AU561103B2 - 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quin oline-3-carboxylic acids and intermediates - Google Patents

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quin oline-3-carboxylic acids and intermediates

Info

Publication number
AU561103B2
AU561103B2 AU85768/82A AU8576882A AU561103B2 AU 561103 B2 AU561103 B2 AU 561103B2 AU 85768/82 A AU85768/82 A AU 85768/82A AU 8576882 A AU8576882 A AU 8576882A AU 561103 B2 AU561103 B2 AU 561103B2
Authority
AU
Australia
Prior art keywords
piperazine
cyclopropyl
dihydro
intermediates
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU85768/82A
Other versions
AU8576882A (en
Inventor
Klaus Grohe
Karl Georg Metzger
Hans-Joachim Zeiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to DE31428541 priority Critical
Priority to DE19813142854 priority patent/DE3142854A1/en
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU8576882A publication Critical patent/AU8576882A/en
Application granted granted Critical
Publication of AU561103B2 publication Critical patent/AU561103B2/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6145081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU561103(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
AU85768/82A 1981-10-29 1982-07-09 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quin oline-3-carboxylic acids and intermediates Expired AU561103B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE31428541 1981-10-29
DE19813142854 DE3142854A1 (en) 1981-10-29 1981-10-29 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids, process for their preparation and antibacterial agents containing

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU71405/87A Division AU573125B2 (en) 1981-10-29 1987-04-09 Derivatives of 2,4-dichloro-5-fluorobenzoyl malonate
AU71406/87A Division AU573126B2 (en) 1981-10-29 1987-04-09 1,4-dihydro-4-oxoquinoline-3-carboxylic acids

Publications (2)

Publication Number Publication Date
AU8576882A AU8576882A (en) 1983-05-05
AU561103B2 true AU561103B2 (en) 1987-04-30

Family

ID=6145081

Family Applications (3)

Application Number Title Priority Date Filing Date
AU85768/82A Expired AU561103B2 (en) 1981-10-29 1982-07-09 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quin oline-3-carboxylic acids and intermediates
AU71406/87A Expired AU573126B2 (en) 1981-10-29 1987-04-09 1,4-dihydro-4-oxoquinoline-3-carboxylic acids
AU71405/87A Expired AU573125B2 (en) 1981-10-29 1987-04-09 Derivatives of 2,4-dichloro-5-fluorobenzoyl malonate

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU71406/87A Expired AU573126B2 (en) 1981-10-29 1987-04-09 1,4-dihydro-4-oxoquinoline-3-carboxylic acids
AU71405/87A Expired AU573125B2 (en) 1981-10-29 1987-04-09 Derivatives of 2,4-dichloro-5-fluorobenzoyl malonate

Country Status (20)

