PH30282A - Use of purified surface modifiers to prevent particle aggregation during sterilization - Google Patents

Use of purified surface modifiers to prevent particle aggregation during sterilization

Info

Publication number
PH30282A
PH30282A PH47231A PH47231A PH30282A PH 30282 A PH30282 A PH 30282A PH 47231 A PH47231 A PH 47231A PH 47231 A PH47231 A PH 47231A PH 30282 A PH30282 A PH 30282A
Authority
PH
Philippines
Prior art keywords
surface modifiers
particle aggregation
during sterilization
aggregation during
prevent particle
Prior art date
Application number
PH47231A
Other languages
English (en)
Inventor
Kenneth Robert Hollister
David L Ladd
Gregory L Mcintire
George C Na
Natarajan Rajagopalan
Barbara O-Ching Yuan
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Publication of PH30282A publication Critical patent/PH30282A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476Particles, beads, capsules, spheres
    • A61K49/0485Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/049Surface-modified nanoparticles, e.g. immune-nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
PH47231A 1992-12-16 1993-11-09 Use of purified surface modifiers to prevent particle aggregation during sterilization PH30282A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/991,639 US5352459A (en) 1992-12-16 1992-12-16 Use of purified surface modifiers to prevent particle aggregation during sterilization

Publications (1)

Publication Number Publication Date
PH30282A true PH30282A (en) 1997-02-20

Family

ID=25537416

Family Applications (1)

Application Number Title Priority Date Filing Date
PH47231A PH30282A (en) 1992-12-16 1993-11-09 Use of purified surface modifiers to prevent particle aggregation during sterilization

Country Status (17)

