PT1107974E - Novas formas de hidratos de alendronato de sodio, processos para a sua producao e suas composicoes farmaceuticas - Google Patents

Novas formas de hidratos de alendronato de sodio, processos para a sua producao e suas composicoes farmaceuticas

Info

Publication number
PT1107974E
PT1107974E PT99944004T PT99944004T PT1107974E PT 1107974 E PT1107974 E PT 1107974E PT 99944004 T PT99944004 T PT 99944004T PT 99944004 T PT99944004 T PT 99944004T PT 1107974 E PT1107974 E PT 1107974E
Authority
PT
Portugal
Prior art keywords
processes
pharmaceutical compositions
hydrates
production
new forms
Prior art date
Application number
PT99944004T
Other languages
English (en)
Portuguese (pt)
Inventor
Nina Finkelstein
Lidor-Hadas Ramy
Aronhime Judith
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of PT1107974E publication Critical patent/PT1107974E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PT99944004T 1998-08-27 1999-08-27 Novas formas de hidratos de alendronato de sodio, processos para a sua producao e suas composicoes farmaceuticas PT1107974E (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9831398P 1998-08-27 1998-08-27
US12974399P 1999-04-16 1999-04-16
US14446199P 1999-07-19 1999-07-19

Publications (1)

Publication Number Publication Date
PT1107974E true PT1107974E (pt) 2006-10-31

Family

ID=27378576

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99944004T PT1107974E (pt) 1998-08-27 1999-08-27 Novas formas de hidratos de alendronato de sodio, processos para a sua producao e suas composicoes farmaceuticas

Country Status (30)

Country Link
US (2) US6281381B1 (https=)
EP (1) EP1107974B1 (https=)
JP (2) JP2002523514A (https=)
KR (2) KR20070034132A (https=)
AT (1) ATE334993T1 (https=)
AU (1) AU5698899A (https=)
BG (1) BG65329B1 (https=)
BR (1) BR9913472A (https=)
CA (1) CA2341459A1 (https=)
CZ (1) CZ2001629A3 (https=)
DE (1) DE69932620T2 (https=)
DK (1) DK1107974T3 (https=)
EA (1) EA002739B1 (https=)
EE (1) EE04552B1 (https=)
ES (1) ES2270613T3 (https=)
HR (1) HRP20010129A2 (https=)
HU (1) HUP0203078A3 (https=)
IL (1) IL141423A (https=)
IS (1) IS5864A (https=)
LT (1) LT4888B (https=)
LV (1) LV12720B (https=)
NO (1) NO20010957L (https=)
NZ (1) NZ510682A (https=)
PL (1) PL346347A1 (https=)
PT (1) PT1107974E (https=)
RO (1) RO122854B1 (https=)
SI (1) SI20581B (https=)
SK (1) SK2482001A3 (https=)
WO (1) WO2000012517A1 (https=)
YU (1) YU14701A (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2336312T3 (es) * 2001-07-16 2010-04-12 Universite Paris 13 Procedimiento de preparacion de derivados de bisfosfonatos.
GB2383042A (en) 2001-10-18 2003-06-18 Cipla Ltd Amorphous alendronate sodium
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
KR100897837B1 (ko) * 2001-12-24 2009-05-15 테바 파마슈티컬 인더스트리즈 리미티드 분말 또는 과립 물질의 압착된 환상체 내에 싸인 활성성분의 코어 정제를 갖는 제형과, 이의 제조 방법 및 툴링
ITMI20020146A1 (it) * 2002-01-29 2003-07-29 Lyogen Ltd Alendronato monosodico amorfo e processo per la sua preparazione
CA2480814A1 (en) * 2002-04-05 2003-10-23 Merck & Co., Inc. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
US20080249068A1 (en) * 2002-09-05 2008-10-09 Deluca Hector F Method of Extending the Dose Range of Vitamin D Compounds
WO2005035542A1 (en) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Solid-state form of alendronate sodium and preparation thereof
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
US20050261250A1 (en) * 2004-05-19 2005-11-24 Merck & Co., Inc., Compositions and methods for inhibiting bone resorption
NZ551118A (en) 2004-05-24 2010-09-30 Warner Chilcott Co Llc Enteric solid oral dosage form of bisphosphonate containing a chelating agent
CZ296937B6 (cs) * 2004-09-02 2006-07-12 Zentiva, A. S Trisodná sul kyseliny 4-amino-1-hydroxybutyliden-1,1-bisfosfonové
AR052321A1 (es) * 2004-10-29 2007-03-14 Sandoz Ag Procesos para la preparacion de un polipeptido
US20060134190A1 (en) * 2004-12-16 2006-06-22 Banner Pharmacaps Inc. Formulations of bisphosphonate drugs with improved bioavailability
CZ297262B6 (cs) * 2004-12-28 2006-10-11 Zentiva, A. S. Trisodná sul kyseliny 4-amino-1-hydroxybutyliden-1,1-bisfosfonové
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
AR058168A1 (es) * 2005-11-07 2008-01-23 Merck & Co Inc Sintesis del alendronato de sodio trihidratado
CA2667345C (en) * 2006-10-27 2016-03-22 Signal Pharmaceuticals, Llc Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol, compositions thereof, and uses therewith
JP5244608B2 (ja) * 2006-11-22 2013-07-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 二糖類化合物のナトリウム塩及びその製造方法並びにその使用
US20090076144A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched bazedoxifene
US20090118238A1 (en) * 2007-09-17 2009-05-07 Protia, Llc Deuterium-enriched alendronate
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
CN102040644B (zh) * 2009-11-03 2014-05-14 刘力 丹参酮衍生物及其制备和用途
MY180626A (en) 2013-11-15 2020-12-03 Akebia Therapeutics Inc Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4711800A (en) * 1985-06-06 1987-12-08 Divincenzo Maureen Needlecraft with metallic substrate
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5039819A (en) 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
US5159108A (en) 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
EP0837863A4 (en) 1995-06-06 1999-06-16 Merck & Co Inc DISODIUM ALENDRONATE PREPARATIONS
ATE289199T1 (de) * 1995-06-06 2005-03-15 Merck & Co Inc Formulierungen mit dem wasserfreien mononatriumsalz von alendronat und deren verwendung zur behandlung von knochenkrankheiten

