MD20150121A2 - Derivaţi de benzimidazol ca inhibitori ai bromodomeniului - Google Patents
Derivaţi de benzimidazol ca inhibitori ai bromodomeniuluiInfo
- Publication number
- MD20150121A2 MD20150121A2 MDA20150121A MD20150121A MD20150121A2 MD 20150121 A2 MD20150121 A2 MD 20150121A2 MD A20150121 A MDA20150121 A MD A20150121A MD 20150121 A MD20150121 A MD 20150121A MD 20150121 A2 MD20150121 A2 MD 20150121A2
- Authority
- MD
- Moldova
- Prior art keywords
- compounds
- benzimidazole derivatives
- bromodomain inhibitors
- bromodomain
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Invenţia se referă la compuşi chimici care pot acţiona ca inhibitori sau care altfel pot modula activitatea proteinei conţinând bromodomeniu, inclusiv a proteinei conţinând bromodomeniul 4 (BRD4), precum şi la compoziţii şi formulări care conţin astfel de compuşi şi metode de obţinere şi utilizare a unor astfel de compuşi. Compuşii includ compuşi cu Formula (I)(I)în care R1a, R1b, R2a, R2b, R3, R4a, R4b şi R5 sunt descrişi în prezentul document.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361821612P | 2013-05-09 | 2013-05-09 | |
US201361826912P | 2013-05-23 | 2013-05-23 | |
US201361860229P | 2013-07-30 | 2013-07-30 | |
US201461951347P | 2014-03-11 | 2014-03-11 | |
PCT/US2014/037344 WO2014182929A1 (en) | 2013-05-09 | 2014-05-08 | Benzimidazole derivatives as bromodomain inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
MD20150121A2 true MD20150121A2 (ro) | 2016-05-31 |
MD4592B1 MD4592B1 (ro) | 2018-09-30 |
Family
ID=50897952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDA20150121A MD4592B1 (ro) | 2013-05-09 | 2014-05-08 | Derivaţi de benzimidazol ca inhibitori ai bromodomeniului |
Country Status (26)
Country | Link |
---|---|
US (4) | US9458145B2 (ro) |
EP (1) | EP2994469B1 (ro) |
JP (1) | JP6049942B2 (ro) |
KR (1) | KR101761049B1 (ro) |
CN (1) | CN105324379B (ro) |
AP (1) | AP2015008869A0 (ro) |
AR (1) | AR096246A1 (ro) |
AU (1) | AU2014262622B2 (ro) |
BR (1) | BR112015028017A2 (ro) |
CA (1) | CA2911408C (ro) |
CL (1) | CL2015003280A1 (ro) |
CR (1) | CR20150639A (ro) |
EA (1) | EA029091B1 (ro) |
ES (1) | ES2710120T3 (ro) |
HK (2) | HK1219278A1 (ro) |
MD (1) | MD4592B1 (ro) |
MX (1) | MX2015015478A (ro) |
NZ (1) | NZ713718A (ro) |
PE (1) | PE20160029A1 (ro) |
PH (1) | PH12015502534A1 (ro) |
PT (1) | PT2994469T (ro) |
SG (1) | SG11201509220XA (ro) |
TW (1) | TWI527811B (ro) |
UA (1) | UA112618C2 (ro) |
UY (1) | UY35559A (ro) |
WO (1) | WO2014182929A1 (ro) |
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JP6243003B2 (ja) | 2013-03-15 | 2017-12-06 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Betタンパク質阻害剤としての三環式複素環 |
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JP6599852B2 (ja) | 2013-06-21 | 2019-10-30 | ゼニス・エピジェネティクス・リミテッド | ブロモドメイン阻害剤としての新規の置換された二環式化合物 |
CA2917319A1 (en) | 2013-07-08 | 2015-01-15 | Incyte Holdings Corporation | Tricyclic heterocycles as bet protein inhibitors |
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US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
WO2015095492A1 (en) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
DK3674302T3 (da) | 2014-04-23 | 2023-04-03 | Incyte Holdings Corp | 1h-pyrrolo[2,3-c]pyridin-7(6h)-oner og pyrazolo[3,4-c]pyridin-7(6h)-oner som inhibitorer af bet-proteiner |
WO2016022312A1 (en) * | 2014-08-05 | 2016-02-11 | Bristol-Myers Squibb Company | Heterocyclic kinase inhibitors |
EP3194406B8 (en) | 2014-09-15 | 2021-03-31 | Incyte Corporation | Tricyclic heterocycles for use as bet protein inhibitors |
CA2966298A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
CA2966303A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
EP3230277B1 (en) | 2014-12-11 | 2019-09-18 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
WO2016097870A1 (en) * | 2014-12-17 | 2016-06-23 | Zenith Epigenetics Corp. | Substituted bicyclic compounds as bromodomain inhibitors |
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2014
- 2014-05-07 TW TW103116235A patent/TWI527811B/zh active
- 2014-05-08 NZ NZ713718A patent/NZ713718A/en not_active IP Right Cessation
- 2014-05-08 SG SG11201509220XA patent/SG11201509220XA/en unknown
- 2014-05-08 KR KR1020157034918A patent/KR101761049B1/ko active IP Right Grant
- 2014-05-08 MD MDA20150121A patent/MD4592B1/ro not_active IP Right Cessation
- 2014-05-08 MX MX2015015478A patent/MX2015015478A/es unknown
- 2014-05-08 JP JP2016513078A patent/JP6049942B2/ja active Active
- 2014-05-08 PT PT14729182T patent/PT2994469T/pt unknown
- 2014-05-08 US US14/273,147 patent/US9458145B2/en active Active
- 2014-05-08 AU AU2014262622A patent/AU2014262622B2/en active Active
- 2014-05-08 US US14/787,374 patent/US20160075695A1/en not_active Abandoned
- 2014-05-08 PE PE2015002375A patent/PE20160029A1/es not_active Application Discontinuation
- 2014-05-08 CN CN201480035623.0A patent/CN105324379B/zh active Active
- 2014-05-08 EA EA201591965A patent/EA029091B1/ru not_active IP Right Cessation
- 2014-05-08 CA CA2911408A patent/CA2911408C/en active Active
- 2014-05-08 ES ES14729182T patent/ES2710120T3/es active Active
- 2014-05-08 EP EP14729182.7A patent/EP2994469B1/en active Active
- 2014-05-08 WO PCT/US2014/037344 patent/WO2014182929A1/en active Application Filing
- 2014-05-08 BR BR112015028017A patent/BR112015028017A2/pt not_active Application Discontinuation
- 2014-05-08 AP AP2015008869A patent/AP2015008869A0/xx unknown
- 2014-05-09 AR ARP140101893A patent/AR096246A1/es unknown
- 2014-05-09 UY UY0001035559A patent/UY35559A/es not_active Application Discontinuation
- 2014-08-05 UA UAA201510960A patent/UA112618C2/uk unknown
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2015
- 2015-11-05 PH PH12015502534A patent/PH12015502534A1/en unknown
- 2015-11-09 CL CL2015003280A patent/CL2015003280A1/es unknown
- 2015-12-04 CR CR20150639A patent/CR20150639A/es unknown
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2016
- 2016-06-24 HK HK16107380.5A patent/HK1219278A1/zh not_active IP Right Cessation
- 2016-08-17 US US15/239,422 patent/US10017501B2/en active Active
- 2016-09-05 HK HK16110539.9A patent/HK1222646A1/zh unknown
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2018
- 2018-06-06 US US16/001,832 patent/US20180282316A1/en not_active Abandoned
Non-Patent Citations (2)
Title |
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