PL1715752T3 - Nowy izolat białka rzepaku - Google Patents

Nowy izolat białka rzepaku

Info

Publication number
PL1715752T3
PL1715752T3 PL05706402T PL05706402T PL1715752T3 PL 1715752 T3 PL1715752 T3 PL 1715752T3 PL 05706402 T PL05706402 T PL 05706402T PL 05706402 T PL05706402 T PL 05706402T PL 1715752 T3 PL1715752 T3 PL 1715752T3
Authority
PL
Poland
Prior art keywords
protein isolate
canola protein
novel canola
novel
isolate
Prior art date
Application number
PL05706402T
Other languages
English (en)
Inventor
Martin Schweizer
Brent E Green
Kevin I Segall
Randy Willardsen
Original Assignee
Burcon Nutrascience Mb Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Burcon Nutrascience Mb Corp filed Critical Burcon Nutrascience Mb Corp
Publication of PL1715752T3 publication Critical patent/PL1715752T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/14Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00Working-up of proteins for foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00Working-up of proteins for foodstuffs
    • A23J3/14Vegetable proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
PL05706402T 2004-01-20 2005-01-20 Nowy izolat białka rzepaku PL1715752T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53703104P 2004-01-20 2004-01-20
PCT/CA2005/000062 WO2005067729A1 (en) 2004-01-20 2005-01-20 Novel canola protein isolate
EP05706402.4A EP1715752B1 (en) 2004-01-20 2005-01-20 Novel canola protein isolate

Publications (1)

Publication Number Publication Date
PL1715752T3 true PL1715752T3 (pl) 2015-10-30

Family

ID=34794437

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05706402T PL1715752T3 (pl) 2004-01-20 2005-01-20 Nowy izolat białka rzepaku

Country Status (14)

