US5206344A
(en)
*
|
1985-06-26 |
1993-04-27 |
Cetus Oncology Corporation |
Interleukin-2 muteins and polymer conjugation thereof
|
CA1283046C
(en)
*
|
1986-05-29 |
1991-04-16 |
Nandini Katre |
Tumor necrosis factor formulation
|
US4745180A
(en)
*
|
1986-06-27 |
1988-05-17 |
Cetus Corporation |
Solubilization of proteins for pharmaceutical compositions using heparin fragments
|
US5004605A
(en)
*
|
1987-12-10 |
1991-04-02 |
Cetus Corporation |
Low pH pharmaceutical compositions of recombinant β-interferon
|
US4847325A
(en)
*
|
1988-01-20 |
1989-07-11 |
Cetus Corporation |
Conjugation of polymer to colony stimulating factor-1
|
IE62463B1
(en)
*
|
1988-07-07 |
1995-02-08 |
Res Dev Foundation |
Immunoconjugates for cancer diagnosis and therapy
|
US5091176A
(en)
*
|
1988-11-02 |
1992-02-25 |
W. R. Grace & Co.-Conn. |
Polymer-modified peptide drugs having enhanced biological and pharmacological activities
|
US6166183A
(en)
*
|
1992-11-30 |
2000-12-26 |
Kirin-Amgen, Inc. |
Chemically-modified G-CSF
|
ATE135370T1
(de)
*
|
1988-12-22 |
1996-03-15 |
Kirin Amgen Inc |
Chemisch modifizierte granulocytenkolonie erregender faktor
|
US4902502A
(en)
*
|
1989-01-23 |
1990-02-20 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
US5166322A
(en)
*
|
1989-04-21 |
1992-11-24 |
Genetics Institute |
Cysteine added variants of interleukin-3 and chemical modifications thereof
|
WO1990015628A1
(en)
*
|
1989-06-14 |
1990-12-27 |
Cetus Corporation |
Polymer/antibiotic conjugate
|
WO1991001146A1
(en)
*
|
1989-07-14 |
1991-02-07 |
Praxis Biologics, Inc. |
Cytokine and hormone carriers for conjugate vaccines
|
IL95031A
(en)
|
1989-07-18 |
2007-03-08 |
Amgen Inc |
A method of producing a recombinant human necrotic factor absorber
|
DE69017180T2
(de)
*
|
1989-08-07 |
1995-07-20 |
Debio Rech Pharma Sa |
Biologisch wirksame polymere arzneistoffderivate.
|
US5393735A
(en)
*
|
1990-08-09 |
1995-02-28 |
Rohm And Haas Company |
Herbicidal glutarimides
|
US5552391A
(en)
*
|
1990-01-16 |
1996-09-03 |
La Jolla Pharmaceutical Company |
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
|
JPH04218000A
(ja)
*
|
1990-02-13 |
1992-08-07 |
Kirin Amgen Inc |
修飾ポリペプチド
|
FR2658519B1
(fr)
*
|
1990-02-19 |
1995-07-07 |
Serbio |
Substrats peptidiques pour identification du facteur xa.
|
FR2658521B1
(fr)
*
|
1990-02-19 |
1994-01-21 |
Serbioo |
Bipeptides symetriques comportant un reste polyalkyleneglycol, procede de preparation et utilisation dans le dosage des proteases.
|
US6552170B1
(en)
|
1990-04-06 |
2003-04-22 |
Amgen Inc. |
PEGylation reagents and compounds formed therewith
|
US5312903A
(en)
*
|
1990-06-01 |
1994-05-17 |
E. I. Du Pont De Nemours And Company |
Lysine-glycosylated recombinant interleukin-2
|
IE912365A1
(en)
*
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
US5229366A
(en)
*
|
1990-10-23 |
1993-07-20 |
Fuji Photo Film Co., Ltd. |
Peptide-containing polyethylene glycol derivatives and application thereof
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
EP1808183A3
(en)
*
|
1993-09-08 |
2009-07-01 |
La Jolla Pharmaceutical Company |
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
|
US5880131A
(en)
*
|
1993-10-20 |
1999-03-09 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
US5629384A
(en)
*
|
1994-05-17 |
1997-05-13 |
Consiglio Nazionale Delle Ricerche |
Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
|
US20030053982A1
(en)
|
1994-09-26 |
2003-03-20 |
Kinstler Olaf B. |
N-terminally chemically modified protein compositions and methods
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
ES2336857T3
(es)
*
|
1995-05-04 |
2010-04-16 |
Gilead Sciences, Inc. |
Complejos de ligandos de acido nucleico.
