PT2236500E - Derivados azo de pirazolona substituída com biciclo, processo para a sua preparação e a sua utilização farmacêutica - Google Patents

Derivados azo de pirazolona substituída com biciclo, processo para a sua preparação e a sua utilização farmacêutica Download PDF

Info

Publication number
PT2236500E
PT2236500E PT97034904T PT09703490T PT2236500E PT 2236500 E PT2236500 E PT 2236500E PT 97034904 T PT97034904 T PT 97034904T PT 09703490 T PT09703490 T PT 09703490T PT 2236500 E PT2236500 E PT 2236500E
Authority
PT
Portugal
Prior art keywords
bicyclo
preparation process
pharmaceutical use
azo derivatives
substituted pyrazolon
Prior art date
Application number
PT97034904T
Other languages
English (en)
Inventor
Peng Cho Tang
Hejun Lü
Hongbo Fei
Yiqian Chen
Hao Zheng
Shenglan Wang
Li Wang
Original Assignee
Jiangsu Hengrui Medicine Co
Shanghai Hengrui Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co, Shanghai Hengrui Pharm Co Ltd filed Critical Jiangsu Hengrui Medicine Co
Publication of PT2236500E publication Critical patent/PT2236500E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18One oxygen or sulfur atom
    • C07D231/20One oxygen atom attached in position 3 or 5
    • C07D231/22One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT97034904T 2008-01-10 2009-01-04 Derivados azo de pirazolona substituída com biciclo, processo para a sua preparação e a sua utilização farmacêutica PT2236500E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA2008100003466A CN101481352A (zh) 2008-01-10 2008-01-10 双环取代吡唑酮偶氮类衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
PT2236500E true PT2236500E (pt) 2015-04-07

Family

ID=40878665

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97034904T PT2236500E (pt) 2008-01-10 2009-01-04 Derivados azo de pirazolona substituída com biciclo, processo para a sua preparação e a sua utilização farmacêutica

Country Status (16)

Country Link
US (2) US8367710B2 (pt)
EP (1) EP2236500B1 (pt)
JP (1) JP5441269B2 (pt)
KR (1) KR101556808B1 (pt)
CN (2) CN101481352A (pt)
AU (1) AU2009207966B2 (pt)
BR (1) BRPI0907234B1 (pt)
CA (1) CA2711535C (pt)
ES (1) ES2533366T3 (pt)
HK (1) HK1134818A1 (pt)
MX (1) MX2010007553A (pt)
PT (1) PT2236500E (pt)
RU (1) RU2488582C2 (pt)
UA (1) UA101172C2 (pt)
WO (1) WO2009092276A1 (pt)
ZA (1) ZA201004794B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0302486D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
CN101921232A (zh) * 2009-06-11 2010-12-22 上海恒瑞医药有限公司 双环取代吡唑酮偶氮类衍生物的盐,其制备方法及其在医药上的应用
JP5704073B2 (ja) * 2009-10-23 2015-04-22 日産化学工業株式会社 縮環へテロ環化合物及びトロンボポエチンレセプター活性化剤
CN103360317B (zh) * 2012-04-11 2016-12-14 齐鲁制药有限公司 双环取代吡唑酮偶氮类衍生物、其制备方法及用途
CN103724206A (zh) * 2014-01-17 2014-04-16 青岛农业大学 化合物2-溴-4-氟-6-硝基苯酚的制备方法和农用生物活性
WO2015111085A2 (en) * 2014-01-27 2015-07-30 Cadila Healthcare Limited Processes for the preparation of eltrombopag and pharmaceutically acceptable salts, solvates and intermediates thereof
KR102323049B1 (ko) 2014-03-10 2021-11-05 마리 케이 인코포레이티드 피부 라이트닝 조성물
CN104592033A (zh) * 2014-12-30 2015-05-06 杭州和泽医药科技有限公司 一种艾曲波帕关键中间体的合成方法
CN106994120B (zh) * 2016-01-22 2021-05-14 江苏恒瑞医药股份有限公司 一种含有双环取代吡唑酮偶氮类衍生物或其盐的药物组合物及其制备方法
RU2733844C2 (ru) * 2016-01-22 2020-10-07 Цзянсу Хэнжуй Медицин Ко., Лтд. Фармацевтическая композиция, включающая бициклозамещенное азопроизводное пиразолона или его соль, и способ их получения
TWI762556B (zh) * 2017-01-19 2022-05-01 大陸商江蘇恆瑞醫藥股份有限公司 一種雙環取代吡唑酮偶氮類衍生物的製備方法及其中間體
CN110028497B (zh) * 2018-01-11 2020-11-17 江苏恒瑞医药股份有限公司 一种血小板生成素模拟物的乙醇胺盐的结晶形式及制备方法
TW202042806A (zh) * 2019-01-08 2020-12-01 大陸商江蘇恒瑞醫藥股份有限公司 雙環取代吡唑酮偶氮類衍生物的給藥方案
CN112062699B (zh) * 2020-11-13 2021-02-26 苏州开元民生科技股份有限公司 一种邻氨基苯硫酚的制备方法
WO2022228551A1 (zh) * 2021-04-30 2022-11-03 江苏恒瑞医药股份有限公司 一种血小板生成素受体激动剂的给药方案
TW202339724A (zh) * 2022-01-25 2023-10-16 大陸商江蘇恆瑞醫藥股份有限公司 一種血小板生成素受體激動劑的給藥方案

