AU561103B2 - 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quin oline-3-carboxylic acids and intermediates - Google Patents

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quin oline-3-carboxylic acids and intermediates

Info

Publication number
AU561103B2
AU561103B2 AU85768/82A AU8576882A AU561103B2 AU 561103 B2 AU561103 B2 AU 561103B2 AU 85768/82 A AU85768/82 A AU 85768/82A AU 8576882 A AU8576882 A AU 8576882A AU 561103 B2 AU561103 B2 AU 561103B2
Authority
AU
Australia
Prior art keywords
cyclopropyl
dihydro
oxo
fluoro
quinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU85768/82A
Other versions
AU8576882A (en
Inventor
Klaus Grohe
Karl Georg Metzger
Hans-Joachim Zeiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6145081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU561103(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU8576882A publication Critical patent/AU8576882A/en
Application granted granted Critical
Publication of AU561103B2 publication Critical patent/AU561103B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Fodder In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

1. Claims (for the Contracting States : AT, BE, CH, DE, FR, GB, IT, LI, NL, SE) Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acids of the formula I see diagramm : EP0078362,P10,F3 in which R denotes hydrogen, methyl, ethyl or beta-hydroxyethyl, and their pharmaceutically usable acid addition salts, alkali metal salts and hydrates, except 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acid and its hydrochloride, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (4-methylpiperazino)-quinoline-3-carboxylic acid and 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (4-ethylpiperazino)-quinoline-3-carboxylic acid hydroiodide. 1. Claims (for the Contracting State LU) 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acids of the formula I see diagramm : EP0078362,P11,F3 in which R denotes hydrogen, methyl, ethyl or beta-hydroxyethyl, and their pharmaceutically usable acid addition salts and hydrates.
AU85768/82A 1981-10-29 1982-07-09 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quin oline-3-carboxylic acids and intermediates Expired AU561103B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE31428541 1981-10-29
DE19813142854 DE3142854A1 (en) 1981-10-29 1981-10-29 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-CHINOLINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU71406/87A Division AU573126B2 (en) 1981-10-29 1987-04-09 1,4-dihydro-4-oxoquinoline-3-carboxylic acids
AU71405/87A Division AU573125B2 (en) 1981-10-29 1987-04-09 Derivatives of 2,4-dichloro-5-fluorobenzoyl malonate

Publications (2)

Publication Number Publication Date
AU8576882A AU8576882A (en) 1983-05-05
AU561103B2 true AU561103B2 (en) 1987-04-30

Family

ID=6145081

Family Applications (3)

Application Number Title Priority Date Filing Date
AU85768/82A Expired AU561103B2 (en) 1981-10-29 1982-07-09 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quin oline-3-carboxylic acids and intermediates
AU71406/87A Expired AU573126B2 (en) 1981-10-29 1987-04-09 1,4-dihydro-4-oxoquinoline-3-carboxylic acids
AU71405/87A Expired AU573125B2 (en) 1981-10-29 1987-04-09 Derivatives of 2,4-dichloro-5-fluorobenzoyl malonate

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU71406/87A Expired AU573126B2 (en) 1981-10-29 1987-04-09 1,4-dihydro-4-oxoquinoline-3-carboxylic acids
AU71405/87A Expired AU573125B2 (en) 1981-10-29 1987-04-09 Derivatives of 2,4-dichloro-5-fluorobenzoyl malonate

Country Status (20)

Country Link
EP (1) EP0078362B1 (en)
JP (5) JPS5874667A (en)
KR (1) KR870000895B1 (en)
AT (1) ATE23040T1 (en)
AU (3) AU561103B2 (en)
CA (1) CA1218067A (en)
DD (1) DD202560A5 (en)
DE (2) DE3142854A1 (en)
DK (2) DK160491C (en)
ES (1) ES8307787A1 (en)
FI (1) FI78689C (en)
GR (1) GR77707B (en)
HU (1) HU187580B (en)
IE (1) IE53709B1 (en)
IL (1) IL66243A (en)
LU (1) LU88325I2 (en)
NO (2) NO158018C (en)
NZ (1) NZ202278A (en)
PH (1) PH18803A (en)
ZA (1) ZA824829B (en)

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Also Published As

Publication number Publication date
AU7140687A (en) 1987-07-30
FI78689B (en) 1989-05-31
DK160491C (en) 1991-08-26
JPH0463067B2 (en) 1992-10-08
FI78689C (en) 1989-09-11
IL66243A (en) 1987-10-20
DK306082A (en) 1983-04-30
FI822442L (en) 1983-04-30
ES516921A0 (en) 1983-07-16
ES8307787A1 (en) 1983-07-16
JPH0824536B2 (en) 1996-03-13
ATE23040T1 (en) 1986-11-15
DK160491B (en) 1991-03-18
LU88325I2 (en) 1994-05-04
JPS5874667A (en) 1983-05-06
GR77707B (en) 1984-09-25
IE53709B1 (en) 1989-01-18
IL66243A0 (en) 1982-11-30
AU573126B2 (en) 1988-05-26
DD202560A5 (en) 1983-09-21
JPH04253963A (en) 1992-09-09
ZA824829B (en) 1983-05-25
IE821606L (en) 1983-04-29
JPS6362510B2 (en) 1988-12-02
AU573125B2 (en) 1988-05-26
NO158018B (en) 1988-03-21
DE3142854A1 (en) 1983-05-11
DK190890A (en) 1990-08-10
NZ202278A (en) 1985-02-28
KR840000525A (en) 1984-02-25
JPS6322076A (en) 1988-01-29
AU8576882A (en) 1983-05-05
KR870000895B1 (en) 1987-05-02
JPH0457674B2 (en) 1992-09-14
EP0078362B1 (en) 1986-10-22
PH18803A (en) 1985-09-27
DK162637C (en) 1992-04-13
JPS6322075A (en) 1988-01-29
DK162637B (en) 1991-11-25
HU187580B (en) 1986-01-28
DK190890D0 (en) 1990-08-10
JPS6322057A (en) 1988-01-29
NO822346L (en) 1983-05-02
CA1218067A (en) 1987-02-17
NO1994030I1 (en) 1994-12-30
NO158018C (en) 1988-06-29
FI822442A0 (en) 1982-07-08
DE3273892D1 (en) 1986-11-27
EP0078362A3 (en) 1984-08-22
JPH0244827B2 (en) 1990-10-05
AU7140587A (en) 1987-08-06
EP0078362A2 (en) 1983-05-11

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