DK190890D0 - 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-CHLOR-QUINOLLIN-3-CARBOXYLIC ACID FOR USE IN PREPARATION OF 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO 7-piperazino-quinoline-3-carboxylic acids - Google Patents

1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-CHLOR-QUINOLLIN-3-CARBOXYLIC ACID FOR USE IN PREPARATION OF 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO 7-piperazino-quinoline-3-carboxylic acids

Info

Publication number
DK190890D0
DK190890D0 DK190890A DK190890A DK190890D0 DK 190890 D0 DK190890 D0 DK 190890D0 DK 190890 A DK190890 A DK 190890A DK 190890 A DK190890 A DK 190890A DK 190890 D0 DK190890 D0 DK 190890D0
Authority
DK
Denmark
Prior art keywords
cyclopropyl
dihydro
oxo
quinoline
fluor
Prior art date
Application number
DK190890A
Other languages
Danish (da)
Other versions
DK162637B (en
DK190890A (en
DK162637C (en
Inventor
Klaus Grohe
Hans-Joachim Zeiler
Karl Georg Metzger
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6145081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK190890(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK190890A publication Critical patent/DK190890A/en
Publication of DK190890D0 publication Critical patent/DK190890D0/en
Publication of DK162637B publication Critical patent/DK162637B/en
Application granted granted Critical
Publication of DK162637C publication Critical patent/DK162637C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Fodder In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1. Claims (for the Contracting States : AT, BE, CH, DE, FR, GB, IT, LI, NL, SE) Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acids of the formula I see diagramm : EP0078362,P10,F3 in which R denotes hydrogen, methyl, ethyl or beta-hydroxyethyl, and their pharmaceutically usable acid addition salts, alkali metal salts and hydrates, except 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acid and its hydrochloride, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (4-methylpiperazino)-quinoline-3-carboxylic acid and 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (4-ethylpiperazino)-quinoline-3-carboxylic acid hydroiodide. 1. Claims (for the Contracting State LU) 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acids of the formula I see diagramm : EP0078362,P11,F3 in which R denotes hydrogen, methyl, ethyl or beta-hydroxyethyl, and their pharmaceutically usable acid addition salts and hydrates.
DK190890A 1981-10-29 1990-08-10 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-CHLOR-QUINOLIN-3-CARBOXYLIC ACID FOR USE IN PREPARATION OF 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO 7-piperazino-quinoline-3-carboxylic acids DK162637C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3142854 1981-10-29
DE19813142854 DE3142854A1 (en) 1981-10-29 1981-10-29 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-CHINOLINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS

Publications (4)

Publication Number Publication Date
DK190890A DK190890A (en) 1990-08-10
DK190890D0 true DK190890D0 (en) 1990-08-10
DK162637B DK162637B (en) 1991-11-25
DK162637C DK162637C (en) 1992-04-13

Family

ID=6145081

Family Applications (2)

Application Number Title Priority Date Filing Date
DK306082A DK160491C (en) 1981-10-29 1982-07-07 METHOD OF ANALOGUE FOR THE PREPARATION OF 1-CYCLO-PROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7- (4-BETA-HYDROXYETHYL-PIPERAZINO) -QUINOLINE-3-CARBOXYLIC ACID ACRODUCTIVE ACID ACRODUCTIVE ACID DRUGE
DK190890A DK162637C (en) 1981-10-29 1990-08-10 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-CHLOR-QUINOLIN-3-CARBOXYLIC ACID FOR USE IN PREPARATION OF 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO 7-piperazino-quinoline-3-carboxylic acids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK306082A DK160491C (en) 1981-10-29 1982-07-07 METHOD OF ANALOGUE FOR THE PREPARATION OF 1-CYCLO-PROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7- (4-BETA-HYDROXYETHYL-PIPERAZINO) -QUINOLINE-3-CARBOXYLIC ACID ACRODUCTIVE ACID ACRODUCTIVE ACID DRUGE

Country Status (20)

