DE3851152D1 - Cyclosporin-augenmittel. - Google Patents

Cyclosporin-augenmittel.

Info

Publication number
DE3851152D1
DE3851152D1 DE3851152T DE3851152T DE3851152D1 DE 3851152 D1 DE3851152 D1 DE 3851152D1 DE 3851152 T DE3851152 T DE 3851152T DE 3851152 T DE3851152 T DE 3851152T DE 3851152 D1 DE3851152 D1 DE 3851152D1
Authority
DE
Germany
Prior art keywords
cyclosporine
enhance
corn oil
agents
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3851152T
Other languages
English (en)
Other versions
DE3851152T2 (de
Inventor
Renee Kaswan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Georgia Research Foundation Inc UGARF
Original Assignee
University of Georgia Research Foundation Inc UGARF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/092,466 external-priority patent/US4839342A/en
Application filed by University of Georgia Research Foundation Inc UGARF filed Critical University of Georgia Research Foundation Inc UGARF
Publication of DE3851152D1 publication Critical patent/DE3851152D1/de
Application granted granted Critical
Publication of DE3851152T2 publication Critical patent/DE3851152T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE3851152T 1987-09-03 1988-08-31 Cyclosporin-augenmittel. Expired - Lifetime DE3851152T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/092,466 US4839342A (en) 1987-09-03 1987-09-03 Method of increasing tear production by topical administration of cyclosporin
US11721887A 1987-11-04 1987-11-04
US18782388A 1988-04-29 1988-04-29
PCT/US1988/003039 WO1989001772A1 (en) 1987-09-03 1988-08-31 Ocular cyclosporin composition

Publications (2)

Publication Number Publication Date
DE3851152D1 true DE3851152D1 (de) 1994-09-22
DE3851152T2 DE3851152T2 (de) 1995-01-26

Family

ID=27377210

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3851152T Expired - Lifetime DE3851152T2 (de) 1987-09-03 1988-08-31 Cyclosporin-augenmittel.

Country Status (12)

