ES547436A0 - Un procedimiento para producir un adn complementario clonadoo su adn modificado que codifica un polipeptido de factor denecrosis de tumores - Google Patents

Un procedimiento para producir un adn complementario clonadoo su adn modificado que codifica un polipeptido de factor denecrosis de tumores

Info

Publication number
ES547436A0
ES547436A0 ES547436A ES547436A ES547436A0 ES 547436 A0 ES547436 A0 ES 547436A0 ES 547436 A ES547436 A ES 547436A ES 547436 A ES547436 A ES 547436A ES 547436 A0 ES547436 A0 ES 547436A0
Authority
ES
Spain
Prior art keywords
denecrosis
tumor
procedure
factor polypeptide
producing cloned
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES547436A
Other languages
English (en)
Other versions
ES8605578A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Publication of ES547436A0 publication Critical patent/ES547436A0/es
Publication of ES8605578A1 publication Critical patent/ES8605578A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
ES547436A 1983-12-02 1985-09-30 Un procedimiento para producir un adn complementario clonadoo su adn modificado que codifica un polipeptido de factor denecrosis de tumores Expired ES8605578A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58228790A JPH0695939B2 (ja) 1983-12-02 1983-12-02 ウサギ癌壊死因子をコ−ドするクロ−ン化ｄνａ

Publications (2)

Publication Number Publication Date
ES547436A0 true ES547436A0 (es) 1986-03-16
ES8605578A1 ES8605578A1 (es) 1986-03-16

Family

ID=16881888

Family Applications (2)

Application Number Title Priority Date Filing Date
ES538000A Expired ES8604309A1 (es) 1983-12-02 1984-11-27 Un procedimiento para obtener un adn que codifica un factor de necrosis de tumor de conejo
ES547436A Expired ES8605578A1 (es) 1983-12-02 1985-09-30 Un procedimiento para producir un adn complementario clonadoo su adn modificado que codifica un polipeptido de factor denecrosis de tumores

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES538000A Expired ES8604309A1 (es) 1983-12-02 1984-11-27 Un procedimiento para obtener un adn que codifica un factor de necrosis de tumor de conejo

Country Status (10)

Country Link
US (1) US5043271A (es)
EP (1) EP0146026B1 (es)
JP (1) JPH0695939B2 (es)
KR (1) KR920009523B1 (es)
AT (1) ATE60933T1 (es)
AU (1) AU577810B2 (es)
DE (1) DE3484125D1 (es)
DK (1) DK572284A (es)
ES (2) ES8604309A1 (es)
PH (1) PH26947A (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1265444A (en) * 1983-06-27 1990-02-06 Lloyd J. Old Effect of human tumor necrosis factor and human interferon on human cancer cells and methods
JPS60112718A (ja) * 1983-11-21 1985-06-19 Kyorin Pharmaceut Co Ltd 抗腫瘍作用を示す蛋白性物質及びその製造方法
JPS60139624A (ja) * 1983-12-27 1985-07-24 Dainippon Pharmaceut Co Ltd 抗腫瘍作用を有する蛋白質
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
GR851626B (es) * 1984-07-05 1985-11-26 Genentech Inc
US6686455B1 (en) 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
ATE73856T1 (de) * 1984-12-21 1992-04-15 Biogen Inc Reinigung, herstellung und verwendung von tumor- nekrosisfaktoren.
US5425940A (en) * 1986-04-09 1995-06-20 Cetus Oncology Corporation Combination therapy using interleukin-2 and tumor necrosis factor
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
ATE148992T1 (de) 1989-08-16 1997-03-15 Chiron Corp Zusammensetzungen zur hemmung der bildung von proteinhormon und deren verwendungen
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
WO1991017180A1 (en) * 1990-04-27 1991-11-14 Peptide Technology Ltd Peptides derived from human tumour necrosis factor alpha and useful against intracellular malarial parasites
US5653974A (en) * 1990-10-18 1997-08-05 Board Of Regents,The University Of Texas System Preparation and characterization of liposomal formulations of tumor necrosis factor
WO1995024501A1 (en) 1994-03-07 1995-09-14 Cetus Oncology Corporation Compositions for the inhibition of tnf formation and uses thereof
CN100434440C (zh) 2002-12-02 2008-11-19 阿布格尼克斯公司 针对肿瘤坏死因子的抗体及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57140725A (en) * 1981-12-28 1982-08-31 Dainippon Pharmaceut Co Ltd Physiologically active substance having carcinostatic action
JPS6019719A (ja) * 1983-07-15 1985-01-31 Asahi Chem Ind Co Ltd 抗腫瘍活性を有する蛋白質
DE3472793D1 (en) * 1983-12-26 1988-08-25 Asahi Chemical Ind A novel physiologically active polypeptide
DE3582183D1 (de) * 1984-03-06 1991-04-25 Dainippon Pharmaceutical Co Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid.
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide

Also Published As

Publication number Publication date
PH26947A (en) 1992-12-03
ES538000A0 (es) 1986-01-16
JPH0695939B2 (ja) 1994-11-30
EP0146026A2 (en) 1985-06-26
ATE60933T1 (de) 1991-03-15
EP0146026A3 (en) 1987-05-20
EP0146026B1 (en) 1991-02-20
US5043271A (en) 1991-08-27
AU3601484A (en) 1985-06-06
DK572284D0 (da) 1984-11-30
JPS60120990A (ja) 1985-06-28
KR920009523B1 (ko) 1992-10-17
ES8604309A1 (es) 1986-01-16
AU577810B2 (en) 1988-10-06
KR850004272A (ko) 1985-07-11
DE3484125D1 (de) 1991-03-28
DK572284A (da) 1985-06-03
ES8605578A1 (es) 1986-03-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010402