PL188749B1 - Zastosowanie przeciwciała anty-4-1BB i kompozycjaleku - Google Patents
Zastosowanie przeciwciała anty-4-1BB i kompozycjalekuInfo
- Publication number
- PL188749B1 PL188749B1 PL97332699A PL33269997A PL188749B1 PL 188749 B1 PL188749 B1 PL 188749B1 PL 97332699 A PL97332699 A PL 97332699A PL 33269997 A PL33269997 A PL 33269997A PL 188749 B1 PL188749 B1 PL 188749B1
- Authority
- PL
- Poland
- Prior art keywords
- antibody
- cells
- binding
- mab
- antibodies
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2827096P | 1996-10-11 | 1996-10-11 | |
| PCT/US1997/018035 WO1998016249A1 (en) | 1996-10-11 | 1997-10-03 | Methods and compositions for immunomodulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL332699A1 PL332699A1 (en) | 1999-09-27 |
| PL188749B1 true PL188749B1 (pl) | 2005-04-29 |
Family
ID=21842492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL97332699A PL188749B1 (pl) | 1996-10-11 | 1997-10-03 | Zastosowanie przeciwciała anty-4-1BB i kompozycjaleku |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6210669B1 (Direct) |
| EP (1) | EP0948353A1 (Direct) |
| JP (1) | JP2001502325A (Direct) |
| KR (1) | KR100520339B1 (Direct) |
| CN (1) | CN1232402A (Direct) |
| AU (1) | AU738981B2 (Direct) |
| BR (1) | BR9712278A (Direct) |
| CA (1) | CA2268340A1 (Direct) |
| HU (1) | HUP9904697A3 (Direct) |
| IL (1) | IL129138A0 (Direct) |
| NO (1) | NO991676L (Direct) |
| NZ (1) | NZ334691A (Direct) |
| PL (1) | PL188749B1 (Direct) |
| RU (1) | RU2192281C2 (Direct) |
| WO (1) | WO1998016249A1 (Direct) |
Families Citing this family (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6312700B1 (en) * | 1998-02-24 | 2001-11-06 | Andrew D. Weinberg | Method for enhancing an antigen specific immune response with OX-40L |
| KR20000034847A (ko) * | 1998-11-17 | 2000-06-26 | 성재갑 | 인간 4-1비비 분자에 대한 인간화 항체 및 이를 포함하는 약학조성물 |
| CA3016482A1 (en) | 1999-11-30 | 2001-06-07 | Mayo Foundation For Medical Education And Research | B7-h1, a novel immunoregulatory molecule |
| US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| KR100468321B1 (ko) * | 2001-02-08 | 2005-01-27 | 학교법인 울산공업학원 | 종양 및 에이즈치료용 폴리펩타이드 |
| DE60232895D1 (de) * | 2001-10-09 | 2009-08-20 | Mayo Foundation | Verwendung von agonistischen 4-1bb antikörpern zur erhöhung der immunantwort |
| KR100452954B1 (ko) * | 2002-02-26 | 2004-10-14 | 주식회사 엘지생명과학 | 가변영역 아미노산 치환을 통한 인간 4-1비비분자에 대한결합 특이성이 증가된 변형 인간화 항체의 제조방법 |
| US20040175373A1 (en) * | 2002-06-28 | 2004-09-09 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| JP2006506987A (ja) * | 2002-06-28 | 2006-03-02 | エクサイト セラピーズ インコーポレーティッド | 自己免疫および臓器または造血幹細胞移植に関連する免疫学的欠損を有する患者における免疫レパートリー回復のための組成物および方法 |
| US20050084967A1 (en) * | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| NZ538216A (en) * | 2002-07-15 | 2008-09-26 | Mayo Foundation | Treatment and prophylaxis with 4-1BB-binding agents |
| WO2004010947A2 (en) * | 2002-07-30 | 2004-02-05 | Bristol-Myers Squibb Company | Humanized antibodies against human 4-1bb |
| EP1575672A2 (en) * | 2002-12-16 | 2005-09-21 | Herbert Schwarz | Use of cd137 antagonists for the treatment of tumors |
| US20040197312A1 (en) | 2003-04-02 | 2004-10-07 | Marina Moskalenko | Cytokine-expressing cellular vaccine combinations |
| AR046094A1 (es) * | 2003-10-10 | 2005-11-23 | Bristol Myers Squibb Co | Anticuerpos completamente humanos contra 4-1bb humano |
| US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
| KR20050082389A (ko) * | 2004-02-18 | 2005-08-23 | 메덱스젠 주식회사 | 직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물 |
| JP2007530588A (ja) | 2004-03-23 | 2007-11-01 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | レセプターカップリング剤およびその治療用途 |
