PH26981A - Intravaginal devices - Google Patents
Intravaginal devices Download PDFInfo
- Publication number
- PH26981A PH26981A PH35384A PH35384A PH26981A PH 26981 A PH26981 A PH 26981A PH 35384 A PH35384 A PH 35384A PH 35384 A PH35384 A PH 35384A PH 26981 A PH26981 A PH 26981A
- Authority
- PH
- Philippines
- Prior art keywords
- estradiol
- core
- elastomer
- ring
- release rate
- Prior art date
Links
- 229960005309 estradiol Drugs 0.000 claims abstract description 30
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims abstract description 24
- 238000000034 method Methods 0.000 claims abstract description 12
- 229920001971 elastomer Polymers 0.000 claims description 29
- 239000000806 elastomer Substances 0.000 claims description 29
- 229920001296 polysiloxane Polymers 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- -1 polydimethylsiloxane Polymers 0.000 claims description 3
- 208000024891 symptom Diseases 0.000 claims description 3
- 230000000144 pharmacologic effect Effects 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 abstract description 4
- 229930182833 estradiol Natural products 0.000 description 11
- 238000000338 in vitro Methods 0.000 description 7
- 150000003431 steroids Chemical class 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 5
- 229940011871 estrogen Drugs 0.000 description 4
- 239000000262 estrogen Substances 0.000 description 4
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 206010030247 Oestrogen deficiency Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-UHFFFAOYSA-N 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2C3CCC(C)(C(CC4)O)C4C3CCC2=C1 VOXZDWNPVJITMN-UHFFFAOYSA-N 0.000 description 1
- BOZRCGLDOHDZBP-UHFFFAOYSA-N 2-ethylhexanoic acid;tin Chemical compound [Sn].CCCCC(CC)C(O)=O BOZRCGLDOHDZBP-UHFFFAOYSA-N 0.000 description 1
- 208000004483 Dyspareunia Diseases 0.000 description 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 101000687911 Homo sapiens Transcription factor SOX-3 Proteins 0.000 description 1
- 206010021067 Hypopituitarism Diseases 0.000 description 1
- 206010027304 Menopausal symptoms Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010027566 Micturition urgency Diseases 0.000 description 1
- 206010033165 Ovarian failure Diseases 0.000 description 1
- 206010036018 Pollakiuria Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102100024276 Transcription factor SOX-3 Human genes 0.000 description 1
- 206010047791 Vulvovaginal dryness Diseases 0.000 description 1
- 206010047998 Withdrawal bleed Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229960003399 estrone Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000010226 intestinal metabolism Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 125000005474 octanoate group Chemical group 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 238000009806 oophorectomy Methods 0.000 description 1
- 201000004535 ovarian dysfunction Diseases 0.000 description 1
- 231100000539 ovarian failure Toxicity 0.000 description 1
- 230000011599 ovarian follicle development Effects 0.000 description 1
- 201000009958 panhypopituitarism Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
- 208000022934 urinary frequency Diseases 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 239000006213 vaginal ring Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Paper (AREA)
- Medicinal Preparation (AREA)
- Prostheses (AREA)
- External Artificial Organs (AREA)
- Materials For Medical Uses (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Window Of Vehicle (AREA)
- Seal Device For Vehicle (AREA)
- Steroid Compounds (AREA)
- Nonmetallic Welding Materials (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8602666A SE8602666D0 (sv) | 1986-06-16 | 1986-06-16 | Intravaginal devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26981A true PH26981A (en) | 1992-12-28 |
Family
ID=20364821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH35384A PH26981A (en) | 1986-06-16 | 1987-06-10 | Intravaginal devices |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4871543A (xx) |
| EP (1) | EP0253109B1 (xx) |
| JP (1) | JP2671953B2 (xx) |
| KR (1) | KR920005824B1 (xx) |
| CN (1) | CN1034391C (xx) |
| AT (1) | ATE68097T1 (xx) |
| AU (1) | AU599988B2 (xx) |
| CA (1) | CA1314482C (xx) |
| DE (1) | DE3773557D1 (xx) |
| DK (1) | DK175529B1 (xx) |
| ES (1) | ES2026481T3 (xx) |
| FI (1) | FI91709C (xx) |
| GR (1) | GR3003551T3 (xx) |
| HU (1) | HU205014B (xx) |
| IE (1) | IE60654B1 (xx) |
| IL (1) | IL82769A (xx) |
| NO (2) | NO172784C (xx) |
| NZ (1) | NZ220616A (xx) |
| PH (1) | PH26981A (xx) |
| PT (1) | PT85082B (xx) |
| SE (1) | SE8602666D0 (xx) |
| ZA (1) | ZA874174B (xx) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5188835A (en) * | 1986-06-16 | 1993-02-23 | Kabi Pharmacia Ab | Intravaginal devices |
| US5084277A (en) * | 1988-08-30 | 1992-01-28 | Greco John C | Vaginal progesterone tablet |
| FI95768C (fi) * | 1993-06-17 | 1996-03-25 | Leiras Oy | Emättimensisäinen antosysteemi |
