PH24814A - Method of increasing tear production by topical administration of cyclosporin - Google Patents

Method of increasing tear production by topical administration of cyclosporin

Info

Publication number
PH24814A
PH24814A PH37495A PH37495A PH24814A PH 24814 A PH24814 A PH 24814A PH 37495 A PH37495 A PH 37495A PH 37495 A PH37495 A PH 37495A PH 24814 A PH24814 A PH 24814A
Authority
PH
Philippines
Prior art keywords
cyclosporine
tear production
cyclosporin
topical administration
enhance
Prior art date
Application number
PH37495A
Other languages
English (en)
Inventor
Renee Kaswan
Original Assignee
Univ Georgia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/092,466 external-priority patent/US4839342A/en
Application filed by Univ Georgia filed Critical Univ Georgia
Publication of PH24814A publication Critical patent/PH24814A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
PH37495A 1987-09-03 1988-09-02 Method of increasing tear production by topical administration of cyclosporin PH24814A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/092,466 US4839342A (en) 1987-09-03 1987-09-03 Method of increasing tear production by topical administration of cyclosporin
US11721887A 1987-11-04 1987-11-04
US18782388A 1988-04-29 1988-04-29

Publications (1)

Publication Number Publication Date
PH24814A true PH24814A (en) 1990-10-30

Family

ID=27377210

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37495A PH24814A (en) 1987-09-03 1988-09-02 Method of increasing tear production by topical administration of cyclosporin

Country Status (12)

