PT2718265E - Processo para a preparação de ácidos, ésteres e amidas [(3-hidroxipiridino-2-carbonil)amino]alcanóicos - Google Patents

Processo para a preparação de ácidos, ésteres e amidas [(3-hidroxipiridino-2-carbonil)amino]alcanóicos Download PDF

Info

Publication number
PT2718265E
PT2718265E PT127963742T PT12796374T PT2718265E PT 2718265 E PT2718265 E PT 2718265E PT 127963742 T PT127963742 T PT 127963742T PT 12796374 T PT12796374 T PT 12796374T PT 2718265 E PT2718265 E PT 2718265E
Authority
PT
Portugal
Prior art keywords
hydroxypyridine
amides
carbonyl
esters
amino
Prior art date
Application number
PT127963742T
Other languages
English (en)
Portuguese (pt)
Inventor
Christopher M Lanthier
Boris Gorin
Jan Oudenes
Craig Edward Dixon
Alan Quigbo Lu
James Densmore Copp
John Michael Janusz
Original Assignee
Akebia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akebia Therapeutics Inc filed Critical Akebia Therapeutics Inc
Publication of PT2718265E publication Critical patent/PT2718265E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
PT127963742T 2011-06-06 2012-06-05 Processo para a preparação de ácidos, ésteres e amidas [(3-hidroxipiridino-2-carbonil)amino]alcanóicos PT2718265E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161493536P 2011-06-06 2011-06-06

Publications (1)

Publication Number Publication Date
PT2718265E true PT2718265E (pt) 2016-02-15

Family

ID=47262177

Family Applications (4)

Application Number Title Priority Date Filing Date
PT127963742T PT2718265E (pt) 2011-06-06 2012-06-05 Processo para a preparação de ácidos, ésteres e amidas [(3-hidroxipiridino-2-carbonil)amino]alcanóicos
PT171913627T PT3290404T (pt) 2011-06-06 2012-06-05 Derivados de 5-((halogenofenil)-3-halogeno-piridin-2-il)-nitrilo como intermediários na preparação de derivados de ácido [(5-(halogenofenil)-3-hidroxipiridin-2-carbonil)-amino]alcanóico
PT151898228T PT3000808T (pt) 2011-06-06 2012-06-05 Derivados de ácido 3-hidroxipiridino-2-il-carbonilamino]alcanóico 5-arilo ou 5-heteroarilo substituído, e seus sais bem como sua preparação a partir dos respectivos derivados de ácido 3-hidroxi-picolínico
PT192144053T PT3683209T (pt) 2011-06-06 2012-06-05 Processo para preparar ácido [(5-(3-clorofenil)-3-hidroxipiridina-2-carbonil)-amino]acético a partir de 5-((3-clorofenil)-3-cloro-piridin-2-il)-nitrilo e processo para preparar derivados 5-((halogenofenil)-3-halogenopiridin-2-il)-nitrilo

Family Applications After (3)

Application Number Title Priority Date Filing Date
PT171913627T PT3290404T (pt) 2011-06-06 2012-06-05 Derivados de 5-((halogenofenil)-3-halogeno-piridin-2-il)-nitrilo como intermediários na preparação de derivados de ácido [(5-(halogenofenil)-3-hidroxipiridin-2-carbonil)-amino]alcanóico
PT151898228T PT3000808T (pt) 2011-06-06 2012-06-05 Derivados de ácido 3-hidroxipiridino-2-il-carbonilamino]alcanóico 5-arilo ou 5-heteroarilo substituído, e seus sais bem como sua preparação a partir dos respectivos derivados de ácido 3-hidroxi-picolínico
PT192144053T PT3683209T (pt) 2011-06-06 2012-06-05 Processo para preparar ácido [(5-(3-clorofenil)-3-hidroxipiridina-2-carbonil)-amino]acético a partir de 5-((3-clorofenil)-3-cloro-piridin-2-il)-nitrilo e processo para preparar derivados 5-((halogenofenil)-3-halogenopiridin-2-il)-nitrilo

