PH27337A - Substituted benzazepines their preparation and pharmaceutical compositions containing them - Google Patents

Substituted benzazepines their preparation and pharmaceutical compositions containing them

Info

Publication number
PH27337A
PH27337A PH36675A PH36675A PH27337A PH 27337 A PH27337 A PH 27337A PH 36675 A PH36675 A PH 36675A PH 36675 A PH36675 A PH 36675A PH 27337 A PH27337 A PH 27337A
Authority
PH
Philippines
Prior art keywords
alkyl
preparation
pharmaceutical compositions
alkoxyalkyl
cycloalkyl
Prior art date
Application number
PH36675A
Other languages
English (en)
Inventor
Joel Gilbert Berger
Wei Kong Chang
Marjorie Peters
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PH27337A publication Critical patent/PH27337A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
PH36675A 1987-03-27 1988-03-23 Substituted benzazepines their preparation and pharmaceutical compositions containing them PH27337A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3213587A 1987-03-27 1987-03-27

Publications (1)

Publication Number Publication Date
PH27337A true PH27337A (en) 1993-06-08

Family

ID=21863286

Family Applications (1)

Application Number Title Priority Date Filing Date
PH36675A PH27337A (en) 1987-03-27 1988-03-23 Substituted benzazepines their preparation and pharmaceutical compositions containing them

Country Status (18)

Country Link
EP (2) EP0285919B1 (de)
JP (1) JPH0662574B2 (de)
KR (1) KR930011489B1 (de)
AT (1) ATE112766T1 (de)
AU (1) AU619744B2 (de)
CA (1) CA1321195C (de)
DE (1) DE3851769T2 (de)
DK (1) DK165688C (de)
FI (1) FI894566A (de)
HU (1) HU205744B (de)
IL (1) IL85855A (de)
MY (1) MY103357A (de)
NO (1) NO174507B (de)
NZ (1) NZ224038A (de)
PH (1) PH27337A (de)
PT (1) PT87068B (de)
WO (1) WO1988007526A1 (de)
ZA (1) ZA882080B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK107688D0 (da) * 1988-03-01 1988-03-01 Novo Industri As Carbaminsyreestere af substituerede 7-hydroxy-2,3,4,5-tetrahydro-1h-3-benzazepiner
DK67489D0 (da) * 1989-02-14 1989-02-14 Novo Industri As Nye benzazepinderivater
US5068326A (en) * 1989-04-03 1991-11-26 Kung Hank F Dopamine receptor ligands and imaging agents
IL98487A0 (en) * 1990-06-15 1992-07-15 Schering Corp 8-lower alkyl-5-cycloalkyl or 5-cycloalkenyl substituted benzazepines and pharmaceutical compositions containing them
EP0551312A1 (de) * 1990-09-25 1993-07-21 Schering Corporation Peri-kondensierte benzazepine
US5241065A (en) * 1992-02-25 1993-08-31 Schering Corporation 2,3,4,5-tetrahydro-1h-3-benzazepines having anti-psychotic activity
CN1449386B (zh) * 2000-07-05 2012-07-04 奥索-麦克尼尔药品公司 作为血管升压素拮抗剂的非肽取代的螺苯并氮杂*
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EP1572215B1 (de) * 2002-12-20 2009-09-02 Glaxo Group Limited Benzo[d]azepinderivate für die behandlung von neurologischen krankheiten
JP2006526021A (ja) 2003-05-22 2006-11-16 シェーリング　コーポレイション 肥満およびｃｎｓ障害を治療する選択的ｄ１／ｄ５レセプタアンタゴニストとしての５ｈ−ベンゾ［ｄ］ナフト［２，１−ｂ］アゼピン誘導体
AU2012200805B2 (en) * 2003-06-17 2015-01-22 Arena Pharmaceuticals, Inc. Benzazepine derivatives useful for the treatment of 5HT2C receptor associated diseases
EP2332921B1 (de) 2003-06-17 2016-03-02 Arena Pharmaceuticals, Inc. 8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochlorid
EP1633720A1 (de) * 2003-06-17 2006-03-15 Arena Pharmaceuticals, Inc. Für die behandlung von mit dem 5ht2c-rezeptor assoziierten krankheiten geeignete benzazepinderivative
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
WO2005042490A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
KR101281919B1 (ko) 2004-12-21 2013-07-03 아레나 파마슈티칼스, 인크. (ｒ)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1ｈ-3-벤즈아제핀 히드로클로라이드의 결정질 형태
JP4886700B2 (ja) 2004-12-23 2012-02-29 アリーナ ファーマシューティカルズ， インコーポレイテッド ５ｈｔ２ｃレセプターモジュレーターの組成物およびその使用方法
CN101466684B (zh) 2006-04-03 2012-06-20 艾尼纳制药公司 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体
ES2522587T3 (es) 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
EP2288585A1 (de) 2008-03-04 2011-03-02 Arena Pharmaceuticals, Inc. Verfahren zur herstellung von mit dem 5-ht2c-agonisten (r)-8-chlor-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepin verwandten zwischenprodukten
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
EA201390335A1 (ru) 2010-09-01 2013-09-30 Арена Фармасьютикалз, Инк. Введение лоркасерина индивидуумам с почечной недостаточностью
CA2808909A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
CA2808904A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
KR101913442B1 (ko) 2010-09-01 2018-10-30 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태
AU2012392187B2 (en) 2012-10-09 2018-07-12 Arena Pharmaceuticals, Inc. Method of weight management
HU230826B1 (hu) 2014-11-19 2018-07-30 Richter Gedeon Nyrt. Eljárás benzazepin származékok előállítására