Country Link
US (1) US5352459A (fr)
EP (1) EP0605024A3 (fr)
JP (1) JPH06211647A (fr)
KR (1) KR940013541A (fr)
AU (1) AU663010B2 (fr)
CA (1) CA2102356A1 (fr)
CZ (1) CZ261693A3 (fr)
FI (1) FI935306A (fr)
HU (1) HUT65783A (fr)
IL (1) IL107518A0 (fr)
MY (1) MY110452A (fr)
NO (1) NO934271L (fr)
NZ (1) NZ250116A (fr)
PH (1) PH30282A (fr)
RU (1) RU2114612C1 (fr)
SK (1) SK141693A3 (fr)
TW (1) TW438606B (fr)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346702A (en) * 1992-12-04 1994-09-13 Sterling Winthrop Inc. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
US5298262A (en) * 1992-12-04 1994-03-29 Sterling Winthrop Inc. Use of ionic cloud point modifiers to prevent particle aggregation during sterilization
US5336507A (en) * 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
US5326552A (en) * 1992-12-17 1994-07-05 Sterling Winthrop Inc. Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants
US5525559A (en) * 1993-02-13 1996-06-11 Tioxide Specialties Limited Preparation of mixed powders
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5466440A (en) * 1994-12-30 1995-11-14 Eastman Kodak Company Formulations of oral gastrointestinal diagnostic X-ray contrast agents in combination with pharmaceutically acceptable clays
DE69633222T2 (de) * 1995-02-24 2005-09-08 Elan Pharma International Ltd. Nanopartikel-dispersionen enthaltende aerosole
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US20050267302A1 (en) * 1995-12-11 2005-12-01 G.D. Searle & Co. Eplerenone crystalline form exhibiting enhanced dissolution rate
GB9603547D0 (en) * 1996-02-20 1996-04-17 Nycomed Imaging As Contrast media
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US20050004049A1 (en) * 1997-03-11 2005-01-06 Elan Pharma International Limited Novel griseofulvin compositions
GB9705340D0 (en) * 1997-03-14 1997-04-30 Nycomed Imaging As Compositions
WO1998048847A1 (fr) * 1997-04-25 1998-11-05 Nycomed Imaging As Composition de nanoparticules contenant une substance de contraste de rayons x iodee destinee a une sterilisation thermique
GB9712981D0 (en) * 1997-06-19 1997-08-27 Nycomed Imaging As Compositions
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
JP2002516267A (ja) 1998-05-29 2002-06-04 アールティーピー・ファーマ・インコーポレーテッド 熱的に保護された微粒子組成物及びその最終蒸気滅菌
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US20080213378A1 (en) * 1998-10-01 2008-09-04 Elan Pharma International, Ltd. Nanoparticulate statin formulations and novel statin combinations
US20070160675A1 (en) * 1998-11-02 2007-07-12 Elan Corporation, Plc Nanoparticulate and controlled release compositions comprising a cephalosporin
US20090297602A1 (en) * 1998-11-02 2009-12-03 Devane John G Modified Release Loxoprofen Compositions
HU230454B1 (hu) 1998-11-02 2016-07-28 Alkermes Pharma Ireland Limited Metilfenidátot tartalmazó módosított felszabadulású sokszemcsés készítmény
US6375986B1 (en) 2000-09-21 2002-04-23 Elan Pharma International Ltd. Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate
US6969529B2 (en) 2000-09-21 2005-11-29 Elan Pharma International Ltd. Nanoparticulate compositions comprising copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers
BR9915738A (pt) 1998-11-20 2001-10-02 Rtp Pharma Inc Micropartìculas estabilizadas em fosfolipìdeos dispersìveis
US6267989B1 (en) 1999-03-08 2001-07-31 Klan Pharma International Ltd. Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions
UA74539C2 (en) 1999-12-08 2006-01-16 Pharmacia Corp Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants)
CN100413881C (zh) * 1999-12-08 2008-08-27 法马西亚公司 依匹乐酮晶形
US20030083493A1 (en) * 1999-12-08 2003-05-01 Barton Kathleen P. Eplerenone drug substance having high phase purity
SK12672001A3 (sk) * 1999-12-08 2002-04-04 Pharmacia Corporation Zloženia inhibítora cyklooxygenázy-2 s rýchlym nástupom terapeutického účinku
MY120279A (en) 2000-05-26 2005-09-30 Pharmacia Corp Use of a celecoxib composition for fast pain relief
US20080241070A1 (en) * 2000-09-21 2008-10-02 Elan Pharma International Ltd. Fenofibrate dosage forms
US7276249B2 (en) * 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
US20030224058A1 (en) * 2002-05-24 2003-12-04 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
US7198795B2 (en) * 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
