MX371334B - Preparacion de normorfinanos. - Google Patents
Preparacion de normorfinanos.Info
- Publication number
- MX371334B MX371334B MX2016005624A MX2016005624A MX371334B MX 371334 B MX371334 B MX 371334B MX 2016005624 A MX2016005624 A MX 2016005624A MX 2016005624 A MX2016005624 A MX 2016005624A MX 371334 B MX371334 B MX 371334B
- Authority
- MX
- Mexico
- Prior art keywords
- normorphinans
- normorphinan
- carbamate
- preparation
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Abstract
La presente invención proporciona procesos para preparar normorfinanos a partir de morfinanos N-sustituidos. En particular, la invención proporciona métodos para eliminar el N-sustituyente del morfinano N-sustituido para formar un carbamato de normorfinano, y luego eliminar la funcionalidad del carbamato del carbamato de normorfinano para formar el normorfinano.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361905312P | 2013-11-18 | 2013-11-18 | |
PCT/US2014/066152 WO2015074049A1 (en) | 2013-11-18 | 2014-11-18 | Preparation of normorphinans |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016005624A MX2016005624A (es) | 2016-08-19 |
MX371334B true MX371334B (es) | 2020-01-27 |
Family
ID=53058181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016005624A MX371334B (es) | 2013-11-18 | 2014-11-18 | Preparacion de normorfinanos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US9127009B2 (es) |
EP (1) | EP3071575B1 (es) |
JP (1) | JP6389252B2 (es) |
AU (1) | AU2014348256B2 (es) |
BR (1) | BR112016010098A2 (es) |
CA (1) | CA2928205C (es) |
ES (1) | ES2770591T3 (es) |
MX (1) | MX371334B (es) |
PL (1) | PL3071575T3 (es) |
WO (1) | WO2015074049A1 (es) |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040087795A1 (en) * | 2000-07-17 | 2004-05-06 | Borrett Gary Thomas | Novel processes for the preparation of 4-phenylpiperidine derivatives |
WO2002081477A1 (fr) * | 2001-03-30 | 2002-10-17 | Toray Industries, Inc. | Derives morphinane 7-substitues et leur utilisation medicinale |
GB2438400A (en) * | 2006-05-25 | 2007-11-28 | Alpharma Aps | N-Demethylation of 14-hydroxy morphinans with alpha-chloroethyl chloroformate |
WO2008137474A1 (en) * | 2007-05-01 | 2008-11-13 | Concert Pharmaceuticals Inc. | Morphinan compounds |
NZ586186A (en) * | 2007-12-17 | 2012-08-31 | Mallinckrodt Llc | Processes for the preparation of normorphinan salts |
AU2008338972A1 (en) * | 2007-12-17 | 2009-06-25 | Mallinckrodt Inc. | N-demethylation of N-methyl morphinans |
WO2009122436A2 (en) | 2008-03-31 | 2009-10-08 | Sun Pharmaceutical Industries Ltd. | An improved process for the preparation of morphinane analogues |
CA2768236C (en) | 2009-07-16 | 2018-05-22 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
WO2012018871A1 (en) * | 2010-08-04 | 2012-02-09 | Mallinckrodt Llc | Tandem process for preparing n-alkyl morphinans |
JP2013532731A (ja) * | 2010-08-04 | 2013-08-19 | マリンクロッド エルエルシー | 6−ケトモルフィナンのn−脱メチル化 |
-
2014
- 2014-11-18 MX MX2016005624A patent/MX371334B/es active IP Right Grant
- 2014-11-18 EP EP14862986.8A patent/EP3071575B1/en active Active
- 2014-11-18 ES ES14862986T patent/ES2770591T3/es active Active
- 2014-11-18 JP JP2016525976A patent/JP6389252B2/ja active Active
- 2014-11-18 US US14/546,617 patent/US9127009B2/en active Active
- 2014-11-18 WO PCT/US2014/066152 patent/WO2015074049A1/en active Application Filing
- 2014-11-18 AU AU2014348256A patent/AU2014348256B2/en active Active
- 2014-11-18 PL PL14862986T patent/PL3071575T3/pl unknown
- 2014-11-18 BR BR112016010098A patent/BR112016010098A2/pt active Search and Examination
- 2014-11-18 CA CA2928205A patent/CA2928205C/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2015074049A1 (en) | 2015-05-21 |
US20150141649A1 (en) | 2015-05-21 |
CA2928205C (en) | 2020-04-21 |
PL3071575T3 (pl) | 2020-06-01 |
CA2928205A1 (en) | 2015-05-21 |
US9127009B2 (en) | 2015-09-08 |
MX2016005624A (es) | 2016-08-19 |
EP3071575B1 (en) | 2019-11-13 |
ES2770591T3 (es) | 2020-07-02 |
AU2014348256A1 (en) | 2016-05-19 |
BR112016010098A2 (pt) | 2021-07-06 |
EP3071575A1 (en) | 2016-09-28 |
JP2016537334A (ja) | 2016-12-01 |
JP6389252B2 (ja) | 2018-09-12 |
EP3071575A4 (en) | 2017-04-19 |
AU2014348256B2 (en) | 2018-06-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
GB | Transfer or rights |
Owner name: SPECGX LLC |
|
FG | Grant or registration |