Country Link
US (1) US5411952A (de)
EP (1) EP0391909B1 (de)
JP (1) JPH0667850B2 (de)
KR (1) KR920003601B1 (de)
AT (1) ATE109970T1 (de)
DE (1) DE3851152T2 (de)
DK (1) DK54390A (de)
ES (1) ES2012116A6 (de)
GR (1) GR1000558B (de)
IE (1) IE65582B1 (de)
PH (1) PH24814A (de)
WO (1) WO1989001772A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
ZA927277B (en) * 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
DE69307505T2 (de) 1992-05-13 1997-07-24 Sandoz-Patent-Gmbh, 79539 Loerrach Opthalmische zusammensetzungen enthaltend ein cyclosporin
US5366739A (en) * 1992-08-06 1994-11-22 Deo Corporation Method of ophthalmic drug delivery
US5830508A (en) 1992-08-06 1998-11-03 Deo Corporation Composition for treating dry eye
US5686436A (en) 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5474979A (en) * 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
IE75744B1 (en) * 1995-04-03 1997-09-24 Elan Corp Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
DE69715382T2 (de) 1996-02-13 2003-04-30 G.D. Searle & Co., Chicago Arzneimittelkombinationen mit immunosuppressiven wirkungen welche cyclooxygenase-2 inhibitoren und leukotrien lta4 hydrase-inhibitoren enthalten
JP2000504723A (ja) 1996-02-13 2000-04-18 ジー．ディー．サール アンド カンパニー シクロオキシゲナーゼ―２阻害剤および５―リポキシゲナーゼ阻害剤投与の免疫抑制効果
JP2000506170A (ja) * 1996-03-05 2000-05-23 メデイノックス，インコーポレイテッド 酸化窒素スキャベンジャーを用いる複合治療方法とそのために有用な組成物
BR9811716A (pt) 1997-10-08 2000-07-18 Isotechnika Inc Análogos de ciclosporina deuterados e o seu emprego como agentes de modulação imunológica
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
US5981607A (en) * 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
GB9818278D0 (en) * 1998-08-22 1998-10-14 Smith & Nephew Compositions
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6255280B1 (en) 1999-04-08 2001-07-03 University Of Kentucky Research Foundation Protection against traumatic brain injury
US6254860B1 (en) 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
DK1220849T3 (da) 1999-10-15 2004-09-27 Sucampo Ag Sammensætninger med bicykliske forbindelser og fremgangsmåde til stabilisering heraf
ES2206363T3 (es) 2000-04-07 2004-05-16 Laboratoire Medidom S.A. Formulaciones oftalmicas a base de ciclosporina, de acido hialuronico y de polisorbato.
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20030021816A1 (en) * 2001-06-06 2003-01-30 Sewon Kang Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes
KR101006206B1 (ko) * 2001-10-19 2011-01-07 이소테크니카 인코포레이티드 시클로스포린 ａ 알데히드의 제조 방법
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US8871241B2 (en) * 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US6930127B2 (en) * 2002-08-15 2005-08-16 Eaton Veterinary Laboratories, Inc. Veterinary treatment of ophthalmic disease in animals using topical tacrolimus
US7354574B2 (en) 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
CA2518265A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
ES2665464T3 (es) * 2003-03-28 2018-04-25 Sigmoid Pharma Limited Forma de dosificación oral sólida que contiene microcápsulas sin costuras
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7087237B2 (en) 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US7923471B2 (en) * 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
US20050277584A1 (en) * 2004-06-09 2005-12-15 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
US20080020018A1 (en) * 2004-09-27 2008-01-24 Joey Moodley Combination Products
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7378391B2 (en) * 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
US7361636B2 (en) * 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US7151085B2 (en) * 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US20060148686A1 (en) * 2004-12-30 2006-07-06 Bausch & Lomb Incorporated Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy
JP4974903B2 (ja) 2005-02-09 2012-07-11 参天製薬株式会社 疾患または状態を処置するための液体処方物
WO2007011880A2 (en) 2005-07-18 2007-01-25 Minu, L.L.C. Enhanced ocular neuroprotection/neurostimulation
US20070014760A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
AU2006304143A1 (en) * 2005-10-14 2007-04-26 Allergan, Inc. Prevention and treatment of drug-associated ocular side effects with a cyclosporin
KR20080065704A (ko) * 2005-11-09 2008-07-14 콤비네이토릭스, 인코포레이티드 의학적 이상의 치료 방법들, 조성물들, 및 키트들
KR20140093764A (ko) 2006-02-09 2014-07-28 산텐 세이야꾸 가부시키가이샤 안정한 제제와 그 제조 및 사용 방법
WO2007095486A1 (en) * 2006-02-13 2007-08-23 Allergan, Inc. Methods of treating blepharospasm using cyclosporine components
US7557082B2 (en) 2006-03-03 2009-07-07 Allergan, Inc. Treatment with cyclosporin A
US20070219127A1 (en) * 2006-03-20 2007-09-20 Walt John G Cyclosporin a compositions
CA2645488C (en) 2006-03-23 2014-09-02 Macusight, Inc. Formulations comprising rapamycin and methods using same for vascular permeability-related diseases or conditions