Country Status (24)

Country Link
US (6) US9145366B2 (da)
EP (5) EP3290404B1 (da)
JP (6) JP6290781B2 (da)
KR (5) KR102000485B1 (da)
CN (1) CN106518759B (da)
AU (4) AU2012268426B2 (da)
CA (2) CA3135440A1 (da)
CY (4) CY1117177T1 (da)
DK (4) DK3290404T3 (da)
ES (4) ES2647602T3 (da)
HK (3) HK1196616A1 (da)
HR (4) HRP20211916T1 (da)
HU (4) HUE034975T2 (da)
IL (1) IL229775A (da)
LT (3) LT3290404T (da)
MX (2) MX347709B (da)
NO (1) NO2686520T3 (da)
PL (4) PL2718265T3 (da)
PT (4) PT2718265E (da)
RS (3) RS54517B1 (da)
RU (2) RU2764667C2 (da)
SI (4) SI3683209T1 (da)
SM (1) SMT201600013B (da)
WO (1) WO2012170377A1 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602007009992D1 (de) 2006-06-26 2010-12-02 Warner Chilcott Co Llc Prolylhydroxylase-hemmer und verfahren zu ihrer anwendung
NO2686520T3 (da) 2011-06-06 2018-03-17
PE20160194A1 (es) * 2013-06-13 2016-04-20 Akebia Therapeutics Inc Composiciones y metodos para tratar anemia
CR20160222U (es) * 2013-11-15 2016-08-26 Akebia Therapeutics Inc Formas solidas de acido { [ -(3- clorofenil) -3- hidroxipiridin -2-carbonil] amino} acetico, composiciones, y usos de las mismas
ES2898476T3 (es) 2014-09-02 2022-03-07 Sunshine Lake Pharma Co Ltd Compuesto de quinolona y uso del mismo
TW201632504A (zh) 2015-01-23 2016-09-16 阿克比治療有限公司 ２－（５－（３－氟苯基）－３－羥吡啶醯胺基）乙酸之固體形式、其組合物及其用途
EP3270922A4 (en) * 2015-03-20 2018-08-01 Akebia Therapeutics Inc. Deuterium-enriched hypoxia-inducible factor prolyl hydroxylase enzyme inhibitors
CN106146395B (zh) * 2015-03-27 2019-01-01 沈阳三生制药有限责任公司 3-羟基吡啶化合物、其制备方法及其制药用途
EA036920B1 (ru) 2015-04-01 2021-01-15 Экебиа Терапьютикс, Инк. Композиции и способы для лечения анемии
MX2019006883A (es) * 2016-12-13 2019-10-21 Crystal Pharmaceutical Suzhou Co Ltd Formas cristalinas novedosas de ácido {[5-(3-clorofenil)-3-idroxip iridina-2-carbonilo] amino} acético y procedimientos para la preparación del mismo.
JP6974496B2 (ja) * 2017-03-29 2021-12-01 エメラルド ヘルス ファーマシューティカルズ，インコーポレイティド Ｈｉｆプロリルヒドロキシラーゼ活性の阻害剤としてのカンナビジオール誘導体
WO2019028150A1 (en) 2017-08-01 2019-02-07 Akebia Therapeutics, Inc. COMPOSITIONS FOR USE IN METHODS OF TREATING HEMOGLOBINOPATHIES
TWI822776B (zh) * 2018-05-09 2023-11-21 美商阿克比治療有限公司 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法
WO2020075199A1 (en) 2018-10-12 2020-04-16 Mylan Laboratories Limited Polymorphic forms of vadadustat
WO2020108941A1 (en) 2018-11-28 2020-06-04 Sandoz Ag Multi-component crystals of an orally available hif prolyl hydroxylase inhibitor
CN113767089B (zh) 2019-04-26 2024-06-11 株式会社钟化 伐度司他中间体的制造方法
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
CN111087343B (zh) * 2019-11-29 2022-02-18 万华化学集团股份有限公司 一种羟基吡啶配体及其制备方法和催化应用
US20230159462A1 (en) * 2019-12-10 2023-05-25 Akebia Therapeutics, Inc. Method for producing nitrogen-containing heteroarylcarboxamide acetic acid derivative
CN115023288A (zh) 2020-01-24 2022-09-06 先技精工(日本)有限公司 光催化组件和包括该光催化组件的口罩
US20230286918A1 (en) * 2020-07-02 2023-09-14 Akebia Therapeutics, Inc. Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
GB202011431D0 (en) * 2020-07-23 2020-09-09 Johnson Matthey Plc Polymorphs of vadadustat and methods for preparing the polymorphs
EP4447963A1 (en) 2021-12-17 2024-10-23 Akebia Therapeutics Inc. Selective phd1 inhibitor compounds, compositions, and methods of use
WO2024165507A1 (en) 2023-02-06 2024-08-15 Institut National de la Santé et de la Recherche Médicale Use of hif-1α stabilizing agents for the treatment of type i interferonopathies

