PT2994469T - Derivados de benzimidazole como inibidores de bromodomínio - Google Patents
Derivados de benzimidazole como inibidores de bromodomínioInfo
- Publication number
- PT2994469T PT2994469T PT14729182T PT14729182T PT2994469T PT 2994469 T PT2994469 T PT 2994469T PT 14729182 T PT14729182 T PT 14729182T PT 14729182 T PT14729182 T PT 14729182T PT 2994469 T PT2994469 T PT 2994469T
- Authority
- PT
- Portugal
- Prior art keywords
- benzimidazole derivatives
- bromodomain inhibitors
- bromodomain
- inhibitors
- benzimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361821612P | 2013-05-09 | 2013-05-09 | |
US201361826912P | 2013-05-23 | 2013-05-23 | |
US201361860229P | 2013-07-30 | 2013-07-30 | |
US201461951347P | 2014-03-11 | 2014-03-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2994469T true PT2994469T (pt) | 2019-03-18 |
Family
ID=50897952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT14729182T PT2994469T (pt) | 2013-05-09 | 2014-05-08 | Derivados de benzimidazole como inibidores de bromodomínio |
Country Status (26)
Country | Link |
---|---|
US (4) | US20160075695A1 (pt) |
EP (1) | EP2994469B1 (pt) |
JP (1) | JP6049942B2 (pt) |
KR (1) | KR101761049B1 (pt) |
CN (1) | CN105324379B (pt) |
AP (1) | AP2015008869A0 (pt) |
AR (1) | AR096246A1 (pt) |
AU (1) | AU2014262622B2 (pt) |
BR (1) | BR112015028017A2 (pt) |
CA (1) | CA2911408C (pt) |
CL (1) | CL2015003280A1 (pt) |
CR (1) | CR20150639A (pt) |
EA (1) | EA029091B1 (pt) |
ES (1) | ES2710120T3 (pt) |
HK (2) | HK1219278A1 (pt) |
MD (1) | MD4592B1 (pt) |
MX (1) | MX2015015478A (pt) |
NZ (1) | NZ713718A (pt) |
PE (1) | PE20160029A1 (pt) |
PH (1) | PH12015502534A1 (pt) |
PT (1) | PT2994469T (pt) |
SG (1) | SG11201509220XA (pt) |
TW (1) | TWI527811B (pt) |
UA (1) | UA112618C2 (pt) |
UY (1) | UY35559A (pt) |
WO (1) | WO2014182929A1 (pt) |
Families Citing this family (62)
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WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
AU2013365926B9 (en) | 2012-12-21 | 2019-01-17 | Zenith Epigenetics Ltd. | Novel heterocyclic compounds as bromodomain inhibitors |
BR112015022942B1 (pt) | 2013-03-15 | 2022-02-22 | Incyte Holdings Corporation | Compostos heterocíciclos tricíclicos, método para inibir proteína bet in vitro e composição farmacêutica compreendendo os referidos compostos |
CA2915622C (en) | 2013-06-21 | 2020-08-18 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
AU2014284616B2 (en) | 2013-06-21 | 2019-02-28 | Zenith Epigenetics Ltd. | Novel bicyclic bromodomain inhibitors |
JP2016523964A (ja) | 2013-07-08 | 2016-08-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Betタンパク質阻害剤としての三環式複素環 |
CA2919948C (en) | 2013-07-31 | 2020-07-21 | Zenith Epigenetics Corp. | Novel quinazolinones as bromodomain inhibitors |
WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
WO2015081189A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
WO2015095492A1 (en) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
NZ763740A (en) | 2014-04-23 | 2023-06-30 | Incyte Holdings Corp | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
CN107108552A (zh) * | 2014-08-05 | 2017-08-29 | 百时美施贵宝公司 | 杂环激酶抑制剂 |
JP6599979B2 (ja) * | 2014-09-15 | 2019-10-30 | インサイト・コーポレイション | Betタンパク質阻害剤として用いるための三環式複素環化合物 |
CA2966303A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
EP3227281A4 (en) | 2014-12-01 | 2018-05-30 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
