PT1896489E - Sais ou complexos de doadores de metilo com ácido fítico ou os seus derivados e método para a sua síntese - Google Patents

Sais ou complexos de doadores de metilo com ácido fítico ou os seus derivados e método para a sua síntese Download PDF

Info

Publication number
PT1896489E
PT1896489E PT06766355T PT06766355T PT1896489E PT 1896489 E PT1896489 E PT 1896489E PT 06766355 T PT06766355 T PT 06766355T PT 06766355 T PT06766355 T PT 06766355T PT 1896489 E PT1896489 E PT 1896489E
Authority
PT
Portugal
Prior art keywords
salt
phytic acid
same
trimethylglycine
methionine
Prior art date
Application number
PT06766355T
Other languages
English (en)
Portuguese (pt)
Inventor
Maria De Luca
Original Assignee
Maria De Luca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maria De Luca filed Critical Maria De Luca
Publication of PT1896489E publication Critical patent/PT1896489E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Seasonings (AREA)
PT06766355T 2005-06-30 2006-06-23 Sais ou complexos de doadores de metilo com ácido fítico ou os seus derivados e método para a sua síntese PT1896489E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000344A ITRM20050344A1 (it) 2005-06-30 2005-06-30 Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi.

Publications (1)

Publication Number Publication Date
PT1896489E true PT1896489E (pt) 2009-04-01

Family

ID=39033793

Family Applications (1)

Application Number Title Priority Date Filing Date
PT06766355T PT1896489E (pt) 2005-06-30 2006-06-23 Sais ou complexos de doadores de metilo com ácido fítico ou os seus derivados e método para a sua síntese

Country Status (14)

Country Link
US (1) US8293254B2 (enExample)
EP (1) EP1896489B1 (enExample)
JP (2) JP4589999B2 (enExample)
KR (1) KR101346974B1 (enExample)
AT (1) ATE419256T1 (enExample)
CY (1) CY1108929T1 (enExample)
DE (1) DE602006004588D1 (enExample)
DK (1) DK1896489T3 (enExample)
ES (1) ES2320489T3 (enExample)
IT (1) ITRM20050344A1 (enExample)
PL (1) PL1896489T3 (enExample)
PT (1) PT1896489E (enExample)
SI (1) SI1896489T1 (enExample)
WO (1) WO2007004244A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20060026A1 (it) * 2006-01-10 2007-07-11 Truffini & Regge Farmaceutici Srl Composizioni per uso rale a base di s-adenosilmetionina e processo per il loro ottenimento
ITMI20060629A1 (it) 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
WO2008004973A2 (en) 2006-07-07 2008-01-10 Telefonaktiebolaget Lm Ericsson (Publ) Resource allocation for co-existin networks
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
JP4598846B2 (ja) * 2008-07-14 2010-12-15 磐田化学工業株式会社 S−アデノシルメチオニン安定化のためのフィチン酸および/またはデキストリンを含む飲食用組成物
IT1393331B1 (it) * 2009-02-09 2012-04-20 Graal S R L Composizioni orosolubili e/o effervescenti contenenti almeno un sale di s-adenosilmetionina (same)
JP5573587B2 (ja) 2010-10-20 2014-08-20 株式会社デンソー 車両用回転電機
KR102186066B1 (ko) 2013-01-16 2020-12-04 허버트 샘-이 엘엘씨 S-아데노실-l-메티오닌의 안정한 인돌-3-프로피오네이트염
ES2486441B1 (es) * 2014-04-02 2015-06-11 Universitat De Les Illes Balears Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico
WO2017040611A1 (en) * 2015-08-31 2017-03-09 Nutramax Laboratories, Inc. Compositions comprising magnolia, phellodendron, theanine and/or whey protein
IT201700074957A1 (it) * 2017-07-04 2019-01-04 Gnosis Spa Sale di (ss)-adenosil metionina con inositolo esafosfato e procedimento per ottenerlo
FR3068602B1 (fr) * 2017-07-10 2020-11-20 Guy Parc Nouveau traitement du cancer par une combinaison d'un derive phosphorique d'inositol et de chlorure de magnesium
EP3556398A1 (en) * 2018-04-16 2019-10-23 Croda Denmark A/S Phytates for use as a biomolecules delivery or adsorption system
JP2021046375A (ja) * 2019-09-19 2021-03-25 ポッカサッポロフード&ビバレッジ株式会社 β3アドレナリン受容体活性化剤
CN115572309B (zh) * 2022-09-20 2024-05-03 浙江工业大学 一种高效阻燃、抗熔滴的环境友好型阻燃剂

