PH26867A - Process for the manufacturing of thrombin inhibitors - Google Patents
Process for the manufacturing of thrombin inhibitors Download PDFInfo
- Publication number
- PH26867A PH26867A PH32401A PH32401A PH26867A PH 26867 A PH26867 A PH 26867A PH 32401 A PH32401 A PH 32401A PH 32401 A PH32401 A PH 32401A PH 26867 A PH26867 A PH 26867A
- Authority
- PH
- Philippines
- Prior art keywords
- hirudin
- dna
- coli
- gene
- plasmid
- Prior art date
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- MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000010396 two-hybrid screening Methods 0.000 description 1
- 108010078580 tyrosylleucine Proteins 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH288284 | 1984-06-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PH26867A true PH26867A (en) | 1992-11-16 |
Family
ID=4243708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH32401A PH26867A (en) | 1984-06-14 | 1985-06-11 | Process for the manufacturing of thrombin inhibitors |
Country Status (23)
Country | Link |
---|---|
US (2) | US5422249A (ko) |
EP (1) | EP0168342B1 (ko) |
JP (1) | JPH0720434B2 (ko) |
KR (1) | KR920009522B1 (ko) |
AT (1) | ATE64956T1 (ko) |
AU (1) | AU591061B2 (ko) |
CA (1) | CA1341426C (ko) |
CY (1) | CY1782A (ko) |
DD (1) | DD240392A5 (ko) |
DE (1) | DE3583361D1 (ko) |
DK (1) | DK175496B1 (ko) |
ES (3) | ES8708012A1 (ko) |
FI (1) | FI90787C (ko) |
GR (1) | GR851428B (ko) |
HK (1) | HK11095A (ko) |
HU (1) | HU202288B (ko) |
IE (1) | IE57999B1 (ko) |
IL (1) | IL75508A (ko) |
NO (2) | NO177433C (ko) |
NZ (1) | NZ212405A (ko) |
PH (1) | PH26867A (ko) |
PT (1) | PT80631B (ko) |
ZA (1) | ZA854418B (ko) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1341414C (fr) * | 1984-03-27 | 2002-12-31 | Paul Tolstoshev | Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine |
US5705355A (en) * | 1984-03-27 | 1998-01-06 | Transgene, S.A. | Hirudin, pharmaceutical compositions comprising it and their use |
DE3429430A1 (de) * | 1984-08-10 | 1986-02-20 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens |
DE3445517C2 (de) * | 1984-12-13 | 1993-11-18 | Ciba Geigy | Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins |
FR2593518B1 (fr) * | 1985-05-02 | 1989-09-08 | Transgene Sa | Vecteurs d'expression et de secretion de l'hirudine par les levures transformees |
US5821079A (en) * | 1985-05-02 | 1998-10-13 | Transgene S.A. | Vectors for the expression and secretion of hirudin by transformed yeasts |
GB8530631D0 (en) | 1985-12-12 | 1986-01-22 | Ciba Geigy Ag | Thrombin inhibitors |
MY101203A (en) * | 1985-12-12 | 1991-08-17 | Ucp Gen Pharma Ag | Production of thrombin iinhibitors. |
GB2188322A (en) * | 1986-03-26 | 1987-09-30 | Bayer Ag | Aprotinin and analogues thereof produced by a recombinant host |
MC1834A1 (fr) * | 1986-07-10 | 1988-06-03 | Transgene Sa | Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation |
FR2607516B2 (fr) * | 1986-12-01 | 1989-12-22 | Transgene Sa | Vecteurs perfectionnes d'expression d'un variant de l'hirudine dans les levures, procede et produit obtenu |
JPH0616716B2 (ja) * | 1986-10-14 | 1994-03-09 | 塩野義製薬株式会社 | 酵母におけるヒトpstiの製造法 |
FR2607517B2 (fr) * | 1986-12-01 | 1989-12-22 | Transgene Sa | Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu |
US5256559A (en) * | 1988-03-04 | 1993-10-26 | Biogen, Inc. | Methods and compositions for inhibiting platelet aggregation |
DE3819079A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Hirudin-derivate mit verzoegerter wirkung |