|
US8071737B2
(en)
|
1995-05-04 |
2011-12-06 |
Glead Sciences, Inc. |
Nucleic acid ligand complexes
|
US5874409A
(en)
|
1995-06-07 |
1999-02-23 |
La Jolla Pharmaceutical Company |
APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
|
WO1997009989A1
(en)
*
|
1995-09-14 |
1997-03-20 |
Lxr Biotechnology Inc. |
Compositions with anti-apoptotic activity, containing a mixture of phospholipids
|
TW517067B
(en)
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
TW555765B
(en)
|
1996-07-09 |
2003-10-01 |
Amgen Inc |
Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
|
ES2275300T3
(es)
*
|
1997-01-15 |
2007-06-01 |
Phoenix Pharmacologics, Inc. |
Factor de necrosis tumoral modificado.
|
US6321909B1
(en)
|
1997-02-13 |
2001-11-27 |
Sky High, Llc |
System for storing polyethylene glycol solutions
|
AU762621B2
(en)
|
1998-04-28 |
2003-07-03 |
Merck Serono Sa |
Polyol-IFN-beta conjugates
|
US6858210B1
(en)
|
1998-06-09 |
2005-02-22 |
La Jolla Pharmaceutical Co. |
Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
|
CN1896231B
(zh)
|
1998-08-06 |
2012-09-05 |
山景药品公司 |
分离四聚体尿酸氧化酶的方法
|
US6783965B1
(en)
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
WO2000023472A2
(en)
*
|
1998-10-16 |
2000-04-27 |
Biogen, Inc. |
Interferon-beta fusion proteins and uses
|
CN101062419B
(zh)
*
|
1998-10-16 |
2016-06-29 |
生物基因Ma公司 |
干扰素-β-1a的聚合物缀合物及其使用
|
US6399578B1
(en)
|
1998-12-09 |
2002-06-04 |
La Jolla Pharmaceutical Company |
Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
|
US6458953B1
(en)
|
1998-12-09 |
2002-10-01 |
La Jolla Pharmaceutical Company |
Valency platform molecules comprising carbamate linkages
|
US7144574B2
(en)
|
1999-08-27 |
2006-12-05 |
Maxygen Aps |
Interferon β variants and conjugates
|
US7431921B2
(en)
|
2000-04-14 |
2008-10-07 |
Maxygen Aps |
Interferon beta-like molecules
|
US6531122B1
(en)
|
1999-08-27 |
2003-03-11 |
Maxygen Aps |
Interferon-β variants and conjugates
|
IL147581A0
(en)
*
|
1999-08-27 |
2002-08-14 |
Maxygen Aps |
New interferon beta-like molecules
|
TR200101086A3
(sv)
*
|
1999-10-15 |
2001-08-21 |
|
|
WO2001036001A2
(en)
|
1999-11-12 |
2001-05-25 |
Maxygen Holdings Ltd |
Interferon gamma conjugates
|
CN1309423C
(zh)
|
1999-11-12 |
2007-04-11 |
马克西根控股公司 |
干扰素γ偶联物
|
JP2003519478A
(ja)
|
2000-01-10 |
2003-06-24 |
マキシゲン・ホールディングズ・リミテッド |
G−csf結合体
|
PT1257295E
(pt)
|
2000-02-11 |
2009-07-16 |
Bayer Healthcare Llc |
Moléculas de tipo factor vii ou viia
|
ZA200305980B
(en)
|
2001-02-12 |
2007-01-31 |
Res Dev Foundation |
Modified proteins, designer toxins, and methods of making thereof
|
CZ20032526A3
(cs)
|
2001-02-27 |
2003-12-17 |
Maxygen Aps |
Nové molekuly podobné interferonu beta
|
US7038015B2
(en)
|
2001-04-06 |
2006-05-02 |
Maxygen Holdings, Ltd. |
Interferon gamma polypeptide variants
|
US6958388B2
(en)
|
2001-04-06 |
2005-10-25 |
Maxygen, Aps |
Interferon gamma polypeptide variants
|
JP4142569B2
(ja)
*
|
2001-06-22 |
2008-09-03 |
協和醗酵工業株式会社 |
軟膏剤
|
IL159894A0
(en)
|
2001-07-17 |
2004-06-20 |
Res Dev Foundation |
Therapeutic agents comprising pro-apoptotic proteins
|
AU2002355955A1
(en)
|
