PH26284A - Antiviral or antibacterial composition and method of use thereof - Google Patents
Antiviral or antibacterial composition and method of use thereof Download PDFInfo
- Publication number
- PH26284A PH26284A PH38684A PH38684A PH26284A PH 26284 A PH26284 A PH 26284A PH 38684 A PH38684 A PH 38684A PH 38684 A PH38684 A PH 38684A PH 26284 A PH26284 A PH 26284A
- Authority
- PH
- Philippines
- Prior art keywords
- composition
- dimer
- lysozyme
- treating
- ribonuclease
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 56
- 238000000034 method Methods 0.000 title claims abstract description 29
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 10
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 9
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 98
- 102000016943 Muramidase Human genes 0.000 claims abstract description 97
- 108010014251 Muramidase Proteins 0.000 claims abstract description 97
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 97
- 229960000274 lysozyme Drugs 0.000 claims abstract description 97
- 239000004325 lysozyme Substances 0.000 claims abstract description 97
- 230000001472 cytotoxic effect Effects 0.000 claims abstract description 26
- 231100000433 cytotoxic Toxicity 0.000 claims abstract description 24
- 241000282414 Homo sapiens Species 0.000 claims abstract description 10
- 239000003937 drug carrier Substances 0.000 claims abstract description 9
- 239000000539 dimer Substances 0.000 claims description 93
- 108020002230 Pancreatic Ribonuclease Proteins 0.000 claims description 24
- 102000005891 Pancreatic ribonuclease Human genes 0.000 claims description 24
- 241001465754 Metazoa Species 0.000 claims description 15
- 239000002674 ointment Substances 0.000 claims description 14
- 230000003612 virological effect Effects 0.000 claims description 13
- 239000000243 solution Substances 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 11
- 108010015937 ribonuclease dimer Proteins 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 208000004396 mastitis Diseases 0.000 claims description 8
- 206010046914 Vaginal infection Diseases 0.000 claims description 6
- 208000035143 Bacterial infection Diseases 0.000 claims description 5
- 206010052428 Wound Diseases 0.000 claims description 5
- 208000027418 Wounds and injury Diseases 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 4
- 230000037396 body weight Effects 0.000 claims description 4
- 208000005141 Otitis Diseases 0.000 claims description 3
- 208000036142 Viral infection Diseases 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 208000019258 ear infection Diseases 0.000 claims description 3
- 239000012266 salt solution Substances 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 208000015898 Bacterial Skin disease Diseases 0.000 claims 1
- 208000012544 Viral Skin disease Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 abstract description 26
- 108090000790 Enzymes Proteins 0.000 abstract description 26
- 229940088598 enzyme Drugs 0.000 abstract description 26
- 102000006382 Ribonucleases Human genes 0.000 abstract description 25
- 108010083644 Ribonucleases Proteins 0.000 abstract description 25
- 208000031295 Animal disease Diseases 0.000 abstract 1
- 238000011282 treatment Methods 0.000 description 35
- 238000012360 testing method Methods 0.000 description 33
- 201000010099 disease Diseases 0.000 description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 28
- 210000004027 cell Anatomy 0.000 description 24
- 230000000694 effects Effects 0.000 description 23
- 239000000178 monomer Substances 0.000 description 21
