PL374877A1 - Nowe tricykliczne spiropiperydyny lub spiropirolidyny - Google Patents

Nowe tricykliczne spiropiperydyny lub spiropirolidyny

Info

Publication number
PL374877A1
PL374877A1 PL03374877A PL37487703A PL374877A1 PL 374877 A1 PL374877 A1 PL 374877A1 PL 03374877 A PL03374877 A PL 03374877A PL 37487703 A PL37487703 A PL 37487703A PL 374877 A1 PL374877 A1 PL 374877A1
Authority
PL
Poland
Prior art keywords
spiropyrrolidines
spiropiperidines
novel tricyclic
tricyclic
novel
Prior art date
Application number
PL03374877A
Other languages
English (en)
Inventor
Nafizal Hossain
Svetlana Ivanova
Marguerite Mensonides-Harsema
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PL374877A1 publication Critical patent/PL374877A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
PL03374877A 2002-07-08 2003-07-07 Nowe tricykliczne spiropiperydyny lub spiropirolidyny PL374877A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0202133A SE0202133D0 (sv) 2002-07-08 2002-07-08 Novel compounds

Publications (1)

Publication Number Publication Date
PL374877A1 true PL374877A1 (pl) 2005-11-14

Family

ID=20288470

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03374877A PL374877A1 (pl) 2002-07-08 2003-07-07 Nowe tricykliczne spiropiperydyny lub spiropirolidyny

Country Status (26)

Country Link
US (2) US7449475B2 (pl)
EP (1) EP1521757B1 (pl)
JP (1) JP2005537255A (pl)
CN (2) CN1326858C (pl)
AR (1) AR040475A1 (pl)
AT (1) ATE385235T1 (pl)
AU (1) AU2003243122B2 (pl)
BR (1) BR0312560A (pl)
CA (1) CA2492122A1 (pl)
CY (1) CY1107915T1 (pl)
DE (1) DE60318948T2 (pl)
DK (1) DK1521757T3 (pl)
ES (1) ES2298575T3 (pl)
HK (1) HK1074622A1 (pl)
IS (1) IS7662A (pl)
MX (1) MXPA05000278A (pl)
NO (1) NO20050635L (pl)
NZ (1) NZ537259A (pl)
PL (1) PL374877A1 (pl)
PT (1) PT1521757E (pl)
RU (1) RU2320664C2 (pl)
SE (1) SE0202133D0 (pl)
TW (1) TW200413386A (pl)
UA (1) UA77809C2 (pl)
WO (1) WO2004005295A1 (pl)
ZA (1) ZA200500024B (pl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
WO2005023771A1 (ja) * 2003-09-05 2005-03-17 Ono Pharmaceutical Co., Ltd. ケモカインレセプターアンタゴニストおよびその医薬用途
SE0302755D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
US20070021498A1 (en) * 2004-10-14 2007-01-25 Nafizal Hossain Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
SE0302811D0 (sv) * 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) * 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303280D0 (sv) * 2003-12-05 2003-12-05 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) * 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
EA200700117A1 (ru) 2004-06-24 2007-06-29 Инсайт Корпорейшн N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
TWI378090B (en) 2005-04-13 2012-12-01 Astex Therapeutics Ltd Pharmaceutical compounds
US8193208B2 (en) 2005-09-09 2012-06-05 Purdue Pharma L.P. Fused and spirocycle compounds and the use thereof
JP5315590B2 (ja) * 2006-02-14 2013-10-16 Ｊｎｃ株式会社 液晶化合物、液晶組成物および液晶表示素子
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
BRPI0714463A2 (pt) * 2006-07-19 2013-04-02 Astrazeneca Ab compostos de espiropiperidina tricÍclicos, sua sÍntese e seus usos como moduladores de atividade receptora de quimiocina
WO2008044027A2 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical compounds having hsp90 inhibitory or modulating activity
JP5721949B2 (ja) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 複合薬剤
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5518478B2 (ja) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド 医薬化合物
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
ES2627221T3 (es) 2006-12-28 2017-07-27 Rigel Pharmaceuticals, Inc. Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso
WO2008103126A1 (en) * 2007-02-23 2008-08-28 Astrazeneca Ab Novel combination of compounds to be used in the treatment of airway diseases, especially chronic obstructive pulmonary disease (copd) and asthma
EP2125728A4 (en) * 2007-02-23 2011-06-22 Astrazeneca Ab NOVEL COMBINATION OF COMPOUNDS FOR THE TREATMENT OF AIRWAY DISEASES, IN PARTICULAR CHRONIC OBSTRUCTIVE BRONCHOPNEUMOPATHY (COPD) AND ASTHMA
WO2008121066A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab Novel tricyclic spiropiperidines or spiropyrrolidines and their use as modulators of chemokine receptors
UY31162A1 (es) * 2007-06-20 2008-11-28 Glaxo Group Ltd Espiroindolinas como moduladores de receptores de quimioquinas
WO2009011653A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab A process for the preparation of intermediates and their us in the synthesis of spiropiperidine compounds
WO2009011655A1 (en) * 2007-07-17 2009-01-22 Astrazeneca Ab Splropiperidine compounds, a process of their preparation, pharmaceutical compositions containing them, and their use in the treatment of airway diseases, inflammatory diseases, copd or asthma
JP5292400B2 (ja) * 2007-07-24 2013-09-18 ブリストル−マイヤーズ スクイブ カンパニー ケモカイン受容体活性のモジュレーターとしてのピペリジン誘導体
EP2190286A4 (en) * 2007-08-14 2011-06-01 Glaxo Group Ltd SPIROINDENES AND SPIROINDANES AS MODULATORS OF CHEMOKINE RECEPTORS
WO2009061881A1 (en) * 2007-11-07 2009-05-14 Glaxo Group Limited Spirodihydrobenzofurans as modulators of chemokine receptors
WO2009097567A1 (en) * 2008-01-30 2009-08-06 Cephalon, Inc. Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands
FR2928150A1 (fr) 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
EP2145891A1 (en) 2008-07-09 2010-01-20 Vetoquinol S.A. 9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
AR078948A1 (es) * 2009-11-30 2011-12-14 Lilly Co Eli Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
US11518739B2 (en) 2017-08-15 2022-12-06 Inflazome Limited Sulfonamide carboxamide compounds