| FI93922C (fi) * | 1993-06-17 | 1995-06-26 | Leiras Oy | Vaikuttavaa ainetta luovuttava laite |
| IL116433A (en) * | 1994-12-19 | 2002-02-10 | Galen Chemicals Ltd | INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS |
| US5861431A (en) * | 1995-06-07 | 1999-01-19 | Iotek, Inc. | Incontinence treatment |
| US6030375A (en) * | 1996-03-29 | 2000-02-29 | Iotek, Inc. | Compressible vaginal insert and method for treating urogenital disorders |
| US5816248A (en) * | 1996-03-29 | 1998-10-06 | Iotek, Inc. | Channeled vaginal insert and method for treating urogenital disorders |
| US5988169A (en) * | 1996-03-29 | 1999-11-23 | Iotek, Inc. | Vaginal insert and method for treating urogenital disorders |
| US5891868A (en) * | 1997-11-21 | 1999-04-06 | Kaiser Foundation Health Plan, Inc. | Methods for treating postmenopausal women using ultra-low doses of estrogen |
| CN1652798A (zh) * | 2002-03-11 | 2005-08-10 | 詹森药业有限公司 | 连续抑制硫酸酯酶的孕激素的激素替代疗法 |
| US20030219471A1 (en) * | 2002-03-11 | 2003-11-27 | Caubel Patrick Michel | Extended cycle estrogen and sulfatase inhibiting progestogen contraceptive regimens |
| EP1482949A1 (en) * | 2002-03-11 | 2004-12-08 | Janssen Pharmaceutica N.V. | Sulfatase inhibiting progestogen-only contraceptive regimens |
| US7833545B2 (en) * | 2003-04-29 | 2010-11-16 | The General Hospital Corporation | Methods and devices for the sustained release of multiple drugs |
| US7816546B2 (en) * | 2003-06-30 | 2010-10-19 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for the synthesis of high purity d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one-oxime |
| JP5507467B2 (ja) * | 2008-02-04 | 2014-05-28 | テバ ウィメンズ ヘルス インコーポレイテッド | プロゲステロンを含むモノリシック膣内リングならびにそれらの製造方法および使用 |
| EP4069248A4 (en) | 2019-12-06 | 2024-01-03 | Prathima Chowdary | SUSTAINED RELEASE VAGINAL RING PESSARY FOR TREATMENT OF ATROPHY, CYSTITIS AND UTEROVAGINAL PROLAPSUS |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3920805A (en) * | 1971-12-09 | 1975-11-18 | Upjohn Co | Pharmaceutical devices and method |
| IN142428B (xx) * | 1974-07-05 | 1977-07-09 | Schering Ag | |
| US4155991A (en) * | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
| DE2450107A1 (de) * | 1974-10-18 | 1976-04-29 | Schering Ag | Vaginalring |
| DE2611535A1 (de) * | 1976-03-16 | 1977-09-29 | Schering Ag | 6alpha-hydroxy-8alpha-oestradiole |
| JPS5845440B2 (ja) * | 1978-08-29 | 1983-10-08 | 呉羽化学工業株式会社 | プロスタグランジン誘導体とその製造方法及び薬剤 |
| US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| US4250611A (en) * | 1979-04-19 | 1981-02-17 | Alza Corporation | Process for making drug delivery device with reservoir |
| US4402695A (en) * | 1980-01-21 | 1983-09-06 | Alza Corporation | Device for delivering agent in vagina |
| US4425339A (en) * | 1981-04-09 | 1984-01-10 | Syntex (U.S.A.) Inc. | Treatment of menopausal symptoms |
| DE3405227A1 (de) * | 1983-02-22 | 1984-08-23 | Joachim Georg Bellaire Tex. Liehr | Verbesserung in bezug auf die behandlung von oestrogenmangelzustaenden |
| AU582540B2 (en) * | 1983-08-05 | 1989-04-06 | Pre Jay Holdings Ltd. | A method of hormonal treatment of perimenopausal, menopausal and post-menopausal disorders and multi-preparation pack therefor |
| US4596576A (en) * | 1984-10-12 | 1986-06-24 | Akzo N.V. | Release system for two or more active substances |
-
1986
- 1986-06-16 SE SE8602666A patent/SE8602666D0/xx unknown
-
1987
- 1987-05-26 IE IE137787A patent/IE60654B1/en not_active IP Right Cessation
- 1987-05-27 ES ES198787107710T patent/ES2026481T3/es not_active Expired - Lifetime
- 1987-05-27 EP EP87107710A patent/EP0253109B1/en not_active Expired - Lifetime
- 1987-05-27 DE DE8787107710T patent/DE3773557D1/de not_active Expired - Lifetime
- 1987-05-27 AT AT87107710T patent/ATE68097T1/de not_active IP Right Cessation
- 1987-06-03 CA CA000538695A patent/CA1314482C/en not_active Expired - Lifetime
- 1987-06-04 IL IL82769A patent/IL82769A/xx not_active IP Right Cessation
- 1987-06-09 NZ NZ220616A patent/NZ220616A/xx unknown
- 1987-06-10 ZA ZA874174A patent/ZA874174B/xx unknown
- 1987-06-10 PH PH35384A patent/PH26981A/en unknown
- 1987-06-12 US US07/060,833 patent/US4871543A/en not_active Expired - Lifetime
- 1987-06-12 CN CN87104229A patent/CN1034391C/zh not_active Expired - Lifetime
- 1987-06-12 FI FI872629A patent/FI91709C/fi not_active IP Right Cessation
- 1987-06-15 PT PT85082A patent/PT85082B/pt unknown
- 1987-06-15 JP JP62148881A patent/JP2671953B2/ja not_active Expired - Lifetime
- 1987-06-15 DK DK198703034A patent/DK175529B1/da not_active IP Right Cessation
- 1987-06-15 NO NO872489A patent/NO172784C/no unknown
- 1987-06-15 HU HU872705A patent/HU205014B/hu unknown
- 1987-06-15 AU AU74222/87A patent/AU599988B2/en not_active Expired
- 1987-06-16 KR KR1019870006101A patent/KR920005824B1/ko not_active IP Right Cessation
-
1992
- 1992-01-09 GR GR920400009T patent/GR3003551T3/el unknown
-
1997
- 1997-01-13 NO NO1997001C patent/NO1997001I1/no unknown
Also Published As
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