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
DE1934150A1 (de) * 1968-07-10 1970-01-15 Pennwalt Corp Neue 1-Alkanoyloxy-1,2,4,5-tetrahydro-3H,3-benzazepine
US4988690A (en) * 1982-06-14 1991-01-29 Hoechst-Roussel Pharmaceuticals Inc. 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines and anti-depressant use thereof
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser
US4707483A (en) * 1985-12-20 1987-11-17 Smithkline Beckman Corporation 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders
GB8807922D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Isoquinoline compound & process for preparation thereof

Also Published As

Publication number Publication date
FI894566A0 (fi) 1989-09-27
NZ224038A (en) 1990-10-26
ATE112766T1 (de) 1994-10-15
JPH02502723A (ja) 1990-08-30
AU619744B2 (en) 1992-02-06
EP0285919B1 (de) 1994-10-12
PT87068A (pt) 1988-04-01
IL85855A0 (en) 1988-09-30
NO885096L (no) 1988-11-15
CA1321195C (en) 1993-08-10
DK652688A (da) 1988-11-23
DK165688B (da) 1993-01-04
DK652688D0 (da) 1988-11-23
ZA882080B (en) 1989-04-26
HUT53882A (en) 1990-12-28
EP0357641A1 (de) 1990-03-14
DK165688C (da) 1993-05-24
HU205744B (en) 1992-06-29
PT87068B (pt) 1992-07-31
NO174507C (de) 1994-05-18
MY103357A (en) 1993-06-30
KR930011489B1 (ko) 1993-12-08
FI894566A (fi) 1989-09-27
DE3851769T2 (de) 1995-03-09
DE3851769D1 (de) 1994-11-17
IL85855A (en) 1993-02-21
NO885096D0 (no) 1988-11-15
NO174507B (no) 1994-02-07
KR890700577A (ko) 1989-04-25
AU1596488A (en) 1988-11-02
EP0285919A1 (de) 1988-10-12
WO1988007526A1 (en) 1988-10-06
JPH0662574B2 (ja) 1994-08-17

Similar Documents

Publication Publication Date Title
ZA882080B (en) Substituted benzazepines,their preparation and pharmaceutical compositions containing them
PH23607A (en) Amide derivatives and pharmaceutical composition containing said compounds
HUT68762A (en) Fungicidal composition containing carboxyanilide and process for their preparation
DE69332577D1 (de) Verfahren zur Herstellung von 13-Ether-Derivaten von Milbemycinen und Zwischenprodukte
HUT54357A (en) Process for producing benzilidene-(azolylmethyl)-cycloalkane and -cycloalkene derivatives, fungicidal compositions comprising such compounds as active ingredient and intermediates usable for the production of the active ingredients
HUT62296A (en) Herbicidal composition comprising hydantoin derivative as active ingredient and process for producing the active ingredient
AU1832988A (en) Thiazole derivatives
DE3873578D1 (de) Verwendung von tetrahydrobenz(c,d)indol-6-carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
EP1147772A4 (de) Medizinische zusammensetzungen zur behandlung der vorhof-fibrillation
GR3003966T3 (de)
IL88657A (en) Preparation of 1-(substituted phenyl)-2-cyclopropylalkanols,novel 1-(substituted phenyl)-3-alkenol derivatives intermediates thereof,and their use as intermediates in the preparation of fungicidal compounds
GB8925032D0 (en) Chemical compounds
DE3671012D1 (de) 5-alkylsulfonylsalicylanilide und mikrobizide zusammensetzungen fuer die regulierung des wachstums von mikroorganismen.
DE69309461D1 (de) Zusammensetzung zur Beschleunigung der Wundheilung
ZA918518B (en) 8-azabicyclo(3.2.1)octylalkylthiazolidinones,a process for their preparation and their use as medicaments
PT84367A (en) Process for the preparation of a fungicidal compound containing a naphthimidezolone
HUT54688A (en) Process for producing compounds utilizable for treating ulcus and pharmaceutical compositions containing them as active components
HUT59083A (en) Improved process for producing 4-methyl-sulfonyl-benzoic acid derivatives
ES2044883T3 (es) Procedimiento para preparar quinoxalinas sustituidas.
WO1999050252A3 (en) Barbituric acid derivative and preventive and therapeutic agent for bone and cartilage containing the same
ES8506702A1 (es) Un derivado del acido furiloxazolilacetico
ES8400751A1 (es) "procedimiento para preparar nuevos derivados organofosfonados".
HUT53890A (en) Fungicides comprising o-(1,2,4-triazol-1-yl)-o-phenylacetate derivatives as active ingredient and process for producing the active ingredients
DE69129605D1 (de) Verfahren zur Herstellung von N-Alkylpyrazolen
MY103596A (en) Insecticidal compounds - characterised by enhanced knockdown effect.