Family Cites Families (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655679A (en) * 1969-06-25 1972-04-11 Merck & Co Inc Certain aryl pyridine carboxylic acid derivatives
US3703582A (en) * 1970-04-20 1972-11-21 Merck & Co Inc Aryl pyridine carboxylic acids in the treatment of inflammation
US3894920A (en) 1971-12-21 1975-07-15 Sagami Chem Res Process for preparing alkyl-substituted 3,6-dihydro-o-dioxin derivatives
US4016287A (en) 1972-07-17 1977-04-05 Boehringer Ingelheim Gmbh Dermatological compositions containing an acylamino-carboxylic acid or an alkyl ester thereof
TW219933B (da) 1990-02-26 1994-02-01 Lilly Co Eli
US5405613A (en) 1991-12-11 1995-04-11 Creative Nutrition Canada Corp. Vitamin/mineral composition
TW352384B (en) 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
DE4219158A1 (de) 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
ES2101421T3 (es) 1993-11-02 1997-07-01 Hoechst Ag Amidas de acidos carboxilicos heterociclicos sustituidos, su preparacion y su utilizacion como medicamentos.
ATE149485T1 (de) 1993-11-02 1997-03-15 Hoechst Ag Substituierte heterocyclische carbonsäureamidester, ihre herstellung und ihre verwendung als arzneimittel
TW406076B (en) 1993-12-30 2000-09-21 Hoechst Ag Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals
DE4410480A1 (de) 1994-03-25 1995-09-28 Hoechst Ag Sulfonamidocarbonylpyridin-2-carbonsäureesteramide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE4410423A1 (de) 1994-03-25 1995-09-28 Hoechst Ag Sulfonamidocarbonylpyridin-2-carbonsäureamide sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5789426A (en) 1995-01-20 1998-08-04 Cornell Research Foundation, Inc. Method for the treatment of fibroproliferative disorders by application of inhibitors of protein hydroxylation
IL135495A (en) 1995-09-28 2002-12-01 Hoechst Ag Intermediate compounds for the preparation of quinoline-converted amines - 2 - carboxylic acid
JPH09221476A (ja) 1995-12-15 1997-08-26 Otsuka Pharmaceut Co Ltd 医薬組成物
JP2000509047A (ja) 1996-04-30 2000-07-18 ヘキスト・アクチエンゲゼルシヤフト ３―アルコキシピリジン―２―カルボキサミドエステル類、その製法および薬剤としてのその使用
DE19620041A1 (de) 1996-05-17 1998-01-29 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
DE19650215A1 (de) 1996-12-04 1998-06-10 Hoechst Ag 3-Hydroxypyridin-2-carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
US6420427B1 (en) 1997-10-09 2002-07-16 Ono Pharmaceutical Co., Ltd. Aminobutyric acid derivatives
DE19746287A1 (de) 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1080075B1 (en) 1998-03-23 2004-08-11 Aventis Pharmaceuticals Inc. Piperididinyl and n-amidinopiperidinyl derivatives
US6159379A (en) 1999-05-04 2000-12-12 Baker Hughes Incorporated Organic ammonium salts for the removal of water soluble organics in produced water
JP2001048786A (ja) 1999-08-05 2001-02-20 Yamanouchi Pharmaceut Co Ltd 三環式ヘテロアリール誘導体
US6589758B1 (en) 2000-05-19 2003-07-08 Amgen Inc. Crystal of a kinase-ligand complex and methods of use
US6849718B2 (en) 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
US6855510B2 (en) 2001-03-20 2005-02-15 Dana Farber Cancer Institute, Inc. Pharmaceuticals and methods for treating hypoxia and screening methods therefor