- 241000282472 Canis lupus familiaris Species 0.000 description 18
- 210000002950 fibroblast Anatomy 0.000 description 18
- 230000001580 bacterial effect Effects 0.000 description 15
- 230000003013 cytotoxicity Effects 0.000 description 13
- 231100000135 cytotoxicity Toxicity 0.000 description 13
- 235000013601 eggs Nutrition 0.000 description 13
- 208000024891 symptom Diseases 0.000 description 12
- 241000283690 Bos taurus Species 0.000 description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 230000035755 proliferation Effects 0.000 description 9
- 241000711408 Murine respirovirus Species 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 238000011160 research Methods 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 241000194017 Streptococcus Species 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 241000700605 Viruses Species 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 241000867607 Chlorocebus sabaeus Species 0.000 description 4
- 230000036528 appetite Effects 0.000 description 4
- 235000019789 appetite Nutrition 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 230000035931 haemagglutination Effects 0.000 description 4
- 230000001771 impaired effect Effects 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 231100001231 less toxic Toxicity 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 208000035473 Communicable disease Diseases 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 208000001688 Herpes Genitalis Diseases 0.000 description 3
- 208000007514 Herpes zoster Diseases 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000193985 Streptococcus agalactiae Species 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 201000004946 genital herpes Diseases 0.000 description 3
- 210000004392 genitalia Anatomy 0.000 description 3
- 230000009931 harmful effect Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 231100000065 noncytotoxic Toxicity 0.000 description 3
- 239000012188 paraffin wax Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 206010004142 Bartholinitis Diseases 0.000 description 2
- 241000701931 Canine parvovirus Species 0.000 description 2
- 206010049583 Douglas' abscess Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000008071 Parvoviridae Infections Diseases 0.000 description 2
- 206010057343 Parvovirus infection Diseases 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- 206010041925 Staphylococcal infections Diseases 0.000 description 2
- 241000194042 Streptococcus dysgalactiae Species 0.000 description 2
- 201000002014 Suppurative Otitis Media Diseases 0.000 description 2
- 208000000558 Varicose Ulcer Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 238000002266 amputation Methods 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 230000003292 diminished effect Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000002350 laparotomy Methods 0.000 description 2
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 2
- 210000002445 nipple Anatomy 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- -1 Acetylstearoyloxy alcohol Chemical compound 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 206010002942 Apathy Diseases 0.000 description 1
- 208000031462 Bovine Mastitis Diseases 0.000 description 1
- 241000224483 Coccidia Species 0.000 description 1
- 208000005156 Dehydration Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 101001013832 Homo sapiens Mitochondrial peptide methionine sulfoxide reductase Proteins 0.000 description 1
- 206010021531 Impetigo Diseases 0.000 description 1
