PT2635583E - Derivados da coelenterazina e métodos de utilização da mesma - Google Patents
Derivados da coelenterazina e métodos de utilização da mesma Download PDFInfo
- Publication number
- PT2635583E PT2635583E PT117852178T PT11785217T PT2635583E PT 2635583 E PT2635583 E PT 2635583E PT 117852178 T PT117852178 T PT 117852178T PT 11785217 T PT11785217 T PT 11785217T PT 2635583 E PT2635583 E PT 2635583E
- Authority
- PT
- Portugal
- Prior art keywords
- methods
- same
- coelenterazine derivatives
- coelenterazine
- derivatives
- Prior art date
Links
- YHIPILPTUVMWQT-UHFFFAOYSA-N Oplophorus luciferin Chemical class C1=CC(O)=CC=C1CC(C(N1C=C(N2)C=3C=CC(O)=CC=3)=O)=NC1=C2CC1=CC=CC=C1 YHIPILPTUVMWQT-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40941310P | 2010-11-02 | 2010-11-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2635583E true PT2635583E (pt) | 2015-09-11 |
Family
ID=44999921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT117852178T PT2635583E (pt) | 2010-11-02 | 2011-11-02 | Derivados da coelenterazina e métodos de utilização da mesma |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9487520B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2635583B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6040157B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101968475B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103180324A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011323455B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013010484B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2815381C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2635583T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2543913T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL225869A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2635583T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2635583E (cg-RX-API-DMAC7.html) |
| SG (1) | SG189494A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012061477A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG189494A1 (en) | 2010-11-02 | 2013-05-31 | Promega Corp | Coelenterazine derivatives and methods of using same |
| EP3498709B1 (en) | 2010-11-02 | 2025-12-31 | Promega Corporation | Luciferases from Oplophorus: Novel Coelenterazine Substrates and Their Methods of Use |
| JP6067019B2 (ja) | 2011-09-02 | 2017-01-25 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 代謝的に活性な細胞の酸化還元状態を評価するための化合物及び方法、ならびにｎａｄ（ｐ）／ｎａｄ（ｐ）ｈを測定するための方法 |
| EP2900833B1 (en) | 2012-09-26 | 2018-05-30 | Promega Corporation | Real-time monitoring |
| US20140271460A1 (en) | 2013-03-15 | 2014-09-18 | G1 Therapeutics, Inc. | Highly Active Anti-Neoplastic and Anti-Proliferative Agents |
| ES2761406T3 (es) | 2013-03-15 | 2020-05-19 | G1 Therapeutics Inc | Protección transitoria de células normales durante una quimioterapia |
| JP6270127B2 (ja) * | 2014-01-17 | 2018-01-31 | 国立研究開発法人物質・材料研究機構 | ニコチンアデニンジヌクレオチド誘導体を検出する方法 |
| WO2015116867A1 (en) * | 2014-01-29 | 2015-08-06 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
| WO2015116806A1 (en) * | 2014-01-29 | 2015-08-06 | Promega Corporation | Pro-substrates for live cell applications |
| WO2016210294A1 (en) | 2015-06-25 | 2016-12-29 | Promega Corporation | Thienopyrrole compounds and uses thereof as inhibitors of oplophorus-derived luciferases |
| WO2017142852A1 (en) | 2016-02-15 | 2017-08-24 | Promega Corporation | Coelenterazine analogues |
| WO2018022865A1 (en) | 2016-07-28 | 2018-02-01 | Promega Corporation | Coelenterazine analogues |
| EP3510035B1 (en) * | 2016-09-09 | 2021-04-07 | Promega Corporation | Dual protected pro-coelenterazine substrates |
| EP3535270B3 (en) | 2016-11-01 | 2024-05-29 | Promega Corporation | Coelenterazine analogues tethered to energy acceptors |