| US20070253961A1 (en) * | 2004-06-09 | 2007-11-01 | Ulsan Industrial Education Foundation | Pharmaceutical Composition Comprising the Anti-4-1Bb Antibody for Treating or Preventing Rheumatoid Arthritis |
| US20080152655A1 (en) * | 2004-09-08 | 2008-06-26 | The Ohio State University Research Foundation | Combination Therapy With Anti-Ctla4 and Anti-4-1BB Antibodies |
| MX2007004176A (es) | 2004-10-06 | 2007-06-15 | Mayo Foundation | B7-h1 y metodos de diagnosis, prognosis, y tratamiento de cancer. |
| US20080249285A1 (en) * | 2004-12-02 | 2008-10-09 | Wilhelmus Josephus Johanna Hermans | Method For Affinity Purification |
| US20080019905A9 (en) * | 2005-02-18 | 2008-01-24 | Strome Scott E | Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection |
| US20060182744A1 (en) * | 2005-02-15 | 2006-08-17 | Strome Scott E | Anti-CD137 antibody as an agent in the treatment of cancer and glycosylation variants thereof |
| WO2006088447A1 (en) * | 2005-02-15 | 2006-08-24 | Gtc Biotherapeutics, Inc. | An anti-cd137 antibody as an agent in the treatement of cancer and glycosylation variants thereof |
| KR101507027B1 (ko) * | 2005-10-21 | 2015-03-31 | 엘에프비 유에스에이, 인크. | 항체 의존성 세포 독성 활성이 증강된 항체, 그 생산 및 사용 방법 |
| WO2007082144A2 (en) * | 2006-01-05 | 2007-07-19 | Mayo Foundation For Medical Education And Research | B7-h1 and survivin in cancer |
| US20090215084A1 (en) * | 2006-01-05 | 2009-08-27 | Mayo Foundation For Medical Education And Research | B7-h1 and b7-h4 in cancer |
| WO2007124361A2 (en) * | 2006-04-20 | 2007-11-01 | Mayo Foundation For Medical Education And Research | Soluble b7-h1 |
| WO2009111315A2 (en) * | 2008-02-29 | 2009-09-11 | Mayo Foundation For Medical Education And Research | Methods for reducing granulomatous inflammation |
| US8475790B2 (en) | 2008-10-06 | 2013-07-02 | Bristol-Myers Squibb Company | Combination of CD137 antibody and CTLA-4 antibody for the treatment of proliferative diseases |
| US20120076722A1 (en) * | 2009-05-14 | 2012-03-29 | University Of Maryland, Baltimore | Methods for treating cancers and diseases associated with 4-1bb (cd137) expression |
| ES2377785B2 (es) | 2010-09-08 | 2012-09-26 | Universidad Miguel Hernández De Elche | Composición farmacéutica para el tratamiento del ojo seco. |
| MY177065A (en) | 2010-09-09 | 2020-09-03 | Pfizer | 4-1bb binding molecules |
| ES2724801T3 (es) * | 2011-04-19 | 2019-09-16 | Pfizer | Combinaciones de anticuerpos anti-4-1BB y anticuerpos inductores de ADCC para el tratamiento del cáncer |
| US20140234320A1 (en) * | 2011-06-20 | 2014-08-21 | La Jolla Institute For Allergy And Immunology | Modulators of 4-1bb and immune responses |
| RU2493873C1 (ru) * | 2012-06-07 | 2013-09-27 | Сергей Михайлович Юдин | Инъекционный препарат для повышения спермопродукции у производителей сельскохозяйственных животных и петухов и способ его применения |
| US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| US10259875B2 (en) | 2013-10-01 | 2019-04-16 | Mayo Foundation For Medical Education And Research | Methods for treating cancer in patients with elevated levels of BIM |
| AU2014339816B2 (en) | 2013-10-25 | 2020-05-28 | Pharmacyclics Llc | Treatment using Bruton's tyrosine kinase inhibitors and immunotherapy |
| WO2015069703A1 (en) | 2013-11-06 | 2015-05-14 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
| EP3102604B1 (en) | 2014-02-04 | 2020-01-15 | Pfizer Inc | Combination of a pd-1 antagonist and a 4-1bb agonist for treating cancer |
| US10302653B2 (en) | 2014-05-22 | 2019-05-28 | Mayo Foundation For Medical Education And Research | Distinguishing antagonistic and agonistic anti B7-H1 antibodies |