CA2966449A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
JP2017538721A (ja) * | 2014-12-17 | 2017-12-28 | ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. | ブロモドメインの阻害剤 |
US20190055235A1 (en) * | 2014-12-17 | 2019-02-21 | Zenith Epigenetics Ltd. | Substituted bicyclic compounds as bromodomain inhibitors |
GB201504689D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
CN104788441A (zh) * | 2015-04-02 | 2015-07-22 | 湖南华腾制药有限公司 | 一种多取代苯并恶唑衍生物的制备方法 |
GB201506658D0 (en) * | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
ES2761824T3 (es) * | 2015-05-15 | 2020-05-21 | Gilead Sciences Inc | Compuestos de carboximidamida de benzimidazol y imidazopiridina que tienen actividad como inhibidores de indoleamina 2,3-dioxigenasa |
WO2016187620A2 (en) * | 2015-05-21 | 2016-11-24 | The Regents Of The University Of California | Anti-cancer compounds |
KR20180052757A (ko) * | 2015-09-21 | 2018-05-18 | 플렉시콘 인코퍼레이티드 | 헤테로시클릭 화합물 및 그의 용도 |
WO2017075377A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
CN105399683B (zh) * | 2015-12-01 | 2018-07-20 | 江苏理工学院 | 苯并咪唑衍生物及其制备方法 |
WO2017106568A1 (en) | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a bromodomain inhibitor for treating cancer |
CN108430993A (zh) | 2015-12-17 | 2018-08-21 | 吉利德科学公司 | Tank-结合激酶抑制剂化合物 |
CN108883311A (zh) * | 2015-12-24 | 2018-11-23 | 赛尔基因昆蒂赛尔研究公司 | 布罗莫结构域和额外末端蛋白抑制剂组合疗法 |
FI3472157T3 (fi) | 2016-06-20 | 2023-06-01 | Incyte Corp | Bet-inhibiittorin kiteisiä kiinteitä muotoja |
IL263917B (en) | 2016-06-24 | 2022-07-01 | Univ California | Pthalazine derivatives as parp1, parp2 and/or tubulin suppressors for use in cancer therapy |
GB201614939D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Ip Dev Ltd | Crystalline hydrate |
GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
GB201617627D0 (en) * | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
CA3041049A1 (en) | 2016-10-27 | 2018-05-03 | Celgene Quanticel Research, Inc. | Bromodomain and extra-terminal protein inhibitor combination therapy |
WO2018085069A1 (en) | 2016-11-03 | 2018-05-11 | Gilead Sciences, Inc. | Combination of a bcl-2 inhibitor and a bromodomain inhibitor for treating cancer |
US20180179191A1 (en) | 2016-11-22 | 2018-06-28 | Gilead Sciences, Inc. | Synthesis of a compound that modulates the activity of bromodomain-containing proteins |
WO2018097977A1 (en) | 2016-11-22 | 2018-05-31 | Gilead Sciences, Inc. | Crystalline forms of a phosphate complex of a bet inhibitor |
US20180153868A1 (en) * | 2016-12-06 | 2018-06-07 | Gilead Sciences, Inc. | Treatment of breast cancer by concomitant administration of a bromodomain inhibitor and a second agent |
WO2018106433A1 (en) * | 2016-12-06 | 2018-06-14 | Gilead Sciences, Inc. | Treatment of prostate cancer by concomitant administration of a bromodomain inhibitor and a second agent |
CN116869457A (zh) * | 2016-12-14 | 2023-10-13 | 比奥拉治疗股份有限公司 | 使用jak抑制剂治疗胃肠道疾病及装置 |
CN108314680A (zh) * | 2017-01-16 | 2018-07-24 | 凯惠科技发展(上海)有限公司 | 一种含芳环化合物、其制备方法、药物组合物及应用 |
JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
US11493520B2 (en) * | 2017-05-19 | 2022-11-08 | Epicypher, Inc. | Assays for nucleosome remodeling activity |
MA50250A (fr) | 2017-09-15 | 2020-07-22 | Forma Therapeutics Inc | Compositions de tétrahydroimidazo quinoléine utilisées en tant qu'inhibiteurs de cbp/p300 |
JP2021506903A (ja) | 2017-12-20 | 2021-02-22 | 貝達薬業股▲ふん▼有限公司Betta Pharmaceuticals Co.,Ltd | ブロモドメインタンパク質阻害剤である化合物、および組成物 |