GB8817161D0 (en) * | 1988-07-19 | 1988-08-24 | Ciba Geigy Ag | Modified proteins |
GB8817160D0 (en) * | 1988-07-19 | 1988-08-24 | Ciba Geigy Ag | Novel proteins |
US5112615A (en) * | 1988-08-03 | 1992-05-12 | New England Deaconess Hospital Corporation | Soluble hirudin conjugates |
US5167960A (en) * | 1988-08-03 | 1992-12-01 | New England Deaconess Hospital Corporation | Hirudin-coated biocompatible substance |
DE3835815A1 (de) * | 1988-10-21 | 1990-04-26 | Hoechst Ag | Neue isohirudine |
ATE119195T1 (de) * | 1989-01-25 | 1995-03-15 | Ciba Geigy Ag | Monoklonale antikörper, spezifisch für hirudin. |
DE69028725T2 (de) * | 1989-02-28 | 1997-03-13 | Canon Kk | Partiell doppelsträngiges Oligonukleotid und Verfahren zu seiner Bildung |
JPH037583A (ja) * | 1989-02-28 | 1991-01-14 | Canon Inc | 部分的二本鎖オリゴヌクレオチド及びオリゴヌクレオチドの形成方法 |
GB9006400D0 (en) | 1990-03-22 | 1990-05-23 | Ciba Geigy Ag | Bacterial vectors |
DE4009268A1 (de) * | 1990-03-22 | 1991-09-26 | Consortium Elektrochem Ind | Sekretion von hirudinderivaten |
US6060451A (en) * | 1990-06-15 | 2000-05-09 | The National Research Council Of Canada | Thrombin inhibitors based on the amino acid sequence of hirudin |
US5296352A (en) * | 1990-10-02 | 1994-03-22 | Ciba-Geigy Corporation | Monoclonal antibodies directed against complexes formed by thrombin and hirudin |
US6514730B1 (en) | 1991-03-21 | 2003-02-04 | Consortium für elektrochemische Industrie GmbH | Secretion of hirudin derivatives |
DE4209110A1 (de) * | 1991-11-26 | 1993-05-27 | Basf Ag | Neue thrombininhibitorische proteine aus landblutegeln |
DE4140381A1 (de) * | 1991-12-07 | 1993-06-09 | Hoechst Ag, 6230 Frankfurt, De | Neue synthetische isohirudine mit verbesserter stabilitaet |
HU214698B (hu) * | 1992-04-09 | 1998-06-29 | Gyógyszerkutató Intézet Kft. | Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására |
DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
US5643580A (en) * | 1994-10-17 | 1997-07-01 | Surface Genesis, Inc. | Biocompatible coating, medical device using the same and methods |
DE19529997C1 (de) * | 1995-08-16 | 1997-04-10 | Hoechst Ag | Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen |
DE19543737A1 (de) * | 1995-11-24 | 1997-05-28 | Hoechst Ag | Verfahren zur Ultrafiltration von Peptide oder Proteine enthaltender biologischer Matrices |
DE19544233A1 (de) | 1995-11-28 | 1997-06-05 | Hoechst Ag | Verfahren zur Nutzung des Hefe-ADH II-Promotorsystems zur biotechnologischen Produktion heterologer Proteine in hohen Ausbeuten |
DE69625623T2 (de) | 1996-01-31 | 2003-11-06 | Sumitomo Bakelite Co. Ltd., Tokio/Tokyo | Verfahren zur Herstellung von in Epoxyharz eingekapselter Halbleitervorrichtung |
US6623981B2 (en) * | 1998-01-27 | 2003-09-23 | Bristol-Myers Squibb Company | Detection of patients at risk for developing integrin antagonist/agonist mediated disease states |
DE10149678A1 (de) | 2001-10-09 | 2009-03-12 | Novel Science International Gmbh | Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung |
US20070016969A1 (en) * | 2002-01-18 | 2007-01-18 | Animal Technology Institute Taiwan | Expression vector for hirudin and transformed cells and transgenic animals containing said vector |
DE10301255A1 (de) | 2003-01-15 | 2004-07-29 | Cpi Creative Pharma International Gmbh | Organische Verbindungen mit biologischer Wirkung als Thrombinhemmer und ihre Verwendung |
JP3535151B1 (ja) * | 2003-07-10 | 2004-06-07 | 株式会社ミナキアドバンス | 生酵母菌を成分とする液剤の製造方法及びその液剤 |
US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