2001-08-13 |
2003-03-03 |
University Of Southern California |
Interleukin-2 mutants with reduced toxicity
|
DK2279755T3
(da)
|
2001-10-10 |
2014-05-26 |
Ratiopharm Gmbh |
Remodellering og glycokonjugering af fibroblastvækstfaktor (FGF)
|
US7696163B2
(en)
|
2001-10-10 |
2010-04-13 |
Novo Nordisk A/S |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
US7179617B2
(en)
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
US7265084B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
US7125843B2
(en)
|
2001-10-19 |
2006-10-24 |
Neose Technologies, Inc. |
Glycoconjugates including more than one peptide
|
US7399613B2
(en)
|
2001-10-10 |
2008-07-15 |
Neose Technologies, Inc. |
Sialic acid nucleotide sugars
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
US7439043B2
(en)
|
2001-10-10 |
2008-10-21 |
Neose Technologies, Inc. |
Galactosyl nucleotide sugars
|
PT2279753E
(pt)
|
2001-10-10 |
2016-01-15 |
Novo Nordisk As |
Remodelação e glicoconjugação de péptidos
|
US7297511B2
(en)
|
2001-10-10 |
2007-11-20 |
Neose Technologies, Inc. |
Interferon alpha: remodeling and glycoconjugation of interferon alpha
|
US7226903B2
(en)
|
2001-10-10 |
2007-06-05 |
Neose Technologies, Inc. |
Interferon beta: remodeling and glycoconjugation of interferon beta
|
US7265085B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycoconjugation methods and proteins/peptides produced by the methods
|
US7473680B2
(en)
|
2001-11-28 |
2009-01-06 |
Neose Technologies, Inc. |
Remodeling and glycoconjugation of peptides
|
DK3025726T3
(da)
|
2002-01-18 |
2019-12-09 |
Biogen Ma Inc |
Polyalkylenpolymerforbindelser og anvendelser deraf
|
CA2490360A1
(en)
|
2002-06-21 |
2003-12-31 |
Novo Nordisk Health Care Ag |
Pegylated factor vii glycoforms
|
EP1539814A2
(en)
|
2002-07-03 |
2005-06-15 |
Maxygen Holdings Ltd. c/o Close Brothers (Cayman) Limited |
Full-length interferon gamma polypeptide variants
|
NZ541124A
(en)
|
2002-12-26 |
2008-08-29 |
Mountain View Pharmaceuticals |
Polymer conjugates of interferon-beta with enhanced biological potency
|
KR20060003862A
(ko)
|
2003-03-14 |
2006-01-11 |
네오스 테크놀로지스, 인크. |
수용성분기폴리머 및 그 접합체
|
WO2004091499A2
(en)
|
2003-04-09 |
2004-10-28 |
Neose Technologies, Inc. |
Intracellular formation of peptide conjugates
|
SG155777A1
(en)
|
2003-04-09 |
2009-10-29 |
Neose Technologies Inc |
Glycopegylation methods and proteins/peptides produced by the methods
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
ES2405209T3
(es)
*
|
2003-08-07 |
2013-05-30 |
Zymogenetics, Inc. |
Preparaciones homogéneas de lL-29
|
JP4850514B2
(ja)
*
|
2003-08-25 |
2012-01-11 |
東レ株式会社 |
インターフェロンβ複合体
|
CA2542179A1
(en)
|
2003-10-10 |
2005-04-21 |
Novo Nordisk A/S |
Il-21 derivatives
|
EP2633866A3
(en)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Combination therapy
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
WO2005051327A2
(en)
|
2003-11-24 |
2005-06-09 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
MXPA06008506A
(es)
|
2004-02-02 |
2007-01-30 |
Ambrx Inc |
Polipeptidos de hormona de crecimiento humana modificada y sus usos.