| WO2018102693A1 (en) | 2016-12-01 | 2018-06-07 | Promega Corporation | Cell impermeable coelenterazine analogues |
| JP7161475B2 (ja) | 2016-12-28 | 2022-10-26 | プロメガ コーポレイション | 官能化ｎａｎｏｌｕｃ阻害剤 |
| EP3395803A1 (en) * | 2017-04-28 | 2018-10-31 | Institut Pasteur | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| JP7419260B2 (ja) | 2018-05-01 | 2024-01-22 | プロメガ コーポレイション | ＮａｎｏＬｕｃ自殺基質としてのセレンテラジン化合物 |
| EP4140991B1 (en) | 2018-06-01 | 2024-05-15 | Promega Corporation | Inhibitors of oplophorus luciferase-derived bioluminescent complexes |
| KR102114088B1 (ko) * | 2018-09-10 | 2020-06-17 | (주)신우에이엔티 | 웨이퍼 세정용 나노 버블 분사 구조 |
| CA3114424A1 (en) | 2018-10-03 | 2020-04-09 | Promega Corporation | Compositions and methods for stabilizing coelenterazine and analogs and derivatives thereof |
| WO2021108765A1 (en) | 2019-11-27 | 2021-06-03 | Promega Corporation | Multipartite luciferase peptides and polypeptides |
| US12061202B2 (en) | 2019-12-10 | 2024-08-13 | Promega Corporation | Compositions and methods for bioluminescent detection using multifunctional probes |
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| DE3477549D1 (en) | 1983-08-17 | 1989-05-11 | Allied Signal Inc | Gas generator and method of generating gas |
| JP3012274B2 (ja) * | 1989-03-22 | 2000-02-21 | 日本臓器製薬株式会社 | 新規ルシフェリン誘導体 |
| US5683888A (en) | 1989-07-22 | 1997-11-04 | University Of Wales College Of Medicine | Modified bioluminescent proteins and their use |
| US5368484A (en) | 1992-05-22 | 1994-11-29 | Atari Games Corp. | Vehicle simulator with realistic operating feedback |
| CA2157476C (en) | 1994-01-03 | 2009-08-25 | Keith V. Wood | Mutant luciferases |
| US6387675B1 (en) | 1994-01-03 | 2002-05-14 | Promega Corporation | Mutant luciferases |
| GB9501170D0 (en) | 1994-03-23 | 1995-03-08 | Secr Defence | Luciferases |
| JP3648763B2 (ja) * | 1994-08-23 | 2005-05-18 | 日本油脂株式会社 | ウミホタルルシフェリン誘導体および糖加水分解酵素の定量方法 |
| GB9417593D0 (en) | 1994-09-01 | 1994-10-19 | Secr Defence | Luciferase labelling method |
| US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
| WO1996022376A1 (en) | 1995-01-20 | 1996-07-25 | The Secretary Of State For Defence | Mutant luciferases |
| JPH08294397A (ja) | 1995-04-27 | 1996-11-12 | Nippon Oil & Fats Co Ltd | 免疫学的活性物質の測定方法 |
| US6522361B2 (en) | 1996-03-08 | 2003-02-18 | Sony Corporation | Electronic apparatus having the function of displaying the battery residual quantity and method for displaying the battery residual quantity |
| JP4026876B2 (ja) * | 1996-09-05 | 2007-12-26 | 日本食品化工株式会社 | 発光性シクロデキストリン誘導体及びその製造方法 |
| US5998204A (en) | 1997-03-14 | 1999-12-07 | The Regents Of The University Of California | Fluorescent protein sensors for detection of analytes |
| GB9707486D0 (en) | 1997-04-11 | 1997-05-28 | Secr Defence | Enzyme assays |
| US6429286B1 (en) | 1997-04-16 | 2002-08-06 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Immunoregulatory molecules for costimulatory signal transduction |
| WO1999014336A2 (en) | 1997-09-19 | 1999-03-25 | Promega Corporation | Thermostable luciferases and methods of production |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| GB9823468D0 (en) | 1998-10-28 | 1998-12-23 | Secr Defence | Novel enzyme |
| JP3694181B2 (ja) | 1999-01-05 | 2005-09-14 | キッコーマン株式会社 | 変異型ルシフェラーゼ、変異型ルシフェラーゼ遺伝子、新規な組み換え体ｄｎａ及び変異型ルシフェラーゼの製造法 |
| NZ518413A (en) | 1999-10-26 | 2004-11-26 | Secr Defence | Novel enzyme |
| GB9925161D0 (en) | 1999-10-26 | 1999-12-22 | Secr Defence | Novel enzyme |
| US20010046687A1 (en) | 2000-03-31 | 2001-11-29 | Dicesare Joseph L. | Method for the enhancement of luminescence intensity from a reaction between adenosine triphosphate (ATP) and a luciferase/luciferin reactant system |
| DE60142761D1 (de) | 2000-04-26 | 2010-09-23 | Chisso Corp | Oplophorus Luciferase |
| JP4613441B2 (ja) | 2000-04-26 | 2011-01-19 | チッソ株式会社 | 新規ルシフェラーゼおよび発光蛋白質 |
