PH26947A - DNA encoding rabbit TNF vector having said DNA inserted thereinto host transformed with said vector rabbit TNF polypeptide and process for production thereof - Google Patents
DNA encoding rabbit TNF vector having said DNA inserted thereinto host transformed with said vector rabbit TNF polypeptide and process for production thereof Download PDFInfo
- Publication number
- PH26947A PH26947A PH31507A PH31507A PH26947A PH 26947 A PH26947 A PH 26947A PH 31507 A PH31507 A PH 31507A PH 31507 A PH31507 A PH 31507A PH 26947 A PH26947 A PH 26947A
- Authority
- PH
- Philippines
- Prior art keywords
- leu
- ser
- ctc
- gly
- glu
- Prior art date
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- 241000283973 Oryctolagus cuniculus Species 0.000 title claims description 117
- 238000000034 method Methods 0.000 title claims description 71
- 230000008569 process Effects 0.000 title claims description 27
- 239000013598 vector Substances 0.000 title claims description 19
- 238000004519 manufacturing process Methods 0.000 title claims description 14
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 131
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 131
- 108020004999 messenger RNA Proteins 0.000 claims description 61
- 239000002299 complementary DNA Substances 0.000 claims description 60
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 40
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 40
- 239000013612 plasmid Substances 0.000 claims description 39
- 229920001184 polypeptide Polymers 0.000 claims description 39
- 150000001413 amino acids Chemical group 0.000 claims description 26
- 108020004705 Codon Proteins 0.000 claims description 22
- 230000000694 effects Effects 0.000 claims description 16
- 241000588724 Escherichia coli Species 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 9
- 230000004071 biological effect Effects 0.000 claims description 6
- 239000000411 inducer Substances 0.000 claims description 6
- 108010070643 prolylglutamic acid Proteins 0.000 claims description 6
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- 238000012986 modification Methods 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
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- 206010028851 Necrosis Diseases 0.000 claims description 2
- KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims description 2
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- 230000017074 necrotic cell death Effects 0.000 claims description 2
- AFWYPMDMDYCKMD-KBPBESRZSA-N Gly-Leu-Tyr Chemical compound NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 AFWYPMDMDYCKMD-KBPBESRZSA-N 0.000 claims 3
- HVKMTOIAYDOJPL-NRPADANISA-N Ser-Gln-Val Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O HVKMTOIAYDOJPL-NRPADANISA-N 0.000 claims 3
- 108010050475 glycyl-leucyl-tyrosine Proteins 0.000 claims 3
- CCUAQNUWXLYFRA-IMJSIDKUSA-N Ala-Asn Chemical compound C[C@H]([NH3+])C(=O)N[C@H](C([O-])=O)CC(N)=O CCUAQNUWXLYFRA-IMJSIDKUSA-N 0.000 claims 2
- 101100273639 Carassius auratus ccna1 gene Proteins 0.000 claims 2
- LKDIBBOKUAASNP-FXQIFTODSA-N Glu-Ala-Glu Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O LKDIBBOKUAASNP-FXQIFTODSA-N 0.000 claims 2
- JSIQVRIXMINMTA-ZDLURKLDSA-N Glu-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O JSIQVRIXMINMTA-ZDLURKLDSA-N 0.000 claims 2
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- 238000004128 high performance liquid chromatography Methods 0.000 description 1
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- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
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- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- RLZZZVKAURTHCP-UHFFFAOYSA-N phenanthrene-3,4-diol Chemical compound C1=CC=C2C3=C(O)C(O)=CC=C3C=CC2=C1 RLZZZVKAURTHCP-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000002644 phorbol ester Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 description 1
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- 229920001451 polypropylene glycol Polymers 0.000 description 1
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- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000001995 reticulocyte Anatomy 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940083575 sodium dodecyl sulfate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
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- 239000004474 valine Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58228790A JPH0695939B2 (ja) | 1983-12-02 | 1983-12-02 | ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26947A true PH26947A (en) | 1992-12-03 |
Family
