PL373670A1 - Nowe pochodne acyklicznych fosfonianów nukleozydowych, ich sole oraz sposób ich wytwarzania - Google Patents

Nowe pochodne acyklicznych fosfonianów nukleozydowych, ich sole oraz sposób ich wytwarzania

Info

Publication number
PL373670A1
PL373670A1 PL02373670A PL37367002A PL373670A1 PL 373670 A1 PL373670 A1 PL 373670A1 PL 02373670 A PL02373670 A PL 02373670A PL 37367002 A PL37367002 A PL 37367002A PL 373670 A1 PL373670 A1 PL 373670A1
Authority
PL
Poland
Prior art keywords
salts
preparation
same
acyclic nucleoside
phosphonate derivatives
Prior art date
Application number
PL02373670A
Other languages
English (en)
Other versions
PL212730B1 (pl
Inventor
Jong-Ryoo Choi
Jeong-Min Kim
Kee-Yoon Roh
Dong-Gyu Cho
Jae-Hong Lim
Jae-Taeg Hwang
Woo-Young Cho
Hyun-Sook Jang
Chang-Ho Lee
Tae-Saeng Choi
Chung-Mi Kim
Yong-Zu Kim
Tae-Kyun Kim
Seung-Joo Cho
Gyoung-Won Kim
Original Assignee
Lg Life Sciences Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd. filed Critical Lg Life Sciences Ltd.
Publication of PL373670A1 publication Critical patent/PL373670A1/pl
Publication of PL212730B1 publication Critical patent/PL212730B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL373670A 2001-01-19 2002-01-18 Pochodne acyklicznych fosfonianów nukleozydowych oraz sposób ich wytwarzania PL212730B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20010003087 2001-01-19

Publications (2)

Publication Number Publication Date
PL373670A1 true PL373670A1 (pl) 2005-09-05
PL212730B1 PL212730B1 (pl) 2012-11-30

Family

ID=36241797

Family Applications (1)

Application Number Title Priority Date Filing Date
PL373670A PL212730B1 (pl) 2001-01-19 2002-01-18 Pochodne acyklicznych fosfonianów nukleozydowych oraz sposób ich wytwarzania

Country Status (22)

Country Link
US (3) US7157448B2 (pl)
EP (1) EP1358198B1 (pl)
JP (1) JP3959348B2 (pl)
KR (1) KR100441638B1 (pl)
CN (1) CN100347185C (pl)
AR (1) AR035933A1 (pl)
AT (1) ATE478887T1 (pl)
AU (1) AU2002230230B2 (pl)
BR (1) BR0206165A (pl)
CA (1) CA2433591C (pl)
DE (1) DE60237429D1 (pl)
DK (1) DK1358198T3 (pl)
EG (1) EG24382A (pl)
ES (1) ES2350197T3 (pl)
MX (1) MXPA03006001A (pl)
MY (1) MY141789A (pl)
NZ (1) NZ526632A (pl)
PL (1) PL212730B1 (pl)
PT (1) PT1358198E (pl)
RU (1) RU2266294C2 (pl)
WO (1) WO2002057288A1 (pl)
ZA (1) ZA200304181B (pl)