| WO2016014148A1 (en) | 2014-07-23 | 2016-01-28 | Mayo Foundation For Medical Education And Research | Targeting dna-pkcs and b7-h1 to treat cancer |
| EP4029508A1 (en) | 2014-10-10 | 2022-07-20 | Idera Pharmaceuticals, Inc. | Treatment of cancer using tlr9 agonists and checkpoint inhibitors |
| DK3283107T3 (da) | 2015-04-17 | 2020-08-31 | Bristol Myers Squibb Co | Sammensætninger omfattende en kombination af ipilimumab og nivolumab |
| BR112017024899A2 (pt) | 2015-05-21 | 2018-11-13 | Harpoon Therapeutics, Inc. | proteínas de ligação trispecíficas e métodos de uso. |
| AU2016291817A1 (en) | 2015-07-16 | 2018-02-22 | Biolinerx Ltd. | Compositions and methods for treating cancer |
| WO2017025871A1 (en) | 2015-08-07 | 2017-02-16 | Glaxosmithkline Intellectual Property Development Limited | Combination therapy comprising anti ctla-4 antibodies |
| US20190022092A1 (en) | 2015-09-15 | 2019-01-24 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor and a GITR Binding Molecule, a 4-1BB Agonist, or an OX40 Agonist |
| WO2017075045A2 (en) | 2015-10-30 | 2017-05-04 | Mayo Foundation For Medical Education And Research | Antibodies to b7-h1 |
| EP3429693B1 (en) | 2016-03-15 | 2023-08-23 | Mersana Therapeutics, Inc. | Napi2b-targeted antibody-drug conjugates and methods of use thereof |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| JP7101621B2 (ja) | 2016-05-20 | 2022-07-15 | ハープーン セラピューティクス，インク． | 単一ドメイン血清アルブミン結合タンパク質 |
| CA3025019A1 (en) | 2016-05-20 | 2017-11-23 | Biohaven Pharmaceutical Holding Company Ltd. | Use of glutamate modulating agents with immunotherapies to treat cancer |
| EP3472178A4 (en) | 2016-06-17 | 2020-02-19 | Magenta Therapeutics, Inc. | COMPOSITION AND METHOD FOR DEPLYING CD117 + CELLS |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| JP7080234B2 (ja) | 2016-11-23 | 2022-06-03 | トランスレイショナル・ドラッグ・ディベロップメント・エルエルシー | ベンズアミドおよび活性化合物組成物および使用方法 |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| AU2018205234B2 (en) | 2017-01-06 | 2024-09-19 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes (TILs) with tumor necrosis factor receptor superfamily (TNFRSF) agonists and therapeutic combinations of TILs and TNFRSF agonists |
| KR20240161216A (ko) | 2017-01-20 | 2024-11-12 | 하이델베르크 파마 리서치 게엠베하 | Cd137+ 세포의 고갈을 위한 조성물 및 방법 |
| TW201834697A (zh) | 2017-02-28 | 2018-10-01 | 美商梅爾莎納醫療公司 | Her2標靶抗體－藥物結合物之組合療法 |
| CA3058175A1 (en) | 2017-03-31 | 2018-10-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
| JP7297672B2 (ja) | 2017-04-13 | 2023-06-26 | アジェナス インコーポレイテッド | 抗ｃｄ１３７抗体およびその使用方法 |
| CA3063359A1 (en) | 2017-05-12 | 2018-11-15 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
| TW201919662A (zh) | 2017-06-05 | 2019-06-01 | 美商艾歐凡斯生物治療公司 | 對雙重難治性黑色素瘤使用腫瘤浸潤性淋巴細胞之方法 |
| CA3069438A1 (en) | 2017-07-11 | 2019-01-17 | Compass Therapeutics Llc | Agonist antibodies that bind human cd137 and uses thereof |
| US11512134B2 (en) | 2017-08-01 | 2022-11-29 | Eli Lilly And Company | Anti-CD137 antibodies |
| AU2018311804B2 (en) | 2017-08-01 | 2021-09-02 | Eli Lilly And Company | Anti-CD137 antibodies |
| KR102425983B1 (ko) | 2017-10-13 | 2022-07-29 | 하푼 테라퓨틱스, 인크. | 삼중특이적 단백질 및 사용 방법 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| CN111247169A (zh) | 2017-10-15 | 2020-06-05 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
| WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
| BR112020009663A2 (pt) | 2017-11-17 | 2020-11-10 | Iovance Biotherapeutics, Inc. | método para a expansão de linfócitos infiltrantes de tumor (tils) em uma população terapêutica de tils, método para o tratamento de um indivíduo com câncer, composição |
