PL3412684T3 - Nowe wektory selekcyjne i sposoby selekcji eukariotycznych komórek gospodarzy - Google Patents
Nowe wektory selekcyjne i sposoby selekcji eukariotycznych komórek gospodarzyInfo
- Publication number
- PL3412684T3 PL3412684T3 PL18179678.0T PL18179678T PL3412684T3 PL 3412684 T3 PL3412684 T3 PL 3412684T3 PL 18179678 T PL18179678 T PL 18179678T PL 3412684 T3 PL3412684 T3 PL 3412684T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- host cells
- eukaryotic host
- selection vectors
- novel selection
- Prior art date
Links
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/40—Systems of functionally co-operating vectors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361860439P | 2013-07-31 | 2013-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3412684T3 true PL3412684T3 (pl) | 2022-08-08 |
Family
ID=51383909
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18179678.0T PL3412684T3 (pl) | 2013-07-31 | 2014-07-29 | Nowe wektory selekcyjne i sposoby selekcji eukariotycznych komórek gospodarzy |
| PL14753158T PL3027646T3 (pl) | 2013-07-31 | 2014-07-29 | Nowe wektory selekcyjne i sposoby selekcji eukariotycznych komórek gospodarza |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14753158T PL3027646T3 (pl) | 2013-07-31 | 2014-07-29 | Nowe wektory selekcyjne i sposoby selekcji eukariotycznych komórek gospodarza |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11807855B2 (enExample) |
| EP (3) | EP4095153A1 (enExample) |
| JP (1) | JP6576924B2 (enExample) |
| KR (1) | KR102288233B1 (enExample) |
| CN (2) | CN105593239B (enExample) |
| AU (1) | AU2014297966B2 (enExample) |
| BR (1) | BR112016001182A2 (enExample) |
| CA (1) | CA2918117C (enExample) |
| DK (2) | DK3412684T3 (enExample) |
| ES (2) | ES2689136T3 (enExample) |
| HU (1) | HUE058885T2 (enExample) |
| IL (1) | IL243352B (enExample) |
| LT (2) | LT3027646T (enExample) |
| MX (1) | MX369109B (enExample) |
| PL (2) | PL3412684T3 (enExample) |
| PT (2) | PT3412684T (enExample) |
| RU (1) | RU2716977C2 (enExample) |
| SG (1) | SG11201510625TA (enExample) |
| WO (1) | WO2015015419A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010097240A1 (en) | 2009-02-27 | 2010-09-02 | Novartis Ag | Expression vector system comprising two selection markers |
| PT3412684T (pt) | 2013-07-31 | 2022-06-27 | Novartis Ag | Novos vetores de seleção e métodos para selecionar células hospedeiras eucarióticas |
| IL309289A (en) * | 2015-10-09 | 2024-02-01 | Genzyme Corp | Improved combustion technology (flow cytometry that reduces the expression of the reporter) for rapid sorting of substances in high masses |
| EP3521435A1 (en) | 2018-02-06 | 2019-08-07 | Bayer AG | A high stringency selection system for protein expression in proline-auxotrophic cells |
| EP3847271A4 (en) * | 2018-09-07 | 2022-10-12 | MedImmune, LLC | Methods of cell selection |
| WO2021053556A1 (en) | 2019-09-18 | 2021-03-25 | Novartis Ag | Nkg2d fusion proteins and uses thereof |
| CN116615462A (zh) | 2020-11-23 | 2023-08-18 | 诺华股份有限公司 | 抗体构建体的表达技术 |
| US20240239871A1 (en) | 2021-04-29 | 2024-07-18 | Novartis Ag | Hypersialylating cells |
| CA3244071A1 (en) * | 2021-12-21 | 2023-06-29 | Absci Corporation | FOLA SELECTION ANALYSIS TO IDENTIFY STRAINS WITH INCREASED SOLUBLE TARGET PROTEIN EXPRESSION |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4771036A (en) | 1986-02-10 | 1988-09-13 | Trustees Of Columbia University In The City Of New York | Method and ophthalmic composition for the prevention and reversal of cataracts |
| JP2585532B2 (ja) | 1986-05-10 | 1997-02-26 | 三井東圧化学株式会社 | 動物細胞の形質転換体及びそれを得る方法並びにその形質転換体を用いてｔ−ＰＡを生産する方法 |
| DE69128037T2 (de) | 1990-11-13 | 1998-05-07 | Immunex Corp., Seattle, Wash. | Bifunktionelle wählbare fusionsgene |
| WO1992017566A2 (en) | 1991-03-29 | 1992-10-15 | Genentech, Inc. | Methods for selection of recombinant host cells expressing high levels of a desired protein |
| CA2163427A1 (en) | 1993-05-21 | 1994-12-08 | Stephen D. Lupton | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5439808A (en) | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| US5830698A (en) | 1997-03-14 | 1998-11-03 | Idec Pharmaceuticals Corporation | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