BRPI0821599A2 (pt) * | 2007-12-28 | 2015-06-16 | Baxter Int | Método de filtração de uma mistura líquida de proteína |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3432596A (en) * | 1967-10-13 | 1969-03-11 | Dresden Arzneimittel | Method for producing highly pure hirudine |
US4704362A (en) * | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
US4517294A (en) * | 1982-03-03 | 1985-05-14 | Genentech, Inc. | Human antithrombin III |
GR79124B (ko) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
WO1985000831A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
DE3342139A1 (de) * | 1983-11-22 | 1985-05-30 | Ciba-Geigy Ag, Basel | Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel |
CA1341414C (fr) * | 1984-03-27 | 2002-12-31 | Paul Tolstoshev | Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine |
FR2562088B1 (fr) * | 1984-03-27 | 1987-11-13 | Transgene Sa | Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine |
DE3438296A1 (de) * | 1984-04-18 | 1985-11-07 | Hoechst Ag, 6230 Frankfurt | Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel |
DE3689525D1 (de) * | 1985-07-17 | 1994-02-24 | Hoechst Ag | Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel. |
DE3541856A1 (de) * | 1985-11-27 | 1987-06-04 | Hoechst Ag | Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens |
MY101203A (en) * | 1985-12-12 | 1991-08-17 | Ucp Gen Pharma Ag | Production of thrombin iinhibitors. |
FR2645175B1 (fr) * | 1989-03-31 | 1994-02-18 | Transgene Sa | Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche |
-
1985
- 1985-06-10 EP EP85810268A patent/EP0168342B1/de not_active Expired - Lifetime
- 1985-06-10 AT AT85810268T patent/ATE64956T1/de not_active IP Right Cessation
- 1985-06-10 DE DE8585810268T patent/DE3583361D1/de not_active Expired - Lifetime
- 1985-06-11 PH PH32401A patent/PH26867A/en unknown
- 1985-06-12 PT PT80631A patent/PT80631B/pt unknown
- 1985-06-12 ZA ZA854418A patent/ZA854418B/xx unknown
- 1985-06-12 GR GR851428A patent/GR851428B/el unknown
- 1985-06-12 FI FI852342A patent/FI90787C/fi not_active IP Right Cessation
- 1985-06-12 DD DD85277301A patent/DD240392A5/de not_active IP Right Cessation
- 1985-06-12 CA CA000483736A patent/CA1341426C/en not_active Expired - Fee Related
- 1985-06-13 DK DK198502656A patent/DK175496B1/da not_active IP Right Cessation
- 1985-06-13 ES ES544126A patent/ES8708012A1/es not_active Expired
- 1985-06-13 NZ NZ212405A patent/NZ212405A/xx unknown
- 1985-06-13 AU AU43655/85A patent/AU591061B2/en not_active Expired
- 1985-06-13 NO NO852389A patent/NO177433C/no unknown
- 1985-06-13 IL IL75508A patent/IL75508A/xx not_active IP Right Cessation
- 1985-06-13 IE IE1475/85A patent/IE57999B1/en not_active IP Right Cessation
- 1985-06-13 JP JP60127266A patent/JPH0720434B2/ja not_active Expired - Lifetime
- 1985-06-13 HU HU852340A patent/HU202288B/hu unknown
- 1985-06-14 KR KR1019850004195A patent/KR920009522B1/ko not_active IP Right Cessation
-
1986
- 1986-10-01 ES ES557115A patent/ES8707765A1/es not_active Expired
- 1986-10-01 ES ES557116A patent/ES8707766A1/es not_active Expired
-
1993
- 1993-09-15 US US08/121,974 patent/US5422249A/en not_active Expired - Lifetime
-
1995
- 1995-01-26 HK HK11095A patent/HK11095A/xx not_active IP Right Cessation
- 1995-03-03 US US08/398,416 patent/US5728549A/en not_active Expired - Lifetime
- 1995-10-20 CY CY178295A patent/CY1782A/xx unknown
-
1999
- 1999-11-17 NO NO1999023C patent/NO1999023I1/no unknown
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