Country Link
US (1) US5411952A (de)
EP (1) EP0391909B1 (de)
JP (1) JPH0667850B2 (de)
KR (1) KR920003601B1 (de)
AT (1) ATE109970T1 (de)
DE (1) DE3851152T2 (de)
DK (1) DK54390A (de)
ES (1) ES2012116A6 (de)
GR (1) GR1000558B (de)
IE (1) IE65582B1 (de)
PH (1) PH24814A (de)
WO (1) WO1989001772A1 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
CA1340994C (en) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
ZA927277B (en) * 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
JP3631490B2 (ja) 1992-05-13 2005-03-23 ノバルティス ファーマ株式会社 シクロスポリン含有眼科用組成物
US5366739A (en) * 1992-08-06 1994-11-22 Deo Corporation Method of ophthalmic drug delivery
US5830508A (en) 1992-08-06 1998-11-03 Deo Corporation Composition for treating dry eye
US5686436A (en) 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5474979A (en) * 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
IE75744B1 (en) * 1995-04-03 1997-09-24 Elan Corp Plc Controlled release biodegradable micro- and nanospheres containing cyclosporin
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
AU1952597A (en) 1996-02-13 1997-09-02 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
EP0888127B1 (de) 1996-02-13 2001-12-12 G.D. Searle & Co. Zusammensetzungen mit immunosuppressiven wirkungen, welche 5-lipoxygenase-inhibitoren und cyclooxygenase-2-inhibitoren enthalten
AU2213197A (en) * 1996-03-05 1997-09-22 Medinox, Inc. Combinational therapeutic methods employing nitric oxide scavengers and compositions useful therefor
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
DK0991660T3 (da) 1997-10-08 2006-02-13 Isotechnika Inc Deuterede og udeuterede cyclosporinanaloger og deres anvendelse som immunmodulerende midler
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
US5981607A (en) * 1998-01-20 1999-11-09 Allergan Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
GB9818278D0 (en) * 1998-08-22 1998-10-14 Smith & Nephew Compositions
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6255280B1 (en) 1999-04-08 2001-07-03 University Of Kentucky Research Foundation Protection against traumatic brain injury
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
CZ303625B6 (cs) * 1999-10-15 2013-01-16 Sucampo Ag Stabilní farmaceutický prostredek obsahující bicyklickou slouceninu a acyglycerol, bicyklická sloucenina, zpusob stabilizace bicyklické slouceniny, farmaceutický prostredek obsahující bicyklickou slouceninu
DE60100866T2 (de) 2000-04-07 2004-07-29 Laboratoire Medidom S.A. Cyklosporin, Hyaluronsäure und Polysorbate enthaltenes Augenarzneimittel
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
CA2449671A1 (en) * 2001-06-06 2002-12-12 The Regents Of The University Of Michigan Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enyzmes
PL210841B1 (pl) 2001-10-19 2012-03-30 Isotechnika Inc Sposób wytwarzania mieszaniny izomerów (E) i (Z) ISATX247
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US8871241B2 (en) 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US6930127B2 (en) * 2002-08-15 2005-08-16 Eaton Veterinary Laboratories, Inc. Veterinary treatment of ophthalmic disease in animals using topical tacrolimus
US7354574B2 (en) 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
JP2006524232A (ja) * 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
WO2004084870A1 (en) * 2003-03-28 2004-10-07 Sigmoid Biotechnologies Limited Solid oral dosage form containing seamless microcapsules
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
WO2005072701A1 (en) 2004-01-20 2005-08-11 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US7923471B2 (en) * 2004-05-14 2011-04-12 Alcon, Inc. Method of treating dry eye disorders and uveitis
US20050277584A1 (en) * 2004-06-09 2005-12-15 Allergan, Inc. Pharmaceutical compositions comprising cyclosporins
WO2006035417A2 (en) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Dihydropyrimidine microcapsule - formulations
EP1809656A4 (de) * 2004-09-29 2009-03-25 Amr Technology Inc Cyclosporinalkinanaloga und deren pharmazeutische anwendungen
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
EP1812037A4 (de) * 2004-10-06 2009-11-11 Amr Technology Inc Neue cyclosporin-alkyne und ihre nutzung als pharmazeutishe mittel
US7151085B2 (en) * 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
US20060148686A1 (en) * 2004-12-30 2006-07-06 Bausch & Lomb Incorporated Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy
ES2564194T3 (es) 2005-02-09 2016-03-18 Santen Pharmaceutical Co., Ltd. Formulaciones líquidas para el tratamiento de enfermedades o dolencias
US20070014760A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
PL1904056T3 (pl) 2005-07-18 2009-09-30 Minu Llc Zastosowanie makrolidu do przywracania czucia rogówkowego
EP2153842B1 (de) * 2005-10-14 2016-04-13 Allergan, Inc. Prävention von mit arzneimitteln in zusammenhang stehenden keratokonjunctivitis mit cyclosporin
US7745400B2 (en) * 2005-10-14 2010-06-29 Gregg Feinerman Prevention and treatment of ocular side effects with a cyclosporin
US9839667B2 (en) 2005-10-14 2017-12-12 Allergan, Inc. Prevention and treatment of ocular side effects with a cyclosporin
RU2008122978A (ru) * 2005-11-09 2009-12-20 Комбинаторкс, Инкорпорейтед (Us) Способы, композиции и наборы для лечения медицинских состояний
BRPI0707612B8 (pt) 2006-02-09 2021-05-25 Macusight Inc vaso lacrado e formulações líquidas contidas no mesmo
WO2007095486A1 (en) * 2006-02-13 2007-08-23 Allergan, Inc. Methods of treating blepharospasm using cyclosporine components
US7557082B2 (en) 2006-03-03 2009-07-07 Allergan, Inc. Treatment with cyclosporin A
US20070219127A1 (en) * 2006-03-20 2007-09-20 Walt John G Cyclosporin a compositions
US8222271B2 (en) 2006-03-23 2012-07-17 Santen Pharmaceutical Co., Ltd. Formulations and methods for vascular permeability-related diseases or conditions
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US20080146497A1 (en) * 2006-07-25 2008-06-19 Graham Richard S Cyclosporin Compositions
ES2400964T3 (es) 2007-04-04 2013-04-15 Sigmoid Pharma Limited Composiciones famacéuticas de ciclosporina
WO2008137617A1 (en) * 2007-05-04 2008-11-13 Allergan, Inc. Use of cyclosporines in the treatment of patients with intraocular lenses
US20090081277A1 (en) * 2007-09-21 2009-03-26 Allergan, Inc. Pharmaceutical formulations and methods for treating ocular conditions
JP5668476B2 (ja) * 2007-10-08 2015-02-12 オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物
ITMI20080003A1 (it) * 2008-01-02 2009-07-03 Alfredo Pulpito Composizioni per uso oftalmico
JP2011527339A (ja) * 2008-07-09 2011-10-27 アスプレバ インターナショナル リミテッド 眼障害を処置するためのミコフェノール酸ナトリウムのｐＨ特異的な溶液
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
CN102271700A (zh) 2009-01-08 2011-12-07 阿勒根公司 用于促进甲生长的环孢菌素组合物
US20110009339A1 (en) * 2009-04-14 2011-01-13 Allergan, Inc Method of treating blurred vision and other conditions of the eye with cyclosporin compositions
CN102470106B (zh) 2009-05-18 2015-09-23 希格默伊德药业有限公司 包含油滴的组合物
BRPI1011710B8 (pt) 2009-06-05 2021-05-25 Allergan Inc composição para ser usada como uma lágrima artificial
WO2010144194A1 (en) * 2009-06-09 2010-12-16 Lux Biosciences, Inc. Topical drug delivery systems for ophthalmic use
IN2012DN00781A (de) 2009-08-12 2015-06-26 Sigmoid Pharma Ltd
EP2335735A1 (de) 2009-12-14 2011-06-22 Novaliq GmbH Pharmazeutische Zusammensetzung zur Behandlung von trockenem Auge
JP2013515741A (ja) * 2009-12-23 2013-05-09 サイヴィーダ ユーエス，インコーポレイテッド 持続放出性送達デバイス
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US8957048B2 (en) 2011-10-06 2015-02-17 Allergan, Inc. Compositions for the treatment of dry eye
JP6204921B2 (ja) 2011-11-15 2017-09-27 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａの形態２およびその作製方法
CN104039309B (zh) 2011-11-15 2018-03-06 阿勒根公司 环孢菌素形式2的持续作用型制剂
RU2641963C2 (ru) 2011-11-15 2018-01-23 Аллерган, Инк. Взвеси циклоспорина а формы 2
US9907826B2 (en) 2011-12-07 2018-03-06 Allergan, Inc. Efficient lipid delivery to human tear film using a salt-sensitive emulsion system
US20130266615A1 (en) * 2012-04-10 2013-10-10 Bin Wu Non-immunogenic delivery vehicle for beta-, gamma-, and delta-tocopherols and methods of using and making same
WO2013158296A1 (en) * 2012-04-20 2013-10-24 Howard University Method of treating an ocular disease and compositions effective for treating an ocular disease
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
ES2858517T3 (es) 2014-11-07 2021-09-30 Sublimity Therapeutics Ltd Composiciones que comprenden ciclosporina
CA2967413C (en) 2014-11-25 2023-08-15 Allergan, Inc. Ophthalmic compositions containing omega-3 oils stabilized by antioxidants
US9820954B2 (en) 2015-08-19 2017-11-21 Jenivision Inc. Quantitative peri-orbital application of ophthalmology drugs
US20190224275A1 (en) 2017-05-12 2019-07-25 Aurinia Pharmaceuticals Inc. Protocol for treatment of lupus nephritis

