PT1725218E - Composição farmacêutica compreendendo pimobendano - Google Patents
Composição farmacêutica compreendendo pimobendano Download PDFInfo
- Publication number
- PT1725218E PT1725218E PT57156259T PT05715625T PT1725218E PT 1725218 E PT1725218 E PT 1725218E PT 57156259 T PT57156259 T PT 57156259T PT 05715625 T PT05715625 T PT 05715625T PT 1725218 E PT1725218 E PT 1725218E
- Authority
- PT
- Portugal
- Prior art keywords
- pimobendan
- pharmaceutical composition
- pharmaceutical
- composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229960002164 pimobendan Drugs 0.000 title 1
- GLBJJMFZWDBELO-UHFFFAOYSA-N pimobendane Chemical compound C1=CC(OC)=CC=C1C1=NC2=CC=C(C=3C(CC(=O)NN=3)C)C=C2N1 GLBJJMFZWDBELO-UHFFFAOYSA-N 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seasonings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004011512.5A DE102004011512B4 (de) | 2004-03-08 | 2004-03-08 | Pharmazeutische Zubereitung enthaltend Pimobendan |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1725218E true PT1725218E (pt) | 2014-09-03 |
Family
ID=34877563
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT57156259T PT1725218E (pt) | 2004-03-08 | 2005-03-01 | Composição farmacêutica compreendendo pimobendano |
PT14171534T PT2783682T (pt) | 2004-03-08 | 2005-03-01 | Composição farmacêutica compreendendo pimobendano |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT14171534T PT2783682T (pt) | 2004-03-08 | 2005-03-01 | Composição farmacêutica compreendendo pimobendano |
Country Status (25)
Country | Link |
---|---|
US (5) | US8846679B2 (pt) |
EP (2) | EP2783682B1 (pt) |
JP (2) | JP4757253B2 (pt) |
KR (2) | KR20070014143A (pt) |
CN (1) | CN100546568C (pt) |
AR (2) | AR047993A1 (pt) |
AU (1) | AU2005218912C1 (pt) |
BR (1) | BRPI0508557B1 (pt) |
CA (1) | CA2557161C (pt) |
CY (2) | CY1115526T1 (pt) |
DE (1) | DE102004011512B4 (pt) |
DK (2) | DK1725218T3 (pt) |
ES (2) | ES2501216T3 (pt) |
HR (2) | HRP20140900T1 (pt) |
HU (1) | HUE045637T2 (pt) |
IN (1) | IN2014DN07624A (pt) |
LT (1) | LT2783682T (pt) |
MX (1) | MXPA06009889A (pt) |
NZ (1) | NZ549630A (pt) |
PL (2) | PL2783682T3 (pt) |
PT (2) | PT1725218E (pt) |
SI (2) | SI2783682T1 (pt) |
TW (1) | TWI355947B (pt) |
WO (1) | WO2005084647A1 (pt) |
ZA (1) | ZA200606154B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004011512B4 (de) * | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmazeutische Zubereitung enthaltend Pimobendan |
US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
EP1579862A1 (en) * | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
JP4572296B2 (ja) * | 2004-07-21 | 2010-11-04 | トーアエイヨー株式会社 | ピモベンダン経口投与製剤 |
JP4572293B2 (ja) * | 2004-07-21 | 2010-11-04 | トーアエイヨー株式会社 | ピモベンダン経口投与製剤 |
JP2006028130A (ja) * | 2004-07-21 | 2006-02-02 | Toa Eiyo Ltd | ピモベンダン経口投与製剤 |
JP4572300B2 (ja) * | 2006-01-19 | 2010-11-04 | トーアエイヨー株式会社 | ピモベンダン経口投与製剤 |
EP1920785A1 (en) * | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
GB0818473D0 (en) | 2008-10-08 | 2008-11-12 | Probio Nutraceuticals As | Composition |
WO2010055119A2 (en) * | 2008-11-17 | 2010-05-20 | Novartis Ag | Pharmaceutical composition comprising pimobendan |
ES2436716T3 (es) | 2008-11-25 | 2014-01-03 | Boehringer Ingelheim Vetmedica Gmbh | Pimobendan para uso en el tratamiento de la cardiomiopatía hipertrófica en gatos |
NL1037569C2 (en) | 2009-12-18 | 2011-06-21 | Eurovet Animal Health B V | Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use. |
BR112014003117A2 (pt) | 2011-08-12 | 2017-06-13 | Boehringer Ingelheim Vetmedica Gmbh | inibidores da corrente funny (if) para uso em um método de tratamento e prevenção de insuficiência cardíaca em felino |
EP3034071B1 (en) | 2011-12-21 | 2017-12-06 | Elanco Tiergesundheit AG | New combination |
EP3167876B1 (en) * | 2012-03-15 | 2021-09-08 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
WO2013135853A1 (en) * | 2012-03-15 | 2013-09-19 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical packaging product for the veterinary medical sector |
US10543170B2 (en) * | 2012-12-19 | 2020-01-28 | Bayer Animal Health Gmbh | Tablets with improved acceptance and good storage stability |
CN113181110A (zh) | 2013-07-19 | 2021-07-30 | 勃林格殷格翰动物保健有限公司 | 含有防腐的醚化的环糊精衍生物的液体水性药物组合物 |
BR112016011111B1 (pt) | 2013-12-04 | 2022-11-16 | Boehringer Ingelheim Vetmedica Gmbh | Composições farmacêuticas aprimoradas de pimobendan |
DK3389638T3 (da) | 2015-12-17 | 2023-11-06 | Ceva Sante Animale | Farmaceutisk sammensætning omfattende pimobendan |
US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
CN106729723A (zh) * | 2016-11-21 | 2017-05-31 | 青岛农业大学 | 一种含匹莫苯丹的药物组合物及其制备方法 |
KR102116712B1 (ko) * | 2017-12-22 | 2020-05-29 | 주식회사 고려비엔피 | 기호성이 증진된 경구 투여 제제를 포함하는 개과 동물의 이첨판 판막 변성증 치료 또는 증상 완화용 제제 |
CN114599353A (zh) * | 2019-10-23 | 2022-06-07 | 皮埃蒙特动物健康公司 | 匹莫苯制剂及其使用方法 |