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CA2464031A1 (en) 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
CA2499889A1 (en) * 2002-09-26 2004-04-08 Lg Life Sciences Ltd. (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl) methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof
WO2005028434A2 (en) * 2003-09-18 2005-03-31 Conforma Therapeutics Corporation Novel heterocyclic compounds as hsp90-inhibitors
KR20050062940A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-할로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
KR20050062944A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-클로로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
US20060052346A1 (en) * 2004-02-17 2006-03-09 Averett Devron R Nucleoside phosphonate derivatives useful in the treatment of HIV infections
KR101033290B1 (ko) 2004-07-02 2011-05-09 주식회사 엘지생명과학 다이아이소프로필((1-(하이드록시메틸)-사이클로프로필)옥시)메틸포스포네이트의 새로운 제조 방법
WO2006066074A2 (en) 2004-12-16 2006-06-22 The Regents Of The University Of California Lung-targeted drugs
CA2602257A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
CN104110609B (zh) * 2006-02-27 2017-03-01 照明管理解决方案公司 一种改进的产生宽光束的led装置
US8434912B2 (en) * 2006-02-27 2013-05-07 Illumination Management Solutions, Inc. LED device for wide beam generation
GB0623493D0 (en) * 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
TWI384986B (zh) * 2007-01-17 2013-02-11 Lg Life Sciences Ltd 抗病毒劑之順丁烯二酸單鹽以及含有該單鹽之醫藥組成物
CA2826272A1 (en) 2007-04-13 2009-02-19 Southern Research Institute Anti-angiogenic agents and methods of use
WO2008144672A1 (en) * 2007-05-21 2008-11-27 Illumination Management Solutions, Inc. An improved led device for wide beam generation and method of making the same
CN103459919B (zh) * 2008-08-14 2016-10-26 库帕技术公司 用于偏置宽光束生成的led设备
MX2011005753A (es) * 2008-12-03 2011-11-18 Illumination Man Solutions Inc Una lámpara led de repuesto y un método de sustitución de luminarias preexistentes con ensamble de luminaria led.
CN102093422B (zh) * 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
CN102286026B (zh) * 2010-06-18 2014-07-02 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物
BR112013014485B1 (pt) 2010-12-10 2021-03-30 Sigmapharm Laboratories, Llc Composições farmacêuticas compreendendo pró-fármacos análogos de nucleotídeos de fosfonato ativos por via oral e sistema de embalagem de recipiente/fechamento contendo as ditas composições
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
LT2970346T (lt) 2013-03-15 2018-11-26 The Regents Of The University Of California Acikliniai nukleozido fosfonato diesteriai
CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
AU2015317972B2 (en) 2014-09-15 2019-10-17 The Regents Of The University Of California Nucleotide analogs
CN106432330B (zh) * 2015-08-11 2019-02-01 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途
EP3350191B9 (en) 2015-09-15 2021-12-22 The Regents of the University of California Nucleotide analogs
CN107849074A (zh) * 2016-01-19 2018-03-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
CN106977548A (zh) * 2016-01-19 2017-07-25 四川海思科制药有限公司 倍司福韦复合物及其制备方法和用途
KR102623581B1 (ko) * 2016-07-18 2024-01-11 일동제약(주) 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물
CN108276443A (zh) * 2017-01-06 2018-07-13 米文君 一种新的化合物及其用途
KR102096144B1 (ko) * 2017-07-03 2020-04-01 주식회사 엘지화학 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
CN113735863A (zh) * 2021-09-29 2021-12-03 武汉九州钰民医药科技有限公司 Wee1抑制剂adavosertib的制备工艺
CN113880883A (zh) * 2021-11-11 2022-01-04 奥锐特药业股份有限公司 核苷类磷酸酯前药的制备方法
CN114560463B (zh) * 2022-03-23 2023-10-20 福州大学 一种核壳结构的氮掺杂碳壳包裹碳化钼核微米球材料的制备方法
JP2025526212A (ja) 2022-07-21 2025-08-13 アンティバ バイオサイエンシズ インコーポレイテッド Ｈｐｖ感染症及びｈｐｖ誘発性新生物の治療用の組成物及び剤形

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Also Published As

Publication number Publication date
CN100347185C (zh) 2007-11-07
MXPA03006001A (es) 2003-09-10
US20100004440A1 (en) 2010-01-07
KR100441638B1 (ko) 2004-07-23
AU2002230230B2 (en) 2005-05-26
PL212730B1 (pl) 2012-11-30
NZ526632A (en) 2005-10-28
CA2433591A1 (en) 2002-07-25
EG24382A (en) 2009-04-05
EP1358198A4 (en) 2008-03-05
US20060293284A1 (en) 2006-12-28
MY141789A (en) 2010-06-30
JP2004518675A (ja) 2004-06-24
US7723319B2 (en) 2010-05-25
US7157448B2 (en) 2007-01-02
US20040063668A1 (en) 2004-04-01
HK1062017A1 (en) 2004-10-15
JP3959348B2 (ja) 2007-08-15
BR0206165A (pt) 2004-02-03
US7605147B2 (en) 2009-10-20
WO2002057288A1 (en) 2002-07-25
KR20020062216A (ko) 2002-07-25
DK1358198T3 (da) 2010-10-04
EP1358198A1 (en) 2003-11-05
EP1358198B1 (en) 2010-08-25
ATE478887T1 (de) 2010-09-15
CN1487949A (zh) 2004-04-07
DE60237429D1 (de) 2010-10-07
PT1358198E (pt) 2010-10-01
CA2433591C (en) 2009-07-28
ZA200304181B (en) 2004-10-06
RU2266294C2 (ru) 2005-12-20
RU2003125372A (ru) 2005-01-20
AR035933A1 (es) 2004-07-28
ES2350197T3 (es) 2011-01-20

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Effective date: 20140118