PL217743B1 - Zastosowanie inhibitorów ICE/kaspazy-1 do leczenia napadów i konwulsji w epilepsji oraz zawierające je kompozycja farmaceutyczna i zestaw - Google Patents
Zastosowanie inhibitorów ICE/kaspazy-1 do leczenia napadów i konwulsji w epilepsji oraz zawierające je kompozycja farmaceutyczna i zestawInfo
- Publication number
- PL217743B1 PL217743B1 PL381823A PL38182305A PL217743B1 PL 217743 B1 PL217743 B1 PL 217743B1 PL 381823 A PL381823 A PL 381823A PL 38182305 A PL38182305 A PL 38182305A PL 217743 B1 PL217743 B1 PL 217743B1
- Authority
- PL
- Poland
- Prior art keywords
- compound
- seizure
- stereoisomer
- formula
- onset
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57131404P | 2004-05-15 | 2004-05-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL381823A1 PL381823A1 (pl) | 2007-07-23 |
| PL217743B1 true PL217743B1 (pl) | 2014-08-29 |
Family
ID=34969808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL381823A PL217743B1 (pl) | 2004-05-15 | 2005-05-16 | Zastosowanie inhibitorów ICE/kaspazy-1 do leczenia napadów i konwulsji w epilepsji oraz zawierające je kompozycja farmaceutyczna i zestaw |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20060128696A1 (enExample) |
| EP (1) | EP1750689A1 (enExample) |
| JP (2) | JP4848367B2 (enExample) |
| CN (2) | CN102362867A (enExample) |
| AU (1) | AU2005247409B2 (enExample) |
| CA (1) | CA2566362C (enExample) |
| IL (1) | IL179248A0 (enExample) |
| MX (1) | MXPA06013256A (enExample) |
| NZ (1) | NZ588448A (enExample) |
| PL (1) | PL217743B1 (enExample) |
| WO (1) | WO2005115362A1 (enExample) |
| ZA (1) | ZA200610133B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117846A2 (en) * | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| EP2037887B1 (en) * | 2006-05-31 | 2010-09-15 | Vertex Pharmaceuticals Incorporated | Oral controlled release formulations of an interleukin-1 beta converting enzyme inhibitor |
| JP2013506686A (ja) | 2009-09-30 | 2013-02-28 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | オートファジー阻害遺伝子産物の変調によりオートファジーを変調する方法 |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| RU2537361C1 (ru) * | 2013-07-18 | 2015-01-10 | Общество С Ограниченной Ответственностью "Синтегал" | Оптические изомеры (+) и (-)-бензгидрилмочевин и (+) и (-)-1-[(3-хлорфенил)-фенил-метил]мочевины, фармацевтическая композиция на их основе и способ их получения |
| US10813898B2 (en) | 2016-03-10 | 2020-10-27 | Orphelia Pharma | Solid dosage forms of vigabatrin |
| JP2023524745A (ja) * | 2020-05-01 | 2023-06-13 | メッドスター ヘルス インコーポレイテッド | Covid-19を治療するための方法 |
| WO2024097731A2 (en) * | 2022-11-02 | 2024-05-10 | Medstar Health, Inc. | Methods for treating covid-19 |
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| US5985863A (en) * | 1996-09-12 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor |
| US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
| US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US6995141B1 (en) * | 1990-04-04 | 2006-02-07 | Vertex Pharmaceuticals Incorporated | Interleukin 1β protease and interleukin 1β protease inhibitors |
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| DK0600880T3 (da) | 1991-08-30 | 2004-04-13 | Vertex Pharma | Interleukin 1-beta-protease og interleukin 1-beta-proteasehæmmere |
| US5985838A (en) * | 1993-04-29 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Peptide analogs as irreversible interleukin-1β protease inhibitors |
| US5462939A (en) * | 1993-05-07 | 1995-10-31 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1β-converting enzyme inhibitors |
| JPH0789951A (ja) * | 1993-06-03 | 1995-04-04 | Sterling Winthrop Inc | インターロイキン−1β転換酵素阻害剤 |
| US5843905A (en) * | 1993-06-04 | 1998-12-01 | Vertex Pharmaceuticals, Incorporated | Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors |
| EP0628550B1 (en) * | 1993-06-08 | 1998-02-25 | Sanofi | Pyridazines as interleukin-1beta converting enzyme inhibitors |
| DE69532113T2 (de) * | 1994-03-31 | 2004-07-29 | Vertex Pharmaceuticals Inc., Cambridge | Pyrimidin-derivate als interleukin inhibitoren |
| US5552400A (en) * | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
| US6420522B1 (en) * | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
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| US6057119A (en) * | 1994-06-17 | 2000-05-02 | Vertex Pharmaceuticals, Incorporated | Crystal structure and mutants of interleukin-1β converting enzyme |
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| AU738341B2 (en) | 1996-10-11 | 2001-09-13 | Abbott Gmbh & Co. Kg | Asparate ester inhibitors of interleukin-1beta converting enzyme |
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| DE69735230D1 (de) | 1996-10-11 | 2006-04-20 | Warner Lambert Company Llc Mor | Sulfonamid-substituierte asparaginsäuren als inhibitoren von interleukin-1beta-konvertierenden enzymen |
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| BRPI9909660B8 (pt) | 1998-03-19 | 2021-05-25 | Vertex Pharma | compostos inibidores de caspases, composição farmacêutica e uso de ditos compostos |