ID=16881888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH31507A PH26947A (en) | 1983-12-02 | 1984-11-29 | DNA encoding rabbit TNF vector having said DNA inserted thereinto host transformed with said vector rabbit TNF polypeptide and process for production thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5043271A (de) |
| EP (1) | EP0146026B1 (de) |
| JP (1) | JPH0695939B2 (de) |
| KR (1) | KR920009523B1 (de) |
| AT (1) | ATE60933T1 (de) |
| AU (1) | AU577810B2 (de) |
| DE (1) | DE3484125D1 (de) |
| DK (1) | DK572284A (de) |
| ES (2) | ES8604309A1 (de) |
| PH (1) | PH26947A (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1265444A (en) * | 1983-06-27 | 1990-02-06 | Lloyd J. Old | Effect of human tumor necrosis factor and human interferon on human cancer cells and methods |
| JPS60112718A (ja) * | 1983-11-21 | 1985-06-19 | Kyorin Pharmaceut Co Ltd | 抗腫瘍作用を示す蛋白性物質及びその製造方法 |
| JPS60139624A (ja) * | 1983-12-27 | 1985-07-24 | Dainippon Pharmaceut Co Ltd | 抗腫瘍作用を有する蛋白質 |
| US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
| US5672347A (en) * | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| US6686455B1 (en) | 1984-07-05 | 2004-02-03 | Genentech, Inc. | Tumor necrosis factor |
| GR851626B (de) * | 1984-07-05 | 1985-11-26 | Genentech Inc | |
| JP2557053B2 (ja) * | 1984-12-21 | 1996-11-27 | バイオジェン インコーポレイテッド | 腫瘍壊死因子の精製、製造および使用法 |
| US5425940A (en) * | 1986-04-09 | 1995-06-20 | Cetus Oncology Corporation | Combination therapy using interleukin-2 and tumor necrosis factor |
| US5843693A (en) * | 1989-08-16 | 1998-12-01 | Chiron Corporation | Assay method for screening for inhibitors of proTNF conversion |
| DE69029970T2 (de) | 1989-08-16 | 1997-06-19 | Chiron Corp | Zusammensetzungen zur hemmung der bildung von proteinhormon und deren verwendungen |
| US5998378A (en) * | 1989-08-16 | 1999-12-07 | Chiron Corporation | Compositions for the inhibition of TNF hormone formation and uses thereof |
| US6586222B1 (en) | 1989-08-16 | 2003-07-01 | Chiron Corporation | Recombinant PR-3 and compositions thereof |
| WO1991017180A1 (en) * | 1990-04-27 | 1991-11-14 | Peptide Technology Ltd | Peptides derived from human tumour necrosis factor alpha and useful against intracellular malarial parasites |
| US5653974A (en) * | 1990-10-18 | 1997-08-05 | Board Of Regents,The University Of Texas System | Preparation and characterization of liposomal formulations of tumor necrosis factor |
| WO1995024501A1 (en) | 1994-03-07 | 1995-09-14 | Cetus Oncology Corporation | Compositions for the inhibition of tnf formation and uses thereof |
| MXPA05005921A (es) | 2002-12-02 | 2005-10-19 | Abgenix Inc | Anticuerpos dirigidos a factor de necrosis tumoral y sus usos. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57140725A (en) * | 1981-12-28 | 1982-08-31 | Dainippon Pharmaceut Co Ltd | Physiologically active substance having carcinostatic action |
| JPS6019719A (ja) * | 1983-07-15 | 1985-01-31 | Asahi Chem Ind Co Ltd | 抗腫瘍活性を有する蛋白質 |
| EP0148311B1 (de) * | 1983-12-26 | 1988-07-20 | Asahi Kasei Kogyo Kabushiki Kaisha | Physiologisch aktives Polypeptid |
| DE3582183D1 (de) * | 1984-03-06 | 1991-04-25 | Dainippon Pharmaceutical Co | Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid. |
| US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
-
1983
- 1983-12-02 JP JP58228790A patent/JPH0695939B2/ja not_active Expired - Lifetime
-
1984
- 1984-11-27 KR KR1019840007423A patent/KR920009523B1/ko not_active IP Right Cessation
- 1984-11-27 DE DE8484114325T patent/DE3484125D1/de not_active Expired - Fee Related
- 1984-11-27 ES ES538000A patent/ES8604309A1/es not_active Expired
- 1984-11-27 EP EP84114325A patent/EP0146026B1/de not_active Expired - Lifetime
- 1984-11-27 AT AT84114325T patent/ATE60933T1/de not_active IP Right Cessation
- 1984-11-29 AU AU36014/84A patent/AU577810B2/en not_active Ceased
- 1984-11-29 PH PH31507A patent/PH26947A/en unknown
- 1984-11-30 US US06/677,680 patent/US5043271A/en not_active Expired - Fee Related
- 1984-11-30 DK DK572284A patent/DK572284A/da not_active Application Discontinuation
-
1985
- 1985-09-30 ES ES547436A patent/ES8605578A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU3601484A (en) | 1985-06-06 |
| DK572284D0 (da) | 1984-11-30 |
| ES8604309A1 (es) | 1986-01-16 |
| JPS60120990A (ja) | 1985-06-28 |
| EP0146026A2 (de) | 1985-06-26 |
| US5043271A (en) | 1991-08-27 |
| JPH0695939B2 (ja) | 1994-11-30 |
| AU577810B2 (en) | 1988-10-06 |
| EP0146026A3 (en) | 1987-05-20 |
| DK572284A (da) | 1985-06-03 |
| KR920009523B1 (ko) | 1992-10-17 |
| ATE60933T1 (de) | 1991-03-15 |
| DE3484125D1 (de) | 1991-03-28 |
| ES538000A0 (es) | 1986-01-16 |
| ES547436A0 (es) | 1986-03-16 |
| EP0146026B1 (de) | 1991-02-20 |
| KR850004272A (ko) | 1985-07-11 |
| ES8605578A1 (es) | 1986-03-16 |
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