- 241001313288 Labia Species 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 102100031767 Mitochondrial peptide methionine sulfoxide reductase Human genes 0.000 description 1
- 108700022034 Opsonin Proteins Proteins 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 206010037569 Purulent discharge Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010042731 Sycosis barbae Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000009200 cobalt therapy Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000009101 diabetic angiopathy Diseases 0.000 description 1
- 201000002249 diabetic peripheral angiopathy Diseases 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000009088 enzymatic function Effects 0.000 description 1
- 108010074605 gamma-Globulins Proteins 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 235000015220 hamburgers Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000037189 immune system physiology Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000002122 leukaemogenic effect Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000001589 microsome Anatomy 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 210000004923 pancreatic tissue Anatomy 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 230000002399 phagocytotic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229940115920 streptococcus dysgalactiae Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 230000010148 water-pollination Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17858888A | 1988-05-26 | 1988-05-26 | |
| PCT/US1988/001785 WO1989011294A1 (en) | 1988-05-26 | 1988-05-26 | Antiviral or antibacterial compound and method of use |
| OA59731A OA09785A (en) | 1988-05-26 | 1990-01-26 | Antiviral or antibacterial compound and method of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26284A true PH26284A (en) | 1992-04-10 |
Family
ID=33162813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH38684A PH26284A (en) | 1988-05-26 | 1989-05-23 | Antiviral or antibacterial composition and method of use thereof |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US5200182A (xx) |
| EP (1) | EP0380484B1 (xx) |
| JP (1) | JPH0649659B2 (xx) |
| AT (1) | ATE93143T1 (xx) |
| AU (1) | AU624331B2 (xx) |
| BG (1) | BG60544B1 (xx) |
| CA (1) | CA1335425C (xx) |
| CS (1) | CS277030B6 (xx) |
| DK (1) | DK173078B1 (xx) |
| ES (1) | ES2011577A6 (xx) |
| FI (1) | FI900412A0 (xx) |
| HK (1) | HK42394A (xx) |
| HU (1) | HU204710B (xx) |
| IL (1) | IL90092A (xx) |
| LV (1) | LV10054B (xx) |
| MA (1) | MA21560A1 (xx) |
| MW (1) | MW390A1 (xx) |
| OA (1) | OA09785A (xx) |
| PH (1) | PH26284A (xx) |
| RU (1) | RU2092183C1 (xx) |
| WO (1) | WO1989011294A1 (xx) |
| YU (1) | YU109289A (xx) |
| ZA (1) | ZA893382B (xx) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU624331B2 (en) * | 1988-05-26 | 1992-06-11 | Nika Health Products Ltd. | A composition having as its active ingredient lysozyme or ribonuclease dimer in a pharmaceutically acceptable carrier |
| JP2732515B2 (ja) * | 1990-01-08 | 1998-03-30 | ニカ ヘルス プロダクツ リミテッド | リボヌクレアーゼ二量体の製造方法 |
| US5989880A (en) | 1990-01-08 | 1999-11-23 | Nika Health Products Ltd. | Method of preparing lysozyme dimers |
| PL173978B1 (pl) * | 1992-07-13 | 1998-05-29 | Nika Health Products Ltd | Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej |
| CH682541A5 (de) * | 1992-06-23 | 1993-10-15 | Urs Viktor Dr Wirth | Biochemische Inaktivierung von RNA-Viren. |
| US6183742B1 (en) | 1992-07-13 | 2001-02-06 | Nika Health Products, Limited | Applications of lysozyme dimer |
| DZ1964A1 (fr) * | 1995-01-13 | 2002-10-15 | Nika Health Products Ltd | Nouvelle applications d'un dimère de lysozyme. |