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2824869A (en) * 1954-08-04 1958-02-25 Bristol Lab Inc Salt of streptomycin and phytic acid
US3019226A (en) * 1959-04-10 1962-01-30 Olin Mathieson Piperazine salt of phytic acid
US3242235A (en) * 1963-06-13 1966-03-22 Squibb & Sons Inc Phytate salts of the tetracyclines
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine
IT1200589B (it) * 1985-02-14 1989-01-27 Gibipharma Spa Derivati naturali attivita farmagologica
JPH0215032A (ja) * 1988-07-01 1990-01-18 Sanwa Kagaku Kenkyusho Co Ltd 肝疾患治療、予防剤及び強肝機能性飲食、し好物
US5434144A (en) * 1994-03-04 1995-07-18 The Procter & Gamble Company Methods of using cyclic polyanionic polyol derivatives for regulating skin wrinkles
IT1318535B1 (it) * 2000-05-25 2003-08-27 Chementecno Srl Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.
US20030069202A1 (en) * 2000-06-02 2003-04-10 Kern Kenneth Norman Compositions, kits, and methods for promoting defined health benefits
WO2002010177A1 (en) 2000-08-01 2002-02-07 Gmp Companies, Inc. Ammonium salts of inositol hexaphosphate and uses thereof
JP2002145783A (ja) * 2000-11-06 2002-05-22 Kohjin Co Ltd S−アデノシルメチオニンまたはその塩類を含有するカプセル製剤
US20030078231A1 (en) * 2001-06-22 2003-04-24 Wilburn Michael D. Orthomolecular sulpho-adenosylmethionine derivatives with antioxidant properties
WO2003087109A1 (en) * 2002-04-12 2003-10-23 Silbiotec Due S.A. Medicaments containing glycerophosphoinositol-4-phosphate derivatives
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
ES2323141T3 (es) * 2004-08-12 2009-07-07 Quest Pharmaceutical Services Composiciones farmaceuticas para el suministro por liberacion controlada de compuestos biologicamente activos.
US20060046982A1 (en) * 2004-08-26 2006-03-02 Waugh William H Orthomolecular medical use of L-citrulline for capillary endothelial protection and adjacent cell protection in neurodegenerative disease

Also Published As

Publication number Publication date
US20090175914A1 (en) 2009-07-09
EP1896489A1 (en) 2008-03-12
SI1896489T1 (sl) 2009-06-30
WO2007004244A1 (en) 2007-01-11
CY1108929T1 (el) 2014-07-02
DK1896489T3 (da) 2009-04-20
PL1896489T3 (pl) 2009-06-30
KR20080028949A (ko) 2008-04-02
ATE419256T1 (de) 2009-01-15
ITRM20050344A1 (it) 2007-01-01
KR101346974B1 (ko) 2014-01-02
EP1896489B1 (en) 2008-12-31
ES2320489T3 (es) 2009-05-22
JP2010235616A (ja) 2010-10-21
US8293254B2 (en) 2012-10-23
JP5283659B2 (ja) 2013-09-04
JP4589999B2 (ja) 2010-12-01
DE602006004588D1 (de) 2009-02-12
JP2009500319A (ja) 2009-01-08

Similar Documents

Publication Publication Date Title
JP5283659B2 (ja) フィチン酸又はその誘導体とのメチル供与体の塩又は錯塩、及びその合成法
Schmelz et al. Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones
US20020187943A1 (en) Bioavailable composition of natural and synthetic hca
US8563605B2 (en) Therapeutic agent for male sterility
JPS5843996A (ja) 安定なs−アデノシルメチオニン塩、それらの製造法及び活性成分としてこれらを含む治療組成物
US9597308B2 (en) N-acetyl L-cysteine chelates and methods for making and using the same
US6054480A (en) Fatty acids as a diet supplement
JP2005515969A (ja) ビタミン貯蔵の調節
JP2004508407A (ja) クレアチンエステル代替栄養素化合物及び調合物
EP2537515A1 (de) Diätetikum zur Behandlung mitochondrialer Dysfunktionen
CZ20023949A3 (cs) Fumarát karnitinu a aminokyseliny a potravinové a dietetní doplňky a léčiva je obsahující
JPS62423A (ja) 肝疾患治療剤
CA2922396C (en) N-acetyl l-cysteine chelates and methods for making and using the same
Birkhahn et al. Potential of the monoglyceride and triglyceride of DL-3-hydroxybutyrate for parenteral nutrition: synthesis and preliminary biological testing in the rat
Leveille et al. Effect of dietary lithocholic acid on liver size of the chick
JP2022067969A (ja) プラズマローゲン含有組成物、プラズマローゲン吸収促進用組成物、及びプラズマローゲン吸収促進方法
JP2011524415A (ja) L−カルニチンフィチン酸塩及びアルカノイル−l−カルニチンフィチン酸塩と、その製造方法
WO2022224776A1 (ja) 脂質減少促進剤
CA2183754A1 (en) Calcium ketopantothenate with acetylating properties
JP2018145129A (ja) 脂質代謝改善用組成物及び脂質代謝改善用食品
PT1572175E (pt) Formulação que pode ser administrada gastrintestinalmente, que contém extracto de chá verde e um dador no
CN118338895A (zh) 新型透析液
Harter NUTRITIONAL AND METABOLIC FACTORS INVOLVED IN THE UTILIZATION AND TOXICITY OF SULFUR-CONTAINING AMINO ACIDS IN THE CHICK.
CA2493398A1 (en) Nutritional and food supplement preparation comprising creatine and orotic acid complexes, derivatives and analogs
CH472841A (fr) Composition stimulant la croissance et le développement des animaux, et procédé de préparation de cette composition