MX2016005624A - Preparacion de normorfinanos. - Google Patents

Preparacion de normorfinanos.

Info

Publication number
MX2016005624A
MX2016005624A MX2016005624A MX2016005624A MX2016005624A MX 2016005624 A MX2016005624 A MX 2016005624A MX 2016005624 A MX2016005624 A MX 2016005624A MX 2016005624 A MX2016005624 A MX 2016005624A MX 2016005624 A MX2016005624 A MX 2016005624A
Authority
MX
Mexico
Prior art keywords
normorphinans
normorphinan
carbamate
preparation
substituted
Prior art date
Application number
MX2016005624A
Other languages
English (en)
Other versions
MX371334B (es
Inventor
X Wang Peter
C Hudson Edmund
Brandt John
Liao Subo
T Jarvi Esa
Schaefer Michael
Original Assignee
Mallinckrodt Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Llc filed Critical Mallinckrodt Llc
Publication of MX2016005624A publication Critical patent/MX2016005624A/es
Publication of MX371334B publication Critical patent/MX371334B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención proporciona procesos para preparar normorfinanos a partir de morfinanos N-sustituidos. En particular, la invención proporciona métodos para eliminar el N-sustituyente del morfinano N-sustituido para formar un carbamato de normorfinano, y luego eliminar la funcionalidad del carbamato del carbamato de normorfinano para formar el normorfinano.
MX2016005624A 2013-11-18 2014-11-18 Preparacion de normorfinanos. MX371334B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361905312P 2013-11-18 2013-11-18
PCT/US2014/066152 WO2015074049A1 (en) 2013-11-18 2014-11-18 Preparation of normorphinans

Publications (2)

Publication Number Publication Date
MX2016005624A true MX2016005624A (es) 2016-08-19
MX371334B MX371334B (es) 2020-01-27

Family

ID=53058181

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016005624A MX371334B (es) 2013-11-18 2014-11-18 Preparacion de normorfinanos.

Country Status (10)

Country Link
US (1) US9127009B2 (es)
EP (1) EP3071575B1 (es)
JP (1) JP6389252B2 (es)
AU (1) AU2014348256B2 (es)
BR (1) BR112016010098A2 (es)
CA (1) CA2928205C (es)
ES (1) ES2770591T3 (es)
MX (1) MX371334B (es)
PL (1) PL3071575T3 (es)
WO (1) WO2015074049A1 (es)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040087795A1 (en) * 2000-07-17 2004-05-06 Borrett Gary Thomas Novel processes for the preparation of 4-phenylpiperidine derivatives
WO2002081477A1 (fr) * 2001-03-30 2002-10-17 Toray Industries, Inc. Derives morphinane 7-substitues et leur utilisation medicinale
GB2438400A (en) * 2006-05-25 2007-11-28 Alpharma Aps N-Demethylation of 14-hydroxy morphinans with alpha-chloroethyl chloroformate
WO2008137474A1 (en) * 2007-05-01 2008-11-13 Concert Pharmaceuticals Inc. Morphinan compounds
NZ586186A (en) * 2007-12-17 2012-08-31 Mallinckrodt Llc Processes for the preparation of normorphinan salts
AU2008338972A1 (en) * 2007-12-17 2009-06-25 Mallinckrodt Inc. N-demethylation of N-methyl morphinans
WO2009122436A2 (en) 2008-03-31 2009-10-08 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
CA2768236C (en) 2009-07-16 2018-05-22 Mallinckrodt Llc (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof
WO2012018871A1 (en) * 2010-08-04 2012-02-09 Mallinckrodt Llc Tandem process for preparing n-alkyl morphinans
JP2013532731A (ja) * 2010-08-04 2013-08-19 マリンクロッド エルエルシー ６−ケトモルフィナンのｎ−脱メチル化

Also Published As

Publication number Publication date
WO2015074049A1 (en) 2015-05-21
US20150141649A1 (en) 2015-05-21
CA2928205C (en) 2020-04-21
PL3071575T3 (pl) 2020-06-01
CA2928205A1 (en) 2015-05-21
US9127009B2 (en) 2015-09-08
EP3071575B1 (en) 2019-11-13
ES2770591T3 (es) 2020-07-02
AU2014348256A1 (en) 2016-05-19
BR112016010098A2 (pt) 2021-07-06
EP3071575A1 (en) 2016-09-28
MX371334B (es) 2020-01-27
JP2016537334A (ja) 2016-12-01
JP6389252B2 (ja) 2018-09-12
EP3071575A4 (en) 2017-04-19
AU2014348256B2 (en) 2018-06-07

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