PH26358A - 5-(substituted-amino)-8-(phenyl or substitutedphenyl)-3H, 6H-1,4 5A,8A-tetraazaacenaphthylen-3-ones and treatment of neutral behavior disorders - Google Patents
5-(substituted-amino)-8-(phenyl or substitutedphenyl)-3H, 6H-1,4 5A,8A-tetraazaacenaphthylen-3-ones and treatment of neutral behavior disorders Download PDFInfo
- Publication number
- PH26358A PH26358A PH38218A PH38218A PH26358A PH 26358 A PH26358 A PH 26358A PH 38218 A PH38218 A PH 38218A PH 38218 A PH38218 A PH 38218A PH 26358 A PH26358 A PH 26358A
- Authority
- PH
- Philippines
- Prior art keywords
- phenyl
- tetraazaacenaphthylen
- trifluoromethyl
- mixture
- stirred
- Prior art date
Links
- 230000007935 neutral effect Effects 0.000 title description 2
- 208000020016 psychiatric disease Diseases 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 85
- 150000001875 compounds Chemical class 0.000 claims description 45
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 36
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 31
- -1 hydroxy, 4-morpholinyl Chemical group 0.000 claims description 30
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 27
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 7
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 150000002367 halogens Chemical class 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N carbonic acid monoamide Natural products NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims description 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 claims description 2
- XBGXGCOLWCMVOI-UHFFFAOYSA-N 3-(trifluoromethyl)benzamide Chemical compound NC(=O)C1=CC=CC(C(F)(F)F)=C1 XBGXGCOLWCMVOI-UHFFFAOYSA-N 0.000 claims 1
- 229940099990 ogen Drugs 0.000 claims 1
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- 238000003756 stirring Methods 0.000 description 27
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- 238000000034 method Methods 0.000 description 7
- 230000001537 neural effect Effects 0.000 description 7
- BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 7
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 6
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 6
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- 238000001704 evaporation Methods 0.000 description 6
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- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 6
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- HGOQXPTZTZPWMD-UHFFFAOYSA-N 1,2,6,8-tetrazatricyclo[6.3.1.04,12]dodeca-2,4(12),6,10-tetraen-5-one Chemical class C1C=CN2N=CC3=C2N1C=NC3=O HGOQXPTZTZPWMD-UHFFFAOYSA-N 0.000 description 5
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15844888A | 1988-02-22 | 1988-02-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26358A true PH26358A (en) | 1992-04-29 |
Family
ID=22568168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH38218A PH26358A (en) | 1988-02-22 | 1989-02-20 | 5-(substituted-amino)-8-(phenyl or substitutedphenyl)-3H, 6H-1,4 5A,8A-tetraazaacenaphthylen-3-ones and treatment of neutral behavior disorders |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0329940B1 (de) |
| JP (1) | JP2641556B2 (de) |
| KR (1) | KR970009226B1 (de) |
| AR (1) | AR247211A1 (de) |
| AT (1) | ATE99686T1 (de) |
| AU (1) | AU611769B2 (de) |
| CA (1) | CA1329594C (de) |
| CZ (1) | CZ284273B6 (de) |
| DD (1) | DD283624A5 (de) |
| DE (1) | DE68911951T2 (de) |
| DK (1) | DK172397B1 (de) |
| ES (1) | ES2061739T3 (de) |
| FI (1) | FI89922C (de) |
| HU (1) | HU203554B (de) |
| IE (1) | IE64147B1 (de) |
| IL (1) | IL88974A (de) |
| NO (1) | NO169589C (de) |
| NZ (1) | NZ228009A (de) |
| PH (1) | PH26358A (de) |
| PL (1) | PL158865B1 (de) |
| PT (1) | PT89766B (de) |
| SK (1) | SK279319B6 (de) |
| ZA (1) | ZA891310B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013737A (en) * | 1988-02-22 | 1991-05-07 | American Cyanamid Company | 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones |
| EP0562236A1 (de) * | 1992-03-26 | 1993-09-29 | American Cyanamid Company | Verfahren zur Synthese von 5-((substituierte)-Amino)-8-(Phenyl oder substituierte Phenyl)-3H,6H-1,4,5a,8a-Tetraazaacenaphthylen-3-Onen |
| ZA9711342B (en) * | 1996-12-19 | 1999-06-17 | American Cyanamid Co | Method of treating or inhibiting neutropenia |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4236005A (en) * | 1979-07-02 | 1980-11-25 | American Cyanamid Company | Imidazo[1,5-a]pyrimidines |
| US4713383A (en) * | 1984-10-01 | 1987-12-15 | Ciba-Geigy Corporation | Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses |
| US4576943A (en) * | 1984-10-09 | 1986-03-18 | American Cyanamid Company | Pyrazolo[1,5-a]pyrimidines |
| EP0264773A1 (de) * | 1986-10-16 | 1988-04-27 | American Cyanamid Company | 4,5-Dihydro- und 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrimidine |
-
1989
- 1989-01-16 DE DE68911951T patent/DE68911951T2/de not_active Expired - Fee Related
- 1989-01-16 AT AT89100657T patent/ATE99686T1/de active
- 1989-01-16 EP EP89100657A patent/EP0329940B1/de not_active Expired - Lifetime
- 1989-01-16 ES ES89100657T patent/ES2061739T3/es not_active Expired - Lifetime
- 1989-01-17 IL IL88974A patent/IL88974A/xx not_active IP Right Cessation
- 1989-02-16 NZ NZ228009A patent/NZ228009A/xx unknown
- 1989-02-17 SK SK1055-89A patent/SK279319B6/sk unknown
- 1989-02-17 CZ CS891055A patent/CZ284273B6/cs not_active IP Right Cessation
- 1989-02-20 CA CA000591526A patent/CA1329594C/en not_active Expired - Fee Related
- 1989-02-20 PH PH38218A patent/PH26358A/en unknown
- 1989-02-20 JP JP1038480A patent/JP2641556B2/ja not_active Expired - Lifetime
- 1989-02-20 DD DD89325854A patent/DD283624A5/de unknown
- 1989-02-20 PT PT89766A patent/PT89766B/pt not_active IP Right Cessation
- 1989-02-21 IE IE54389A patent/IE64147B1/en not_active IP Right Cessation
- 1989-02-21 AU AU30172/89A patent/AU611769B2/en not_active Ceased
- 1989-02-21 FI FI890826A patent/FI89922C/fi not_active IP Right Cessation
- 1989-02-21 ZA ZA891310A patent/ZA891310B/xx unknown
- 1989-02-21 NO NO890724A patent/NO169589C/no not_active IP Right Cessation
- 1989-02-21 PL PL1989277837A patent/PL158865B1/pl unknown
- 1989-02-21 AR AR89313253A patent/AR247211A1/es active
- 1989-02-21 KR KR89002051A patent/KR970009226B1/ko not_active IP Right Cessation
- 1989-02-21 DK DK079589A patent/DK172397B1/da not_active IP Right Cessation
- 1989-02-22 HU HU89856A patent/HU203554B/hu not_active IP Right Cessation
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