TWI796596B (zh) | 2018-02-13 | 2023-03-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
CA3093130C (en) | 2018-04-19 | 2023-10-17 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
CN114145817A (zh) * | 2018-05-08 | 2022-03-08 | 贝利斯医疗公司 | 在穿刺线上制造至少一个位置标记物的方法 |
BR112020021648A2 (pt) | 2018-05-14 | 2021-01-26 | Gilead Sciences, Inc. | inibidores de mcl-1 |
BR112020026783A2 (pt) | 2018-06-29 | 2021-03-30 | Forma Therapeutics, Inc. | Inibição da proteína de ligação creb (cbp) |
KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
CN109912584B (zh) * | 2019-03-22 | 2021-08-13 | 中国药科大学 | 一种具有抗肿瘤活性的brd4蛋白抑制剂及其制备方法和应用 |
CN113544129A (zh) * | 2019-04-04 | 2021-10-22 | 上海华汇拓医药科技有限公司 | 三环类化合物制备方法及其在医药领域的应用 |
CN112625036A (zh) * | 2019-10-08 | 2021-04-09 | 上海海和药物研究开发股份有限公司 | 一类具有brd4抑制活性的化合物、其制备方法及用途 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
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GB201106799D0 (en) * | 2011-04-21 | 2011-06-01 | Glaxosmithkline Llc | Novel compounds |
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WO2013097052A1 (en) * | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
-
2014
- 2014-05-07 TW TW103116235A patent/TWI527811B/zh active
- 2014-05-08 CA CA2911408A patent/CA2911408C/en active Active
- 2014-05-08 ES ES14729182T patent/ES2710120T3/es active Active
- 2014-05-08 US US14/787,374 patent/US20160075695A1/en not_active Abandoned
- 2014-05-08 PT PT14729182T patent/PT2994469T/pt unknown
- 2014-05-08 MD MDA20150121A patent/MD4592B1/ro not_active IP Right Cessation
- 2014-05-08 BR BR112015028017A patent/BR112015028017A2/pt not_active Application Discontinuation
- 2014-05-08 EA EA201591965A patent/EA029091B1/ru not_active IP Right Cessation
- 2014-05-08 SG SG11201509220XA patent/SG11201509220XA/en unknown
- 2014-05-08 EP EP14729182.7A patent/EP2994469B1/en active Active
- 2014-05-08 US US14/273,147 patent/US9458145B2/en active Active
- 2014-05-08 KR KR1020157034918A patent/KR101761049B1/ko active IP Right Grant
- 2014-05-08 AU AU2014262622A patent/AU2014262622B2/en active Active
- 2014-05-08 MX MX2015015478A patent/MX2015015478A/es unknown
- 2014-05-08 WO PCT/US2014/037344 patent/WO2014182929A1/en active Application Filing
- 2014-05-08 AP AP2015008869A patent/AP2015008869A0/xx unknown
- 2014-05-08 PE PE2015002375A patent/PE20160029A1/es not_active Application Discontinuation
- 2014-05-08 JP JP2016513078A patent/JP6049942B2/ja active Active
- 2014-05-08 NZ NZ713718A patent/NZ713718A/en not_active IP Right Cessation
- 2014-05-08 CN CN201480035623.0A patent/CN105324379B/zh active Active
- 2014-05-09 UY UY0001035559A patent/UY35559A/es not_active Application Discontinuation
- 2014-05-09 AR ARP140101893A patent/AR096246A1/es unknown
- 2014-08-05 UA UAA201510960A patent/UA112618C2/uk unknown
-
2015
- 2015-11-05 PH PH12015502534A patent/PH12015502534A1/en unknown
- 2015-11-09 CL CL2015003280A patent/CL2015003280A1/es unknown
- 2015-12-04 CR CR20150639A patent/CR20150639A/es unknown
-
2016
- 2016-06-24 HK HK16107380.5A patent/HK1219278A1/zh not_active IP Right Cessation
- 2016-08-17 US US15/239,422 patent/US10017501B2/en active Active
- 2016-09-05 HK HK16110539.9A patent/HK1222646A1/zh unknown
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2018
- 2018-06-06 US US16/001,832 patent/US20180282316A1/en not_active Abandoned
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