US7998507B2 (en) * 2000-09-21 2011-08-16 Elan Pharma International Ltd. Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors
CA2436574A1 (fr) * 2000-12-06 2002-06-13 Pharmacia Corporation Procede de broyage a echelle de laboratoire
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US20050048126A1 (en) 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US6869617B2 (en) * 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20030072807A1 (en) * 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
US6976647B2 (en) * 2001-06-05 2005-12-20 Elan Pharma International, Limited System and method for milling materials
US7758890B2 (en) 2001-06-23 2010-07-20 Lyotropic Therapeutics, Inc. Treatment using dantrolene
JP4464129B2 (ja) * 2001-09-19 2010-05-19 エラン ファーマ インターナショナル,リミティド ナノ粒子インスリン製剤
EP1429772A1 (fr) * 2001-09-25 2004-06-23 Pharmacia Corporation Formes a l'etat solide du n-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
IL160570A0 (en) 2001-09-26 2004-07-25 Baxter Int Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
CA2463495C (fr) * 2001-10-12 2011-05-24 Elan Pharma International Ltd. Compositions combinant des caracteristiques de liberation immediate et de liberation prolongee
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
EP1450863A4 (fr) * 2001-11-07 2009-01-07 Imcor Pharmaceutical Company Procedes d'imagerie vasculaire comprenant l'utilisation d'agents de contraste nanoparticulaires
US20030129242A1 (en) * 2002-01-04 2003-07-10 Bosch H. William Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer
PT1471887E (pt) 2002-02-04 2010-07-16 Elan Pharma Int Ltd ComposiãŽes de nanopartculas com lisozima como um estabilizador superficial
US20030215502A1 (en) * 2002-03-20 2003-11-20 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
WO2003082213A2 (fr) * 2002-03-28 2003-10-09 Imcor Pharmaceutical Company Compositions et procedes de distribution d'agents pharmaceutiquement actifs au moyen de nanoparticules
US20040105889A1 (en) * 2002-12-03 2004-06-03 Elan Pharma International Limited Low viscosity liquid dosage forms
PT1494649E (pt) 2002-04-12 2012-04-11 Alkermes Pharma Ireland Ltd Formulações de megestrol em nanopartículas
US9101540B2 (en) 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
US20100226989A1 (en) * 2002-04-12 2010-09-09 Elan Pharma International, Limited Nanoparticulate megestrol formulations
EP1503737B1 (fr) * 2002-05-06 2009-01-07 Elan Pharma International Limited Formulations de nystatine nanoparticulaires
US20070264348A1 (en) * 2002-05-24 2007-11-15 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
CA2488498A1 (fr) * 2002-06-10 2003-12-18 Elan Pharma International Limited Formulation de polycosanol nanoparticulaires et nouvelles combinaisons de polycosanol
WO2004006959A1 (fr) * 2002-07-16 2004-01-22 Elan Pharma International, Ltd Compositions pour doses liquides d'agents actifs nanoparticulaires stables
UY27939A1 (es) 2002-08-21 2004-03-31 Glaxo Group Ltd Compuestos
CA2498207C (fr) * 2002-09-11 2012-03-13 Elan Pharma International Ltd. Compositions d'agents actifs nanoparticulaires stabilisees sous forme de gel
US20040105778A1 (en) * 2002-10-04 2004-06-03 Elan Pharma International Limited Gamma irradiation of solid nanoparticulate active agents
US20040156895A1 (en) * 2002-11-12 2004-08-12 Elan Pharma International Ltd. Solid dosage forms comprising pullulan
WO2004058216A2 (fr) * 2002-12-17 2004-07-15 Elan Pharma International Ltd. Broyage de quantites de composes candidats nanoparticulaires de l'ordre du microgramme
JP4469846B2 (ja) * 2003-01-31 2010-06-02 エラン ファーマ インターナショナル,リミティド ナノ粒子状トピラメート製剤
US20040208833A1 (en) * 2003-02-04 2004-10-21 Elan Pharma International Ltd. Novel fluticasone formulations
US20100297252A1 (en) * 2003-03-03 2010-11-25 Elan Pharma International Ltd. Nanoparticulate meloxicam formulations
US8512727B2 (en) * 2003-03-03 2013-08-20 Alkermes Pharma Ireland Limited Nanoparticulate meloxicam formulations
JP2007501683A (ja) * 2003-05-22 2007-02-01 エラン ファーマ インターナショナル リミテッド γ線照射によるナノ粒子活性物質分散体の滅菌法
WO2005016310A1 (fr) * 2003-08-08 2005-02-24 Elan Pharma International Ltd. Nouvelles compositions de metaxalone
CA2544627A1 (fr) * 2003-11-05 2005-05-19 Elan Pharma International Ltd. Compositions nanoparticulaires comprenant un peptide comme stabilisant de surface