Country Link
EP (1) EP0078362B1 (en)
JP (5) JPS6362510B2 (en)
KR (1) KR870000895B1 (en)
AT (1) AT23040T (en)
AU (3) AU561103B2 (en)
CA (1) CA1218067A (en)
DD (1) DD202560A5 (en)
DE (1) DE3142854A1 (en)
DK (2) DK160491C (en)
ES (1) ES8307787A1 (en)
FI (1) FI78689C (en)
GR (1) GR77707B (en)
HU (1) HU187580B (en)
IE (1) IE53709B1 (en)
IL (1) IL66243A (en)
LU (1) LU88325I2 (en)
NO (2) NO158018C (en)
NZ (1) NZ202278A (en)
PH (1) PH18803A (en)
ZA (1) ZA8204829B (en)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248506A1 (en) * 1982-12-29 1984-07-05 Bayer Ag 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7 (alkyl-1-piperazinyl) -3-quinolinecarboxylic acids, a process for their preparation and antibacterial agents containing
DE3248505A1 (en) * 1982-12-29 1984-07-05 Bayer Ag 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7 (4- (oxoalkyl) -1-piperazinyl / -3-quinolinecarboxylic acids and their derivatives, processes for their preparation and antibacterial agents containing
DE3306772A1 (en) * 1983-02-25 1984-08-30 Bayer Ag Chinolonsaeuren, process for their production and compositions antibacterial agents
DE3306771A1 (en) * 1983-02-25 1984-08-30 Bayer Ag Quinolone carboxylic acids, process for their production and compositions antibacterial agents
DE3318145A1 (en) * 1983-05-18 1984-11-22 Bayer Ag 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, a process for their preparation and antibacterial agents containing
US4551456A (en) * 1983-11-14 1985-11-05 Merck & Co., Inc. Ophthalmic use of norfloxacin and related antibiotics
DE3574380D1 (en) * 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US4540694A (en) * 1984-04-26 1985-09-10 Abbott Laboratories 1-Pyridine substituted quino-benoxazines and antibacterial use
US4542133A (en) * 1984-04-26 1985-09-17 Abbott Laboratories Methylenedioxy quino-benoxazine derivatives and antibacterial use
US4533663A (en) * 1984-04-26 1985-08-06 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4528285A (en) * 1984-04-26 1985-07-09 Abbott Laboratories Methylenedioxy quino-benzothiazine derivatives
US4607032A (en) * 1984-04-26 1986-08-19 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4529725A (en) * 1984-04-26 1985-07-16 Abbott Laboratories 1-Pyridine substituted quino-benzothiazine
GB8412094D0 (en) * 1984-05-11 1984-06-20 Scras Quinoline derivatives
DE3420798A1 (en) * 1984-06-04 1985-12-05 Bayer Ag 7- (3-aryl-l-piperazinyl) - and 7- (3-cyclohexyl-l-piperazinyl) -3-quinolonecarboxylic acids
DE3426482A1 (en) * 1984-07-18 1986-01-30 Bayer Ag A process for the preparation of halogenated aroylessigestern
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
DE3502935A1 (en) * 1984-09-29 1986-04-10 Bayer Ag 3-amino-2-benzoyl-acrylsaeurederivate and a process for their preparation
FR2574404B1 (en) * 1984-12-12 1987-04-24 Provesan Sa 1-substituted derivatives of the acid 6-fluoro-7- (pyrrol-1-yl) -1,4-dihydro-4-oxoquinoline-3-carboxylic acid, their preparation and their application as medicaments
JPH0566945B2 (en) * 1984-12-14 1993-09-22 Daiichi Seiyaku Co
JPH0376306B2 (en) * 1985-01-05 1991-12-05 Bayer Ag
DE3517709A1 (en) * 1985-01-05 1986-07-10 Bayer Ag Basic preparations of quinolone carboxylic acids
DE3508816A1 (en) * 1985-01-10 1986-07-10 Bayer Ag 6,7-disubstituted 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids
DE3501247A1 (en) * 1985-01-16 1986-07-17 Bayer Ag Aminoacrylic derivatives
AT392791B (en) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd Process for the preparation of 1-substituted aryl-1,4- dihydro-4-oxonaphthyridine derivatives
AT392789B (en) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd A process for preparing 1-substituted aryl-1,4-dihydro-4-oxonaphthyridinderivaten
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
DE3509546A1 (en) * 1985-03-16 1986-09-25 Bayer Ag 7-amino-1- (subst.cyclopropyl) -1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, a process for their preparation and antibacterial agents containing
DE3608745A1 (en) * 1985-07-24 1987-01-29 Bayer Ag Bactericidal preparations for the application area on the veterinary medicine
EP0224121A3 (en) * 1985-11-19 1987-11-11 ROTTAPHARM S.p.A. 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
DE3542002A1 (en) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl) -3-quinolinecarboxylic acids, a process for their preparation and antibacterial agents containing
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4772706A (en) * 1986-01-13 1988-09-20 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
JPS62246541A (en) * 1986-01-20 1987-10-27 Kyorin Pharmaceut Co Ltd Benzoylacetic acid ester derivative and production thereof
DE3705621C2 (en) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclic substituted quinolonecarboxylic acid derivatives