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US20080146497A1 (en) * 2006-07-25 2008-06-19 Graham Richard S Cyclosporin Compositions
CA2683409A1 (en) * 2007-04-04 2008-10-16 Sigmoid Pharma Limited A pharmaceutical composition of tacrolimus
RU2009144186A (ru) * 2007-05-04 2011-06-10 Аллерган, Инк. (Us) Применение циклоспоринов при лечении пациентов с интраокулярными линзами
US20090081277A1 (en) * 2007-09-21 2009-03-26 Allergan, Inc. Pharmaceutical formulations and methods for treating ocular conditions
CN101918019B (zh) * 2007-10-08 2014-11-26 奥里尼亚制药有限公司 包含钙调神经磷酸酶抑制剂或mTOR抑制剂的眼科组合物
ITMI20080003A1 (it) * 2008-01-02 2009-07-03 Alfredo Pulpito Composizioni per uso oftalmico
US20100010082A1 (en) * 2008-07-09 2010-01-14 Aspreva International Ltd. Formulations for treating eye disorders
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
JP2012514644A (ja) 2009-01-08 2012-06-28 アラーガン インコーポレイテッド 爪成長の増進用シクロスポリン組成物
US20110009339A1 (en) * 2009-04-14 2011-01-13 Allergan, Inc Method of treating blurred vision and other conditions of the eye with cyclosporin compositions
SG176145A1 (en) 2009-05-18 2011-12-29 Sigmoid Pharma Ltd Composition comprising oil drops
PT2437762T (pt) 2009-06-05 2017-11-14 Allergan Inc Lágrimas artificiais e usos terapêuticos
WO2010144194A1 (en) * 2009-06-09 2010-12-16 Lux Biosciences, Inc. Topical drug delivery systems for ophthalmic use
US9878036B2 (en) 2009-08-12 2018-01-30 Sigmoid Pharma Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
EP2335735A1 (de) 2009-12-14 2011-06-22 Novaliq GmbH Pharmazeutische Zusammensetzung zur Behandlung von trockenem Auge
EP2515864A4 (de) * 2009-12-23 2013-09-11 Psivida Inc Vorrichtung mit verzögerter freisetzung
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
RU2641963C2 (ru) * 2011-11-15 2018-01-23 Аллерган, Инк. Взвеси циклоспорина а формы 2
ES2578154T3 (es) 2011-11-15 2016-07-21 Allergan, Inc. Forma 2 de ciclosporina y método para prepararla
KR102029513B1 (ko) 2011-11-15 2019-10-07 알러간, 인코포레이티드 사이클로스포린 제2형의 지속 작용 제형
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US20130266615A1 (en) * 2012-04-10 2013-10-10 Bin Wu Non-immunogenic delivery vehicle for beta-, gamma-, and delta-tocopherols and methods of using and making same
EP2844268A4 (de) * 2012-04-20 2015-11-25 Univ Howard Verfahren zur behandlung einer augenkrankheit und zusammensetzungen zur behandlung einer augenkrankheit
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
EP3881829A1 (de) 2014-11-07 2021-09-22 Sublimity Therapeutics Limited Cyclosporin enthaltende zusammensetzungen
US10279005B2 (en) 2014-11-25 2019-05-07 Allergan, Inc. Stabilized omega-3 ophthalmic compositions
US9820954B2 (en) 2015-08-19 2017-11-21 Jenivision Inc. Quantitative peri-orbital application of ophthalmology drugs
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608073A (en) * 1968-07-16 1971-09-21 Barnes Hind Pharm Inc Emulsion of pilocarpine for ophthalmic use
CH614931A5 (de) * 1975-11-04 1979-12-28 Sandoz Ag
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4115544A (en) * 1976-08-18 1978-09-19 Alza Corporation Ocular system made of bioerodible esters having linear ether
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
DE2907460A1 (de) * 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0098457B1 (de) * 1980-02-14 1987-08-05 Sandoz Ag (1S,2R,3R)- und (1R,2S,3S)-Nitrilo-1-carbonyl-3-methyl-2-oxy-heptane und -hept-5-enen verwendbar für Totalsynthese von Cyclosporinen und Verfahren zu ihrer Herstellung
EP0056782B1 (de) * 1981-01-09 1984-08-01 Sandoz Ag Cyclosporine
WO1983001252A1 (en) * 1981-10-09 1983-04-14 Hakanson, Rolf A drug based on a substance p antagonist
EP0145714A1 (de) * 1983-05-25 1985-06-26 Alcon Laboratories, Inc. Ophthalmisches gel
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
EP0365044A3 (de) * 1984-08-02 1990-08-22 Sandoz Ag Pharmazeutische Verwendung von (NVA)2-Cyclosporin
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
JPS61249918A (ja) * 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
US4745100A (en) * 1985-05-14 1988-05-17 Eye Research Institute Of Retina Foundation Stimulation of tear secretion
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
GB8528032D0 (en) * 1985-11-13 1985-12-18 Ici Plc Ocular treatment
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension

Also Published As

Publication number Publication date
DK54390A (da) 1990-05-03
DE3851152D1 (de) 1994-09-22
ATE109970T1 (de) 1994-09-15
JPH0667850B2 (ja) 1994-08-31
KR890701084A (ko) 1989-12-19
KR920003601B1 (ko) 1992-05-04
EP0391909A1 (de) 1990-10-17
GR880100578A (en) 1989-06-22
WO1989001772A1 (en) 1989-03-09
DK54390D0 (da) 1990-03-01
DE3851152T2 (de) 1995-01-26
IE882663L (en) 1989-03-03
IE65582B1 (en) 1995-11-01
ES2012116A6 (es) 1990-03-01
GR1000558B (el) 1992-08-26
JPH03503159A (ja) 1991-07-18
EP0391909B1 (de) 1994-08-17
US5411952A (en) 1995-05-02

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