Country Link
US (5) US7611735B2 (pl)
EP (1) EP1715752B1 (pl)
JP (1) JP2007518409A (pl)
KR (1) KR101206988B1 (pl)
CN (1) CN1933738B (pl)
AU (1) AU2005204436B2 (pl)
BR (1) BRPI0506976B8 (pl)
CA (1) CA2553640C (pl)
MX (1) MXPA06008222A (pl)
NZ (1) NZ549134A (pl)
PL (1) PL1715752T3 (pl)
RU (1) RU2375909C2 (pl)
WO (1) WO2005067729A1 (pl)
ZA (1) ZA200606733B (pl)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8741356B2 (en) 2001-05-04 2014-06-03 Burcon Nutrascience (Mb) Corp. Production of oil seed protein isolate
US8470385B2 (en) * 2004-01-20 2013-06-25 Burcon Nutrascience (Mb) Corp. Beverage having purified or isolate protein component
CA2553640C (en) * 2004-01-20 2014-12-23 Burcon Nutrascience (Mb) Corp. Novel canola protein isolate
US8460741B2 (en) * 2004-01-20 2013-06-11 Burcon Nutrascience (Mb) Corp. Process for the preparation of a canola protein isolate
WO2005107492A1 (en) * 2004-05-07 2005-11-17 Burcon Nutrascience (Mb) Corp. Protein isolation procedures for reducing phytic acid
US7105732B1 (en) * 2005-03-24 2006-09-12 Wu-Hong Hsieh Musical instrument stand with a self-locking neck lock assembly
KR101310640B1 (ko) 2005-07-01 2013-09-24 버콘 뉴트라사이언스 (엠비) 코포레이션 카놀라 단백질의 생산
AU2006294324B2 (en) 2005-09-21 2012-01-19 Burcon Nutrascience (Mb) Corp. Preparation of canola protein isolate involving isoelectric precipitation
US7764145B2 (en) * 2006-11-30 2010-07-27 Nihon Dempa Kogyo Co., Ltd. Piezoelectric resonator, method of manufacturing the same and electronic part using the same
DK2155779T3 (da) * 2007-06-01 2013-02-18 Ca Minister Agriculture & Food Fremgangsmåde til vandig proteinekstraktion fra Brassicaceae-oliefrø
KR20100051807A (ko) * 2007-08-03 2010-05-18 버콘 뉴트라사이언스 (엠비) 코포레이션 이온 교환을 포함하는 2s 카놀라 단백질의 제조방법
US8821955B2 (en) 2008-05-16 2014-09-02 Siebte Pmi Verwaltungs Gmbh Protein concentrates and isolates, and processes for the production thereof
US8623445B2 (en) 2008-05-16 2014-01-07 Bio-Extraction Inc. Protein concentrates and isolates, and processes for the production thereof
EP2591683B1 (en) * 2008-05-16 2017-03-01 Siebte PMI Verwaltungs GmbH Oilseed protein concentrates and processes for the production thereof
US7981450B2 (en) * 2008-06-20 2011-07-19 Burcon Nutrascience (Mb) Corp. Canola protein isolate
US8142822B2 (en) * 2008-06-20 2012-03-27 Burcon Nutrascience (Mb) Corp. Canola protein isolate
US8609153B2 (en) * 2008-06-20 2013-12-17 Burcon Nutrascience (Mb) Corp. Canola protein isolate
RU2475036C2 (ru) 2008-07-11 2013-02-20 Баркон Ньютрасайнс (Мб) Корп. Получение растворимого изолята белка канолы
US20100036099A1 (en) 2008-07-11 2010-02-11 Martin Schweizer Soluble canola protein isolate production ("nutratein")
EP2323499B1 (en) 2008-08-18 2019-04-03 Burcon Nutrascience (MB) Corp. Production of canola protein isolate without heat treatment
NZ591364A (en) * 2008-08-19 2013-03-28 Burcon Nutrascience Mb Corp Soluble canola protein isolate production from protein micellar mass
WO2010031165A1 (en) * 2008-09-17 2010-03-25 Burcon Nutrascience (Mb) Corp. Emulsified foods
EP2395855A4 (en) * 2009-02-11 2014-08-13 Burcon Nutrascience Mb Corp PREPARATION OF A SOY PROTEIN PRODUCT BY WATER EXTRACTION (S803)
CA2753896C (en) * 2009-03-06 2018-08-28 Biopolymer Technologies, Ltd. Protein-containing foams, manufacture and use thereof
NZ594868A (en) 2009-03-06 2014-01-31 Biopolymer Technologies Ltd Protein-containing emulsions and adhesives, and manufacture and use thereof
CA2760606C (en) 2009-05-14 2021-07-27 Burcon Nutrascience (Mb) Corp. Production of canola protein product without heat treatment ("c200cac")