JPS62215572A (en) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd Quinolone carboxylic acid derivative
JPH0581590B2 (en) * 1986-03-31 1993-11-15 Sankyo Co
DE3641312A1 (en) * 1986-12-03 1988-06-09 Bayer Ag A process for preparing quinolinecarboxylic acids
HU198709B (en) * 1987-04-08 1989-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
DE3713672A1 (en) * 1987-04-24 1988-11-17 Bayer Ag A process for preparing parenterally administrable quinolone carboxylic acids
JP2556330B2 (en) * 1987-07-09 1996-11-20 杏林製薬株式会社 Anisole derivative and method for producing the same
DE3724466A1 (en) * 1987-07-24 1989-02-02 Bayer Ag Process for the preparation of chinolon carboxyanese
US5164392A (en) * 1987-10-16 1992-11-17 Dainippon Pharmaceutical Co., Ltd. Quinoline derivatives and antibacterial agent containing them
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
EP0342849A3 (en) * 1988-05-19 1990-03-14 Pfizer Inc. Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
KR910003630B1 (en) * 1988-06-17 1991-06-07 전학제 Benzoyl acetic ester derivatives and there of method
GR1000201B (en) * 1988-06-23 1992-03-20 Tsetis Kleon Method for the synthesis of 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid as basis for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quinoline-3-carboxylic acids
FI95130C (en) * 1988-07-20 1995-12-27 Sankyo Co Process for the preparation of 4-oxoquinoline-3-carboxylic acid derivatives useful as a medicament
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5219781A (en) * 1988-12-08 1993-06-15 Mitsubishi Denki Kabushiki Kaisha Method for manufacturing semiconductor memory device having a stacked type capacitor
FR2655545B1 (en) * 1989-12-11 1994-06-10 Rhone Poulenc Sante New therapeutic application of the derivatives of fluoroquinolones.
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
ES2039301B1 (en) * 1991-11-20 1994-05-16 Genesis Para La Investigacion Method for obtaining new synthesis intermediates useful for the preparation of fluoroquinolones.
ES2050594B1 (en) * 1991-12-31 1994-12-16 Ind Quimica Agropecuaria S A Procedure for obtaining acid 6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic substituted 1-n.
ES2050613B1 (en) * 1992-10-16 1996-03-16 Iteve S A New procedure for the preparation of derivatives of the acid 1-ciclopropil-3-quinolincarboxilico.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
ES2088742B1 (en) 1994-06-29 1997-03-16 Salvat Lab Sa Antibiotic composition of otic application.
WO1996037191A1 (en) * 1995-05-24 1996-11-28 Alcon Laboratories, Inc. Antibacterial compositions
DE19547635A1 (en) 1995-12-20 1997-06-26 Bayer Ag Process for the preparation of cyclopropanecarboxamides
US6326391B1 (en) 1998-12-04 2001-12-04 Influx, Inc. Inhibitors of multidrug transporters
JP3477466B2 (en) 1999-09-02 2003-12-10 湧永製薬株式会社 Quinolinecarboxylic acid derivatives or salts thereof
SE9904108D0 (en) 1999-11-15 1999-11-15 New Pharma Research Ab novel compounds
DE10031043A1 (en) 2000-06-26 2002-02-14 Bayer Ag Retarded preparations of quinolone antibiotics and process for their preparation
DE60117861T2 (en) 2000-12-21 2006-11-02 Pharmacia & Upjohn Co. Llc, Kalamazoo Antimicrobial chinolon derivatives and their use for the treatment of bacterial infections
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
DE102007004732A1 (en) * 2007-01-31 2008-08-07 Bayer Healthcare Ag Enrofloxacin hexahydrate
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5188973A (en) * 1975-01-29 1976-08-04 Shinkinakinoronkarubonsanjudotainoseiho
JPS5534144B2 (en) * 1977-05-16 1980-09-04
CA1175836A (en) * 1977-09-20 1984-10-09 Marcel Pesson Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives
JPS5738581B2 (en) * 1977-09-20 1982-08-16
DE2808070A1 (en) * 1978-02-24 1979-08-30 Bayer Ag A process for the preparation of 4-pyridone-3-carboxylic acids and / or derivatives thereof
DE3033157A1 (en) * 1980-09-03 1982-04-01 Bayer Ag 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridine-3-carboxylic acids, process for their preparation and antibacterial agents containing
JPH0130823B2 (en) * 1980-09-05 1989-06-22 Kyorin Seiyaku Kk
IE52125B1 (en) * 1980-10-02 1987-06-24 Fox Charles L Jun 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quino-line carboxylic acid and metal salts thereof useful in burn therapy
US4788320A (en) * 1986-01-20 1988-11-29 Kyorin Pharmaceutical Co., Ltd. Benzoylacetic acid ester derivatives and process for their preparations
US4689423A (en) * 1986-04-01 1987-08-25 Warner-Lambert Company Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates
JPH0425767B2 (en) * 1986-08-27 1992-05-01 Kubota Kk
CA2017090A1 (en) * 1990-05-17 1991-11-17 Stephen Dunn Coating composition

