CY1108929T1 - Αλατα ή συμπλοκα δοτων μεθυλιου με φυτικο οξυ ή τα παραγωγα αυτου και μεθοδος για τη συνθεση αυτων - Google Patents
Αλατα ή συμπλοκα δοτων μεθυλιου με φυτικο οξυ ή τα παραγωγα αυτου και μεθοδος για τη συνθεση αυτωνInfo
- Publication number
- CY1108929T1 CY1108929T1 CY20091100356T CY091100356T CY1108929T1 CY 1108929 T1 CY1108929 T1 CY 1108929T1 CY 20091100356 T CY20091100356 T CY 20091100356T CY 091100356 T CY091100356 T CY 091100356T CY 1108929 T1 CY1108929 T1 CY 1108929T1
- Authority
- CY
- Cyprus
- Prior art keywords
- salts
- donors
- synthesis
- derivatives
- compounds
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- YDBYJHTYSHBBAU-YFKPBYRVSA-N S-methyl-L-methioninate Chemical compound C[S+](C)CC[C@H](N)C([O-])=O YDBYJHTYSHBBAU-YFKPBYRVSA-N 0.000 title 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 abstract 3
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 abstract 3
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 229940068041 phytic acid Drugs 0.000 abstract 3
- 235000002949 phytic acid Nutrition 0.000 abstract 3
- 239000000467 phytic acid Substances 0.000 abstract 3
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 2
- 229960000367 inositol Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 abstract 2
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 abstract 1
- 229960003237 betaine Drugs 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 230000000378 dietary effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002417 nutraceutical Substances 0.000 abstract 1
- 235000021436 nutraceutical agent Nutrition 0.000 abstract 1
- 239000000590 phytopharmaceutical Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Seasonings (AREA)
Abstract
Η εφεύρεση αφορά στην παραγωγή αλάτων ή χηλικών ενώσεων δοτών μεθυλίου, ειδικότερα S-αδενοσυλ-L-μεθειονίνης ή SAMe και βεταϊνης ή Ν,Ν,Ν-τριμεθυλογλυκίνης με φυτικό οξύ ή με φωσφορυλιωμένη ινοσιτόλη, πιθανά μετά από μερική αλατοποίηση με μεταλλικά κατιόντα, με το σχηματισμό σταθερών, εντελώς φυσικών, χημικών ενώσεων που έχουν βιολογική δράση αντιπροσωπευτική των αρχικών δοτών μεθυλίου και επίσης συνδυασμένη και επαυξημένη από τη βιολογική δράση που είναι αντιπροσωπευτική του φυτικού οξέος ή της ινοσιτόλης. Η εφεύρεση αφορά επίσης σε θρεπτικές και θεραπευτικές, φαρμακευτικές, διαιτητικές, φυτοφαρμακευτικές ή κτηνιατρικές συνθέσεις οι οποίες περιλαμβάνουν ένα ή περισσότερα άλατα ή σύμπλοκα δοτών μεθυλίου με φυτικό οξύ ή τα παράγωγα αυτού και στη μέθοδο για τη σύνθεση αυτών.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000344A ITRM20050344A1 (it) | 2005-06-30 | 2005-06-30 | Sali o complessi di sostanze metil-donatrici con acido fitico o suoi derivati e relativo metodo di sintesi. |
| EP06766355A EP1896489B1 (en) | 2005-06-30 | 2006-06-23 | Salts or complexes of methyl donors with phytic acid or its derivatives and method for the synthesis thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108929T1 true CY1108929T1 (el) | 2014-07-02 |
Family