US20090004277A1 (en) * 2004-05-18 2009-01-01 Franchini Miriam K Nanoparticle dispersion containing lactam compound
US20090155331A1 (en) * 2005-11-16 2009-06-18 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
US7910577B2 (en) * 2004-11-16 2011-03-22 Elan Pharma International Limited Injectable nanoparticulate olanzapine formulations
UA89513C2 (uk) * 2004-12-03 2010-02-10 Элан Фарма Интернешнл Лтд. Стабільна композиція з наночастинок ралоксифену гідрохлориду
KR20070116581A (ko) * 2004-12-15 2007-12-10 엘란 파마 인터내셔널 리미티드 나노입자형 타크롤리무스 제제
WO2006069098A1 (fr) * 2004-12-22 2006-06-29 Elan Pharma International Ltd. Formulations de la bicalutamide nanoparticulaire
MX2007008212A (es) * 2005-01-06 2007-08-16 Elan Pharma Int Ltd Formulaciones de candesartan en nanoparticulas.
WO2006088894A2 (fr) * 2005-02-15 2006-08-24 Elan Pharma International Limited Formulations aerosol et injectables de nanoparticules de benzodiazepine
WO2006099121A2 (fr) * 2005-03-10 2006-09-21 Elan Pharma International Limited Preparations de finasteride, de dutasteride et de chlorhydrate de tamsulosine nanoparticulaires et de melanges de ceux-ci
JP2008533174A (ja) * 2005-03-16 2008-08-21 エラン ファーマ インターナショナル リミテッド ナノ粒子ロイコトリエン受容体拮抗薬/副腎皮質ステロイド製剤
CN101198316A (zh) * 2005-03-17 2008-06-11 伊兰制药国际有限公司 纳米微粒双膦酸盐组合物
MX2007011772A (es) * 2005-03-23 2007-12-05 Elan Pharma Int Ltd Formulaciones de antihistaminico y corticosteroide de materia en nanoparticulas.
BRPI0609071A2 (pt) * 2005-04-12 2010-11-16 Elan Pharma Int Ltd composicão estável de ciclosporina nanoparticulada, método para preparar uma ciclosporina nanoparticulada, uso da composição de ciclosporina nanoparticulada estável, e, composição de liberação controlada
WO2006110809A2 (fr) * 2005-04-12 2006-10-19 Elan Pharma International, Limited Formulations inhibitrices de lipase nanoparticulaire
AU2006235487B2 (en) * 2005-04-12 2011-12-22 Elan Pharma International Limited Nanoparticulate quinazoline derivative formulations
WO2006132752A1 (fr) * 2005-05-10 2006-12-14 Elan Pharma International Limited Compositions nanoparticulaires a liberation regulee comprenant de la vitamine k2
AU2006336417A1 (en) * 2005-05-10 2007-08-02 Elan Pharma International, Limited Nanoparticulate clopidogrel formulations
WO2006133045A1 (fr) * 2005-06-03 2006-12-14 Elan Pharma International, Limited Préparations de benidipine nanoparticulaire
CA2610480A1 (fr) * 2005-06-03 2007-05-10 Scott Jenkins Preparations nanoparticulaires a base d'acetaminophene
AU2006255177A1 (en) * 2005-06-03 2006-12-14 Elan Pharma International, Limited Nanoparticulate imatinib mesylate formulations
WO2008073068A1 (fr) 2005-06-08 2008-06-19 Elan Pharma International Limited Compositions à nanoparticules et à libération contrôlée comprenant du cefditoren
ES2335608T3 (es) * 2005-06-09 2010-03-30 Elan Pharma International Limited Formulaciones de ebistina nanoparticuladas.
MX2007015882A (es) * 2005-06-13 2008-03-04 Elan Pharma Int Ltd Formulaciones en combinacion nanoparticulada de clopidogrel y aspirina.
WO2006138421A2 (fr) * 2005-06-15 2006-12-28 Elan Pharma International Limited Formulations d'azelnidipine nanoparticulaire
US20070015719A1 (en) * 2005-07-07 2007-01-18 Elan Pharma International Limited Nanoparticulate clarithromycin formulations
CA2622200A1 (fr) * 2005-09-13 2007-03-22 Elan Pharma International, Limited Formulations nanoparticulaires de tadalafil
EP1933814A2 (fr) 2005-09-15 2008-06-25 Elan Pharma International Limited Formulations aripiprazoliques nanoparticulaires
CA2631233C (fr) 2005-11-28 2011-11-08 Marinus Pharmaceuticals Formes galeniques de ganaxolone et procedes de preparation et d'utilisation de celles-ci
US8367112B2 (en) * 2006-02-28 2013-02-05 Alkermes Pharma Ireland Limited Nanoparticulate carverdilol formulations
CL2007002689A1 (es) 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
EP2101735A2 (fr) 2006-11-28 2009-09-23 Marinus Pharmaceuticals, Inc. Formulations de nanoparticules et procédés de préparation et d'utilisation de celles-ci
US8309129B2 (en) 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8703204B2 (en) 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2008149230A2 (fr) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticules comprenant un médicament, un polymère cellulosique non ionisable et du tocophéryl polyéthylène glycol succinate