| US11851497B2 (en) | 2017-11-20 | 2023-12-26 | Compass Therapeutics Llc | CD137 antibodies and tumor antigen-targeting antibodies and uses thereof |
| EP3717021A1 (en) | 2017-11-27 | 2020-10-07 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| EP3727463A1 (en) | 2017-12-21 | 2020-10-28 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine antibody conjugates |
| WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| SG11202006541UA (en) | 2018-01-08 | 2020-08-28 | Iovance Biotherapeutics Inc | Processes for generating til products enriched for tumor antigen-specific t-cells |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| CA3089260A1 (en) * | 2018-01-22 | 2019-07-25 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-4-1bb antibody, antigen-binding fragment thereof and medical use thereof |
| JP2021512962A (ja) | 2018-02-13 | 2021-05-20 | アイオバンス バイオセラピューティクス，インコーポレイテッド | アデノシンａ２ａ受容体アンタゴニストによる腫瘍浸潤性リンパ球（ｔｉｌ）の拡大培養並びにｔｉｌ及びアデノシンａ２ａ受容体アンタゴニストの治療的組み合わせ |
| US11242393B2 (en) | 2018-03-23 | 2022-02-08 | Bristol-Myers Squibb Company | Antibodies against MICA and/or MICB and uses thereof |
| EP3768711B1 (en) | 2018-03-23 | 2023-05-03 | Eli Lilly and Company | Anti-cd137 antibodies for combination with anti-pd-l1 antibodies |
| ES2982509T3 (es) | 2018-03-29 | 2024-10-16 | Iovance Biotherapeutics Inc | Procedimientos para la preparación de linfocitos infiltrantes de tumor y usos de los mismos en inmunoterapia |
| WO2019191676A1 (en) | 2018-03-30 | 2019-10-03 | Bristol-Myers Squibb Company | Methods of treating tumor |
| MA52533A (fr) | 2018-04-27 | 2021-03-03 | Iovance Biotherapeutics Inc | Procédé en circuit fermé pour l'amplification et l'edition de gènes de lymphocytes d'infiltration des tumeurs et leurs utilisations en immunothérapie |
| US12473532B2 (en) | 2018-05-10 | 2025-11-18 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| TW202031273A (zh) | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | 抗ｐｄ－１抗體難治療性之非小細胞肺癌（ｎｓｃｌｃ）病患的治療 |
| AU2019342749B2 (en) | 2018-09-20 | 2025-07-10 | Iovance Biotherapeutics, Inc. | Expansion of tils from cryopreserved tumor samples |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| EP3856771A4 (en) | 2018-09-25 | 2022-06-29 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| CN113365664A (zh) | 2018-10-29 | 2021-09-07 | 梅尔莎纳医疗公司 | 具有含肽接头的半胱氨酸工程化的抗体-药物缀合物 |
| WO2020092839A1 (en) | 2018-10-31 | 2020-05-07 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| EP3873540A4 (en) | 2018-10-31 | 2022-07-27 | Mayo Foundation for Medical Education and Research | METHODS AND MATERIALS FOR THE TREATMENT OF CANCER |
| KR20210091213A (ko) | 2018-11-05 | 2021-07-21 | 이오반스 바이오테라퓨틱스, 인크. | 종양 침윤 림프구의 생성 방법 및 면역치료법에서 이의 용도 |
| CA3118634A1 (en) | 2018-11-05 | 2020-05-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients refractory for anti-pd-1 antibody |
| JP2022506508A (ja) | 2018-11-05 | 2022-01-17 | アイオバンス バイオセラピューティクス，インコーポレイテッド | Ａｋｔ経路阻害剤を利用したｔｉｌの拡大培養 |
| BR112021008266A2 (pt) | 2018-11-05 | 2022-01-04 | Iovance Biotherapeutics Inc | Métodos para expandir linfócitos infiltrantes de tumor em uma população terapêutica de linfócitos infiltrantes de tumor e para tratar um sujeito com câncer, e, população terapêutica de linfócitos infiltrantes de tumor |
| EP3898949A1 (en) | 2018-12-19 | 2021-10-27 | Iovance Biotherapeutics, Inc. | Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof |
| JP7760374B2 (ja) | 2019-03-29 | 2025-10-27 | ターンストーン バイオロジクス コーポレイション | Ｔ細胞治療薬を生成するためのエクスビボ方法ならびに関連する組成物および方法 |
| WO2020232029A1 (en) | 2019-05-13 | 2020-11-19 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| EP3976832A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
