fr) Anticorps contre l'antigene ctla-4 humain et utilisation
FR2784282B1 (fr) Systeme d'osteosynthese rachidienne a rigidite amelioree
DE69500014D1 (de) Widerlager zur Klammerung von weichem Gewebe
DE69723710D1 (de) Medizinische instrumente mit verbesserter elastizität
LU91411I2 (fr) Panitumumab et ses dérivés pharmaceutiquement acceptables (VECTIBIX)
ATE297754T1 (de) Heilung von bruchverletzungen unter verwendung von pthrp analogen
DE69621260D1 (de) Biokompatible hydrophile gleitmittel fur medizinische instrumente
EA199800946A1 (ru) Концентрированный препарат антител
ATE529444T1 (de) Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten
DE69626152D1 (de) Chirurgisches Nähinstrument
DE69435105D1 (de) Derivate therapeutischer Peptide
SE9500566L (sv) L-platta
ATE342970T1 (de) Verwendung eines menschlichen interleukin-11 rezeptors
NO974322D0 (no) DNA som koder for human papillomvirus type 18
DE69737651D1 (de) Cortistatin: neuropeptide, zusammensetzungen und methoden
DE69735039D1 (de) Acetylhydrolase des Plättchen aktivierenden Faktors, und entsprechendes Gen
ATE314861T1 (de) Verwendung von antikörper gegen mag zur behandlung ischämischer schlaganfälle
SE9803962D0 (sv) Nucleic acid encoding a nervous tissue sodium channel
ATE407944T1 (de) Mit trp-proteinen verwandtes protein mtr1 und dieses codierende dna-sequenz
PT878195E (pt) Utilizacao de um composto 2-aroil-3-arilbenzo(b)tiofeno para a reducao de fibrinogenio
DK0795008T3 (da) Humane hypertrofe chondrocyt-cellelinjer
AU8499501A (en) Slo2 and slo4, novel potassium channel proteins from human brain