|
EP1745141B2
(en)
|
2004-05-04 |
2019-09-25 |
Novo Nordisk Health Care AG |
O-linked glycoforms of faktor vii and method to manufacture them
|
AU2005265163B2
(en)
|
2004-06-18 |
2009-10-01 |
Ambrx, Inc. |
Novel antigen-binding polypeptides and their uses
|
WO2006010143A2
(en)
|
2004-07-13 |
2006-01-26 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
|
EP1799249A2
(en)
|
2004-09-10 |
2007-06-27 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
PL2586456T3
(pl)
|
2004-10-29 |
2016-07-29 |
Ratiopharm Gmbh |
Remodeling i glikopegilacja czynnika wzrostu fibroblastów (FGF)
|
MX2007007580A
(es)
|
2004-12-22 |
2007-12-11 |
Ambrx Inc |
Hormona del crecimiento humana modificada.
|
ES2449195T3
(es)
|
2005-01-10 |
2014-03-18 |
Ratiopharm Gmbh |
Factor estimulante de colonias de granulocitos glicopegilado
|
WO2006121569A2
(en)
|
2005-04-08 |
2006-11-16 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
JP2008535500A
(ja)
|
2005-04-11 |
2008-09-04 |
サビエント ファーマセウティカルズ インク. |
変異型尿酸オキシダーゼおよびその利用
|
EP2975135A1
(en)
|
2005-05-25 |
2016-01-20 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
EP1893632B1
(en)
|
2005-06-17 |
2015-08-12 |
Novo Nordisk Health Care AG |
Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
US20090048440A1
(en)
|
2005-11-03 |
2009-02-19 |
Neose Technologies, Inc. |
Nucleotide Sugar Purification Using Membranes
|
EP1951890A4
(en)
|
2005-11-16 |
2009-06-24 |
Ambrx Inc |
PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
|
RU2304586C1
(ru)
*
|
2006-03-27 |
2007-08-20 |
Михаил Николаевич Смирнов |
Препарат интерлейкина-2 и способ его получения
|
RU2322452C2
(ru)
*
|
2006-03-27 |
2008-04-20 |
Михаил Николаевич Смирнов |
Иммуномодулирующая композиция
|
JP2009537609A
(ja)
|
2006-05-24 |
2009-10-29 |
ノボ ノルディスク ヘルス ケア アーゲー |
延長されたfixアナログ及び誘導体
|
CN101516388B
(zh)
|
2006-07-21 |
2012-10-31 |
诺和诺德公司 |
通过o-联糖基化序列的肽的糖基化
|
KR20090060294A
(ko)
|
2006-09-08 |
2009-06-11 |
암브룩스, 인코포레이티드 |
변형된 인간 혈장 폴리펩티드 또는 Fc 스캐폴드 및 그의 용도
|
AU2007296843C1
(en)
*
|
2006-09-15 |
2012-08-16 |
Creabilis Therapeutics S.P.A. |
Polymer conjugates of Box-A of HMGB1 and Box-A variants of HMGB1
|
WO2008057683A2
(en)
|
2006-10-03 |
2008-05-15 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates
|
PL2068909T3
(pl)
|
2007-03-30 |
2012-09-28 |
Ambrx Inc |
Modyfikowane polipeptydy fgf-21 i ich zastosowanie
|
AU2008237411B2
(en)
|
2007-04-03 |
2013-10-03 |
Ratiopharm Gmbh |
Methods of treatment using glycopegylated G-CSF
|
WO2008154639A2
(en)
|
2007-06-12 |
2008-12-18 |
Neose Technologies, Inc. |
Improved process for the production of nucleotide sugars
|
CN104689333B
(zh)
|
2007-08-27 |
2018-05-29 |
拉蒂奥法姆有限责任公司 |
G-csf 缀合物的液体制剂
|
KR101656107B1
(ko)
|
2007-11-20 |
2016-09-08 |
암브룩스, 인코포레이티드 |
변형된 인슐린 폴리펩티드 및 이의 용도
|
BRPI0905707B1
(pt)
*
|
2008-01-18 |
2024-02-27 |
Dow Global Technologies Inc |
Método para aumentar a solubilidade aquosa de um composto ativo e composição compreendendo um composto ativo