AU2002241154A1 (en) 2001-03-21 2002-10-03 Isis Innovation Ltd. Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase
SE0101327D0 (sv) 2001-04-12 2001-04-12 Astrazeneca Ab New crystalline forms
US6566088B1 (en) 2001-10-04 2003-05-20 Board Of Regents, The University Of Texas System Prolyl-4-hydroxylases
GB0124941D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
CA2916093C (en) 2001-12-06 2020-11-03 Fibrogen, Inc. Use of hif prolyl hydroxylase inhibitors for treating neurological disorders
EP1556033A4 (en) 2002-05-17 2006-05-31 Celgene Corp METHODS AND COMPOSITIONS USING CYTOKINE INHIBITOR SELECTIVE MEDICAMENTS FOR THE TREATMENT AND MANAGEMENT OF CANCERS AND OTHER DISEASES
IL166426A0 (en) * 2002-08-29 2006-01-15 Merck & Co Inc N-biarylmethyl aminocycloalkanecarboxamide derivatives
AU2003274330B2 (en) 2002-10-16 2009-06-04 Isis Innovation Limited Asparaginyl hydroxylases and modulators thereof
CA2506799A1 (en) 2002-11-21 2004-06-10 Eli Lilly And Company Mixed lineage kinase modulators
US8124582B2 (en) 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US7618940B2 (en) 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US7183287B2 (en) 2003-04-03 2007-02-27 Pharmacia Corporation Substituted pyrimidinones
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
CN102977016B (zh) 2003-06-06 2015-01-14 菲布罗根有限公司 含氮杂芳基化合物及其在增加内源性促红细胞生成素中的用途
US20060251638A1 (en) 2003-06-06 2006-11-09 Volkmar Guenzler-Pukall Cytoprotection through the use of hif hydroxylase inhibitors
GB0314129D0 (en) 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
WO2005108370A1 (ja) 2004-04-16 2005-11-17 Ajinomoto Co., Inc. ベンゼン化合物
DE602005016800D1 (de) 2004-05-28 2009-11-05 Fibrogen Inc Hif-prolylhydroxylase-aktivitätstest
US20070185116A1 (en) 2004-05-31 2007-08-09 Tanabe Seiyaku Co., Ltd. Bicyclic compounds
WO2006019831A1 (en) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
TW200616969A (en) 2004-09-17 2006-06-01 Tanabe Seiyaku Co Imidazole compound
WO2006084210A2 (en) 2005-02-04 2006-08-10 Regents Of The University Of California, San Diego Hif modulating compounds and methods of use thereof
DE102005019712A1 (de) 2005-04-28 2006-11-09 Bayer Healthcare Ag Dipyridyl-dihydropyrazolone und ihre Verwendung
CN101394843A (zh) 2005-06-06 2009-03-25 菲布罗根公司 使用HIFα稳定剂的改进的贫血治疗
CN101242817B (zh) 2005-06-15 2016-08-31 菲布罗根公司 HIF1α调节剂在治疗癌症中的用途
WO2007033216A2 (en) 2005-09-12 2007-03-22 Beth Israel Deaconess Medical Center Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
WO2007038571A2 (en) 2005-09-26 2007-04-05 Smithkline Beecham Corporation Prolyl hydroxylase antagonists
WO2007047194A2 (en) 2005-10-11 2007-04-26 Dana-Farber Cancer Institute, Inc. Methods for treating mitf-related disorders
ES2446416T3 (es) 2005-12-09 2014-03-07 Amgen, Inc. Compuestos basados en quinolona que presentan actividad inhibidora de prolil hidroxilasa, composiciones y usos de los mismos
BRPI0706377A2 (pt) 2006-01-09 2011-03-22 Btg Int Ltd moduladores de fator -1 induzìvel por hipoxia e usos relacionados