| US6106825A (en) | 1997-05-07 | 2000-08-22 | University Of Florida | Entomopoxvirus-vertebrate gene delivery vector and method |
| FR2784030B1 (fr) | 1998-10-02 | 2002-12-20 | Inst Nat Sante Rech Med | Utilisation de bloqueurs des canaux calciques et/ou cgmp-dependants pour le traitement de pathologies de la retine |
| FR2823221B1 (fr) | 2001-04-06 | 2004-04-02 | Univ Pasteur | Sequences associees a la degenerescence retinienne et applications |
| DE10256083A1 (de) | 2002-11-29 | 2004-08-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Expressionsvektor, Verfahren zur Herstellung von heterologen Genprodukten und Selektionsverfahren für hochproduzierende rekombinante Zellen |
| US7384744B2 (en) | 2002-11-29 | 2008-06-10 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products |
| WO2004081167A2 (en) * | 2003-03-11 | 2004-09-23 | Applied Research Systems Ars Holding N.V. | Expression vectors comprising the mcmv ie2 promoter |
| DK1716233T3 (da) | 2004-01-30 | 2009-10-26 | Maxygen Holdings Ltd | Reguleret stopkodongennemlæsning |
| US20060275794A1 (en) | 2005-03-07 | 2006-12-07 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| DK1987150T3 (da) | 2006-02-21 | 2011-09-19 | Chromagenics Bv | Selektion af værtsceller, der udtrykker protein på høje niveauer |
| KR101202498B1 (ko) | 2006-05-17 | 2012-11-16 | 에프. 호프만-라 로슈 아게 | 폴리펩티드 생성 세포 |
| WO2009080720A1 (en) | 2007-12-21 | 2009-07-02 | Novartis Ag | Mammalian expression vector |
| CN101903526B (zh) * | 2007-12-21 | 2014-02-12 | 诺华股份有限公司 | 有机化合物 |
| MX2011002273A (es) | 2008-08-28 | 2011-03-30 | Novartis Ag | Despliegue de isoformas de polipeptido en la superficie celular por ultralectura del codon de paro. |
| WO2010029130A1 (en) | 2008-09-10 | 2010-03-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Neuronal viability factor and use thereof |
| MX2011009023A (es) | 2009-02-27 | 2011-09-28 | Novartis Ag | Metodos para seleccionar celulas eucarioticas que expresan una proteina heterologa. |
| WO2010097240A1 (en) | 2009-02-27 | 2010-09-02 | Novartis Ag | Expression vector system comprising two selection markers |
| CN102030754B (zh) * | 2009-09-28 | 2013-07-10 | 中国科学院微生物研究所 | 非病毒载体及其制备方法与应用 |
| PT3412684T (pt) | 2013-07-31 | 2022-06-27 | Novartis Ag | Novos vetores de seleção e métodos para selecionar células hospedeiras eucarióticas |
-
2014
- 2014-07-29 PT PT181796780T patent/PT3412684T/pt unknown
- 2014-07-29 LT LTEP14753158.6T patent/LT3027646T/lt unknown
- 2014-07-29 MX MX2016001396A patent/MX369109B/es active IP Right Grant
- 2014-07-29 EP EP22166577.1A patent/EP4095153A1/en not_active Withdrawn
- 2014-07-29 ES ES14753158.6T patent/ES2689136T3/es active Active
- 2014-07-29 EP EP18179678.0A patent/EP3412684B1/en active Active
- 2014-07-29 KR KR1020167002307A patent/KR102288233B1/ko active Active
- 2014-07-29 SG SG11201510625TA patent/SG11201510625TA/en unknown
- 2014-07-29 EP EP14753158.6A patent/EP3027646B1/en active Active
- 2014-07-29 PL PL18179678.0T patent/PL3412684T3/pl unknown
- 2014-07-29 CN CN201480054263.9A patent/CN105593239B/zh active Active
- 2014-07-29 CN CN202010947233.8A patent/CN112029791A/zh active Pending
- 2014-07-29 PT PT14753158T patent/PT3027646T/pt unknown
- 2014-07-29 CA CA2918117A patent/CA2918117C/en active Active
- 2014-07-29 AU AU2014297966A patent/AU2014297966B2/en active Active
- 2014-07-29 PL PL14753158T patent/PL3027646T3/pl unknown
- 2014-07-29 BR BR112016001182A patent/BR112016001182A2/pt not_active Application Discontinuation
- 2014-07-29 WO PCT/IB2014/063517 patent/WO2015015419A1/en not_active Ceased
- 2014-07-29 JP JP2016530647A patent/JP6576924B2/ja active Active
- 2014-07-29 LT LTEP18179678.0T patent/LT3412684T/lt unknown
- 2014-07-29 HU HUE18179678A patent/HUE058885T2/hu unknown
- 2014-07-29 US US14/907,866 patent/US11807855B2/en active Active
- 2014-07-29 ES ES18179678T patent/ES2920510T3/es active Active
- 2014-07-29 RU RU2016106270A patent/RU2716977C2/ru active
- 2014-07-29 DK DK18179678.0T patent/DK3412684T3/da active
- 2014-07-29 DK DK14753158.6T patent/DK3027646T3/en active
-
2015
- 2015-12-24 IL IL243352A patent/IL243352B/en active IP Right Grant
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