PH25941A - Yeast production of hepatitis B surface antigen - Google Patents

Yeast production of hepatitis B surface antigen

Info

Publication number
PH25941A
PH25941A PH34520A PH34520A PH25941A PH 25941 A PH25941 A PH 25941A PH 34520 A PH34520 A PH 34520A PH 34520 A PH34520 A PH 34520A PH 25941 A PH25941 A PH 25941A
Authority
PH
Philippines
Prior art keywords
hepatitis
surface antigen
regulatory regions
yeast production
carbon sources
Prior art date
Application number
PH34520A
Other languages
English (en)
Inventor
Juerg Friedrich Tschopp
Michael Miller Harpold
James Michael Cregg
Richard Gordon Buckholz
Original Assignee
Phillips Petroleum Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phillips Petroleum Co filed Critical Phillips Petroleum Co
Publication of PH25941A publication Critical patent/PH25941A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PH34520A 1985-11-26 1986-11-24 Yeast production of hepatitis B surface antigen PH25941A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/801,713 US4895800A (en) 1985-11-26 1985-11-26 Yeast production of hepatitis B surface antigen

Publications (1)

Publication Number Publication Date
PH25941A true PH25941A (en) 1991-12-19

Family

ID=25181867

Family Applications (2)

Application Number Title Priority Date Filing Date
PH34520A PH25941A (en) 1985-11-26 1986-11-24 Yeast production of hepatitis B surface antigen
PH36040A PH25539A (en) 1985-11-26 1987-11-06 Process for preparing hepatitis b-surface antigen

Family Applications After (1)

Application Number Title Priority Date Filing Date
PH36040A PH25539A (en) 1985-11-26 1987-11-06 Process for preparing hepatitis b-surface antigen

Country Status (28)

Country Link
US (1) US4895800A (fr)
EP (1) EP0226846B1 (fr)
JP (1) JPH0763372B2 (fr)
KR (1) KR920004050B1 (fr)
CN (1) CN86107885A (fr)
AT (1) ATE92527T1 (fr)
AU (1) AU583683B2 (fr)
CA (1) CA1285895C (fr)
CS (1) CS276453B6 (fr)
DD (1) DD252614A5 (fr)
DE (1) DE3688831T2 (fr)
DK (1) DK565186A (fr)
EG (1) EG17949A (fr)
ES (1) ES2058055T3 (fr)
FI (1) FI95929C (fr)
HU (1) HUT43112A (fr)
IE (1) IE64519B1 (fr)
IL (1) IL80754A (fr)
IN (1) IN166428B (fr)
MX (1) MX4334A (fr)
NO (1) NO176025C (fr)
NZ (1) NZ218286A (fr)
PH (2) PH25941A (fr)
PL (1) PL152882B1 (fr)
PT (1) PT83819B (fr)
TW (1) TW215457B (fr)
YU (1) YU46031B (fr)
ZA (1) ZA868601B (fr)