WO2007082899A1 (en) 2006-01-17 2007-07-26 Vib Vzw Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration
JP4801451B2 (ja) 2006-01-19 2011-10-26 株式会社日立ハイテクノロジーズ 走査電子顕微鏡等に用いる電子銃の制御装置及び制御方法
JP2009523812A (ja) 2006-01-19 2009-06-25 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 融合へテロ二環式キナーゼ阻害剤
ITMI20060179A1 (it) 2006-02-02 2007-08-03 Abiogen Pharma Spa Procedimento per la risoluzione di miscele racemiche e complesso diastereoisomerico di un agente risolvente e di unantiomero di interesse
US7625927B2 (en) 2006-02-27 2009-12-01 Alcon Research, Ltd. Method of treating glaucoma
AR059733A1 (es) 2006-03-07 2008-04-23 Smithkline Beecham Corp Compuesto derivado de glicina n- sustituida con heteroaromaticos bicicicos, composicion farmaceutica que lo comprende, uso para preparar un medicamento para tratar la anemia y proceso para su preparacion
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
WO2007136990A2 (en) 2006-05-16 2007-11-29 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
PE20080209A1 (es) 2006-06-23 2008-05-15 Smithkline Beecham Corp Derivados de glicina como inhibidores de prolil hidroxilasa
DE602007009992D1 (de) 2006-06-26 2010-12-02 Warner Chilcott Co Llc Prolylhydroxylase-hemmer und verfahren zu ihrer anwendung
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
CL2008000065A1 (es) 2007-01-12 2008-09-22 Smithkline Beecham Corp Compuestos derivados de glicina n-sustituida, inhibidores de hif prolil hidroxilasas; su proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anemia.
JP2010524935A (ja) 2007-04-18 2010-07-22 メルク・シャープ・エンド・ドーム・コーポレイション 新規１，８−ナフチリジン化合物
CA2683738C (en) 2007-04-18 2012-03-20 Amgen Inc. Indanone derivatives that inhibit prolyl hydroxylase
CA2685216C (en) 2007-05-04 2014-07-08 Amgen Inc. Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity
US8309544B2 (en) 2007-05-16 2012-11-13 Merck Sharp & Dohme Corp. Spiroindalones
CN101765596B (zh) 2007-05-18 2015-04-29 拜耳知识产权有限责任公司 用于治疗过增生症状和与血管生成有关疾病的缺氧诱导因子(hif)抑制剂
US8268794B2 (en) 2007-08-06 2012-09-18 Senju Pharmaceutical Co., Ltd. Pharmaceutical containing HIF-1 alpha and HIF-2 alpha expression inhibitor
TW200908984A (en) 2007-08-07 2009-03-01 Piramal Life Sciences Ltd Pyridyl derivatives, their preparation and use
EP2188295A4 (en) 2007-08-10 2011-11-16 Crystalgenomics Inc PYRIDINE DERIVATIVES AND METHODS OF USE
WO2009035534A2 (en) 2007-09-07 2009-03-19 The Cleveland Clinic Foundation Treatment of ischemic eye disease by the systematic pharmaceutical activation of hypoxia inducible factor (hif)
WO2009039321A1 (en) 2007-09-19 2009-03-26 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009039323A1 (en) 2007-09-19 2009-03-26 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009043093A1 (en) 2007-10-04 2009-04-09 Newsouth Innovations Pty Limited Hif inhibition
WO2009049112A1 (en) 2007-10-10 2009-04-16 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009067790A1 (en) 2007-11-26 2009-06-04 Uti Limited Partnership STIMULATION OF HYPOXIA INDUCIBLE FACTOR -1 ALPHA (HIF-1α) FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE (CDAD), FOR INTESTINAL MOTILITY AND FOR DETECTING INFECTION