| KR20220016157A (ko) | 2019-05-30 | 2022-02-08 | 브리스톨-마이어스 스큅 컴퍼니 | 세포 국재화 시그너쳐 및 조합 요법 |
| JP2022534967A (ja) | 2019-05-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | 多腫瘍遺伝子シグネチャーおよびその使用 |
| WO2021081378A1 (en) | 2019-10-25 | 2021-04-29 | Iovance Biotherapeutics, Inc. | Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| EP4065229A1 (en) | 2019-11-27 | 2022-10-05 | Myst Therapeutics, LLC | Method of producing tumor-reactive t cell composition using modulatory agents |
| WO2021118990A1 (en) | 2019-12-11 | 2021-06-17 | Iovance Biotherapeutics, Inc. | Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same |
| US20230106973A1 (en) | 2020-02-17 | 2023-04-06 | Board Of Regents, The University Of Texas System | Methods for expansion of tumor infiltrating lymphocytes and use thereof |
| AU2021226903A1 (en) | 2020-02-27 | 2022-10-20 | Turnstone Biologics Corp. | Methods for ex vivo enrichment and expansion of tumor reactive T cells and related compositions thereof |
| WO2021226061A1 (en) | 2020-05-04 | 2021-11-11 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| US20230293685A1 (en) | 2020-05-04 | 2023-09-21 | Iovance Biotherapeutics, Inc. | Selection of improved tumor reactive t-cells |
| KR20230012559A (ko) | 2020-05-19 | 2023-01-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 암 치료를 위한 결합 분자 |
| US20230303700A1 (en) | 2020-08-31 | 2023-09-28 | Bristol-Myers Squibb Company | Cell localization signature and immunotherapy |
| US20230372397A1 (en) | 2020-10-06 | 2023-11-23 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| WO2022076606A1 (en) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| WO2022125941A1 (en) | 2020-12-11 | 2022-06-16 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with braf inhibitors and/or mek inhibitors |
| US20240123067A1 (en) | 2020-12-17 | 2024-04-18 | Iovance Biotherapeutics, Inc. | Treatment of cancers with tumor infiltrating lymphocyte therapies |
| CA3202483A1 (en) | 2020-12-17 | 2022-06-23 | Maria Fardis | Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors |
| MX2023007734A (es) | 2020-12-28 | 2023-08-21 | Bristol Myers Squibb Co | Composiciones de anticuerpos y metodos de uso de las mismas. |
| MX2023007650A (es) | 2020-12-28 | 2023-09-11 | Bristol Myers Squibb Co | Metodos de tratamiento de tumores. |
| EP4288140A1 (en) | 2021-02-05 | 2023-12-13 | Iovance Biotherapeutics, Inc. | Adjuvant therapy for cancer |
| CN117279506A (zh) | 2021-03-05 | 2023-12-22 | 艾欧凡斯生物治疗公司 | 肿瘤储存及细胞培养组合物 |
| JP2024514530A (ja) | 2021-04-02 | 2024-04-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 切断型ｃｄｃｐ１に対する抗体およびその使用 |
| EP4326287A2 (en) | 2021-04-19 | 2024-02-28 | Iovance Biotherapeutics, Inc. | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
| JP2024519029A (ja) | 2021-05-17 | 2024-05-08 | アイオバンス バイオセラピューティクス，インコーポレイテッド | Ｐｄ－１遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用 |
| CA3226942A1 (en) | 2021-07-28 | 2023-02-02 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors |
| JP2024534581A (ja) | 2021-09-24 | 2024-09-20 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 腫瘍浸潤リンパ球のための拡張プロセス及び薬剤 |
| EP4423755A2 (en) | 2021-10-27 | 2024-09-04 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| AU2022388729A1 (en) | 2021-11-10 | 2024-05-16 | Iovance Biotherapeutics, Inc. | Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes |
| WO2023147486A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Tumor infiltrating lymphocytes engineered to express payloads |
| WO2023178329A1 (en) | 2022-03-18 | 2023-09-21 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
