ES8604309A1 - Un procedimiento para obtener un adn que codifica un factor de necrosis de tumor de conejo - Google Patents

Un procedimiento para obtener un adn que codifica un factor de necrosis de tumor de conejo

Info

Publication number
ES8604309A1
ES8604309A1 ES538000A ES538000A ES8604309A1 ES 8604309 A1 ES8604309 A1 ES 8604309A1 ES 538000 A ES538000 A ES 538000A ES 538000 A ES538000 A ES 538000A ES 8604309 A1 ES8604309 A1 ES 8604309A1
Authority
ES
Spain
Prior art keywords
vector
rabbit tnf
dna
polypeptide
inserted thereinto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538000A
Other languages
English (en)
Other versions
ES538000A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of ES8604309A1 publication Critical patent/ES8604309A1/es
Publication of ES538000A0 publication Critical patent/ES538000A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

METODO DE PRODUCCION DE POLIPEPTIDOS QUE TIENEN O CONTIENEN UN FACTOR DE NECROSIS DE TUMORES DE CONEJO O UNA PORCION PRINCIPAL DEL MISMO. COMPRENDE EL CULTIVO DE MACROFAGOS DE CONEJO; SEPARACION DE UNA FRACCION QUE CONTIENE UN ARN MENSAJERO DE FACTOR DE NECROSIS DE TUMORES DE CONEJO A PARTIR DE LOS MACROFAGOS; PREPARACION DE UNA BIBLIOTECA DE ADN COMPLEMENTARIO A PARTIR DE LA FRACCION; CLONACION DEL ADN COMPLEMENTARIO; INSERCION DE DICHO ADN CLONADO O UN ADN MODIFICADO DEL MISMO EN UN VECTOR DE EXPRESION; INTRODUCCION DEL VECTOR EN UN HOSPEDANTE PARA TRANSFOMARLO; CULTIVAR EL TRANSFORMANTE Y RECOGER EL POLIPEPTIDO RESULTANTE. ESTOS POLIPETIDOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTITUMORALES.
ES538000A 1983-12-02 1984-11-27 Un procedimiento para obtener un adn que codifica un factor de necrosis de tumor de conejo Expired ES8604309A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58228790A JPH0695939B2 (ja) 1983-12-02 1983-12-02 ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ

Publications (2)

Publication Number Publication Date
ES8604309A1 true ES8604309A1 (es) 1986-01-16
ES538000A0 ES538000A0 (es) 1986-01-16

Family

ID=16881888

Family Applications (2)

Application Number Title Priority Date Filing Date
ES538000A Expired ES8604309A1 (es) 1983-12-02 1984-11-27 Un procedimiento para obtener un adn que codifica un factor de necrosis de tumor de conejo
ES547436A Expired ES8605578A1 (es) 1983-12-02 1985-09-30 Un procedimiento para producir un adn complementario clonadoo su adn modificado que codifica un polipeptido de factor denecrosis de tumores

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES547436A Expired ES8605578A1 (es) 1983-12-02 1985-09-30 Un procedimiento para producir un adn complementario clonadoo su adn modificado que codifica un polipeptido de factor denecrosis de tumores

Country Status (10)

Country Link
US (1) US5043271A (es)
EP (1) EP0146026B1 (es)
JP (1) JPH0695939B2 (es)
KR (1) KR920009523B1 (es)
AT (1) ATE60933T1 (es)
AU (1) AU577810B2 (es)
DE (1) DE3484125D1 (es)
DK (1) DK572284A (es)
ES (2) ES8604309A1 (es)
PH (1) PH26947A (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1265444A (en) * 1983-06-27 1990-02-06 Lloyd J. Old Effect of human tumor necrosis factor and human interferon on human cancer cells and methods
JPS60112718A (ja) * 1983-11-21 1985-06-19 Kyorin Pharmaceut Co Ltd 抗腫瘍作用を示す蛋白性物質及びその製造方法
JPS60139624A (ja) * 1983-12-27 1985-07-24 Dainippon Pharmaceut Co Ltd 抗腫瘍作用を有する蛋白質
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
US6686455B1 (en) 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
GR851626B (es) * 1984-07-05 1985-11-26 Genentech Inc
JP2557053B2 (ja) * 1984-12-21 1996-11-27 バイオジェン インコーポレイテッド 腫瘍壊死因子の精製、製造および使用法
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
DE69029970T2 (de) 1989-08-16 1997-06-19 Chiron Corp Zusammensetzungen zur hemmung der bildung von proteinhormon und deren verwendungen
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
WO1991017180A1 (en) * 1990-04-27 1991-11-14 Peptide Technology Ltd Peptides derived from human tumour necrosis factor alpha and useful against intracellular malarial parasites
US5653974A (en) * 1990-10-18 1997-08-05 Board Of Regents,The University Of Texas System Preparation and characterization of liposomal formulations of tumor necrosis factor
WO1995024501A1 (en) 1994-03-07 1995-09-14 Cetus Oncology Corporation Compositions for the inhibition of tnf formation and uses thereof
MXPA05005921A (es) 2002-12-02 2005-10-19 Abgenix Inc Anticuerpos dirigidos a factor de necrosis tumoral y sus usos.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57140725A (en) * 1981-12-28 1982-08-31 Dainippon Pharmaceut Co Ltd Physiologically active substance having carcinostatic action
JPS6019719A (ja) * 1983-07-15 1985-01-31 Asahi Chem Ind Co Ltd 抗腫瘍活性を有する蛋白質
EP0148311B1 (en) * 1983-12-26 1988-07-20 Asahi Kasei Kogyo Kabushiki Kaisha A novel physiologically active polypeptide
DE3582183D1 (de) * 1984-03-06 1991-04-25 Dainippon Pharmaceutical Co Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide

Also Published As

Publication number Publication date
AU3601484A (en) 1985-06-06
DK572284D0 (da) 1984-11-30
JPS60120990A (ja) 1985-06-28
EP0146026A2 (en) 1985-06-26
US5043271A (en) 1991-08-27
JPH0695939B2 (ja) 1994-11-30
AU577810B2 (en) 1988-10-06
EP0146026A3 (en) 1987-05-20
DK572284A (da) 1985-06-03
KR920009523B1 (ko) 1992-10-17
ATE60933T1 (de) 1991-03-15
DE3484125D1 (de) 1991-03-28
ES538000A0 (es) 1986-01-16
ES547436A0 (es) 1986-03-16
EP0146026B1 (en) 1991-02-20
KR850004272A (ko) 1985-07-11
ES8605578A1 (es) 1986-03-16
PH26947A (en) 1992-12-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981103