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608073A (en) * 1968-07-16 1971-09-21 Barnes Hind Pharm Inc Emulsion of pilocarpine for ophthalmic use
CH614931A5 (de) * 1975-11-04 1979-12-28 Sandoz Ag
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4115544A (en) * 1976-08-18 1978-09-19 Alza Corporation Ocular system made of bioerodible esters having linear ether
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
SE448386B (sv) * 1978-10-18 1987-02-16 Sandoz Ag Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
US4396542A (en) * 1980-02-14 1983-08-02 Sandoz Ltd. Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
IE54936B1 (en) * 1980-02-14 1990-03-28 Sandoz Ltd A method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
EP0056782B1 (de) * 1981-01-09 1984-08-01 Sandoz Ag Cyclosporine
WO1983001252A1 (en) * 1981-10-09 1983-04-14 Hakanson, Rolf A drug based on a substance p antagonist
EP0145714A1 (de) * 1983-05-25 1985-06-26 Alcon Laboratories, Inc. Ophthalmisches gel
US4708861A (en) * 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
EP0170623B1 (de) * 1984-08-02 1990-11-28 Sandoz Ag Pharmazeutische Anwendung von (NVA)2-Cyclosporine
GB8422253D0 (en) * 1984-09-04 1984-10-10 Sandoz Ltd Organic compounds
EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
JPS61249918A (ja) * 1985-04-26 1986-11-07 Yutaka Mizushima 点眼剤
US4745100A (en) * 1985-05-14 1988-05-17 Eye Research Institute Of Retina Foundation Stimulation of tear secretion
US4861580A (en) * 1985-10-15 1989-08-29 The Liposome Company, Inc. Composition using salt form of organic acid derivative of alpha-tocopheral
GB8528032D0 (en) * 1985-11-13 1985-12-18 Ici Plc Ocular treatment
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension

Also Published As

Publication number Publication date
EP0391909A1 (de) 1990-10-17
JPH03503159A (ja) 1991-07-18
KR920003601B1 (ko) 1992-05-04
GR880100578A (en) 1989-06-22
ES2012116A6 (es) 1990-03-01
EP0391909B1 (de) 1994-08-17
GR1000558B (el) 1992-08-26
WO1989001772A1 (en) 1989-03-09
KR890701084A (ko) 1989-12-19
IE882663L (en) 1989-03-03
ATE109970T1 (de) 1994-09-15
IE65582B1 (en) 1995-11-01
DE3851152T2 (de) 1995-01-26
DK54390A (da) 1990-05-03
DK54390D0 (da) 1990-03-01
JPH0667850B2 (ja) 1994-08-31
PH24814A (en) 1990-10-30
US5411952A (en) 1995-05-02

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