US20110070343A1 (en) * 2009-09-17 2011-03-24 Sarah Medina Canola protein product from supernatant
LT2498619T (lt) 2009-11-11 2017-08-25 Siebte Pmi Verwaltungs Gmbh Baltymų koncentratai ir izoliatai bei jų gavimo būdai iš skrudintų aliejinių augalų sėklų miltų
US8486675B2 (en) 2009-11-11 2013-07-16 Bioexx Specialty Proteins Ltd. Protein concentrates and isolates, and processes for the production thereof from macroalgae and/or microalgae
US9456621B2 (en) * 2009-12-22 2016-10-04 Burcon Nutrascience (Mb) Corp. pH adjusted soy protein isolate and uses
ES2619849T3 (es) 2010-06-07 2017-06-27 Evertree Adhesivos que contienen proteína, y fabricación y uso de los mismos
DE102011105909A1 (de) 2011-06-28 2013-01-03 Süd-Chemie AG Prozess zur Herstellung eines Rapsproteinisolats
CA2848056C (en) 2011-09-09 2020-04-28 Biopolymer Technologies, Ltd. Protein-containing adhesives, and manufacture and use thereof
LT2753633T (lt) 2011-09-09 2017-04-10 Evertree Baltymo turintys klijai, jų gamyba ir panaudojimas
US9533526B1 (en) 2012-06-15 2017-01-03 Joel Nevins Game object advances for the 3D printing entertainment industry
WO2014020447A2 (en) 2012-07-30 2014-02-06 Biopolymer Tecnologies, Ltd. Protein adhesives containing an anhydride, carboxylic acid, and/or carboxylate salt compound and their use
DE102014005466A1 (de) * 2014-04-12 2015-10-15 Klaus Düring Verfahren zur Gewinnung von Napin und Cruciferin oder einem Gemisch davon aus Raps
CN107072243A (zh) * 2014-09-18 2017-08-18 帝斯曼知识产权资产管理有限公司 生产含油种子蛋白质混合物的方法
WO2017102535A1 (en) 2015-12-17 2017-06-22 Dsm Ip Assets B.V. Rapeseed protein isolate, food comprising the isolate and use as foaming or emulsifying agent
CA3025417C (en) 2016-07-07 2023-08-29 Dsm Ip Assets B.V. Emulsion comprising rapeseed protein isolate, process for obtaining it and use in food
CN109414036A (zh) 2016-07-07 2019-03-01 帝斯曼知识产权资产管理有限公司 获得油菜籽蛋白质分离物的方法以及由此获得的蛋白质分离物
WO2018007493A1 (en) 2016-07-07 2018-01-11 Dsm Ip Assets B.V. Rapeseed protein isolate, food comprising the isolate and use as foaming or emulsifying agent
WO2018007491A1 (en) 2016-07-07 2018-01-11 Dsm Ip Assets B.V. Food grade native rapeseed protein isolate and process for obtaining it
WO2018007494A1 (en) 2016-07-07 2018-01-11 Dsm Ip Assets B.V. Sweet rapeseed protein isolate and process for obtaining it
CN109803539A (zh) 2016-07-07 2019-05-24 帝斯曼知识产权资产管理有限公司 包含油菜籽蛋白质分离物的泡沫
EP3720288B1 (en) * 2017-12-05 2022-01-05 DSM IP Assets B.V. Decolored rapeseed protein isolate
CA3084552A1 (en) * 2017-12-05 2019-06-13 Dsm Ip Assets B.V. Sweet rapeseed protein isolate
CA3085231A1 (en) 2018-01-05 2019-07-11 Dsm Ip Assets B.V. Foam comprising rapeseed and dairy proteins
PL3801068T3 (pl) 2018-06-07 2025-12-08 Dsm Ip Assets B.V. Izolat modyfikowanego białka rzepakowego
EP4373291A2 (en) 2021-07-22 2024-05-29 DSM IP Assets B.V. Pea and rapeseed protein isolate
WO2023052590A1 (en) 2021-09-30 2023-04-06 Dsm Ip Assets B.V. Rapeseed protein isolate
EP4197342A1 (en) 2021-12-20 2023-06-21 DSM IP Assets B.V. Rapeseed protein isolate
WO2025008469A1 (en) 2023-07-05 2025-01-09 Dsm Ip Assets B.V. Augmenting protein content of rapeseed protein meal
WO2025012442A1 (en) 2023-07-13 2025-01-16 Dsm Ip Assets B.V. Rapeseed protein hydrolysate
US20250081986A1 (en) 2023-08-11 2025-03-13 Louis Dreyfus Company Plant Proteins LLC Canola Protein Concentrate and Process for Production
US20250049069A1 (en) 2023-08-11 2025-02-13 Louis Dreyfus Company Plant Proteins LLC Oil Seed Protein Isolate and Process for Production
WO2025038302A1 (en) 2023-08-11 2025-02-20 Louis Dreyfus Company Plant Proteins LLC Canola protein isolate and process for production