|
WO2009094172A2
(en)
|
2008-01-22 |
2009-07-30 |
Araim Pharmaceuticals, Inc. |
Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
|
EP3103880A1
(en)
|
2008-02-08 |
2016-12-14 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
CN103497246B
(zh)
|
2008-02-27 |
2016-08-10 |
诺沃—诺迪斯克有限公司 |
缀合的因子viii分子
|
DK2279405T3
(da)
|
2008-05-13 |
2014-01-13 |
Advanced Liquid Logic Inc |
Dråbeaktuatorindretninger, -systemer og -fremgangsmåder
|
MX2011000859A
(es)
|
2008-07-23 |
2011-02-24 |
Ambrx Inc |
Polipeptidos g-csf bovinos modificados y sus usos.
|
TR201802361T4
(tr)
|
2008-09-26 |
2018-03-21 |
Ambrx Inc |
Doğal olmayan amino asit replikasyonuna bağımlı mikroorganizmalar ve aşılar.
|
MX346001B
(es)
|
2008-09-26 |
2017-03-01 |
Ambrx Inc |
Polipeptidos de eritropoyetina animal modificados y sus usos.
|
SG176897A1
(en)
|
2009-06-25 |
2012-01-30 |
Savient Pharmaceuticals Inc |
Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
|
BR112012015461A2
(pt)
|
2009-12-21 |
2017-01-10 |
Ambrx Inc |
polipeptídeos de somatotropina boviina modificados e seus usos
|
CN104017063A
(zh)
|
2009-12-21 |
2014-09-03 |
Ambrx公司 |
经过修饰的猪促生长素多肽和其用途
|
US9815876B2
(en)
|
2010-03-05 |
2017-11-14 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
WO2011143274A1
(en)
|
2010-05-10 |
2011-11-17 |
Perseid Therapeutics |
Polypeptide inhibitors of vla4
|
MY162837A
(en)
|
2010-08-17 |
2017-07-31 |
Ambrx Inc |
Modified relaxin polypeptides and their uses
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
KR102591732B1
(ko)
|
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2023-10-19 |
넥타르 테라퓨틱스 |
Il-2 부분 및 중합체의 접합체
|
DK3489255T3
(da)
|
2011-02-10 |
2021-08-23 |
Roche Glycart Ag |
Muterede interleukin-2-polypeptider
|
EP2726502A1
(en)
|
2011-07-01 |
2014-05-07 |
Bayer Intellectual Property GmbH |
Relaxin fusion polypeptides and uses thereof
|
US20150030564A1
(en)
|
2012-02-29 |
2015-01-29 |
Toray Industries, Inc. |
Inhibitory agent for body cavity fluid accumulation
|
JP2015512927A
(ja)
|
2012-04-16 |
2015-04-30 |
カンタブ バイオファーマシューティカルズ パテンツ リミテッド |
最適化された皮下治療薬
|
WO2013177187A2
(en)
*
|
2012-05-22 |
2013-11-28 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-pk il-2 and therapeutic agents
|
HUE043552T2
(hu)
|
2012-06-08 |
2019-09-30 |
Sutro Biopharma Inc |
Antitestek, amelyek tartalmaznak helyspecifikus nem természetes aminosav maradékokat, eljárások elõállításukra és eljárások használatukra
|
EP2863955B1
(en)
|
2012-06-26 |
2016-11-23 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
BR112015004022B1
(pt)
|
2012-08-31 |
2023-04-25 |
Sutro Biopharma, Inc |
Aminoácidos modificados compreendendo um grupo azido
|
US20150017120A1
(en)
*
|
2013-06-13 |
2015-01-15 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-pk il-2 and adoptive cell therapy
|
EP3019522B1
(en)
|
2013-07-10 |
2017-12-13 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