| GB2304048A (en) * | 1995-08-12 | 1997-03-12 | John William Carson | Medicament containing saliva extract |
| US6123937A (en) * | 1997-03-14 | 2000-09-26 | Nika Health Products, Limited | Applications of lysozyme dimer |
| US6716813B2 (en) * | 2000-11-28 | 2004-04-06 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| US7338936B2 (en) * | 2000-11-28 | 2008-03-04 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| JP2002187853A (ja) * | 2000-12-21 | 2002-07-05 | Shinei Ferumentekku:Kk | 動物の乳頭除菌剤および菌環境改善方法 |
| DE10210285A1 (de) * | 2002-03-08 | 2003-11-13 | Medigene Ag | Reversibles Toxin und seine Verwendung |
| WO2005115477A2 (en) | 2004-04-13 | 2005-12-08 | Quintessence Biosciences, Inc. | Non-natural ribonuclease conjugates as cytotoxic agents |
| US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
| US7348301B2 (en) * | 2006-02-16 | 2008-03-25 | Buckman Laboratories International, Inc. | Lysozyme-based method and composition to control the growth of microorganisms in aqueous systems |
| JP2009541333A (ja) * | 2006-06-23 | 2009-11-26 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 修飾リボヌクレアーゼ |
| EP2049151A4 (en) | 2006-07-17 | 2010-03-24 | Quintessence Biosciences Inc | METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
| WO2008109401A2 (en) * | 2007-03-02 | 2008-09-12 | Saint Simeon Lda | Composition and method for treating papilloma virus and equine sarcoids |
| US20100317677A1 (en) * | 2007-09-11 | 2010-12-16 | Hassel Bret A | Methods of Treating a Microbial Infection by Modulating RNase-L Expression and/or Activity |
| JP2010540681A (ja) * | 2007-10-08 | 2010-12-24 | クインテッセンス バイオサイエンシズ，インコーポレーテッド | リボヌクレアーゼに基づく治療のための組成物及び方法 |
| BRPI0920743A2 (pt) | 2008-10-01 | 2016-09-20 | Quintessence Biosciences Inc | ribonucleases terapeuticas |
| WO2010099182A1 (en) * | 2009-02-25 | 2010-09-02 | Board Of Regents Of The University Of Nebraska | Activated creatinine and precursors as antibacterial agents, compositions and products containing such agents and uses thereof |
| NZ600269A (en) | 2009-05-20 | 2014-02-28 | Dec Int Nz Ltd | Delivery device for treatment of mastitis |
| EP2457576B1 (en) | 2010-11-29 | 2020-07-08 | Eurochit Danuta Kruszewska | Lactobacillus reuteri strain for use in the medical and veterinary prophylaxis and treatment of metabolic syndrome or infections |
| RU2548803C2 (ru) * | 2011-11-28 | 2015-04-20 | Общество с ограниченной ответственностью " Фарматренд" | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ЛЕЧЕНИЯ ГЛАЗНЫХ ИНФЕКЦИЙ P. Aeruginosa, СОДЕРЖАЩАЯ РЕКОМБИНАНТНЫЙ ЛИЗОЦИМ |
| RU2509801C2 (ru) * | 2012-03-22 | 2014-03-20 | Борис Михайлович Куриненко | СПОСОБ ИСПОЛЬЗОВАНИЯ РИБОНУКЛЕАЗЫ Bacillus intermedius |
| EP2674162A1 (en) | 2012-05-29 | 2013-12-18 | Danuta Kruszewska | Nanoproduct comprising lactobacillus reuteri dan080 useful in prophylaxis and medicine, both human and veterinary and medical use of the same |
| US20160032413A1 (en) | 2012-05-29 | 2016-02-04 | Danuta KRUSZEWSKA | Nanoproduct comprising lactobacillus reuteri dan080 useful in prophylaxis and medicine, both human and veterinary and medical use of the same |
| RU2504397C1 (ru) * | 2012-10-25 | 2014-01-20 | Леонид Леонидович Клопотенко | Фармацевтическая композиция, содержащая фермент рибонуклеазу и глицирризиновую кислоту или ее соли: глицирризинат аммония, или дикалия, или тринатрия |
| US9573980B2 (en) | 2013-03-15 | 2017-02-21 | Spogen Biotech Inc. | Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing Bacillus spores on plant roots |
| WO2014152678A1 (en) | 2013-03-15 | 2014-09-25 | University Of Massachusetts | Compositions and methods for delivering agents to the central nervous system |