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2819626A1 (de) * 1977-05-09 1978-11-23 Procter & Gamble Verfahren zur herstellung von abgewandeltem sojaprotein, nach dem verfahren hergestelltes sojaprotein und dessen verwendung in ersatznahrung
GB2077739B (en) * 1980-06-11 1983-10-26 Gen Foods Ltd Process for isolation of proteins using food grade salt solutions at specified ph and ionic strength
US4418013A (en) * 1981-03-16 1983-11-29 General Foods, Inc. Rapeseed protein isolate
US4500454A (en) * 1982-12-03 1985-02-19 Stauffer Chemical Company Vegetable protein evidencing improved solution viscosity
FR2575400A1 (fr) * 1984-12-28 1986-07-04 Grenet Edouard Procede de traitement de produits agricoles et de leurs dechets renfermant de l'eau et des proteines, en vue de recuperer de l'eau pure directement potable et un residu sec enrichi en proteines, et application de celui-ci
US4889921A (en) * 1987-04-29 1989-12-26 The University Of Toronto Innovations Foundation Production of rapeseed protein materials
JPH0499448A (ja) * 1990-08-14 1992-03-31 Kao Corp 油糧種子由来蛋白質
JP2720646B2 (ja) * 1991-08-12 1998-03-04 不二製油株式会社 7s蛋白の分画法
RU2136180C1 (ru) * 1995-08-04 1999-09-10 Общество с ограниченной ответственностью Компания по производству специальных продуктов питания "Динкома" Безалкогольный тонизирующий напиток
US5844086A (en) 1996-01-31 1998-12-01 Stilts Corporation Oil seed protein extraction
US6094559A (en) * 1997-07-14 2000-07-25 Canon Kabushiki Kaisha Fixing apparatus having cleaning mode and storage medium storing program therefor
US6175699B1 (en) * 1998-05-29 2001-01-16 Canon Kabushiki Kaisha Image fixing device with heater control
JP3644283B2 (ja) * 1998-12-28 2005-04-27 不二製油株式会社 大豆の11sグロブリンよりサブユニットを分画・調製する方法及びその製品
US6459878B1 (en) * 1999-09-30 2002-10-01 Canon Kabushiki Kaisha Heating assembly, image-forming apparatus, and process for producing silicone rubber sponge and roller
US6516166B2 (en) * 2000-09-28 2003-02-04 Canon Kabushiki Kaisha Image fixing apparatus
JP3814542B2 (ja) * 2001-02-20 2006-08-30 キヤノン株式会社 像加熱装置
JP2002270345A (ja) * 2001-03-12 2002-09-20 Canon Inc 加熱体及び加熱装置
US7687087B2 (en) * 2001-05-04 2010-03-30 Burcon Nutrascience (Mb) Corp. Production of oil seed protein isolate
NZ529509A (en) 2001-05-04 2005-01-28 Burcon Nutrascience Mb Corp Production of oil seed protein isolate
EP1389921B1 (en) * 2001-05-04 2010-11-10 Burcon Nutrascience (MB) Corp. Canola protein isolate functionality i
US8741356B2 (en) * 2001-05-04 2014-06-03 Burcon Nutrascience (Mb) Corp. Production of oil seed protein isolate
US20050202154A1 (en) * 2002-05-28 2005-09-15 Diosady Levente L. Production of high-quality protein isolated from defatted meals of Brassica seeds
JP4933002B2 (ja) * 2001-07-26 2012-05-16 キヤノン株式会社 加熱定着装置および加熱用金属製スリーブ
JP2003131502A (ja) * 2001-08-10 2003-05-09 Canon Inc イミド系摺動層を有するヒータ及びこのヒータを用いた像加熱装置
JP3970122B2 (ja) * 2001-08-10 2007-09-05 キヤノン株式会社 ヒータに接触する金属製回転体を有する像加熱装置及びこの回転体及びこの回転体の製造方法
JP4261859B2 (ja) * 2001-10-09 2009-04-30 キヤノン株式会社 像加熱装置
BR0213541A (pt) 2001-10-23 2004-08-31 Burcon Nutrascience Mb Corp Composição alimentìcia que compreende um isolado de proteìna de canola
CN100334963C (zh) 2001-11-20 2007-09-05 伯康营养科学(Mb)公司 生产油籽蛋白分离物的连续方法
CA2363451C (en) * 2001-11-20 2005-05-10 Mcn Bioproducts Inc. Oilseed processing
BR0214946B1 (pt) * 2001-12-13 2013-09-10 processo de preparaÇço de um isolado de proteÍna de canola
US7566556B2 (en) * 2002-03-01 2009-07-28 Academia Sinica Enhancing enzyme thermostability by mixing with sorghum liquor waste
JP4494797B2 (ja) * 2002-03-12 2010-06-30 バーコン ニュートラサイエンス (エムビー) コーポレイション カノーラタンパク質単離物機能性iii
WO2003088760A1 (en) * 2002-04-15 2003-10-30 Burcon Nutrascience (Mb) Corp. Canola protein isolate compositions
AU2003213943A1 (en) * 2002-04-15 2003-11-03 Burcon Nutrascience (Mb) Corp. Flavour-enhanced food product
JP2004006299A (ja) * 2002-04-22 2004-01-08 Canon Inc 基板に発熱抵抗体を有するヒータ及びこのヒータを用いた像加熱装置
JP4298410B2 (ja) * 2002-08-19 2009-07-22 キヤノン株式会社 像加熱装置及びこの装置に用いられる加圧ローラ
US6947679B2 (en) * 2002-08-29 2005-09-20 Canon Kabushiki Kaisha Image forming apparatus and fixing temperature control method
JP2004144833A (ja) * 2002-10-22 2004-05-20 Canon Inc 加熱装置
US7989017B2 (en) * 2002-10-22 2011-08-02 Burcon Nutrascience (Mb) Corp. Canola protein isolate functionality II
JP2004170950A (ja) * 2002-11-06 2004-06-17 Canon Inc 像加熱装置
US8460741B2 (en) * 2004-01-20 2013-06-11 Burcon Nutrascience (Mb) Corp. Process for the preparation of a canola protein isolate
US8470385B2 (en) * 2004-01-20 2013-06-25 Burcon Nutrascience (Mb) Corp. Beverage having purified or isolate protein component
CA2553640C (en) * 2004-01-20 2014-12-23 Burcon Nutrascience (Mb) Corp. Novel canola protein isolate
US8057511B2 (en) * 2004-05-07 2011-11-15 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
KR101310640B1 (ko) * 2005-07-01 2013-09-24 버콘 뉴트라사이언스 (엠비) 코포레이션 카놀라 단백질의 생산
AU2006294324B2 (en) * 2005-09-21 2012-01-19 Burcon Nutrascience (Mb) Corp. Preparation of canola protein isolate involving isoelectric precipitation
KR20100051807A (ko) * 2007-08-03 2010-05-18 버콘 뉴트라사이언스 (엠비) 코포레이션 이온 교환을 포함하는 2s 카놀라 단백질의 제조방법
US8609153B2 (en) * 2008-06-20 2013-12-17 Burcon Nutrascience (Mb) Corp. Canola protein isolate
US7981450B2 (en) * 2008-06-20 2011-07-19 Burcon Nutrascience (Mb) Corp. Canola protein isolate
US20110070343A1 (en) * 2009-09-17 2011-03-24 Sarah Medina Canola protein product from supernatant