US20240197727A1 (en) | 2022-12-15 | 2024-06-20 | Boehringer Ingelheim Vetmedica Gmbh | Solid dispersions comprising amorphous pimobendan and one or more stabilizing polymers |
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ES8101067A1 (es) | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
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EP0306846A3 (de) | 1987-09-11 | 1990-05-02 | Dr. Karl Thomae GmbH | Neue synergistische Kombination bestehend aus einem Phosphodiesterase-Hemmer und einem Thromboxan-A2-Antagonisten und deren Verwendung bzw. Herstellung |
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DE68906942T3 (de) | 1988-03-29 | 1999-05-12 | University Of Florida, Gainesville, Fla. | Pharmazeutische Zusammensetzungen für die parenterale Anwendung. |
GB8824458D0 (en) * | 1988-10-19 | 1988-11-23 | Orion Yhtymae Oy | Substituted pyridazinones |
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US5364646A (en) * | 1990-01-10 | 1994-11-15 | Dr. Karl Thomae Gmbh | Oral pharmaceutical forms of pimobendan |
DE4001623A1 (de) * | 1990-01-20 | 1991-07-25 | Thomae Gmbh Dr K | Verwendung von benzimidazolen zur herstellung eines zur behandlung von akuten und chronischen obstruktiven atemwegserkrankungen geeigneten arzneimittels |
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JP2004532838A (ja) | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物 |
DE60237696D1 (de) | 2001-08-01 | 2010-10-28 | Univ Utah | Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a |
US20030190343A1 (en) * | 2002-03-05 | 2003-10-09 | Pfizer Inc. | Palatable pharmaceutical compositions for companion animals |
DE10209982A1 (de) * | 2002-03-07 | 2003-09-25 | Boehringer Ingelheim Pharma | Oral zu applizierende Darreichungsform für schwerlösliche basische Wirkstoffe |
PE20040468A1 (es) | 2002-05-17 | 2004-09-14 | Novartis Ag | Combinacion de compuestos organicos |
WO2003099194A2 (en) | 2002-05-23 | 2003-12-04 | Pfizer Limited | Pharmaceutical combination of pde5 inhibitors with ace inhibitors |
DE10228049A1 (de) | 2002-06-24 | 2004-01-15 | Merck Patent Gmbh | Flüssige Zubereitung enthaltend Oligopeptide |
US20040037869A1 (en) | 2002-08-16 | 2004-02-26 | Douglas Cleverly | Non-animal product containing veterinary formulations |
CA2501534A1 (en) | 2002-10-07 | 2004-04-22 | Artesian Therapeutics, Inc. | Dihydropyridine compounds having simultaneous ability to block l-type calcium channels and to inhibit phosphodiesterase type 3 activity |
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-
2004
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2005
- 2005-03-01 ES ES05715625.9T patent/ES2501216T3/es active Active
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- 2005-03-01 JP JP2007501196A patent/JP4757253B2/ja active Active
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- 2005-03-01 HU HUE14171534A patent/HUE045637T2/hu unknown
- 2005-03-01 KR KR1020067020830A patent/KR20070014143A/ko not_active Application Discontinuation
- 2005-03-01 CA CA2557161A patent/CA2557161C/en active Active
- 2005-03-01 PT PT57156259T patent/PT1725218E/pt unknown
- 2005-03-01 SI SI200531881T patent/SI1725218T1/sl unknown
- 2005-03-01 CN CNB2005800075878A patent/CN100546568C/zh active Active
- 2005-03-01 LT LTEP14171534.2T patent/LT2783682T/lt unknown
- 2005-03-01 ES ES14171534T patent/ES2736022T3/es active Active
- 2005-03-01 IN IN7624DEN2014 patent/IN2014DN07624A/en unknown
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- 2005-03-01 AU AU2005218912A patent/AU2005218912C1/en active Active
- 2005-03-01 KR KR1020117031245A patent/KR101290077B1/ko active IP Right Grant
- 2005-03-01 BR BRPI0508557A patent/BRPI0508557B1/pt active IP Right Grant
- 2005-03-01 PL PL14171534T patent/PL2783682T3/pl unknown
- 2005-03-01 NZ NZ549630A patent/NZ549630A/en unknown
- 2005-03-01 WO PCT/EP2005/002133 patent/WO2005084647A1/en active Application Filing
- 2005-03-01 PT PT14171534T patent/PT2783682T/pt unknown
- 2005-03-01 PL PL05715625T patent/PL1725218T3/pl unknown
- 2005-03-01 DK DK05715625.9T patent/DK1725218T3/da active
- 2005-03-01 DK DK14171534.2T patent/DK2783682T3/da active
- 2005-03-04 US US11/072,207 patent/US8846679B2/en active Active
- 2005-03-04 AR ARP050100830A patent/AR047993A1/es active Pending
- 2005-03-07 TW TW094106822A patent/TWI355947B/zh active
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2006
- 2006-07-25 ZA ZA200606154A patent/ZA200606154B/xx unknown
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- 2011-02-03 JP JP2011021706A patent/JP5875231B2/ja active Active
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- 2012-02-22 US US13/402,292 patent/US8846680B2/en active Active
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- 2016-11-30 AR ARP160103652A patent/AR106850A2/es not_active Application Discontinuation
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