PH18803A - 1-cyclopropyl 6 fluoro 1,4 dihydro 4-oxo piperazino quinoline 3 carboxylic acids and antibacterial agent containing these compounds - Google Patents
1-cyclopropyl 6 fluoro 1,4 dihydro 4-oxo piperazino quinoline 3 carboxylic acids and antibacterial agent containing these compoundsInfo
- Publication number
- PH18803A PH18803A PH28052A PH28052A PH18803A PH 18803 A PH18803 A PH 18803A PH 28052 A PH28052 A PH 28052A PH 28052 A PH28052 A PH 28052A PH 18803 A PH18803 A PH 18803A
- Authority
- PH
- Philippines
- Prior art keywords
- quinoline
- cyclopropyl
- dihydro
- oxo
- fluoro
- Prior art date
Links
- -1 1-cyclopropyl Chemical group 0.000 title abstract 4
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 125000001153 fluoro group Chemical group F* 0.000 title 1
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical class C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- TXJIOKSSHCOKKH-UHFFFAOYSA-N 1-cyclopropyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid Chemical compound C1CN(C)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 TXJIOKSSHCOKKH-UHFFFAOYSA-N 0.000 abstract 1
- NYCAUWIIPPYOAQ-UHFFFAOYSA-N 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxoquinoline-3-carboxylic acid;hydroiodide Chemical compound I.C1CN(CC)CCN1C(C(=C1)F)=CC2=C1C(=O)C(C(O)=O)=CN2C1CC1 NYCAUWIIPPYOAQ-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Fodder In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813142854 DE3142854A1 (de) | 1981-10-29 | 1981-10-29 | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
Publications (1)
Publication Number | Publication Date |
---|---|
PH18803A true PH18803A (en) | 1985-09-27 |
Family
ID=6145081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PH28052A PH18803A (en) | 1981-10-29 | 1982-10-28 | 1-cyclopropyl 6 fluoro 1,4 dihydro 4-oxo piperazino quinoline 3 carboxylic acids and antibacterial agent containing these compounds |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0078362B1 (en, 2012) |
JP (5) | JPS5874667A (en, 2012) |
KR (1) | KR870000895B1 (en, 2012) |
AT (1) | ATE23040T1 (en, 2012) |
AU (3) | AU561103B2 (en, 2012) |
CA (1) | CA1218067A (en, 2012) |
DD (1) | DD202560A5 (en, 2012) |
DE (2) | DE3142854A1 (en, 2012) |
DK (2) | DK160491C (en, 2012) |
ES (1) | ES516921A0 (en, 2012) |
FI (1) | FI78689C (en, 2012) |
GR (1) | GR77707B (en, 2012) |
HU (1) | HU187580B (en, 2012) |
IE (1) | IE53709B1 (en, 2012) |
IL (1) | IL66243A (en, 2012) |
LU (1) | LU88325I2 (en, 2012) |
NO (2) | NO158018C (en, 2012) |
NZ (1) | NZ202278A (en, 2012) |
PH (1) | PH18803A (en, 2012) |
ZA (1) | ZA824829B (en, 2012) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3248506A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3248505A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(4- (oxoalkyl)-1-piperazinyl/-3-chinolincarbonsaeuren und ihre derivate, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3306771A1 (de) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3306772A1 (de) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3318145A1 (de) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US4730000A (en) * | 1984-04-09 | 1988-03-08 | Abbott Laboratories | Quinoline antibacterial compounds |
US4551456A (en) * | 1983-11-14 | 1985-11-05 | Merck & Co., Inc. | Ophthalmic use of norfloxacin and related antibiotics |
DE3574380D1 (en) * | 1984-02-17 | 1989-12-28 | Daiichi Seiyaku Co | 1,8-naphthyridine derivatives |
US4542133A (en) * | 1984-04-26 | 1985-09-17 | Abbott Laboratories | Methylenedioxy quino-benoxazine derivatives and antibacterial use |
US4529725A (en) * | 1984-04-26 | 1985-07-16 | Abbott Laboratories | 1-Pyridine substituted quino-benzothiazine |
US4528285A (en) * | 1984-04-26 | 1985-07-09 | Abbott Laboratories | Methylenedioxy quino-benzothiazine derivatives |