Also Published As

Publication number Publication date
NO20010957L (no) 2001-04-26
EE04552B1 (et) 2005-10-17
DE69932620T2 (de) 2006-12-14
JP2009143955A (ja) 2009-07-02
LT4888B (lt) 2002-02-25
IL141423A0 (en) 2002-03-10
US20030065214A1 (en) 2003-04-03
LT2001016A (en) 2001-10-25
JP2002523514A (ja) 2002-07-30
IS5864A (is) 2001-02-26
KR20010079701A (ko) 2001-08-22
ES2270613T3 (es) 2007-04-01
WO2000012517A1 (en) 2000-03-09
BG105292A (en) 2001-12-29
ATE334993T1 (de) 2006-08-15
YU14701A (sh) 2003-01-31
NZ510682A (en) 2003-09-26
EE200100126A (et) 2002-06-17
LV12720A (lv) 2001-09-20
EA200100184A1 (ru) 2001-10-22
IL141423A (en) 2005-09-25
BR9913472A (pt) 2002-03-05
WO2000012517A9 (en) 2000-07-13
EA002739B1 (ru) 2002-08-29
US6281381B1 (en) 2001-08-28
PL346347A1 (en) 2002-02-11
EP1107974A4 (en) 2001-09-26
CZ2001629A3 (cs) 2001-08-15
SI20581A (sl) 2001-12-31
NO20010957D0 (no) 2001-02-26
HUP0203078A3 (en) 2005-01-28
AU5698899A (en) 2000-03-21
BG65329B1 (bg) 2008-02-29
KR20070034132A (ko) 2007-03-27
HRP20010129A2 (en) 2005-04-30
DE69932620D1 (de) 2006-09-14
EP1107974A1 (en) 2001-06-20
US6696601B2 (en) 2004-02-24
SK2482001A3 (en) 2002-01-07
DK1107974T3 (da) 2006-10-30
LV12720B (en) 2002-02-20
CA2341459A1 (en) 2000-03-09
HUP0203078A2 (hu) 2003-01-28
EP1107974B1 (en) 2006-08-02
RO122854B1 (ro) 2010-03-30
SI20581B (sl) 2008-06-30

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