EP2197429B9 (fr) 2007-09-03 2016-10-26 Nanotherapeutics, Inc. Compositions particulaires pour l'administration de médicaments faiblement solubles
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
EP2240162A4 (fr) 2007-12-06 2013-10-09 Bend Res Inc Nanoparticules comprenant un polymère non ionisable et un copolymère de méthacrylate fonctionnalisé par amine
EP2231169B1 (fr) 2007-12-06 2016-05-04 Bend Research, Inc. Compositions pharmaceutiques comprenant des nanoparticules et une matière de remise en suspension
US20090238867A1 (en) * 2007-12-13 2009-09-24 Scott Jenkins Nanoparticulate Anidulafungin Compositions and Methods for Making the Same
CA2715422A1 (fr) * 2008-03-21 2009-09-24 Elan Pharma International Limited Compositions pour la delivrance d'imatinib specifique du site et procedes d'utilisation
US20090311335A1 (en) * 2008-06-12 2009-12-17 Scott Jenkins Combination of a triptan and an nsaid
DK3045043T3 (da) 2009-02-26 2020-08-03 Relmada Therapeutics Inc Orale farmaceutiske sammensætninger af 3-hydroxy-n-methylmorphinan med forlænget frigivelse og fremgangsmåde til anvendelse
US7828996B1 (en) * 2009-03-27 2010-11-09 Abbott Cardiovascular Systems Inc. Method for the manufacture of stable, nano-sized particles
FR2945950A1 (fr) 2009-05-27 2010-12-03 Elan Pharma Int Ltd Compositions de nanoparticules anticancereuses et procedes pour les preparer
EP3167875A1 (fr) 2009-05-27 2017-05-17 Alkermes Pharma Ireland Limited Réduction d'agrégation de type paillettes dans des compositions de meloxicam nanoparticulaire
AR077692A1 (es) 2009-08-06 2011-09-14 Vitae Pharmaceuticals Inc Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
US9012511B2 (en) 2010-05-19 2015-04-21 Alkermes Pharma Ireland Limited Nanoparticulate cinacalcet compositions
TWI577377B (zh) 2010-09-16 2017-04-11 Viiv醫療保健公司 醫藥組合物
JP6166721B2 (ja) 2011-07-22 2017-07-19 ケモセントリックス, インコーポレイテッド 4−tert−ブチル−N−[4−クロロ−2−(1−オキシ−ピリジン−4−カルボニル)−フェニル]−ベンゼンスルホンアミドのナトリウム塩の多形
ES2625286T3 (es) 2011-07-22 2017-07-19 Chemocentryx, Inc. Una forma cristalina de la sal sódica de 4-terc-butil-n-[4-cloro-2-(1-oxi-piridin-4-carbonil)-fenil]-bencenosulfonamida
CA2847066C (fr) 2011-09-01 2019-04-30 Glaxo Group Limited Forme cristalline de rilapladib
CN103376650B (zh) * 2012-04-25 2016-03-02 东京应化工业株式会社 遮光层形成用感光性基材组合物的制造方法
US9251937B2 (en) * 2012-06-29 2016-02-02 General Electric Company Heat stable nanoparticle preparations and associated methods thereof
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
HUE054454T2 (hu) 2014-06-25 2021-09-28 Glaxosmithkline Ip Dev Ltd (S)-6-((1-Acetilpiperidin-4-il)amino)-N-(3-(3,4-dihidroizokinolin-2(1H)-il)-2- hidroxipropil)pirimidin-4-karboxamid kristályos sói
WO2016038519A1 (fr) 2014-09-08 2016-03-17 Glaxosmithkline Intellectual Property Development Limited Formes cristallines de 2-(4-(4-éthoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophényl)-n-(5-(1,1,1-trifluoro-2-méthylpropan-2-yl)isoxazol-3-yl)acétamide
CA2984421C (fr) 2015-05-01 2024-04-09 Cocrystal Pharma, Inc. Analogues de nucleosides a utiliser pour le traitement d'infections par des virus de la famille des flaviviridae et du cancer
CA3001722A1 (fr) 2015-10-16 2017-04-20 Marinus Pharmaceuticals, Inc. Formulations injectables de neurosteroide contenant des nanoparticules
KR102518846B1 (ko) 2016-08-11 2023-04-05 오비드 테라퓨틱스 인크. 간질 장애의 치료를 위한 방법 및 조성물
US10391105B2 (en) 2016-09-09 2019-08-27 Marinus Pharmaceuticals Inc. Methods of treating certain depressive disorders and delirium tremens
JP6784553B2 (ja) * 2016-09-20 2020-11-11 第一工業製薬株式会社 セルロースナノファイバー濃縮物の製造方法
WO2020118142A1 (fr) 2018-12-07 2020-06-11 Marinus Pharmaceuticals, Inc. Ganaxolone destiné à être utilisé dans la prophylaxie et le traitement de la dépression post-partum
WO2021026124A1 (fr) 2019-08-05 2021-02-11 Marinus Pharmaceuticals, Inc. Ganaxolone destinée à être utilisée dans le traitement de l'état de mal épileptique
MX2022006014A (es) 2019-12-06 2022-06-22 Marinus Pharmaceuticals Inc Ganaxolona para uso en el tratamiento del complejo de esclerosis tuberosa.
CA3184868A1 (fr) * 2020-07-09 2022-01-13 Rene Holm Formulations a action prolongee