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4010201A (en) * 1974-04-12 1977-03-01 The Upjohn Company Organic compounds
US4166119A (en) 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4166120A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4263317A (en) * 1979-09-06 1981-04-21 Hoechst-Roussel Pharmaceuticals, Inc. Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
US5366986A (en) 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
DE3930262A1 (de) 1989-09-11 1991-03-21 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
NZ258412A (en) * 1992-12-11 1997-01-29 Merck & Co Inc Spiro-fused piperidine derivatives and pharmaceutical compositions
JPH08505880A (ja) * 1993-01-28 1996-06-25 メルク エンド カンパニー インコーポレーテッド タキキニン受容体拮抗薬としてのスピロ置換アザ環式化合物
EP0755392A4 (en) * 1994-04-14 1997-05-02 Merck & Co Inc ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS
US5576321A (en) 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5902824A (en) 1995-05-18 1999-05-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenyldihydrobenzofuranes
US5931917A (en) * 1996-09-26 1999-08-03 Verifone, Inc. System, method and article of manufacture for a gateway system architecture with system administration information accessible from a browser
US5962462A (en) * 1996-12-13 1999-10-05 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
WO1998025605A1 (en) * 1996-12-13 1998-06-18 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
WO1998031364A1 (en) 1997-01-21 1998-07-23 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
CN1290251A (zh) 1998-02-04 2001-04-04 万有制药株式会社 N－酰基环胺衍生物
US6151675A (en) * 1998-07-23 2000-11-21 Tumbleweed Software Corporation Method and apparatus for effecting secure document format conversion
US6288083B1 (en) * 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6212640B1 (en) * 1999-03-25 2001-04-03 Sun Microsystems, Inc. Resources sharing on the internet via the HTTP
US6226752B1 (en) * 1999-05-11 2001-05-01 Sun Microsystems, Inc. Method and apparatus for authenticating users
WO2001030780A2 (en) 1999-10-27 2001-05-03 Cor Therapeutics, Inc. Pyridyl-containing spirocyclic compounds as inhibitors of fibrinogen-dependent platelet aggregation
WO2001064213A1 (en) * 2000-03-02 2001-09-07 Smithkline Beecham Corporation Compounds and methods
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
US7017175B2 (en) * 2001-02-02 2006-03-21 Opentv, Inc. Digital television application protocol for interactive television
WO2002102387A1 (en) 2001-06-18 2002-12-27 H. Lundbeck A/S Treatment of neuropathic pain
US20050143372A1 (en) 2001-10-30 2005-06-30 Shomir Ghosh Compounds, pharmaceutical compositions and methods of use therefor
SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
US7247725B2 (en) 2002-10-30 2007-07-24 Merck & Co., Inc. Gamma-aminoamide modulators of chemokine receptor activity
WO2004050024A2 (en) * 2002-11-27 2004-06-17 Incyte Corporation 3-aminopyrrolidine derivatives as modulators of chemokine receptors
AU2003298797A1 (en) * 2002-12-04 2004-06-23 Entriq Inc. Multiple content provider user interface
US7966418B2 (en) * 2003-02-21 2011-06-21 Axeda Corporation Establishing a virtual tunnel between two computer programs
US20070021498A1 (en) * 2004-10-14 2007-01-25 Nafizal Hossain Novel tricyclic spiroderivatives as modulators of chemokine receptor activity
SE0302755D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
SE0302811D0 (sv) 2003-10-23 2003-10-23 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303280D0 (sv) 2003-12-05 2003-12-05 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
EP1732893A2 (en) 2004-03-29 2006-12-20 Pfizer Japan, Inc. Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as orl1-receptor antagonist