| US20170049863A1 (en) * | 2014-02-21 | 2017-02-23 | National University Corporation Tokyo University Of Marine Science And Technology | Norovirus deactivator and method for producing same, method for deactivating norovirus, method for producing lysozyme component for norovirus deactivation use, prophylactic or therapeutic agent for norovirus infection, and external preparation for skin for norovirus deactivation purposes |
| WO2016017784A1 (ja) * | 2014-07-31 | 2016-02-04 | キユーピー株式会社 | 含水流動状組成物及びその製造方法、並びに、リゾチーム加工品及び／又はその塩並びにその製造方法 |
| EP3194425A1 (en) | 2014-09-17 | 2017-07-26 | Spogen Biotech Inc. | Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria |
| LV15071B (lv) * | 2015-07-14 | 2016-02-20 | Rīgas Stradiņa Universitāte | Kompozīcija subklīniska mastīta ārstēšanai govīm |
| RU2634264C1 (ru) * | 2016-09-19 | 2017-10-24 | Александр Ливиевич Ураков | Крем-молочко для лечения опоясывающего лишая |
| WO2018123821A1 (ja) | 2016-12-28 | 2018-07-05 | Dic株式会社 | 分散体及びそれを用いたインクジェット用インク組成物、光変換層、及び液晶表示素子 |
| NZ763625A (en) | 2017-09-20 | 2024-07-26 | Spogen Biotech Inc | Fusion proteins, recombinant bacteria, and exosporium fragments for plant health |
| US20220273733A1 (en) * | 2019-07-26 | 2022-09-01 | Evolve Biosystems, Inc. | Nutritive compositions with bioactive proteins |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1268M (fr) * | 1961-06-29 | 1962-04-24 | Puiseux | Médicament antimitotique et antiviral. |
| FR4020M (xx) * | 1965-01-29 | 1966-03-21 | ||
| DE1517751C3 (de) * | 1965-07-08 | 1975-02-27 | Eisai Co., Ltd., Tokio | Verfahren zum Verhindern der Bildung von flockigen Lysozym- und/oder Lysozymsalzniederschlägen in wässrigen Lösungen, die Lysozym und/oder Lysozymsalze enthalten |
| DE1545644A1 (de) * | 1965-12-06 | 1969-08-07 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen quaternaeren Scopolammoniumsalzen |
| GB1110504A (en) * | 1966-03-18 | 1968-04-18 | Prodotti Antibiotici Spa | Pharmaceutical compositions |
| US4221794A (en) * | 1979-06-21 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | Method of imparting immunomodulating and antiviral activity |
| US4510144A (en) * | 1981-08-26 | 1985-04-09 | Newport Pharmaceuticals International | Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives |
| EP0187705A3 (en) * | 1985-01-08 | 1988-05-11 | Norwich Eaton Pharmaceuticals, Inc. | Imidazo(4,5-f)quinolines useful as immunomodulating agents |
| US4739046A (en) * | 1985-08-19 | 1988-04-19 | Luzio Nicholas R Di | Soluble phosphorylated glucan |
| US4744984A (en) * | 1985-10-08 | 1988-05-17 | Vetrepharm Research, Inc. | Antiviral immunotherapeutic agent and preparation thereof |
| AU624331B2 (en) * | 1988-05-26 | 1992-06-11 | Nika Health Products Ltd. | A composition having as its active ingredient lysozyme or ribonuclease dimer in a pharmaceutically acceptable carrier |
-
1988
- 1988-05-26 AU AU19408/88A patent/AU624331B2/en not_active Expired
- 1988-05-26 EP EP88905146A patent/EP0380484B1/en not_active Expired - Lifetime
- 1988-05-26 HU HU883981A patent/HU204710B/hu unknown
- 1988-05-26 US US07/459,738 patent/US5200182A/en not_active Expired - Lifetime
- 1988-05-26 WO PCT/US1988/001785 patent/WO1989011294A1/en active IP Right Grant
- 1988-05-26 JP JP63504463A patent/JPH0649659B2/ja not_active Expired - Fee Related
- 1988-05-26 RU SU884743095A patent/RU2092183C1/ru active
- 1988-05-26 AT AT88905146T patent/ATE93143T1/de not_active IP Right Cessation
-
1989
- 1989-04-20 CA CA000597341A patent/CA1335425C/en not_active Expired - Fee Related