US4607032A (en) * | 1984-04-26 | 1986-08-19 | Abbott Laboratories | Quino-benoxazine antibacterial compounds |
US4540694A (en) * | 1984-04-26 | 1985-09-10 | Abbott Laboratories | 1-Pyridine substituted quino-benoxazines and antibacterial use |
US4533663A (en) * | 1984-04-26 | 1985-08-06 | Abbott Laboratories | Quino-benzothiazine antibacterial compounds |
GB8412094D0 (en) * | 1984-05-11 | 1984-06-20 | Scras | Quinoline derivatives |
DE3420798A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren |
DE3426482A1 (de) * | 1984-07-18 | 1986-01-30 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von halogenierten aroylessigestern |
IE58742B1 (en) * | 1984-07-20 | 1993-11-05 | Warner Lambert Co | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds |
DE3502935A1 (de) * | 1984-09-29 | 1986-04-10 | Bayer Ag, 5090 Leverkusen | 3-amino-2-benzoyl-acrylsaeurederivate und ein verfahren zu ihrer herstellung |
FR2574404B1 (fr) * | 1984-12-12 | 1987-04-24 | Provesan Sa | Derives 1-substitues de l'acide 6-fluoro-7-(pyrrol-1-yl)-1,4-dihydro-4-oxoquinoleine-3-carboxylique, leur preparation et leur application en tant que medicaments |
DE3576335D1 (de) * | 1984-12-14 | 1990-04-12 | Daiichi Seiyaku Co | Chinolincarbonsaeure-derivate. |
JPS61180771A (ja) * | 1985-01-05 | 1986-08-13 | バイエル・アクチエンゲゼルシヤフト | 安定な抗バクテリア剤水溶液 |
DE3517709A1 (de) * | 1985-01-05 | 1986-07-10 | Bayer Ag | Basische zubereitungen von chinoloncarbonsaeuren |
DE3508816A1 (de) * | 1985-01-10 | 1986-07-10 | Bayer Ag, 5090 Leverkusen | 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridin-3-carbonsaeuren |
DE3501247A1 (de) * | 1985-01-16 | 1986-07-17 | Bayer Ag, 5090 Leverkusen | Aminoacrylsaeure-derivate |
US4851535A (en) * | 1985-01-23 | 1989-07-25 | Toyama Chemical Co., Ltd. | Nicotinic acid derivatives |
AT392791B (de) * | 1985-01-23 | 1991-06-10 | Toyama Chemical Co Ltd | Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten |
AT392789B (de) * | 1985-01-23 | 1991-06-10 | Toyama Chemical Co Ltd | Verfahren zur herstellung von 1-substituierten aryl-1,4-dihydro-4-oxonaphthyridinderivaten |
DE3509546A1 (de) * | 1985-03-16 | 1986-09-25 | Bayer Ag, 5090 Leverkusen | 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3608745A1 (de) * | 1985-07-24 | 1987-01-29 | Bayer Ag | Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin |
EP0224121A3 (en) * | 1985-11-19 | 1987-11-11 | ROTTAPHARM S.p.A. | 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them |
DE3542002A1 (de) * | 1985-11-28 | 1987-06-04 | Bayer Ag | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US4668680A (en) * | 1985-12-12 | 1987-05-26 | Warner-Lambert Company | 5-amino-6,8-difluoroquinolones as antibacterial agents |
US4689325A (en) * | 1985-12-23 | 1987-08-25 | Abbott Laboratories | Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives |
US4687770A (en) * | 1985-12-23 | 1987-08-18 | Abbott Laboratories | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives |
US4772706A (en) * | 1986-01-13 | 1988-09-20 | Warner-Lambert Company | Process for quinoline-3-carboxylic acid antibacterial agents |
JPS62246541A (ja) * | 1986-01-20 | 1987-10-27 | Kyorin Pharmaceut Co Ltd | ベンゾイル酢酸エステル誘導体とその製造方法 |
DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
JPS63198664A (ja) * | 1986-03-31 | 1988-08-17 | Sankyo Co Ltd | キノロンカルボン酸誘導体 |
DE3641312A1 (de) * | 1986-12-03 | 1988-06-09 | Bayer Ag | Verfahren zur herstellung von chinolincarbonsaeuren |
HU198709B (en) * | 1987-04-08 | 1989-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing quinoline-carboxylic acid derivatives |
US5563138A (en) * | 1987-04-16 | 1996-10-08 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
DE3713672A1 (de) * | 1987-04-24 | 1988-11-17 | Bayer Ag | Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren |
JP2556330B2 (ja) * | 1987-07-09 | 1996-11-20 | 杏林製薬株式会社 | アニソ−ル誘導体並びにその製造方法 |
DE3724466A1 (de) * | 1987-07-24 | 1989-02-02 | Bayer Ag | Verfahren zur herstellung von chinoloncarbonsaeuren |
US5164392A (en) * | 1987-10-16 | 1992-11-17 | Dainippon Pharmaceutical Co., Ltd. | Quinoline derivatives and antibacterial agent containing them |
IL88003A (en) * | 1987-10-16 | 1992-11-15 | Dainippon Pharmaceutical Co | Quinoline derivatives,their preparation and pharmaceutical compositions containing them |
EP0342849A3 (en) * | 1988-05-19 | 1990-03-14 | Pfizer Inc. | Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters |
KR910003630B1 (ko) * | 1988-06-17 | 1991-06-07 | 한국과학기술원 | 벤조일 아세틱 에스테르 유도체 및 그 제조방법 |
GR1000201B (el) * | 1988-06-23 | 1992-03-20 | Tsetis Kleon | Mέ?οδος για την παρασκευή του 1-κυκλοπροπυλο-6-φ?ορο-1,4-διϋδρο-4-οξο-7κινολίνο-3-καρβοξυλικού οξέος δομικού λί?ου παρασκευής των 1-κυκλοπρόπυλο-6-φ?όρο-1,4-διϋδρο-4οξο-7-πιπεράζινο-κινολινο 3καρβοξυλικών οξέων. |
AU618823B2 (en) * | 1988-07-20 | 1992-01-09 | Sankyo Company Limited | 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use |
US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
US5219781A (en) * | 1988-12-08 | 1993-06-15 | Mitsubishi Denki Kabushiki Kaisha | Method for manufacturing semiconductor memory device having a stacked type capacitor |
FR2655545B1 (fr) * | 1989-12-11 | 1994-06-10 | Rhone Poulenc Sante | Nouvelle application therapeutique des derives des fluoroquinolones. |
EP0449445A3 (en) * | 1990-03-27 | 1993-08-25 | Pfizer Inc. | Preparation of beta-ketoesters useful in preparing quinolone antibiotics |
ES2039301B1 (es) * | 1991-11-20 | 1994-05-16 | Genesis Para La Investigacion | Procedimiento de obtencion de nuevos intermedios de sintesis utiles para la preparacion de fluoroquinolonas. |
ES2050594B1 (es) * | 1991-12-31 | 1994-12-16 | Ind Quimica Agropecuaria S A | Procedimiento para la obtencion de acidos 6-fluoro-1,4-dihidro-4-oxo-7-piperazino-quinolin-3-carboxilicos sustituidos en 1-n. |
ES2050613B1 (es) * | 1992-10-16 | 1996-03-16 | Iteve S A | Nuevo procedimiento para la preparacion de derivados del acido 1-ciclopropil-3-quinolincarboxilico. |
US5532239A (en) * | 1993-08-02 | 1996-07-02 | Assistance Publique - Hopitaux De Paris | Therapeutic application of fluoroquinolone derivatives |
ES2088742B1 (es) | 1994-06-29 | 1997-03-16 | Salvat Lab Sa | Composicion antibiotica de aplicacion otica. |
JP2944759B2 (ja) * | 1995-05-24 | 1999-09-06 | アルコン ラボラトリーズ,インコーポレイテッド | 抗菌性組成物 |
DE19547635A1 (de) | 1995-12-20 | 1997-06-26 | Bayer Ag | Verfahren zur Herstellung von Cyclopropancarbonsäureamiden |
DE1135132T1 (de) | 1998-12-04 | 2002-08-22 | Influx, Inc. | Inhibitoren des multidrogentransportes |
AU6868700A (en) | 1999-09-02 | 2001-04-10 | Wakunaga Pharmaceutical Co., Ltd | Quinolinecarboxylic acid derivative or its salt |
SE9904108D0 (sv) * | 1999-11-15 | 1999-11-15 | New Pharma Research Ab | Nya föreningar |
DE10031043A1 (de) | 2000-06-26 | 2002-02-14 | Bayer Ag | Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung |
DE60117861T2 (de) | 2000-12-21 | 2006-11-02 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen |
US7973022B2 (en) | 2006-02-17 | 2011-07-05 | Idexx Laboratories, Inc. | Fluoroquinolone carboxylic acid salt compositions |
US20070197548A1 (en) | 2006-02-17 | 2007-08-23 | Murthy Yerramilli V S | Fluoroquinolone compositions |
DE102007004732A1 (de) * | 2007-01-31 | 2008-08-07 | Bayer Healthcare Ag | Enrofloxacin-Hexahydrat |
US7902227B2 (en) * | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
WO2013157018A1 (en) | 2012-04-18 | 2013-10-24 | Indian Institute Of Technology Madras | A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics |
CN109311818A (zh) | 2016-06-15 | 2019-02-05 | 湧永制药株式会社 | 新型吡啶酮羧酸衍生物或其盐 |