| EP4507704A1 (en) | 2022-04-15 | 2025-02-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
| CA3258064A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | ANTIBODY COMPOSITIONS AND THEIR METHODS OF USE |
| EP4565683A1 (en) | 2022-08-01 | 2025-06-11 | Iovance Biotherapeutics, Inc. | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
| WO2024151885A1 (en) | 2023-01-13 | 2024-07-18 | Iovance Biotherapeutics, Inc. | Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy |
| WO2025038763A1 (en) | 2023-08-15 | 2025-02-20 | Bristol-Myers Squibb Company | Ceramic hydroxyapatite chromatography flow through method |
| WO2025101484A1 (en) | 2023-11-06 | 2025-05-15 | Iovance Biotherapeutics, Inc. | Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies |
| WO2025145207A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg-depleting agent |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3815472A1 (de) * | 1988-05-06 | 1989-11-16 | Centre Regional De Transfusion | Monoklonaler antikoerper und seine verwendung |
| US5474771A (en) * | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| MX9306682A (es) | 1992-10-30 | 1994-04-29 | Bristol Myers Squibb Co | Ligandos del receptor de la matriz extracelular, que modulan la funcion de los leucocitos. |
| CA2429027C (en) * | 1993-09-16 | 2011-04-05 | Indiana University Foundation | Antibodies against human receptor h4-1bb |
| WO1996029348A1 (en) * | 1995-03-23 | 1996-09-26 | Indiana University Foundation | Monoclonal antibody against human receptor protein 4-1bb and methods of its use for treatment of diseases |
| ES2185770T3 (es) * | 1995-04-08 | 2003-05-01 | Lg Chemical Ltd | Anticuerpo monoclonal especifico para 4-1bb humano y linea celular que lo produce. |
| KR960035080U (ko) * | 1995-04-25 | 1996-11-21 | 보일러용 연소 버너 |
-
1997
- 1997-10-03 EP EP97909987A patent/EP0948353A1/en not_active Withdrawn
- 1997-10-03 CA CA002268340A patent/CA2268340A1/en not_active Abandoned
- 1997-10-03 AU AU47470/97A patent/AU738981B2/en not_active Expired
- 1997-10-03 CN CN97198565A patent/CN1232402A/zh active Pending
- 1997-10-03 PL PL97332699A patent/PL188749B1/pl unknown
- 1997-10-03 WO PCT/US1997/018035 patent/WO1998016249A1/en not_active Ceased
- 1997-10-03 NZ NZ334691A patent/NZ334691A/xx not_active IP Right Cessation
- 1997-10-03 KR KR10-1999-7003114A patent/KR100520339B1/ko not_active Expired - Lifetime
- 1997-10-03 JP JP10518414A patent/JP2001502325A/ja not_active Ceased
- 1997-10-03 US US08/943,529 patent/US6210669B1/en not_active Expired - Lifetime
- 1997-10-03 HU HU9904697A patent/HUP9904697A3/hu unknown
- 1997-10-03 BR BR9712278-5A patent/BR9712278A/pt not_active Application Discontinuation
- 1997-10-03 IL IL12913897A patent/IL129138A0/xx unknown
- 1997-10-03 RU RU99109594/14A patent/RU2192281C2/ru active
-
1999
- 1999-04-09 NO NO991676A patent/NO991676L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO991676D0 (no) | 1999-04-09 |
| CA2268340A1 (en) | 1998-04-23 |
| NZ334691A (en) | 2000-12-22 |
| RU2192281C2 (ru) | 2002-11-10 |
| CN1232402A (zh) | 1999-10-20 |
| PL332699A1 (en) | 1999-09-27 |
| KR20000049045A (ko) | 2000-07-25 |
| IL129138A0 (en) | 2000-02-17 |
| NO991676L (no) | 1999-04-09 |
| EP0948353A1 (en) | 1999-10-13 |
| KR100520339B1 (ko) | 2005-10-12 |
| HUP9904697A2 (hu) | 2000-08-28 |
| JP2001502325A (ja) | 2001-02-20 |
| US6210669B1 (en) | 2001-04-03 |
| HUP9904697A3 (en) | 2001-06-28 |
| WO1998016249A1 (en) | 1998-04-23 |
| AU738981B2 (en) | 2001-10-04 |
| AU4747097A (en) | 1998-05-11 |
| BR9712278A (pt) | 1999-08-31 |
| EP0948353A4 (Direct) | 1999-10-13 |
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