US9840493B2
(en)
|
2013-10-11 |
2017-12-12 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
CN107108710B
(zh)
|
2014-10-24 |
2022-02-15 |
百时美施贵宝公司 |
修饰的fgf-21多肽及其用途
|
WO2017189988A1
(en)
|
2016-04-29 |
2017-11-02 |
Araim Pharmaceuticals, Inc. |
Tissue protective peptides for preventing and treating diseases and disorders associated with tissue damage
|
US10266578B2
(en)
|
2017-02-08 |
2019-04-23 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
CN110382525B
(zh)
|
2017-04-03 |
2023-10-20 |
豪夫迈·罗氏有限公司 |
免疫缀合物
|
LT3606946T
(lt)
|
2017-04-03 |
2022-10-25 |
F. Hoffmann-La Roche Ag |
Anti-pd-1 antikūno imunokonjugatai su mutantiniu il-2 arba su il-15
|
WO2019131964A1
(ja)
*
|
2017-12-27 |
2019-07-04 |
協和発酵キリン株式会社 |
Il-2改変体
|
CA3111576A1
(en)
|
2018-09-11 |
2020-03-19 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and their uses
|
US20220009986A1
(en)
|
2018-10-19 |
2022-01-13 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
CA3124682A1
(en)
|
2019-01-28 |
2020-08-06 |
Toray Industries, Inc. |
Polyethylene glycol-modified form of hepatocyte growth factor or active fragment thereof
|
CN113382775A
(zh)
|
2019-01-28 |
2021-09-10 |
东丽株式会社 |
肝细胞生长因子或其活性片段的聚乙二醇修饰物
|
CA3128081A1
(en)
|
2019-02-12 |
2020-08-20 |
Ambrx, Inc. |
Compositions containing, methods and uses of antibody-tlr agonist conjugates
|
WO2021001289A1
(en)
|
2019-07-02 |
2021-01-07 |
F. Hoffmann-La Roche Ag |
Immunoconjugates comprising a mutant interleukin-2 and an anti-cd8 antibody
|
AU2021233909A1
(en)
|
2020-03-11 |
2022-09-29 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
AU2021256936A1
(en)
|
2020-04-15 |
2022-07-21 |
F. Hoffmann-La Roche Ag |
Immunoconjugates
|
WO2021231278A1
(en)
|
2020-05-11 |
2021-11-18 |
F. Hoffmann-La Roche Ag |
Combination therapy with modified pbmcs and an immunoconjugate
|
US20230302150A1
(en)
|
2020-08-20 |
2023-09-28 |
Ambrx, Inc. |
Antibody-tlr agonist conjugates, methods and uses thereof
|
PE20232045A1
(es)
|
2020-12-04 |
2023-12-27 |
Hoffmann La Roche |
Polipeptidos de interleucina-2 mutante dependientes del ph
|
WO2022148853A1
(en)
|
2021-01-11 |
2022-07-14 |
F. Hoffmann-La Roche Ag |
Immunoconjugates
|
WO2022212899A1
(en)
|
2021-04-03 |
2022-10-06 |
Ambrx, Inc. |
Anti-her2 antibody-drug conjugates and uses thereof
|
WO2023052541A1
(en)
|
2021-09-30 |
2023-04-06 |
Imcheck Therapeutics |
Combination of an anti-btn3a activating antibody and an il-2 agonist for use in therapy
|
IL312005A
(en)
|
2021-10-14 |
2024-06-01 |
Hoffmann La Roche |
NEW INTERLEUKIN-7 IMMUNOCONJUGATES
|
CN118139648A
(zh)
|
2021-10-14 |
2024-06-04 |
豪夫迈·罗氏有限公司 |
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|
WO2024153725A1
(en)
|
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2024-07-25 |
F. Hoffmann-La Roche Ag |
Recombinant fc domain - il2 variant polypeptides and combination therapy with membrane-anchored antigen binding polypeptides
|