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ATE91304T1 (de) * 1987-02-27 1993-07-15 Merck & Co Inc Verfahren zur herstellung des pres 1/s2/shepatitis-b-antigens aus hefe.
US5026828A (en) * 1987-02-27 1991-06-25 Merck & Co., Inc. Method of purifying recombinant pres-1/S-2/S/S hepatitis B antigen from yeast
ATE93891T1 (de) * 1987-03-09 1993-09-15 Merck & Co Inc Reinigung von rekombiniertem hepatitis-boberfl|chen-antigen.
ES2167304T3 (es) * 1987-06-22 2002-05-16 Medeva Holdings Bv Peptido que contiene el antigeno de superficie de la hepatitis b.
US5011915A (en) * 1987-10-26 1991-04-30 Merck & Co., Inc. Process for purifying recombinant hepatitis antigens
EP0314240A3 (fr) * 1987-10-26 1990-03-28 Merck & Co. Inc. Procédé de purification d'antigènes recombinants d'hépatite
US5004688A (en) * 1988-04-15 1991-04-02 Phillips Petroleum Company Purification of hepatitis proteins
IL89992A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human serum albumin in methylotrophic yeasts
NZ228774A (en) * 1988-04-25 1991-05-28 Phillips Petroleum Co Hbv particles containing pres 2 proteins and recombinant processes for their production in yeast cells
IL89993A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of the hiv 24kda gag protein in methylotrophic yeasts
IL89989A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human interleukin-2 in methylotrophic yeasts
IL90021A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Process for the production of interferon
IL90161A0 (en) * 1988-05-13 1989-12-15 Phillips Petroleum Co Expression of hepatitis b s and pres2 proteins in methylotrophic yeasts
JPH04501662A (ja) * 1988-09-26 1992-03-26 ザ・サルク・インスティチュート・バイオテクノロジー／インダストリアル・アソシエイツ・インコーポレーテッド 混合給送組換え酵母発酵
DD297841A5 (de) * 1989-02-13 1992-01-23 The Salk Institute Biotechnology/Industrial Associates,Us Herstellung von superoxiddismutase in pichia pastoris hefezellen
US6197548B1 (en) 1990-04-02 2001-03-06 Medeva Pharma Limited Transformed Pichia expressing the pertactin antigen
CA2090969C (fr) * 1990-09-04 2001-08-21 Russell Arthur Brierley Production de facteur de croissance insulinoide dans les cellules de levure methylotrophiques
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
CU22290A1 (es) * 1990-10-08 1995-01-31 Cigb Procedimiento para la obtencion de antigeno de superficie del virus de la hepatitis b de superior capacidad inmunoganica y su uso en un preparado vacunal
US5268273A (en) * 1990-12-14 1993-12-07 Phillips Petroleum Company Pichia pastoris acid phosphatase gene, gene regions, signal sequence and expression vectors comprising same
EP0491077A1 (fr) * 1990-12-19 1992-06-24 Medeva Holdings B.V. Composition utilisée comme agent thérapeutique contre des maladies hépatiques chroniques
WO1992013951A1 (fr) * 1991-02-04 1992-08-20 The Salk Institute Biotechnology/Industrial Associates, Inc. Production de serumalbumine humaine dans des cellules de levure methylotrophique
CA2063890C (fr) * 1991-03-27 2007-03-13 Masami Miura Promoteur aox2 mutant, microorganisme le renfermant, methode pour le preparer et production d'une proteine heterologue a l'aide de ce microorganisme
WO1992017595A1 (fr) * 1991-04-01 1992-10-15 The Salk Institute Biotechnology/Industrial Associates, Inc. Genes influançant l'activite proteolytique de pichia, et leurs utilisations
CA2058820C (fr) * 1991-04-25 2003-07-15 Kotikanyad Sreekrishna Cassettes d'expression et vecteurs pour la secretion de serum albumine humaine dans des cellules pichia pastoris
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
US5850025A (en) * 1991-09-19 1998-12-15 Sibia Neurosciences, Inc. Protection of plants against plant pathogens
ATE168271T1 (de) 1992-05-23 1998-08-15 Smithkline Beecham Biolog Kombinierte impfstoffe, die hepatitis b oberfläche antigen und andere antigenen enthalten
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JPH06209763A (ja) * 1993-01-13 1994-08-02 Green Cross Corp:The 変異株
US5872098A (en) * 1995-06-05 1999-02-16 Corvas International, Inc. Nematode-extracted anticoagulant protein
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WO1996012021A2 (fr) * 1994-10-18 1996-04-25 Corvas International, Inc. Proteines anticoagulantes et inhibiteurs de la serine-protease extraits de nematodes
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US5716808A (en) * 1995-11-09 1998-02-10 Zymogenetics, Inc. Genetic engineering of pichia methanolica
US5955349A (en) * 1996-08-26 1999-09-21 Zymogenetics, Inc. Compositions and methods for producing heterologous polypeptides in Pichia methanolica
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CA2347099C (fr) 1998-10-16 2014-08-05 Smithkline Beecham Biologicals S.A. Systemes d'adjuvants comprenant un immunostimulant absorbe sur une particule de sel metallique et vaccins derives
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DE60335602D1 (de) * 2002-12-18 2011-02-17 Roche Diagnostics Gmbh Rekombinante Desoxyribonuclease I aus Rinder-Pankreas mit hoher spezifischer Aktivität
DE60319333D1 (de) * 2002-12-20 2008-04-10 Roche Diagnostics Gmbh Hitzelabile Desoxyribonuklease I-Varianten
EP1460425A1 (fr) * 2003-03-17 2004-09-22 Boehringer Mannheim Gmbh Enzymes déglycosylés pour conjugués
JP4411192B2 (ja) * 2003-12-05 2010-02-10 エフ．ホフマン−ラ ロシュ アーゲー 組換えで発現されるカルボキシペプチダーゼｂおよびその精製
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BRPI0708865A8 (pt) 2006-03-14 2019-01-22 Univ Oregon Health & Science métodos para produzir uma resposta imune à tuberculose
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EP2293813A4 (fr) 2008-05-23 2012-07-11 Univ Michigan Vaccins à nanoémulsion
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WO2010099472A2 (fr) 2009-02-27 2010-09-02 The U.S.A. Of America, As Represented By The Secretary, Department Of Health And Human Services Polypeptides spanx-b et leur utilisation
WO2011047340A1 (fr) 2009-10-16 2011-04-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Insertion de gènes étrangers dans le virus de la rubéole et leur expression stable dans un vaccin viral vivant atténué
GB201105981D0 (en) 2011-04-08 2011-05-18 Glaxosmithkline Biolog Sa Novel process
WO2013152352A1 (fr) 2012-04-06 2013-10-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Vecteur de la rubéole atténué, vivant, pour exprimer des antigènes de vaccin
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SG11201506858SA (en) 2013-03-08 2015-09-29 Crucell Holland Bv Acellular pertussis vaccine
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FR2480779B2 (fr) * 1979-08-30 1986-07-18 Anvar Vecteur contenant une sequence nucleotidique de l'antigene de surface du virus de l'hepatite b et procede de fabrication d'une molecule immunogene mettant en oeuvre ce vecteur
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EP0103201B1 (fr) * 1982-08-16 1990-05-30 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Vecteur "navette"
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US4515714A (en) * 1983-03-09 1985-05-07 Juridicial Foundation, The Chemo-Semo-Sero-Therapeutic Research Institute Method for purification of hepatitis B virus surface antigen
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Also Published As