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB775216A (en) * 1954-02-23 1957-05-22 Sandoz Ltd Improvements in or relating to monoazo dyestuffs of the benzene-azo-pyrazolone series and their chromium-complex compounds
GB806709A (en) * 1955-04-22 1958-12-31 Bayer Ag Monoazo dyestuffs of the benzene-azo-pyrazolone series and metal complexes thereof
US5869451A (en) 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
ES2303338T3 (es) 1995-06-07 2008-08-01 Glaxo Group Limited Peptidos y compuestos que se unen a un receptor de trombopoyetina.
JPH111477A (ja) 1997-06-12 1999-01-06 Hokuriku Seiyaku Co Ltd 1,4−ベンゾジアゼピン誘導体及びその用途
WO1999011262A1 (en) 1997-09-02 1999-03-11 Roche Diagnostics Gmbh Mpl-receptor ligands, process for their preparation, medicaments containing them and their use for the treatment and prevention of thrombocytopaenia and anaemia
US6498155B1 (en) 1998-11-17 2002-12-24 Smithkline Beecham Corporation Methods of treating thrombocytopenia
WO2000039773A1 (de) 1998-12-14 2000-07-06 Mannesmann Ag Verfahren zur übertragung von verkehrsinformationen
GC0000177A (en) 1998-12-17 2006-03-29 Smithkline Beecham Thrombopoietin mimetics
CA2380206A1 (en) 1999-07-26 2001-02-01 Shionogi & Co., Ltd. Pharmaceutical compositions exhibiting thrombopoietin receptor agonism
ES2256038T3 (es) 1999-09-10 2006-07-16 Smithkline Beecham Corporation Mimeticos de trombopoyetina.
EP1228051A1 (en) 1999-11-05 2002-08-07 SmithKline Beecham Corporation Semicarbazone derivatives and their use as thrombopoietin mimetics
WO2001039773A1 (en) 1999-12-06 2001-06-07 Smithkline Beecham Corporation Thrombopoietin mimetics
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
TWI280128B (en) * 2002-05-22 2007-05-01 Smithkline Beecham Corp 3'-[(2Z)-[1-(3,4- dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
JP4895807B2 (ja) * 2003-04-29 2012-03-14 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 変性疾患/損傷の治療方法
DE602004019685D1 (de) 2003-12-26 2009-04-09 Allergan Inc DISUBSTITUIERTE CHALCOGENOXIME MIT ANTAGONISTISCHER WIRKUNG AM RAR(Gamma)-RETINOIDREZEPTOR
JP4518819B2 (ja) * 2004-03-17 2010-08-04 富士フイルム株式会社 アゾ化合物
RU2401259C2 (ru) 2004-12-14 2010-10-10 Ниссан Кемикал Индастриз, ЛТД Амидные соединения и активаторы рецептора тромбопоэтина
US20080286865A1 (en) * 2005-10-13 2008-11-20 Connie Lynn Erickson-Miller Methods for the Preservation of Platelet Efficacy During Storage
JP2009519352A (ja) * 2005-11-23 2009-05-14 リガンド・ファーマシューティカルズ・インコーポレイテッド トロンボポエチン活性調節化合物および方法