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| EP1232253A2 (en) * | 1999-11-16 | 2002-08-21 | Vertex Pharmaceuticals Incorporated | Crystallizable compositions comprising a caspase-7 |
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| NZ521639A (en) * | 2000-03-29 | 2004-05-28 | Vertex Pharma | Carbamate caspase inhibitors and uses thereof |
| DE60142470D1 (de) * | 2000-04-24 | 2010-08-12 | Vertex Pharma | Verfahren und zwischenprodukte zur herstellung von substituierten asparaginsäure-acetalen |
| ATE311370T1 (de) * | 2000-05-04 | 2005-12-15 | Vertex Pharma | Assymetrische synthese von piperazinsäure und ihre derivate |
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| CA2380935A1 (en) * | 2000-05-23 | 2001-11-29 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
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| PE20020500A1 (es) | 2000-09-13 | 2002-06-25 | Vertex Pharma | Derivados de piperidina, tetrahidroquinolina, tetrahidroisoquinolina como inhibidores de caspasas |
| BR0115546A (pt) * | 2000-11-21 | 2003-09-16 | Vertex Pharma | Inibidores de imidazol e de benzimidazol caspase e usos dos mesmos |
| MXPA03009647A (es) * | 2001-04-19 | 2004-01-29 | Vertex Pharma | Heterociclildicarbamidas como inhibidores de caspasa. |
| AU2002305552A1 (en) | 2001-05-10 | 2002-11-18 | Abbott Gmbh And Co.Kg | Arylsulfonamide ethers, and methods of use thereof |
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| EP1480999A2 (en) | 2002-02-08 | 2004-12-01 | Idun Pharmaceuticals | (substituted)acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| WO2003068242A1 (en) * | 2002-02-11 | 2003-08-21 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
| EP1494700A2 (en) | 2002-04-05 | 2005-01-12 | Cytovia, Inc. | Caspase inhibitors for the treatment of diseases and conditions caused by exposure to radionuclides, biological agents, or chemical agents |
| US7960398B2 (en) * | 2002-04-19 | 2011-06-14 | Vertex Pharmaceuticals Incorporated | Regulation of TNF-alpha |
| US7138395B2 (en) | 2002-06-10 | 2006-11-21 | The Procter & Gamble Company | Interleukin-1β converting enzyme inhibitors |
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| PL374598A1 (en) | 2002-06-28 | 2005-10-31 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| CN100366612C (zh) | 2002-12-20 | 2008-02-06 | 沃泰克斯药物股份有限公司 | 4-氧代-3-(1-氧代-1h-异喹啉-2-基乙酰氨基)-戊酸酯和酰胺衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 |
| PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| CN1984660B (zh) | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| JP2007510931A (ja) * | 2003-11-10 | 2007-04-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | Il−18をモニターするための方法 |
| WO2005117846A2 (en) * | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
| US20050233974A1 (en) * | 2003-12-01 | 2005-10-20 | John Randle | Treating infectious diseases using ice inhibitors |
| EP1718639A2 (en) * | 2004-02-27 | 2006-11-08 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| CA2768700C (en) * | 2004-03-12 | 2014-04-29 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
| WO2006057961A1 (en) * | 2004-11-24 | 2006-06-01 | Vertex Pharmaceuticals Incorporated | 3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors |
| ATE529430T1 (de) * | 2005-07-28 | 2011-11-15 | Vertex Pharma | Caspase-hemmer-propharmaka |
-
2005
- 2005-05-16 US US11/130,659 patent/US20060128696A1/en not_active Abandoned
- 2005-05-16 WO PCT/US2005/017177 patent/WO2005115362A1/en not_active Ceased
- 2005-05-16 CA CA2566362A patent/CA2566362C/en not_active Expired - Fee Related
- 2005-05-16 NZ NZ588448A patent/NZ588448A/en not_active IP Right Cessation
- 2005-05-16 EP EP05749516A patent/EP1750689A1/en not_active Withdrawn
- 2005-05-16 ZA ZA200610133A patent/ZA200610133B/en unknown
- 2005-05-16 MX MXPA06013256A patent/MXPA06013256A/es active IP Right Grant
- 2005-05-16 CN CN2011101550931A patent/CN102362867A/zh active Pending
- 2005-05-16 JP JP2007513479A patent/JP4848367B2/ja not_active Expired - Fee Related
- 2005-05-16 PL PL381823A patent/PL217743B1/pl unknown
- 2005-05-16 AU AU2005247409A patent/AU2005247409B2/en not_active Ceased
- 2005-05-16 CN CNA2005800228318A patent/CN1980648A/zh active Pending
-
2006
- 2006-11-14 IL IL179248A patent/IL179248A0/en unknown
-
2011
- 2011-08-02 JP JP2011169647A patent/JP2011213741A/ja active Pending
-
2014
- 2014-12-18 US US14/574,947 patent/US20150190404A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NZ588448A (en) | 2012-01-12 |
| ZA200610133B (en) | 2008-05-28 |
| AU2005247409B2 (en) | 2011-11-10 |
| WO2005115362A1 (en) | 2005-12-08 |
| JP2007538013A (ja) | 2007-12-27 |
| CN102362867A (zh) | 2012-02-29 |
| AU2005247409A1 (en) | 2005-12-08 |
| JP2011213741A (ja) | 2011-10-27 |
| CA2566362A1 (en) | 2005-12-08 |
| EP1750689A1 (en) | 2007-02-14 |
| MXPA06013256A (es) | 2007-02-08 |
| JP4848367B2 (ja) | 2011-12-28 |
| IL179248A0 (en) | 2008-04-13 |
| CN1980648A (zh) | 2007-06-13 |
| CA2566362C (en) | 2013-09-10 |
| US20060128696A1 (en) | 2006-06-15 |
| US20150190404A1 (en) | 2015-07-09 |
| PL381823A1 (pl) | 2007-07-23 |
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