ID=39033793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100356T CY1108929T1 (el) | 2005-06-30 | 2009-03-26 | Αλατα ή συμπλοκα δοτων μεθυλιου με φυτικο οξυ ή τα παραγωγα αυτου και μεθοδος για τη συνθεση αυτων |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8293254B2 (el) |
| EP (1) | EP1896489B1 (el) |
| JP (2) | JP4589999B2 (el) |
| KR (1) | KR101346974B1 (el) |
| AT (1) | ATE419256T1 (el) |
| CY (1) | CY1108929T1 (el) |
| DE (1) | DE602006004588D1 (el) |
| DK (1) | DK1896489T3 (el) |
| ES (1) | ES2320489T3 (el) |
| IT (1) | ITRM20050344A1 (el) |
| PL (1) | PL1896489T3 (el) |
| PT (1) | PT1896489E (el) |
| SI (1) | SI1896489T1 (el) |
| WO (1) | WO2007004244A1 (el) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20060026A1 (it) | 2006-01-10 | 2007-07-11 | Truffini & Regge Farmaceutici Srl | Composizioni per uso rale a base di s-adenosilmetionina e processo per il loro ottenimento |
| ITMI20060629A1 (it) | 2006-03-31 | 2007-10-01 | Daniele Giovannone | Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento |
| US9236938B2 (en) | 2006-07-07 | 2016-01-12 | Telefonaktiebolaget L M Ericsson (Publ) | Resource allocation for co-existing networks |
| ITMI20071374A1 (it) * | 2007-07-10 | 2009-01-11 | Gnosis Spa | Sali stabili di s-adenosilmetionina e processo per il loro ottenimento. |
| JP4598846B2 (ja) * | 2008-07-14 | 2010-12-15 | 磐田化学工業株式会社 | Ｓ−アデノシルメチオニン安定化のためのフィチン酸および／またはデキストリンを含む飲食用組成物 |
| IT1393331B1 (it) * | 2009-02-09 | 2012-04-20 | Graal S R L | Composizioni orosolubili e/o effervescenti contenenti almeno un sale di s-adenosilmetionina (same) |
| JP5573587B2 (ja) | 2010-10-20 | 2014-08-20 | 株式会社デンソー | 車両用回転電機 |
| CN105073767B (zh) * | 2013-01-16 | 2018-01-02 | 赫伯特·山姆-E有限责任公司 | 稳定的s‑腺苷‑l‑蛋氨酸的吲哚‑3‑丙酸盐 |
| ES2486441B1 (es) * | 2014-04-02 | 2015-06-11 | Universitat De Les Illes Balears | Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico |
| CA3208235A1 (en) | 2015-08-31 | 2017-03-09 | Nutramax Laboratories, Inc. | Compositions comprising magnolia, phellodendron, theanine and/or whey protein |
| IT201700074957A1 (it) | 2017-07-04 | 2019-01-04 | Gnosis Spa | Sale di (ss)-adenosil metionina con inositolo esafosfato e procedimento per ottenerlo |
| FR3068602B1 (fr) * | 2017-07-10 | 2020-11-20 | Guy Parc | Nouveau traitement du cancer par une combinaison d'un derive phosphorique d'inositol et de chlorure de magnesium |
| CN115572309B (zh) * | 2022-09-20 | 2024-05-03 | 浙江工业大学 | 一种高效阻燃、抗熔滴的环境友好型阻燃剂 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2824869A (en) * | 1954-08-04 | 1958-02-25 | Bristol Lab Inc | Salt of streptomycin and phytic acid |
| US3019226A (en) * | 1959-04-10 | 1962-01-30 | Olin Mathieson | Piperazine salt of phytic acid |
| US3242235A (en) * | 1963-06-13 | 1966-03-22 | Squibb & Sons Inc | Phytate salts of the tetracyclines |
| IE39517B1 (en) * | 1973-06-27 | 1978-10-25 | Bioresearch Sas | Double salts of s-adenosyl-l-methhionine |
| IT1200589B (it) * | 1985-02-14 | 1989-01-27 | Gibipharma Spa | Derivati naturali attivita farmagologica |
