PL2453895T3 - (+)-morfinany jako antagonisty receptora toll-like 9 i ich zastosowania terapeutyczne - Google Patents

(+)-morfinany jako antagonisty receptora toll-like 9 i ich zastosowania terapeutyczne

Info

Publication number
PL2453895T3
PL2453895T3 PL10736929T PL10736929T PL2453895T3 PL 2453895 T3 PL2453895 T3 PL 2453895T3 PL 10736929 T PL10736929 T PL 10736929T PL 10736929 T PL10736929 T PL 10736929T PL 2453895 T3 PL2453895 T3 PL 2453895T3
Authority
PL
Poland
Prior art keywords
morphinans
toll
antagonists
receptor
therapeutic uses
Prior art date
Application number
PL10736929T
Other languages
English (en)
Polish (pl)
Inventor
Bobby N. Trawick
David W. Berberich
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of PL2453895T3 publication Critical patent/PL2453895T3/pl

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    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D217/18—Aralkyl radicals
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    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
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    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
PL10736929T 2009-07-16 2010-07-16 (+)-morfinany jako antagonisty receptora toll-like 9 i ich zastosowania terapeutyczne PL2453895T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22601509P 2009-07-16 2009-07-16
US28687709P 2009-12-16 2009-12-16
EP10736929.0A EP2453895B1 (en) 2009-07-16 2010-07-16 (+) - morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
PCT/US2010/042210 WO2011009015A1 (en) 2009-07-16 2010-07-16 (+) - morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
PL2453895T3 true PL2453895T3 (pl) 2018-10-31

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US (1) US20110015219A1 (OSRAM)
EP (1) EP2453895B1 (OSRAM)
JP (1) JP5864417B2 (OSRAM)
AU (1) AU2010273253B2 (OSRAM)
CA (1) CA2768236C (OSRAM)
DK (1) DK2453895T3 (OSRAM)
ES (1) ES2674018T3 (OSRAM)
NO (1) NO2453895T3 (OSRAM)
PL (1) PL2453895T3 (OSRAM)
TR (1) TR201809739T4 (OSRAM)
WO (1) WO2011009015A1 (OSRAM)

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PL2222643T3 (pl) 2007-12-17 2019-12-31 SpecGx LLC Pochodne synomeniny i sposób ich wytwarzania
NZ586203A (en) * 2007-12-17 2012-10-26 Mallinckrodt Llc Process and compounds for the production of (+) opiates
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
US10363251B2 (en) 2009-07-16 2019-07-30 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
PL2593095T3 (pl) * 2010-07-16 2019-12-31 Mallinckrodt Llc (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania
GB201014026D0 (en) * 2010-08-20 2010-10-06 Ucl Business Plc Treatment
CN103327977B (zh) 2011-01-31 2016-05-04 东丽株式会社 恶液质的治疗或预防剂
PH12014500791A1 (en) 2011-10-26 2022-12-02 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
CN102617470A (zh) * 2012-03-07 2012-08-01 江苏大学 青藤碱4-羟基醚化和酯化衍生物、制备方法及用途
CN103387539A (zh) * 2012-05-08 2013-11-13 长沙理工大学 4-苄氧基-17-乙酰基吗啡喃-6-酮的合成
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