- 1989-04-27 IL IL9009289A patent/IL90092A/en not_active IP Right Cessation
- 1989-05-08 ZA ZA893382A patent/ZA893382B/xx unknown
- 1989-05-16 ES ES8901637A patent/ES2011577A6/es not_active Expired - Fee Related
- 1989-05-23 PH PH38684A patent/PH26284A/en unknown
- 1989-05-24 MA MA21811A patent/MA21560A1/fr unknown
- 1989-05-26 YU YU01092/89A patent/YU109289A/xx unknown
- 1989-05-26 CS CS893180A patent/CS277030B6/cs not_active IP Right Cessation
-
1990
- 1990-01-22 MW MW3/90A patent/MW390A1/xx unknown
- 1990-01-22 DK DK199000168A patent/DK173078B1/da not_active IP Right Cessation
- 1990-01-25 FI FI900412A patent/FI900412A0/fi not_active IP Right Cessation
- 1990-01-26 OA OA59731A patent/OA09785A/en unknown
- 1990-02-22 BG BG91270A patent/BG60544B1/bg unknown
-
1992
- 1992-04-08 US US07/865,002 patent/US5466449A/en not_active Expired - Lifetime
- 1992-12-28 LV LVP-92-508A patent/LV10054B/en unknown
-
1994
- 1994-05-05 HK HK42394A patent/HK42394A/xx not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/474,663 patent/US6099835A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0649659B2 (ja) | 1994-06-29 |
| DK173078B1 (da) | 1999-12-20 |
| ES2011577A6 (es) | 1990-01-16 |
| MW390A1 (en) | 1990-11-14 |
| AU624331B2 (en) | 1992-06-11 |
| YU109289A (en) | 1991-08-31 |
| ZA893382B (en) | 1991-01-30 |
| HUT54060A (en) | 1991-01-28 |
| HU204710B (en) | 1992-02-28 |
| BG91270A (bg) | 1993-12-24 |
| BG60544B1 (en) | 1995-08-28 |
| JPH03504121A (ja) | 1991-09-12 |
| CS318089A3 (en) | 1992-05-13 |
| HK42394A (en) | 1994-05-13 |
| US6099835A (en) | 2000-08-08 |
| IL90092A (en) | 1995-03-30 |
| CS277030B6 (en) | 1992-11-18 |
| WO1989011294A1 (en) | 1989-11-30 |
| EP0380484B1 (en) | 1993-08-18 |
| EP0380484A1 (en) | 1990-08-08 |
| CA1335425C (en) | 1995-05-02 |
| FI900412A0 (fi) | 1990-01-25 |
| DK16890A (da) | 1990-01-22 |
| ATE93143T1 (de) | 1993-09-15 |
| DK16890D0 (da) | 1990-01-22 |
| US5466449A (en) | 1995-11-14 |
| OA09785A (en) | 1994-04-15 |
| AU1940888A (en) | 1989-12-12 |
| LV10054B (en) | 1995-02-20 |
| MA21560A1 (fr) | 1989-12-31 |
| HU883981D0 (en) | 1990-12-28 |
| US5200182A (en) | 1993-04-06 |
| LV10054A (lv) | 1994-05-10 |
| RU2092183C1 (ru) | 1997-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5200182A (en) | Antiviral or antibacterial composition and method of use | |
| CN109985069B (zh) | 益生菌组合物及其用途 | |
| CN1578670B (zh) | 乳清脱辅基蛋白在预防或治疗微生物或病毒感染中的用途 | |
| US6132715A (en) | Method of inhibiting biosynthesis of tumor necrosis factor | |
| CN113143862A (zh) | 富马酸二甲酯滴眼液及其制备方法和作为真菌性角膜炎治疗药物的应用 | |
| US5342612A (en) | Compositions for the treatment of mammalian diseases | |
| US20040138174A1 (en) | Use of n-acetyl-d-glucosamine in the manufacture of pharmaceutical useful for treating cervical erosion | |
| CN100388949C (zh) | 一种用于防治牛子宫内膜炎的溶葡萄球菌酶冻干粉剂 | |
| KR930004599B1 (ko) | 항바이러스성 또는 항균성 조성물 | |
| Cox | Cefazolin therapy of urinary tract infections | |
| DE3883392T2 (de) | Verwendung eines Lysozymdimeren und/oder Ribonucleasedimeren zur Herstellung eines antiviralen oder antibakteriellen Arzneimittels. | |
| RO110037B1 (ro) | Compoziții antivirale sau antibacteriene și metodă de tratare a infecțiilor, cu acestea | |
| Iyengar et al. | Plumbago zeylanica L.(Chitrak) a gastrointestinal flora normaliser | |
| EP1535620A1 (en) | The use of n-acetyl-d-glucosamine for preparing medicines for urogenital tract infection's treatment and prevention | |
| JOHNSON | Dermatologic evaluation of yeast, tyrothricin, chlorophyll and nitrofurazone | |
| Powell, SJ & MacLeod | Ambilhar, a nitrothiazole derivative, in urinary tract bilharzia | |
| CN114767708A (zh) | 一种稳定的妇科抑菌组合物及妇科护理液 |