WO2009070644A1 (en) 2007-11-30 2009-06-04 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
NZ585701A (en) 2007-11-30 2012-09-28 Glaxosmithkline Llc Benzopyrazine derivatives as prolyl hydroxylase inhibitors
WO2009073669A1 (en) 2007-12-03 2009-06-11 Fibrogen, Inc. Isoxazolopyridine derivatives for use in the treatment of hif-mediated conditions
EP2240178A4 (en) 2007-12-19 2011-10-26 Glaxosmithkline Llc PROLYLHYDROXYLASEHEMMER
WO2009086592A1 (en) 2008-01-04 2009-07-16 Garvan Institute Of Medical Research Method of increasing metabolism
US8952160B2 (en) 2008-01-11 2015-02-10 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity
JP5380465B2 (ja) * 2008-03-03 2014-01-08 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｔｌｒ活性モジュレーターとしての化合物および組成物
US20090228298A1 (en) * 2008-03-04 2009-09-10 The General Electric Company System and method of morphology feature analysis of physiological data
EP2268143A4 (en) * 2008-03-20 2012-06-27 Forest Lab Holdings Ltd NEW PIPERIDINE DERIVATIVES AS INHIBITORS OF THE STEAROYL COA DESATURASE
AR071997A1 (es) 2008-06-04 2010-07-28 Bristol Myers Squibb Co Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
CN102099335A (zh) 2008-07-23 2011-06-15 弗·哈夫曼-拉罗切有限公司 杂环抗病毒化合物
CN102149703B (zh) 2008-09-15 2014-09-10 卡斯娜莱拉伊诺制药私人有限公司 抗癌药物及将其用于治疗转移性恶性黑色素瘤及其他癌症
NZ592741A (en) 2008-11-14 2013-03-28 Fibrogen Inc Thiochromene derivatives as hif hydroxylase inhibitors
PT2415771E (pt) * 2009-03-31 2013-10-03 Kissei Pharmaceutical Derivado de indolizina e sua utilização para fins médicos
ES2533128T3 (es) 2009-11-06 2015-04-07 Aerpio Therapeutics Inc. Inhibidores de la prolilhidroxilasa
NO2686520T3 (da) * 2011-06-06 2018-03-17
EP2717870B1 (en) 2011-06-06 2017-09-27 Akebia Therapeutics Inc. Composition for stabilizing hypoxia inducible factor-2 alpha useful for treating cancer
WO2012174256A2 (en) 2011-06-17 2012-12-20 The Regents Of The University Of Michigan Dna methylation profiles in cancer
CN104024227B (zh) 2011-07-22 2015-12-02 北京贝美拓新药研发有限公司 抑制脯氨酸羟化酶活性的化合物的晶型及其应用
JP2016519684A (ja) 2013-04-08 2016-07-07 デニス エム ブラウン 準最適に投与された薬物療法の有効性を改善するための及び／又は副作用を低減するための方法および組成物
PE20160194A1 (es) 2013-06-13 2016-04-20 Akebia Therapeutics Inc Composiciones y metodos para tratar anemia
CN105979779A (zh) 2013-08-16 2016-09-28 俄亥俄州国家创新基金会 调整dna甲基化的组合物和方法
CR20160222U (es) 2013-11-15 2016-08-26 Akebia Therapeutics Inc Formas solidas de acido { [ -(3- clorofenil) -3- hidroxipiridin -2-carbonil] amino} acetico, composiciones, y usos de las mismas
RU2016133980A (ru) 2014-01-23 2018-03-01 Экебиа Терапьютикс, Инк. Композиции и способы для лечения заболеваний глаз
TW201632504A (zh) 2015-01-23 2016-09-16 阿克比治療有限公司 ２－（５－（３－氟苯基）－３－羥吡啶醯胺基）乙酸之固體形式、其組合物及其用途
EP3270922A4 (en) 2015-03-20 2018-08-01 Akebia Therapeutics Inc. Deuterium-enriched hypoxia-inducible factor prolyl hydroxylase enzyme inhibitors
EA036920B1 (ru) 2015-04-01 2021-01-15 Экебиа Терапьютикс, Инк. Композиции и способы для лечения анемии
TWI822776B (zh) 2018-05-09 2023-11-21 美商阿克比治療有限公司 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法