| US7118878B1 (en) | 2000-06-09 | 2006-10-10 | Promega Corporation | Method for increasing luminescence assay sensitivity |
| US7879540B1 (en) | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| JP2004508833A (ja) | 2000-09-13 | 2004-03-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | バイオマスの検出および測定のための方法 |
| US7268229B2 (en) | 2001-11-02 | 2007-09-11 | Promega Corporation | Compounds to co-localize luminophores with luminescent proteins |
| CA2474695A1 (en) | 2002-02-01 | 2003-08-14 | Promega Corporation | Bioluminescent protease assay |
| ATE513838T1 (de) | 2002-09-20 | 2011-07-15 | Promega Corp | Auf lumineszenz basierende verfahren und sonden zur messung der cytochrom-p450-aktivität |
| EP1413584B1 (en) * | 2002-10-21 | 2005-03-02 | AXXAM S.r.l. | Photoprotein with improved bioluminescence |
| CA2508072A1 (en) | 2002-12-23 | 2004-07-15 | Promega Corporation | Protecting luciferase activity from luciferase enzyme interfering compounds using detergents for the accurate measurement of luciferase activity |
| DE10303265A1 (de) | 2003-01-28 | 2004-07-29 | Roche Diagnostics Gmbh | Fluorimetrische Bestimmung von Analyten durch ein intramolekulares Quencher-Fluorophor-Konjugat |
| US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
| JP4748685B2 (ja) | 2003-01-31 | 2011-08-17 | プロメガ コーポレイション | タンパク質に対する官能基の共有結合的テザリング |
| AU2004210982B2 (en) | 2003-02-12 | 2008-12-18 | Promega Corporation | Methods and kits for dual enzymatic assays whereby light is quenched from luminescent reactions |
| US20040178545A1 (en) | 2003-03-14 | 2004-09-16 | Cates Larry E. | System for optically analyzing a molten metal bath |
| CA2541765A1 (en) | 2003-10-10 | 2004-10-01 | Promega Corporation | Luciferase biosensor |
| CA2552916C (en) | 2004-01-08 | 2014-11-18 | Universitat Zurich | Metal complexes having vitamin b12 as a ligand |
| US7416854B2 (en) | 2004-01-22 | 2008-08-26 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| US7553632B2 (en) | 2004-01-22 | 2009-06-30 | Promega Corporation | Luminogenic and nonluminogenic multiplex assay |
| EP3179252B1 (en) | 2004-07-30 | 2018-11-14 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
| US20070087400A1 (en) | 2004-07-30 | 2007-04-19 | Aldis Darzins | Covalent tethering of functional groups to proteins and substrates therefor |
| US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
| US7728118B2 (en) | 2004-09-17 | 2010-06-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| JP4453528B2 (ja) * | 2004-10-26 | 2010-04-21 | 東京化成工業株式会社 | 新規化学発光試薬 |
| EP1700865A1 (en) | 2005-03-11 | 2006-09-13 | AXXAM S.r.l. | Photoproteins with enhanced bioluminescence and their use as intracellular calcium indicators |
| JP4639904B2 (ja) | 2005-03-30 | 2011-02-23 | チッソ株式会社 | 蛍光活性を有するルシフェラーゼの活性増強方法 |
| JP3844082B2 (ja) | 2005-04-08 | 2006-11-08 | キッコーマン株式会社 | 耐熱性ホタルルシフェラーゼ、耐熱性ホタルルシフェラーゼ遺伝子、新規な組み換え体ｄｎａ及び耐熱性ホタルルシフェラーゼの製造法 |
| EP1935986B1 (en) | 2005-05-31 | 2014-04-16 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| EP2272972A1 (en) | 2005-05-31 | 2011-01-12 | Promega Corporation | Luminogenic and fluorogenic compounds and methods to detect molecules or conditions |
| MX2008002123A (es) * | 2005-08-17 | 2008-04-17 | Yeda Res & Dev | Metodos y composiciones para determinar un nivel de paraoxonasa de suero biologicamente activa. |
| JP4999341B2 (ja) | 2005-09-06 | 2012-08-15 | 株式会社バイオエネックス | 変異型ホタルルシフェラーゼ、遺伝子、組換えベクター、形質転換体、及び変異型ホタルルシフェラーゼの製造方法 |
| CA2648263A1 (en) | 2006-04-03 | 2007-10-25 | Promega Corporation | Permuted and nonpermuted luciferase biosensors |
| EP2843411B1 (en) | 2006-10-24 | 2017-12-27 | Gene Stream Pty Ltd. | Luciferase signal enhancing compositions |
| WO2008054821A2 (en) | 2006-10-30 | 2008-05-08 | Promega Corporation | Mutant hydrolase proteins with enhanced kinetics and functional expression |