Also Published As

Publication number Publication date
US20070244300A1 (en) 2007-10-18
CA2553640C (en) 2014-12-23
US7611735B2 (en) 2009-11-03
RU2375909C2 (ru) 2009-12-20
US20120116055A1 (en) 2012-05-10
KR20060127887A (ko) 2006-12-13
US8541046B2 (en) 2013-09-24
US7959968B2 (en) 2011-06-14
CN1933738B (zh) 2010-06-23
ZA200606733B (en) 2007-12-27
HK1103944A1 (en) 2008-01-04
US20060121171A1 (en) 2006-06-08
NZ549134A (en) 2009-12-24
EP1715752A1 (en) 2006-11-02
AU2005204436B2 (en) 2010-06-10
CA2553640A1 (en) 2005-07-28
AU2005204436A1 (en) 2005-07-28
WO2005067729A1 (en) 2005-07-28
EP1715752A4 (en) 2010-05-05
EP1715752B1 (en) 2015-01-07
MXPA06008222A (es) 2007-01-26
CN1933738A (zh) 2007-03-21
US7682646B2 (en) 2010-03-23
BRPI0506976A (pt) 2007-07-03
BRPI0506976B1 (pt) 2015-04-28
RU2006129908A (ru) 2008-02-27
US20110159166A1 (en) 2011-06-30
JP2007518409A (ja) 2007-07-12
BRPI0506976B8 (pt) 2016-09-13
KR101206988B1 (ko) 2012-11-30
US20050181112A1 (en) 2005-08-18

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