Also Published As

Publication number Publication date
HUE057571T2 (hu) 2022-05-28
SI3683209T1 (sl) 2022-03-31
KR20190032617A (ko) 2019-03-27
EP3000808A1 (en) 2016-03-30
EP4026829A1 (en) 2022-07-13
SI3290404T1 (sl) 2020-03-31
AU2012268426A1 (en) 2014-01-09
HUE048044T2 (hu) 2020-05-28
KR102293016B1 (ko) 2021-08-26
CY1117177T1 (el) 2017-04-05
IL229775A (en) 2016-06-30
ES2647602T3 (es) 2017-12-22
JP6290781B2 (ja) 2018-03-07
KR20140037192A (ko) 2014-03-26
EP2718265A4 (en) 2014-11-19
JP2023103414A (ja) 2023-07-26
RU2016139352A (ru) 2018-12-13
EP2718265A1 (en) 2014-04-16
DK3683209T3 (da) 2021-12-06
JP7284309B2 (ja) 2023-05-30
KR20190031593A (ko) 2019-03-26
KR102000485B1 (ko) 2019-07-16
KR20200121911A (ko) 2020-10-26
ES2771232T3 (es) 2020-07-06
EP3000808B1 (en) 2017-09-27
JP6816195B2 (ja) 2021-01-20
EP3683209B1 (en) 2021-11-10
DK2718265T3 (da) 2016-01-25
SMT201600013B (it) 2016-02-25
AU2020204528B2 (en) 2022-07-14
LT3000808T (lt) 2018-01-25
EP2718265B1 (en) 2015-12-16
DK3290404T3 (da) 2020-02-17
US9145366B2 (en) 2015-09-29
JP2019123741A (ja) 2019-07-25
PL3683209T3 (pl) 2022-02-21
JP2018111697A (ja) 2018-07-19
RS56580B1 (sr) 2018-02-28
US20120309977A1 (en) 2012-12-06
US10738010B2 (en) 2020-08-11
HRP20200197T1 (hr) 2020-05-15
MX337216B (es) 2016-02-18
HUE026096T2 (en) 2016-05-30
HRP20211916T1 (hr) 2022-03-18
PL3290404T3 (pl) 2020-06-01
US20210122715A1 (en) 2021-04-29
CN106518759B (zh) 2019-07-30
SI2718265T1 (sl) 2016-03-31
US20190375713A1 (en) 2019-12-12
CY1122639T1 (el) 2021-03-12
KR102059366B1 (ko) 2019-12-26
HRP20151416T1 (hr) 2016-03-25
SI3000808T1 (en) 2018-02-28
AU2017202414B2 (en) 2018-07-19
HUE034975T2 (en) 2018-05-02
RU2016139352A3 (da) 2020-01-27
NO2686520T3 (da) 2018-03-17
CN103717575A (zh) 2014-04-09
RU2602083C2 (ru) 2016-11-10
CA3135440A1 (en) 2012-12-13
MX347709B (es) 2017-05-10
AU2012268426B2 (en) 2017-02-16
JP2022081597A (ja) 2022-05-31
RS54517B1 (en) 2016-06-30
CA2838194A1 (en) 2012-12-13
MX2013014228A (es) 2014-03-26
NZ618570A (en) 2015-07-31
PL3000808T3 (pl) 2018-03-30
RU2013158640A (ru) 2015-07-20
JP2014522409A (ja) 2014-09-04
JP2021059573A (ja) 2021-04-15
KR102171315B1 (ko) 2020-10-28
HK1252109A1 (zh) 2019-05-17
RU2764667C2 (ru) 2022-01-19
CA2838194C (en) 2022-01-11
AU2018250355A1 (en) 2018-11-08
AU2017202414A1 (en) 2017-05-04
EP3290404A1 (en) 2018-03-07
WO2012170377A1 (en) 2012-12-13
US20150361043A1 (en) 2015-12-17
JP7039682B2 (ja) 2022-03-22
US11267785B2 (en) 2022-03-08
US20230002323A1 (en) 2023-01-05
RS59902B1 (sr) 2020-03-31
HK1196616A1 (zh) 2014-12-19
AU2020204528A1 (en) 2020-07-30
LT3683209T (lt) 2022-01-10
PT3000808T (pt) 2017-11-23
HRP20171740T1 (hr) 2018-03-09
DK3000808T3 (da) 2017-11-27
ES2900572T3 (es) 2022-03-17
CY1119605T1 (el) 2018-04-04
PT3683209T (pt) 2021-12-15
LT3290404T (lt) 2020-02-25
US10246416B2 (en) 2019-04-02
EP3683209A1 (en) 2020-07-22
ES2559850T3 (es) 2016-02-16
EP3290404B1 (en) 2019-12-11
PT3290404T (pt) 2020-02-19
US20170362178A1 (en) 2017-12-21
PL2718265T3 (pl) 2016-04-29
HK1216173A1 (zh) 2016-10-21
KR20190141805A (ko) 2019-12-24
US9776969B2 (en) 2017-10-03
CN106518759A (zh) 2017-03-22
CY1124874T1 (el) 2022-11-25
KR102032864B1 (ko) 2019-10-16
AU2018250355B2 (en) 2020-04-09
JP6510094B2 (ja) 2019-05-08