Also Published As

Publication number Publication date
EP2236500A4 (en) 2012-08-22
HK1134818A1 (en) 2010-05-14
US20130123507A1 (en) 2013-05-16
CN101481352A (zh) 2009-07-15
EP2236500B1 (en) 2014-12-24
JP5441269B2 (ja) 2014-03-12
AU2009207966A1 (en) 2009-07-30
KR101556808B1 (ko) 2015-10-01
MX2010007553A (es) 2010-10-04
WO2009092276A1 (zh) 2009-07-30
CN101679286B (zh) 2011-06-08
US20100316601A1 (en) 2010-12-16
UA101172C2 (ru) 2013-03-11
CN101679286A (zh) 2010-03-24
ES2533366T3 (es) 2015-04-09
BRPI0907234B1 (pt) 2021-08-10
JP2011509263A (ja) 2011-03-24
RU2010127786A (ru) 2012-02-20
BRPI0907234A2 (pt) 2020-08-04
AU2009207966B2 (en) 2013-03-21
CA2711535C (en) 2015-12-15
CA2711535A1 (en) 2009-07-30
RU2488582C2 (ru) 2013-07-27
US8367710B2 (en) 2013-02-05
EP2236500A1 (en) 2010-10-06
ZA201004794B (en) 2011-09-28
KR20100120141A (ko) 2010-11-12

Similar Documents

Publication Publication Date Title
ZA201004794B (en) Bicyclo-substituted pyrazolon azo derivatives,preparation process and pharmaceutical use thereof
IL205665A (en) The history of terroiril, the process of preparing them, the drugs containing them and their use in the preparation of drugs
HK1161878A1 (en) Dihydropteridinone derivatives, preparation process and pharmaceutical use thereof
HK1117164A1 (en) Dicyclic azaalkane derivatives, preparing method and pharmaceutical use thereof
ZA201005202B (en) Azabicyclic carboxamide derivatives,preparation thereof and theapeutic use thereof
HK1121757A1 (en) Pyrroloazacyclic derivatives, preparing method and use thereof
HK1159108A1 (en) Pyridino-pyridinone derivatives, preparation thereof, and therapeutic use thereof
IL204663A0 (en) Nicotinamide derivatives, preparastion thereof and therapeutic use thereof
IL206394A (en) Derivatives of 2-Benzylpyridine Filtration as Met Kinase Inhibitors, Process for their Preparation, Medication and Use
IL208336A (en) Pyridazinone derivatives, drugs containing them and their uses and process for preparation
EP1988090A4 (en) IMIDAZOLE-5-CARBOXYLIC ACID DERIVATIVES, METHOD OF MANUFACTURE AND USE THEREOF
ZA201108249B (en) Salts of bicyclo-substituted pyrazolon azo derivatives, preparation method and use thereof
HK1126760A1 (en) Novel pyrone-indole derivatives and process for their preparation
IL209840A0 (en) Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors
IL219888A0 (en) Pyridine-pyridinone derivatives, preparation and therapeutic use thereof
IL207629A0 (en) Novel 3-aminoalkyl-1,3-dihydro-2h-indol-2-one derivatives, preparation thereof and therapeutic use thereof
HK1169387A1 (en) Pyrazole derivatives, their preparation and therapeutical use
HK1158632A1 (en) Derivatives of 2-oxo-alkyl-1-piperazin-2-one, preparation method thereof and therapeutic use of same 2--1--2-
EP2322505A4 (en) 1-ADAMANTYLAZETIDIN-2-ON DERIVATIVE, PREPARATION THEREOF AND PHARMACEUTICAL PREPARATION THEREWITH
IL219872A (en) Quinazoline derivatives, their uses, their preparation, and their medications
HK1164861A1 (en) Substituted 3-benzofuranyl-indol-2-one-3-acetamidopiperazine derivatives, preparation thereof, and therapeutic use thereof
IL202474A0 (en) 1-benzylpyrazole derivatives, preparation thereof and therapeutic use thereof
IL191892A0 (en) 2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof
HK1163110A1 (en) Derivatives of morphine-6-glucuronide, process for their preparation and their use in therapy -6-
SI2421864T1 (sl) 1-pirazolo(4,3-c)izokinolinski derivati, njihova priprava in njihova terapevtska uporaba