Publication number Publication date
PL262598A1 (en) 1987-09-21
HUT43112A (en) 1987-09-28
ES2058055T3 (es) 1994-11-01
AU6538486A (en) 1987-05-28
NO176025B (no) 1994-10-10
NO864704D0 (no) 1986-11-25
EP0226846B1 (fr) 1993-08-04
FI95929B (fi) 1995-12-29
KR920004050B1 (ko) 1992-05-23
TW215457B (fr) 1993-11-01
DK565186A (da) 1987-05-27
AU583683B2 (en) 1989-05-04
IE863021L (en) 1987-05-26
NO176025C (no) 1995-01-18
US4895800A (en) 1990-01-23
JPS62190085A (ja) 1987-08-20
MX4334A (es) 1993-12-01
FI864791A (fi) 1987-05-27
YU201386A (en) 1988-10-31
CS864186A3 (en) 1992-01-15
DK565186D0 (da) 1986-11-25
EG17949A (en) 1991-03-30
IL80754A0 (en) 1987-02-27
CN86107885A (zh) 1987-09-23
PT83819A (en) 1986-12-01
ATE92527T1 (de) 1993-08-15
YU46031B (sh) 1992-12-21
NZ218286A (en) 1991-07-26
PL152882B1 (en) 1991-02-28
EP0226846A1 (fr) 1987-07-01
CA1285895C (fr) 1991-07-09
ZA868601B (en) 1987-06-24
CS276453B6 (en) 1992-06-17
JPH0763372B2 (ja) 1995-07-12
IE64519B1 (en) 1995-08-09
FI864791A0 (fi) 1986-11-25
FI95929C (fi) 1996-04-10
IN166428B (fr) 1990-05-05
IL80754A (en) 1993-03-15
PT83819B (pt) 1988-10-14
PH25539A (en) 1991-07-24
DD252614A5 (de) 1987-12-23
DE3688831D1 (de) 1993-09-09
KR870005099A (ko) 1987-06-04
DE3688831T2 (de) 1993-11-25

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