| JPH0215032A (ja) * | 1988-07-01 | 1990-01-18 | Sanwa Kagaku Kenkyusho Co Ltd | 肝疾患治療、予防剤及び強肝機能性飲食、し好物 |
| US5434144A (en) * | 1994-03-04 | 1995-07-18 | The Procter & Gamble Company | Methods of using cyclic polyanionic polyol derivatives for regulating skin wrinkles |
| IT1318535B1 (it) * | 2000-05-25 | 2003-08-27 | Chementecno Srl | Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina. |
| US20030069202A1 (en) * | 2000-06-02 | 2003-04-10 | Kern Kenneth Norman | Compositions, kits, and methods for promoting defined health benefits |
| AU2001279118A1 (en) * | 2000-08-01 | 2002-02-13 | Gmp Companies, Inc. | Ammonium salts of inositol hexaphosphate and uses thereof |
| JP2002145783A (ja) * | 2000-11-06 | 2002-05-22 | Kohjin Co Ltd | Ｓ−アデノシルメチオニンまたはその塩類を含有するカプセル製剤 |
| US20030078231A1 (en) * | 2001-06-22 | 2003-04-24 | Wilburn Michael D. | Orthomolecular sulpho-adenosylmethionine derivatives with antioxidant properties |
| AU2002253441A1 (en) * | 2002-04-12 | 2003-10-27 | Silbiotec Due S.A. | Medicaments containing glycerophosphoinositol-4-phosphate derivatives |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| AU2005271242B9 (en) * | 2004-08-12 | 2012-04-12 | Foresee Pharmaceuticals Co., Ltd. | Pharmaceutical compositions for controlled release delivery of biologically active compounds |
| US20060046982A1 (en) * | 2004-08-26 | 2006-03-02 | Waugh William H | Orthomolecular medical use of L-citrulline for capillary endothelial protection and adjacent cell protection in neurodegenerative disease |
-
2005
- 2005-06-30 IT IT000344A patent/ITRM20050344A1/it unknown
-
2006
- 2006-06-23 DK DK06766355T patent/DK1896489T3/da active
- 2006-06-23 SI SI200630246T patent/SI1896489T1/sl unknown
- 2006-06-23 DE DE602006004588T patent/DE602006004588D1/de active Active
- 2006-06-23 PL PL06766355T patent/PL1896489T3/pl unknown
- 2006-06-23 EP EP06766355A patent/EP1896489B1/en active Active
- 2006-06-23 PT PT06766355T patent/PT1896489E/pt unknown
- 2006-06-23 AT AT06766355T patent/ATE419256T1/de active
- 2006-06-23 WO PCT/IT2006/000484 patent/WO2007004244A1/en active Application Filing
- 2006-06-23 US US11/923,000 patent/US8293254B2/en active Active
- 2006-06-23 ES ES06766355T patent/ES2320489T3/es active Active
- 2006-06-23 JP JP2008519145A patent/JP4589999B2/ja not_active Expired - Fee Related
- 2006-06-23 KR KR1020087001591A patent/KR101346974B1/ko active IP Right Grant
-
2009
- 2009-03-26 CY CY20091100356T patent/CY1108929T1/el unknown
-
2010
- 2010-05-19 JP JP2010115119A patent/JP5283659B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PL1896489T3 (pl) | 2009-06-30 |
| JP2009500319A (ja) | 2009-01-08 |
| EP1896489A1 (en) | 2008-03-12 |
| SI1896489T1 (sl) | 2009-06-30 |
| JP2010235616A (ja) | 2010-10-21 |
| DE602006004588D1 (de) | 2009-02-12 |
| PT1896489E (pt) | 2009-04-01 |
| DK1896489T3 (da) | 2009-04-20 |
| US20090175914A1 (en) | 2009-07-09 |
| ES2320489T3 (es) | 2009-05-22 |
| US8293254B2 (en) | 2012-10-23 |
| ATE419256T1 (de) | 2009-01-15 |