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE5852T1 (de) * 1978-11-20 1984-02-15 American Home Products Corporation Therapeutische zusammensetzungen mit gesteigerter bioverfuegbarkeit und verfahren zu deren herstellung.
SE464743B (sv) * 1989-06-21 1991-06-10 Ytkemiska Inst Foerfarande foer framstaellning av laekemedelspartiklar
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
US5298262A (en) * 1992-12-04 1994-03-29 Sterling Winthrop Inc. Use of ionic cloud point modifiers to prevent particle aggregation during sterilization
US5346702A (en) * 1992-12-04 1994-09-13 Sterling Winthrop Inc. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
US5336507A (en) * 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation

Also Published As

Publication number Publication date
NO934271D0 (no) 1993-11-25
CA2102356A1 (fr) 1994-06-17
NO934271L (no) 1994-06-17
NZ250116A (en) 1994-09-27
HUT65783A (en) 1994-07-28
TW438606B (en) 2001-06-07
MY110452A (en) 1998-05-30
IL107518A0 (en) 1994-02-27
AU663010B2 (en) 1995-09-21
CZ261693A3 (en) 1994-07-13
FI935306A0 (fi) 1993-11-29
HU9303604D0 (en) 1994-04-28
EP0605024A2 (fr) 1994-07-06
SK141693A3 (en) 1994-09-07
US5352459A (en) 1994-10-04
RU2114612C1 (ru) 1998-07-10
EP0605024A3 (fr) 1995-04-12
AU5046693A (en) 1994-06-30
JPH06211647A (ja) 1994-08-02
KR940013541A (ko) 1994-07-15
FI935306A (fi) 1994-06-17

Similar Documents

Publication Publication Date Title
PH30282A (en) Use of purified surface modifiers to prevent particle aggregation during sterilization
HU9303439D0 (en) Use of nonionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
HU9303539D0 (en) Use of charged phospholipids to recuce nanoparticle aggregation
IL107692A0 (en) Use of ionic cloud point modifiers to prevent particle aggregation during sterilization
HK1005985A1 (en) Combined use of hyaluronic acid and therapeutic agents to improve the therapeutic effect
NZ254550A (en) Use of nitrogen-substituted pyrimidines to prepare medicaments useful for treatment or prevention of diabetic complications
GB8706373D0 (en) Pelletising treatment of particles
HU9300536D0 (en) Compounds of medical effect
EP0460912A3 (en) Medicaments for the treatment of sexual disorder
HUT67538A (en) Modified catalyst-composition and process for oxychlorination of ethylene to 1,-2-dichloroethane
EP0331620A3 (en) Agent for the treatment of parkinson's disease
GB8900678D0 (en) Compositions for the prevention and medical treatment of parodonthopathy
EP0486809A3 (en) Use of suramin against tnf-related diseases
ZA931489B (en) Use of interleuken-10 to suppress graft-vs-host disease
GB2261227B (en) Surface treatment of metals
ZA934092B (en) Preparation of carbonaceous particles
GB9222012D0 (en) Improvements relating to the treatment of haemophilia
IL105690A0 (en) Pharmaceutical compositions for the treatment of arrhythmia
GB9219776D0 (en) New compounds for use in the treatment of cancer
NZ271496A (en) Treating hiv; use of azaspirane compounds to manufacture medicaments
GB2270324B (en) Treatment of y"-hardening nickel-based alloys
GB9010190D0 (en) Composition for the treatment of protozoal disease and their use
EP0584339A4 (en) Method of delivering therapeutic substances to the brain
GB9216360D0 (en) Treatment of blood
GB2266241B (en) Treatment of pastures