Also Published As

Publication number Publication date
AU573125B2 (en) 1988-05-26
JPH0463067B2 (en) 1992-10-08
JPS6322076A (en) 1988-01-29
NO1994030I1 (en) 1994-12-30
DE3142854A1 (en) 1983-05-11
AT23040T (en) 1986-11-15
CA1218067A (en) 1987-02-17
DK190890D0 (en) 1990-08-10
PH18803A (en) 1985-09-27
KR870000895B1 (en) 1987-05-02
FI822442L (en) 1983-04-30
NO158018C (en) 1988-06-29
FI78689C (en) 1989-09-11
FI822442D0 (en)
HU187580B (en) 1986-01-28
DK162637B (en) 1991-11-25
AU7140587A (en) 1987-08-06
AU7140687A (en) 1987-07-30
JPH0457674B2 (en) 1992-09-14
LU88325A9 (en)
DK162637C (en) 1992-04-13
JPS5874667A (en) 1983-05-06
IL66243D0 (en) 1982-11-30
EP0078362A3 (en) 1984-08-22
LU88325I2 (en) 1994-05-04
EP0078362A2 (en) 1983-05-11
GR77707B (en) 1984-09-25
IE53709B1 (en) 1989-01-18
JPS6362510B2 (en) 1988-12-02
JPH0244827B2 (en) 1990-10-05
JPH04253963A (en) 1992-09-09
DK306082A (en) 1983-04-30
ES8307787A1 (en) 1983-07-16
KR840000525A (en) 1984-02-25
FI78689B (en) 1989-05-31
DK190890A (en) 1990-08-10
JPS6322075A (en) 1988-01-29
IL66243A (en) 1987-10-20
NO822346L (en) 1983-05-02
JPS6322057A (en) 1988-01-29
ES516921A0 (en) 1983-07-16
AU8576882A (en) 1983-05-05
DK160491C (en) 1991-08-26
FI822442A0 (en) 1982-07-08
IE821606L (en) 1983-04-29
CA1218067A1 (en)
DD202560A5 (en) 1983-09-21
NZ202278A (en) 1985-02-28
FI822442A (en)
EP0078362B1 (en) 1986-10-22
ES516921D0 (en)
AU573126B2 (en) 1988-05-26
NO158018B (en) 1988-03-21
ZA8204829B (en) 1983-05-25
JPH0824536B2 (en) 1996-03-13
DK160491B (en) 1991-03-18

Similar Documents

Publication Publication Date Title
AU573765B2 (en) 7 amino-1-cyclopropyl-6, 8-difluoro-1, 4-dihydro-4- oxoquinoline-3-carboxylic acids
AU547849B2 (en) Quinoline carboxamides and their derivatives
AU544351B2 (en) Anilides
AU549328B2 (en) Modified ionomer and application thereof
AU562081B2 (en) Quinolone derivatives
IE862479L (en) Substituted bridged-diazabicycloalkyl quinolone carboxylic¹acids.
AU573125B2 (en) Derivatives of 2,4-dichloro-5-fluorobenzoyl malonate
AU8163882A (en) p
AU8219882A (en) Communicating system
AU556515B2 (en) 1-hydroxyethyl-azole derivatives and intermediates
AU547824B2 (en) Hotplate
AU6509286A (en) Electroweld fitting or electroweld collar
AU8333982A (en) **
AU8452682A (en) **
AU8730982A (en) **
IE851365L (en) Quinoline carboxylic acids.
AU561395B2 (en) 3-amino-benzazepin-2-ones
AU551769B2 (en) Imidazodiazepines
AU8623282A (en) Adaptable value-token
AU8001482A (en) **
AU559550B2 (en) Vaccines
AU576323B2 (en) Antibacterial quinoline-3-carboxylic acids
AU543861B2 (en) Oltahydro-1h-indole-2-carboxylic acids
AU3958485A (en) Cooking system
AU6775481A (en) **

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired