PT2114931E - Agonistas de gpcr de piperidina - Google Patents
Agonistas de gpcr de piperidina Download PDFInfo
- Publication number
- PT2114931E PT2114931E PT08700184T PT08700184T PT2114931E PT 2114931 E PT2114931 E PT 2114931E PT 08700184 T PT08700184 T PT 08700184T PT 08700184 T PT08700184 T PT 08700184T PT 2114931 E PT2114931 E PT 2114931E
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- Portugal
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- compound
- formula
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title description 4
- 229940125633 GPCR agonist Drugs 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 180
- 150000003839 salts Chemical class 0.000 claims description 63
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- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 7
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 7
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Landscapes
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| GB0719762A GB0719762D0 (en) | 2007-10-10 | 2007-10-10 | GPCR agonists |
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| WO2007003961A2 (en) | 2005-06-30 | 2007-01-11 | Prosidion Limited | Gpcr agonists |
| NZ571869A (en) * | 2006-04-06 | 2011-11-25 | Prosidion Ltd | Heterocyclic GPCR agonists |
| EP2325182A1 (en) * | 2006-12-06 | 2011-05-25 | Glaxosmithkline LLC | Bicyclic compounds and use as antidiabetics |
| CA2674348A1 (en) * | 2007-01-04 | 2008-07-10 | Prosidion Limited | Piperidine gpcr agonists |
| EP2114936A1 (en) * | 2007-01-04 | 2009-11-11 | Prosidion Limited | Piperidine gpcr agonists |
| AR064735A1 (es) * | 2007-01-04 | 2009-04-22 | Prosidion Ltd | Agonistas de gpcr y composicion farmaceutica en base al compuesto |
-
2008
- 2008-01-03 PE PE2008000085A patent/PE20081849A1/es not_active Application Discontinuation
- 2008-01-03 AR ARP080100018A patent/AR064736A1/es not_active Application Discontinuation
- 2008-01-03 CL CL200800017A patent/CL2008000017A1/es unknown
- 2008-01-04 EP EP11172885A patent/EP2383270A1/en not_active Withdrawn
- 2008-01-04 DK DK08700184.8T patent/DK2114931T3/da active
- 2008-01-04 RS RS20120031A patent/RS52168B/sr unknown
- 2008-01-04 AU AU2008203673A patent/AU2008203673A1/en not_active Abandoned
- 2008-01-04 EP EP08700184A patent/EP2114931B1/en active Active
- 2008-01-04 CA CA002674093A patent/CA2674093A1/en not_active Abandoned
- 2008-01-04 MX MX2009007180A patent/MX2009007180A/es active IP Right Grant
- 2008-01-04 KR KR1020097016214A patent/KR20090104092A/ko not_active Withdrawn
- 2008-01-04 BR BRPI0806468-7A patent/BRPI0806468A2/pt not_active IP Right Cessation
- 2008-01-04 EA EA200900796A patent/EA015805B9/ru not_active IP Right Cessation
- 2008-01-04 NZ NZ578144A patent/NZ578144A/en not_active IP Right Cessation
- 2008-01-04 AT AT08700184T patent/ATE531710T1/de active
- 2008-01-04 PL PL08700184T patent/PL2114931T3/pl unknown
- 2008-01-04 CN CN200880007091A patent/CN101627036A/zh active Pending
- 2008-01-04 PT PT08700184T patent/PT2114931E/pt unknown
- 2008-01-04 SI SI200830517T patent/SI2114931T1/sl unknown
- 2008-01-04 TW TW097100419A patent/TWI380818B/zh not_active IP Right Cessation
- 2008-01-04 WO PCT/GB2008/050011 patent/WO2008081205A1/en not_active Ceased
- 2008-01-04 HR HR20110964T patent/HRP20110964T1/hr unknown
- 2008-01-04 US US12/522,018 patent/US20100022591A1/en not_active Abandoned
- 2008-01-04 ES ES08700184T patent/ES2376015T3/es active Active
- 2008-01-04 JP JP2009544448A patent/JP2010514829A/ja active Pending
- 2008-01-05 SA SA8280756A patent/SA08280756B1/ar unknown
-
2009
- 2009-07-02 IL IL199680A patent/IL199680A0/en unknown
- 2009-07-03 MA MA32072A patent/MA31084B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA015805B9 (ru) | 2012-03-30 |
| PL2114931T3 (pl) | 2012-03-30 |
| ATE531710T1 (de) | 2011-11-15 |
| EP2114931A1 (en) | 2009-11-11 |
| SI2114931T1 (sl) | 2012-02-29 |
| CL2008000017A1 (es) | 2008-08-01 |
| HK1135704A1 (en) | 2010-06-11 |
| AR064736A1 (es) | 2009-04-22 |
| EA015805B1 (ru) | 2011-12-30 |
| DK2114931T3 (da) | 2012-02-13 |
| NZ578144A (en) | 2011-03-31 |
| US20100022591A1 (en) | 2010-01-28 |
| CA2674093A1 (en) | 2008-07-10 |
| CN101627036A (zh) | 2010-01-13 |
| WO2008081205A1 (en) | 2008-07-10 |
| SA08280756B1 (ar) | 2011-01-24 |
| MA31084B1 (fr) | 2010-01-04 |
| IL199680A0 (en) | 2010-04-15 |
| AU2008203673A1 (en) | 2008-07-10 |
| EA200900796A1 (ru) | 2010-02-26 |
| JP2010514829A (ja) | 2010-05-06 |
| RS52168B (sr) | 2012-08-31 |
| HRP20110964T1 (hr) | 2012-01-31 |
| TWI380818B (zh) | 2013-01-01 |
| ES2376015T3 (es) | 2012-03-08 |
| PE20081849A1 (es) | 2009-01-26 |
| MX2009007180A (es) | 2009-07-15 |
| EP2114931B1 (en) | 2011-11-02 |
| BRPI0806468A2 (pt) | 2011-09-27 |
| EP2383270A1 (en) | 2011-11-02 |
| KR20090104092A (ko) | 2009-10-05 |
| TW200835489A (en) | 2008-09-01 |
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