CN113912539B (zh) * | 2021-12-13 | 2022-03-11 | 山东国邦药业有限公司 | 一种环丙羧酸的合成方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5188973A (ja) * | 1975-01-29 | 1976-08-04 | Shinkinakinoronkarubonsanjudotainoseiho | |
JPS53141286A (en) * | 1977-05-16 | 1978-12-08 | Kyorin Seiyaku Kk | Novel substituted quinolinecarboxylic acid |
JPS5466686A (en) * | 1977-09-20 | 1979-05-29 | Dainippon Pharmaceut Co Ltd | Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same |
CA1175836A (en) * | 1977-09-20 | 1984-10-09 | Marcel Pesson | Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives |
DE2808070A1 (de) * | 1978-02-24 | 1979-08-30 | Bayer Ag | Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten |
DE3033157A1 (de) * | 1980-09-03 | 1982-04-01 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
JPS5762259A (en) * | 1980-09-05 | 1982-04-15 | Kyorin Pharmaceut Co Ltd | Preparation of substituted quinolinecarboxylic acid derivative |
IE52125B1 (en) * | 1980-10-02 | 1987-06-24 | Fox Charles L Jun | 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quino-line carboxylic acid and metal salts thereof useful in burn therapy |
US4788320A (en) * | 1986-01-20 | 1988-11-29 | Kyorin Pharmaceutical Co., Ltd. | Benzoylacetic acid ester derivatives and process for their preparations |
US4689423A (en) * | 1986-04-01 | 1987-08-25 | Warner-Lambert Company | Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates |
JPS6356224A (ja) * | 1986-08-27 | 1988-03-10 | 株式会社クボタ | マルチ作業機の覆土装置 |
CA2017090A1 (en) * | 1990-05-17 | 1991-11-17 | Stephen Dunn | Coating composition |
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1981
- 1981-10-29 DE DE19813142854 patent/DE3142854A1/de not_active Withdrawn
-
1982
- 1982-07-01 IE IE1606/82A patent/IE53709B1/en not_active IP Right Cessation
- 1982-07-05 NO NO822346A patent/NO158018C/no not_active IP Right Cessation
- 1982-07-06 IL IL66243A patent/IL66243A/xx not_active IP Right Cessation
- 1982-07-07 DK DK306082A patent/DK160491C/da not_active IP Right Cessation
- 1982-07-07 ZA ZA824829A patent/ZA824829B/xx unknown
- 1982-07-08 FI FI822442A patent/FI78689C/fi not_active IP Right Cessation
- 1982-07-09 AU AU85768/82A patent/AU561103B2/en not_active Expired
- 1982-07-16 DD DD82241728A patent/DD202560A5/de unknown
- 1982-07-19 KR KR8203203A patent/KR870000895B1/ko not_active Expired
- 1982-07-19 AT AT82106472T patent/ATE23040T1/de not_active IP Right Cessation
- 1982-07-19 EP EP82106472A patent/EP0078362B1/de not_active Expired
- 1982-07-19 DE DE8282106472T patent/DE3273892D1/de not_active Expired
- 1982-07-29 JP JP57131346A patent/JPS5874667A/ja active Granted
- 1982-08-13 CA CA000409435A patent/CA1218067A/en not_active Expired
- 1982-10-25 GR GR69612A patent/GR77707B/el unknown
- 1982-10-26 NZ NZ202278A patent/NZ202278A/en unknown
- 1982-10-28 PH PH28052A patent/PH18803A/en unknown
- 1982-10-28 ES ES516921A patent/ES516921A0/es active Granted
- 1982-10-28 HU HU823457A patent/HU187580B/hu unknown
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1987
- 1987-04-09 AU AU71406/87A patent/AU573126B2/en not_active Expired
- 1987-04-09 AU AU71405/87A patent/AU573125B2/en not_active Expired
- 1987-05-25 JP JP62127877A patent/JPS6322076A/ja active Granted
- 1987-05-25 JP JP62127878A patent/JPS6322057A/ja active Granted
- 1987-05-25 JP JP62127876A patent/JPS6322075A/ja active Granted
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1990
- 1990-08-10 DK DK190890A patent/DK162637C/da not_active IP Right Cessation
-
1991
- 1991-05-27 JP JP3151073A patent/JPH0824536B2/ja not_active Expired - Lifetime
-
1993
- 1993-06-24 LU LU88325C patent/LU88325I2/fr unknown
-
1994
- 1994-12-30 NO NO1994030C patent/NO1994030I1/no unknown
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