| WO2008086035A2 (en) | 2007-01-10 | 2008-07-17 | Promega Corporation | Split mutant hydrolase fusion reporter and uses thereof |
| US20080248511A1 (en) | 2007-03-26 | 2008-10-09 | Promega Corporation | Methods to quench light from optical reactions |
| CN101849005A (zh) | 2007-11-05 | 2010-09-29 | 普罗梅加公司 | 杂合融合报道子及其应用 |
| JP6110591B2 (ja) | 2008-05-19 | 2017-04-05 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | ｃＡＭＰのためのルシフェラーゼバイオセンサー |
| EP2326953B1 (en) | 2008-07-22 | 2018-03-21 | Promega Corporation | Adp detection based luminescent phosphotransferase or atp hydrolase assay |
| TWI354101B (en) | 2008-08-19 | 2011-12-11 | Univ Nat Taipei Technology | Fluorimetric indicator for biosensing and manufact |
| WO2010119721A1 (ja) | 2009-04-17 | 2010-10-21 | 独立行政法人産業技術総合研究所 | 超高輝度で安定な人工生物発光酵素 |
| EP2456864B1 (en) | 2009-05-01 | 2015-11-11 | Promega Corporation | Synthetic oplophorus luciferases with enhanced light output |
| WO2011038219A1 (en) | 2009-09-24 | 2011-03-31 | Promega Corporation | Proteases having improved stability, solubility and activity |
| EP3508570B1 (en) | 2010-05-11 | 2020-07-22 | Promega Corporation | Mutant protease biosensors with enhanced detection characteristics |
| EP2611929B1 (en) | 2010-09-01 | 2016-01-13 | Promega Corporation | Oxidized glutathione assay |
| US9284188B2 (en) | 2010-09-03 | 2016-03-15 | The Regents Of The University Of California | Cytosolic delivery of materials with endosome-disrupting colloids |
| EP3498709B1 (en) | 2010-11-02 | 2025-12-31 | Promega Corporation | Luciferases from Oplophorus: Novel Coelenterazine Substrates and Their Methods of Use |
| SG189494A1 (en) | 2010-11-02 | 2013-05-31 | Promega Corp | Coelenterazine derivatives and methods of using same |
| JP6067019B2 (ja) | 2011-09-02 | 2017-01-25 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 代謝的に活性な細胞の酸化還元状態を評価するための化合物及び方法、ならびにｎａｄ（ｐ）／ｎａｄ（ｐ）ｈを測定するための方法 |
-
2011
- 2011-11-02 SG SG2013030317A patent/SG189494A1/en unknown
- 2011-11-02 AU AU2011323455A patent/AU2011323455B2/en active Active
- 2011-11-02 ES ES11785217.8T patent/ES2543913T3/es active Active
- 2011-11-02 KR KR1020137014031A patent/KR101968475B1/ko active Active
- 2011-11-02 DK DK11785217.8T patent/DK2635583T3/en active
- 2011-11-02 PL PL11785217T patent/PL2635583T3/pl unknown
- 2011-11-02 CA CA2815381A patent/CA2815381C/en active Active
- 2011-11-02 US US13/287,519 patent/US9487520B2/en active Active
- 2011-11-02 WO PCT/US2011/058924 patent/WO2012061477A1/en not_active Ceased
- 2011-11-02 EP EP11785217.8A patent/EP2635583B1/en active Active
- 2011-11-02 PT PT117852178T patent/PT2635583E/pt unknown
- 2011-11-02 BR BR112013010484A patent/BR112013010484B1/pt active IP Right Grant
- 2011-11-02 CN CN201180052806XA patent/CN103180324A/zh active Pending
- 2011-11-02 JP JP2013537779A patent/JP6040157B2/ja active Active
-
2013
- 2013-04-21 IL IL225869A patent/IL225869A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR101968475B1 (ko) | 2019-04-15 |
| PL2635583T3 (pl) | 2015-11-30 |
| CA2815381A1 (en) | 2012-05-10 |
| CA2815381C (en) | 2019-03-19 |
| BR112013010484B1 (pt) | 2019-09-03 |
| US9487520B2 (en) | 2016-11-08 |
| JP6040157B2 (ja) | 2016-12-07 |
| ES2543913T3 (es) | 2015-08-25 |
| DK2635583T3 (en) | 2015-08-03 |
| EP2635583A1 (en) | 2013-09-11 |
| US20120107849A1 (en) | 2012-05-03 |
| WO2012061477A1 (en) | 2012-05-10 |
| JP2013544242A (ja) | 2013-12-12 |
| KR20140003430A (ko) | 2014-01-09 |
| EP2635583B1 (en) | 2015-06-03 |
| IL225869A0 (en) | 2013-07-31 |
| SG189494A1 (en) | 2013-05-31 |
| AU2011323455B2 (en) | 2017-07-27 |
| AU2011323455A1 (en) | 2013-05-30 |
| BR112013010484A2 (pt) | 2016-07-05 |
| CN103180324A (zh) | 2013-06-26 |
| IL225869A (en) | 2017-09-28 |
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