Also Published As

Publication number Publication date
NO20050635L (no) 2005-03-31
HK1074622A1 (en) 2005-11-18
CN1974574A (zh) 2007-06-06
AU2003243122A1 (en) 2004-01-23
DE60318948T2 (de) 2009-05-20
RU2320664C2 (ru) 2008-03-27
ZA200500024B (en) 2006-02-22
CN1675218A (zh) 2005-09-28
DK1521757T3 (da) 2008-05-05
ATE385235T1 (de) 2008-02-15
MXPA05000278A (es) 2005-03-31
PT1521757E (pt) 2008-04-03
AU2003243122B2 (en) 2006-09-28
NZ537259A (en) 2006-08-31
AR040475A1 (es) 2005-04-06
ES2298575T3 (es) 2008-05-16
EP1521757B1 (en) 2008-01-30
US20090062322A1 (en) 2009-03-05
UA77809C2 (en) 2007-01-15
BR0312560A (pt) 2005-05-10
CY1107915T1 (el) 2013-09-04
WO2004005295A1 (en) 2004-01-15
JP2005537255A (ja) 2005-12-08
RU2004137278A (ru) 2005-09-10
US7449475B2 (en) 2008-11-11
TW200413386A (en) 2004-08-01
EP1521757A1 (en) 2005-04-13
CA2492122A1 (en) 2004-01-15
DE60318948D1 (de) 2008-03-20
US20050245741A1 (en) 2005-11-03
IS7662A (is) 2005-01-24
SE0202133D0 (sv) 2002-07-08
CN1326858C (zh) 2007-07-18

Similar Documents

Publication Publication Date Title
PL374877A1 (pl) Nowe tricykliczne spiropiperydyny lub spiropirolidyny
AP1858A (en) Pre-organized tricyclic anhibitor coumpounds
AUPS137402A0 (en) Novel tricyclic compounds
IL166084A0 (en) Novel benzodioxoles
PL371678A1 (pl) Nowe pochodne pirydyny i pirymidyny
PL373598A1 (pl) Nowe benzonaftyrydyny
IL172098A0 (en) Triazolopyrimidines
EP1632492A4 (en) TRICYCLIC CONNECTION
ZA200510276B (en) Triazolopyrimidines
IL163529A0 (en) Novel spinosyn-producing polyketidesynthases
ZA200603778B (en) Novel oxy-nitriles
GB0221788D0 (en) Clopidogrel
PL372989A1 (pl) Triazolopirymidyny
IL164975A0 (en) Novel combination
PL375567A1 (pl) 8-Podstawione imidazopirydyny
GB0214784D0 (en) Novel combination
GB0325291D0 (en) Novel combination
GB0318094D0 (en) Novel combination
PL372591A1 (pl) Nitrozowane imidazopirydyny
SI1521757T1 (sl) Triciklični spiropiperidini ali spiropirolidini
GB0229743D0 (en) Novel benzoxazocines
IL165695A0 (en) Novel tricyclic spiropiperidines or spiropyrrolidines
PL371413A1 (pl) Tricykliczne związki N-acylowe
SI1601677T1 (sl) Spiro-substituirani pirolopirimidini
GB0219635D0 (en) Novel combination

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)