KR890701084A - 점안 싸이클로스포린(cyclspoorin)의 조성 및 투여방법 - Google Patents

점안 싸이클로스포린(cyclspoorin)의 조성 및 투여방법

Info

Publication number
KR890701084A
KR890701084A KR1019890700680A KR890700680A KR890701084A KR 890701084 A KR890701084 A KR 890701084A KR 1019890700680 A KR1019890700680 A KR 1019890700680A KR 890700680 A KR890700680 A KR 890700680A KR 890701084 A KR890701084 A KR 890701084A
Authority
KR
South Korea
Prior art keywords
composition
cyclosporine
cyclospoorin
enhance
eye drops
Prior art date
Application number
KR1019890700680A
Other languages
English (en)
Other versions
KR920003601B1 (ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/092,466 external-priority patent/US4839342A/en
Application filed filed Critical
Publication of KR890701084A publication Critical patent/KR890701084A/ko
Application granted granted Critical
Publication of KR920003601B1 publication Critical patent/KR920003601B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
KR1019890700680A 1987-09-03 1988-08-31 점안 싸이클로스포린(cyclosporin)의 조성물 KR920003601B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US07/092,466 US4839342A (en) 1987-09-03 1987-09-03 Method of increasing tear production by topical administration of cyclosporin
US092,466 1987-09-03
US11721887A 1987-11-04 1987-11-04
US117,218 1987-11-04
US18782388A 1988-04-29 1988-04-29
US187,823 1988-04-29
PCT/US1988/003039 WO1989001772A1 (en) 1987-09-03 1988-08-31 Ocular cyclosporin composition

Publications (2)

Publication Number Publication Date
KR890701084A true KR890701084A (ko) 1989-12-19
KR920003601B1 KR920003601B1 (ko) 1992-05-04

Family

ID=27377210

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890700680A KR920003601B1 (ko) 1987-09-03 1988-08-31 점안 싸이클로스포린(cyclosporin)의 조성물

Country Status (12)