| KR20080028949A (ko) | 2008-04-02 |
| KR101346974B1 (ko) | 2014-01-02 |
| EP1896489B1 (en) | 2008-12-31 |
| JP5283659B2 (ja) | 2013-09-04 |
| JP4589999B2 (ja) | 2010-12-01 |
| WO2007004244A1 (en) | 2007-01-11 |
| ITRM20050344A1 (it) | 2007-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1108929T1 (el) | Αλατα ή συμπλοκα δοτων μεθυλιου με φυτικο οξυ ή τα παραγωγα αυτου και μεθοδος για τη συνθεση αυτων | |
| BR112015021838A2 (pt) | amatoxina, método de síntese, composição farmacêutica | |
| BRPI0518758A2 (pt) | compostos de acetamida como fungicidas | |
| CY1116929T1 (el) | Παραγωγα πυρρολο[2,3-d]πυριμιδινης ως αναστολεις πρωτεϊνικης κινασης β | |
| CY1115199T1 (el) | Κυτταροτοξικοι παραγοντες που περιεχουν νεα παραγωγα τομαϋμυκινης και η θεραπευτικη τους χρηση | |
| ATE447564T1 (de) | Zwischenprodukte für die herstellung von trans-5- chlor-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenzä , 3:6,7üoxepinoä4,5-cüpyrrol | |
| EA200700096A1 (ru) | Производные 2-карбамид-4-фенилтиазола, способ их получения и их применение в терапии | |
| UY31046A1 (es) | Derivados sustituidos de n-(3,4-dihidro-2h-cromen-3-il)formamida y n-(1, 2,3 ,4-tetrahidronaftalen-2-il)formamida, sales de los mismos, composiciones que los contienen, procedimientos para su preparacion y aplicaciones | |
| CY1111045T1 (el) | Μεθοδος παραγωγης ενος παραγωγου βενζιμιδαζολιου | |
| UY28968A1 (es) | (orto-fenil)-anilidas de ácido 1-metil-3-trifluorometil-pirazol-4-carboxílico y su uso como fungicida | |
| ATE493425T1 (de) | Verfahren zur herstellung ortho-metallierter metallverbindungen | |
| CY1117461T1 (el) | Παραγωγα κιναζολινοδιονης, παρασκευη αυτων και οι θεραπευτικες εφαρμογες τους | |
| AR069531A1 (es) | Derivados de indolinona y procedimiento para su fabricacion | |
| CY1110034T1 (el) | Παραγωγα 1,2,4,5-τετραϋδρο-3h-βενζαζεπινων, μεθοδος παρασκευης αυτων και οι φαρμακευτικες συνθεσεις που τα περιεχουν | |
| CY1110541T1 (el) | Φαρμακευτικα σκευασματα με βελτιωμενες φαρμακευτικες ιδιοτητες που περιεχουν βελτιωτικα γευσης | |
| BRPI0816911A8 (pt) | Processo para preparação de 4-aminobut-2-enolidas | |
| EA200701817A1 (ru) | Новые соли 6-гетероциклических замещенных производных гексагидрофенантридина | |
| GT200800285A (es) | Aminopirazolopiridinas sustituidas y sus sales, sus preparaciones y composiciones farmaceuticas que las comprenden | |
| UY32704A (es) | Compuestos de 2,3-dihidro-1h-indeno | |
| UY29510A1 (es) | Derivados de urea, metodos para su fabricación, y usos de los mismos | |
| CO6420351A2 (es) | Composiciones plaguicidas | |
| CY1111954T1 (el) | Παραγωγα τετραϋδροναφθαλινιου, μεθοδοι για την παραγωγη αυτων και η χρηση αυτων ως αντιφλεγμονωδη | |
| DE602006019870D1 (de) | Verfahren zur synthese von triazolen | |
| CR20110215A (es) | Compuestos de triazol y de imidazol, su uso, asi como productos que los contienen | |
| AR064658A1 (es) | Proceso para preparar duloxetina y sus compuestos relacionados, asi como tambien intermediarios utiles en la misma |