Similar Documents

Publication Publication Date Title
HK1196616A1 (zh) 用於製備 -羥基吡啶- -羰基 氨基 鏈烷酸、酯和醯胺的方法
IL249227A0 (en) Process for preparing 4)-n-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetamidic acid ethyl ester
PL2584912T3 (pl) Wodny sposób wytwarzania izolatu białkowego i zhydrolizowanego białka z nasion oleistych
PL2566842T3 (pl) Sposób wytwarzania nasyconych amino-kwasów lub nasyconych amino-estrów obejmujący etap metatezy
HUE041867T2 (hu) Eljárás zsírsavak elõállítására és tisztítására
PL2665826T3 (pl) Sposób fermentacyjnego wytwarzania aminokwasów zawierających siarkę
ZA201108291B (en) Protein product and process for preparing injectable protein product
EP2804488A4 (en) METHOD OF INSTANCING AMINO ACIDS
ZA201108290B (en) Protein product and process for making injectable protein product
ZA201201237B (en) Process for preparing decanecarboxylic acids
PL2625262T3 (pl) Sposób wytwarzania białka
PT2808330T (pt) Complexos de germânio com aminoácdos e ácidos carboxílicos e método para preparar os mesmos
IL231645A0 (en) Process for the preparation of isoxazolyl-methoxy-nicotinic acids
PL2569272T3 (pl) Sposób wytwarzania dwukwasów karboksylowych
EP2757089A4 (en) PROCESS FOR PRODUCING AMINO ACID
PT2417859E (pt) Produto de concentrados proteicos e métodos para a sua produção
EP2497765A4 (de) Verfahren zur herstellung von kreatinamiden
LT2673282T (lt) Drono rūgščių naujas gavimo būdas
GB201111641D0 (en) A process for producing amides and acids using a nitrile-metabolising enzyme
GB201111639D0 (en) A process for producing amides and acids using a nitrile-metabolising enzyme
PL2794552T3 (pl) SPOSÓB WYTWARZANIA RACEMICZNYCH α-AMINOKWASÓW
IL229602A0 (en) Method for the production of fluoromethyl esters of androstene-17-beta carboxylic acids
IL231776A0 (en) Process and intermediates for the preparation of modified arylthiazole-2 carboxylic acids
HUP1100546A2 (en) Feed block and process for its production