Country Link
US (1) US5411952A (ko)
EP (1) EP0391909B1 (ko)
JP (1) JPH0667850B2 (ko)
KR (1) KR920003601B1 (ko)
AT (1) ATE109970T1 (ko)
DE (1) DE3851152T2 (ko)
DK (1) DK54390A (ko)
ES (1) ES2012116A6 (ko)
GR (1) GR1000558B (ko)
IE (1) IE65582B1 (ko)
PH (1) PH24814A (ko)
WO (1) WO1989001772A1 (ko)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
ZA927277B (en) * 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
ATE147619T1 (de) 1992-05-13 1997-02-15 Sandoz Ag Opthalmische zusammensetzungen enthaltend ein cyclosporin
US5366739A (en) * 1992-08-06 1994-11-22 Deo Corporation Method of ophthalmic drug delivery
US5830508A (en) 1992-08-06 1998-11-03 Deo Corporation Composition for treating dry eye
US5686436A (en) 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5474979A (en) * 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
IE75744B1 (en) * 1995-04-03 1997-09-24 Elan Corp Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
CA2246336A1 (en) * 1996-02-13 1997-08-21 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing a cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
ES2169351T3 (es) 1996-02-13 2002-07-01 Searle & Co Combinaciones que tienen efectos inmunosupresores, que contienen inhibidores de ciclooxigenasa-2 y 5-lipoxigenasa.
WO1997032585A1 (en) * 1996-03-05 1997-09-12 Medinox, Inc. Combinational therapeutic methods employing nitric oxide scavengers and compositions useful therefor
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
KR100585348B1 (ko) 1997-10-08 2006-06-01 이소테크니카 인코포레이티드 중수소화된 시클로스포린 유사체 및 면역조절제로서 그의용도
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
US5981607A (en) * 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
GB9818278D0 (en) * 1998-08-22 1998-10-14 Smith & Nephew Compositions
US6217895B1 (en) * 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US6255280B1 (en) 1999-04-08 2001-07-03 University Of Kentucky Research Foundation Protection against traumatic brain injury
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
DK1220849T3 (da) * 1999-10-15 2004-09-27 Sucampo Ag Sammensætninger med bicykliske forbindelser og fremgangsmåde til stabilisering heraf
TR200302105T4 (tr) * 2000-04-07 2004-02-23 Laboratoire Medidom S. A. Siklosporin, hiyalüronik asit ve polisorbat içeren göz formülasyonları.
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20030021816A1 (en) * 2001-06-06 2003-01-30 Sewon Kang Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes
ATE332917T1 (de) 2001-10-19 2006-08-15 Isotechnika Inc Synthese von cyclosporin-analogen
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US6930127B2 (en) * 2002-08-15 2005-08-16 Eaton Veterinary Laboratories, Inc. Veterinary treatment of ophthalmic disease in animals using topical tacrolimus
US7354574B2 (en) 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
AU2004222306A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
ES2496102T3 (es) * 2003-03-28 2014-09-18 Sigmoid Pharma Limited Forma de dosificación oral sólida que contiene microcápsulas sin fisuras
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US7087237B2 (en) 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
BRPI0506983A (pt) 2004-01-20 2007-07-03 Allergan Inc composições para terapia localizada dos olhos, compreendendo preferencialmente acetonida de triancinolona e ácido hialurÈnico
US7923471B2 (en) * 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
US20050277584A1 (en) * 2004-06-09 2005-12-15 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
ATE413165T1 (de) * 2004-09-27 2008-11-15 Sigmoid Pharma Ltd Mikrokapseln mit einem methylxanthin und einem kortikosteroid
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7378391B2 (en) * 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
US7361636B2 (en) * 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US7151085B2 (en) * 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
WO2006073786A2 (en) * 2004-12-30 2006-07-13 Bausch & Lomb Incorporated Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy
CA2597590A1 (en) 2005-02-09 2006-08-17 Macusight, Inc. Formulations for ocular treatment
WO2007011880A2 (en) 2005-07-18 2007-01-25 Minu, L.L.C. Enhanced ocular neuroprotection/neurostimulation
US20070014760A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
AU2006304143A1 (en) * 2005-10-14 2007-04-26 Allergan, Inc. Prevention and treatment of drug-associated ocular side effects with a cyclosporin
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
BRPI0707612B8 (pt) 2006-02-09 2021-05-25 Macusight Inc vaso lacrado e formulações líquidas contidas no mesmo
US7655625B2 (en) * 2006-02-13 2010-02-02 Allergan, Inc. Methods of treating blepharospasm using cyclosporine components
US7557082B2 (en) 2006-03-03 2009-07-07 Allergan, Inc. Treatment with cyclosporin A
US20070219127A1 (en) * 2006-03-20 2007-09-20 Walt John G Cyclosporin a compositions
BRPI0709016A2 (pt) 2006-03-23 2011-06-21 Macusight Inc formulações e métodos para doenças ou condições relacionadas com a permeabilidade vascular
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US20080146497A1 (en) * 2006-07-25 2008-06-19 Graham Richard S Cyclosporin Compositions
US8911777B2 (en) * 2007-04-04 2014-12-16 Sigmoid Pharma Limited Pharmaceutical composition of tacrolimus
JP2010525929A (ja) * 2007-05-04 2010-07-29 アラーガン、インコーポレイテッド 眼内レンズを用いる患者の処置におけるシクロスポリンの使用
US20090081277A1 (en) * 2007-09-21 2009-03-26 Allergan, Inc. Pharmaceutical formulations and methods for treating ocular conditions
CA2701482C (en) 2007-10-08 2018-10-23 Lux Biosciences, Inc. Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors
ITMI20080003A1 (it) * 2008-01-02 2009-07-03 Alfredo Pulpito Composizioni per uso oftalmico
US20100010082A1 (en) * 2008-07-09 2010-01-14 Aspreva International Ltd. Formulations for treating eye disorders
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
MX2011007088A (es) 2009-01-08 2011-07-28 Allergan Inc Composiciones de ciclosporina para mejorar el crecimiento de uñas.
US20110009339A1 (en) * 2009-04-14 2011-01-13 Allergan, Inc Method of treating blurred vision and other conditions of the eye with cyclosporin compositions
US9278070B2 (en) 2009-05-18 2016-03-08 Sigmoid Pharma Limited Composition comprising oil drops
PL2437762T3 (pl) 2009-06-05 2018-01-31 Allergan Inc Sztuczne łzy i ich zastosowania terapeutyczne
ES2537385T3 (es) * 2009-06-09 2015-06-08 Aurinia Pharmaceuticals Inc. Sistemas de suministro tópico para uso oftálmico
EP2464341B1 (en) 2009-08-12 2022-07-06 Sublimity Therapeutics Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
EP2335735A1 (en) 2009-12-14 2011-06-22 Novaliq GmbH Pharmaceutical composition for treatment of dry eye syndrome
WO2011079232A1 (en) * 2009-12-23 2011-06-30 Psivida Us, Inc. Sustained release delivery devices
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
AU2012339632A1 (en) * 2011-11-15 2014-06-05 Allergan, Inc. Suspensions of cyclosporin A Form 2
AU2012339695B2 (en) 2011-11-15 2017-10-05 Allergan, Inc. Sustained action formulation of cyclosporin Form 2
EP3067363B1 (en) 2011-11-15 2018-01-17 Allergan, Inc. A process for crystallization of cyclosporin a form 2
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US20130266615A1 (en) * 2012-04-10 2013-10-10 Bin Wu Non-immunogenic delivery vehicle for beta-, gamma-, and delta-tocopherols and methods of using and making same
CA2871070C (en) * 2012-04-20 2024-01-02 Howard University Method of treating an ocular disease and compositions effective for treating an ocular disease
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
KR20170102223A (ko) 2014-11-07 2017-09-08 시그모이드 파마 리미티드 사이클로스포린을 포함하는 조성물
WO2016085885A1 (en) 2014-11-25 2016-06-02 Allergan, Inc. Stabilized omega-3 ophthalmic compositions
US9820954B2 (en) 2015-08-19 2017-11-21 Jenivision Inc. Quantitative peri-orbital application of ophthalmology drugs
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608073A (en) * 1968-07-16 1971-09-21 Barnes Hind Pharm Inc Emulsion of pilocarpine for ophthalmic use
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
CH614931A5 (ko) * 1975-11-04 1979-12-28 Sandoz Ag
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4115544A (en) * 1976-08-18 1978-09-19 Alza Corporation Ocular system made of bioerodible esters having linear ether
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
IE54936B1 (en) * 1980-02-14 1990-03-28 Sandoz Ltd A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
US4384996A (en) * 1981-01-09 1983-05-24 Sandoz Ltd. Novel cyclosporins
JPS58501675A (ja) * 1981-10-09 1983-10-06 フエ−リング・ア−ベ− 物質ｐ「きつ」抗質からなる薬材
WO1984004680A1 (en) * 1983-05-25 1984-12-06 Alcon Lab Inc Ophthalmic gel
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
EP0365044A3 (en) * 1984-08-02 1990-08-22 Sandoz Ag Novel pharmaceutical use of (nva)2-cyclosporine
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
JPS61249918A (ja) * 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
US4745100A (en) * 1985-05-14 1988-05-17 Eye Research Institute Of Retina Foundation Stimulation of tear secretion
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
GB8528032D0 (en) * 1985-11-13 1985-12-18 Ici Plc Ocular treatment
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension

Also Published As

Publication number Publication date
KR920003601B1 (ko) 1992-05-04
WO1989001772A1 (en) 1989-03-09
DE3851152T2 (de) 1995-01-26
JPH0667850B2 (ja) 1994-08-31
IE65582B1 (en) 1995-11-01
IE882663L (en) 1989-03-03
ES2012116A6 (es) 1990-03-01
DK54390A (da) 1990-05-03
EP0391909B1 (en) 1994-08-17
GR880100578A (en) 1989-06-22
PH24814A (en) 1990-10-30
ATE109970T1 (de) 1994-09-15
DE3851152D1 (de) 1994-09-22
US5411952A (en) 1995-05-02
DK54390D0 (da) 1990-03-01
EP0391909A1 (en) 1990-10-17
JPH03503159A (ja) 1991-07-18
GR1000558B (el) 1992-08-26

Similar Documents

Publication Publication Date Title
KR890701084A (ko) 점안 싸이클로스포린(cyclspoorin)의 조성 및 투여방법
US4976969A (en) Ophthalmic solution comprising iodine-polyvinylpyrrolidone complex
ES8500738A1 (es) Un procedimiento para la preparacion de una composicion antiinflamatoria topica como unguento en forma de gel
AU690377B2 (en) Application of superoxide dismutase in liposomes
CA2059403A1 (en) Use of Carrageenans in Topical Ophthalmic Compositions
ATE165237T1 (de) Starkschaumende orale zusammensetzung
ATE153855T1 (de) Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten
IE811654L (en) Ophthalmic composition
GB2075341B (en) Pharmaceutical compositions
IT1177863B (it) Una miscela gangliosidica come agente terapeutico capare di eliminare il dolore nele neuropatie periferiche
US4269835A (en) Nasal composition for relieving nasal distress
DE69928806D1 (de) (-)-pseudoephedrin als sympathomimetisches arzneimittel
DE3167210D1 (en) Pharmaceutical composition
KR880007068A (ko) 13-시스 레티노산의 용도
KR950000138A (ko) 안(眼)국소용 조성물
KR880001290A (ko) β-차단제 및 필로카르핀-함유 제제
KR880009656A (ko) 국소 치근막 질환의 치료 또는 예방법
MY100229A (en) Topical anti-inflammatory compositions.
BE904737A (fr) Derives de l'acide octenoique.
IT1257884B (it) Formulazioni farmaceutiche per il trattamento di malattie periferiche vascolari a base di vincamina o di un suo sale farmaceuticamente accettabile.
IT1241928B (it) Composizione oftalmica per l'uso nel mantenimento della midriasi oculare
IT1273628B (it) Composizioni farmaceutiche per la cura della talassemia contenenti derivati dell'acido butirrico e in particolare isobutirramide

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20080425

Year of fee payment: 17

EXPY Expiration of term