Country Link
EP (1) EP0078362B1 (en)
JP (5) JPS5874667A (en)
KR (1) KR870000895B1 (en)
AT (1) ATE23040T1 (en)
AU (3) AU561103B2 (en)
CA (1) CA1218067A (en)
DD (1) DD202560A5 (en)
DE (2) DE3142854A1 (en)
DK (2) DK160491C (en)
ES (1) ES516921A0 (en)
FI (1) FI78689C (en)
GR (1) GR77707B (en)
HU (1) HU187580B (en)
IE (1) IE53709B1 (en)
IL (1) IL66243A (en)
LU (1) LU88325I2 (en)
NO (2) NO158018C (en)
NZ (1) NZ202278A (en)
PH (1) PH18803A (en)
ZA (1) ZA824829B (en)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3248506A1 (en) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7 (ALKYL-1-PIPERAZINYL) -3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
DE3248505A1 (en) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7 (4- (OXOALKYL) -1-PIPERAZINYL / -3-QUINOLINE CARBONIC ACIDS AND THEIR DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND THEIR CONTAINERS
DE3306771A1 (en) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen CHINOLONIC CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
DE3306772A1 (en) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen CHINOLONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
DE3318145A1 (en) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US4551456A (en) * 1983-11-14 1985-11-05 Merck & Co., Inc. Ophthalmic use of norfloxacin and related antibiotics
DE3574380D1 (en) * 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
US4529725A (en) * 1984-04-26 1985-07-16 Abbott Laboratories 1-Pyridine substituted quino-benzothiazine
US4533663A (en) * 1984-04-26 1985-08-06 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4540694A (en) * 1984-04-26 1985-09-10 Abbott Laboratories 1-Pyridine substituted quino-benoxazines and antibacterial use
US4528285A (en) * 1984-04-26 1985-07-09 Abbott Laboratories Methylenedioxy quino-benzothiazine derivatives
US4607032A (en) * 1984-04-26 1986-08-19 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4542133A (en) * 1984-04-26 1985-09-17 Abbott Laboratories Methylenedioxy quino-benoxazine derivatives and antibacterial use
GB8412094D0 (en) * 1984-05-11 1984-06-20 Scras Quinoline derivatives
DE3420798A1 (en) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7- (3-ARYL-L-PIPERAZINYL) - AND 7- (3-CYCLOHEXYL-L-PIPERAZINYL) -3-CHINOLONIC CARBONIC ACIDS
DE3426482A1 (en) * 1984-07-18 1986-01-30 Bayer Ag, 5090 Leverkusen METHOD FOR PRODUCING HALOGENATED AROYLESSE ESTERS
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
DE3502935A1 (en) * 1984-09-29 1986-04-10 Bayer Ag, 5090 Leverkusen 3-AMINO-2-BENZOYL-ACRYLIC ACID DERIVATIVES AND A METHOD FOR THE PRODUCTION THEREOF
FR2574404B1 (en) * 1984-12-12 1987-04-24 Provesan Sa 1-SUBSTITUTED DERIVATIVES OF 6-FLUORO-7- (PYRROL-1-YL) -1,4-DIHYDRO-4-OXOQUINOLEIN-3-CARBOXYLIC ACID, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
JPS6212760A (en) * 1984-12-14 1987-01-21 Dai Ichi Seiyaku Co Ltd 1-(2-halogenocyclopropyl)quinolinecarboxylic acid derivative
DE3517709A1 (en) * 1985-01-05 1986-07-10 Bayer Ag BASIC PREPARATIONS OF CHINOLON CARBON ACIDS
JPS61180771A (en) * 1985-01-05 1986-08-13 バイエル・アクチエンゲゼルシヤフト Basic prescription of quinolone carboxylic acid
DE3508816A1 (en) * 1985-01-10 1986-07-10 Bayer Ag, 5090 Leverkusen 6,7-DISUBSTITUTED 1-CYCLOPROPYL-1,4-DIHYDRO-4-OXO-1,8-NAPHTYRIDINE-3-CARBONIC ACIDS
DE3501247A1 (en) * 1985-01-16 1986-07-17 Bayer Ag, 5090 Leverkusen AMINO ACRYLIC ACID DERIVATIVES
AT392791B (en) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd Process for the preparation of 1-substituted aryl-1,4- dihydro-4-oxonaphthyridine derivatives
US4851535A (en) * 1985-01-23 1989-07-25 Toyama Chemical Co., Ltd. Nicotinic acid derivatives
AT392789B (en) * 1985-01-23 1991-06-10 Toyama Chemical Co Ltd METHOD FOR PRODUCING 1-SUBSTITUTED ARYL-1,4-DIHYDRO-4-OXONAPHTHYRIDINE DERIVATIVES
DE3509546A1 (en) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-AMINO-1- (SUBST.CYCLOPROPYL) -1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
DE3608745A1 (en) * 1985-07-24 1987-01-29 Bayer Ag BACTERICIDAL PREPARATIONS FOR APPLICATION IN THE VETERINE MEDICINE AREA
EP0224121A3 (en) * 1985-11-19 1987-11-11 ROTTAPHARM S.p.A. 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them
DE3542002A1 (en) * 1985-11-28 1987-06-04 Bayer Ag 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7- (1-PIPERAZINYL) -3-QUINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR ANTIBACTERIAL AGENTS CONTAINING THEM
US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4772706A (en) * 1986-01-13 1988-09-20 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
JPS62246541A (en) * 1986-01-20 1987-10-27 Kyorin Pharmaceut Co Ltd Benzoylacetic acid ester derivative and production thereof
DE3705621C2 (en) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclic substituted quinolonecarboxylic acid derivatives
JPS62215572A (en) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd Quinolone carboxylic acid derivative
JPS63198664A (en) * 1986-03-31 1988-08-17 Sankyo Co Ltd Quinolonecarboxylic acid derivative
DE3641312A1 (en) * 1986-12-03 1988-06-09 Bayer Ag METHOD FOR PRODUCING CHINOLINE CARBONIC ACIDS
HU198709B (en) * 1987-04-08 1989-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing quinoline-carboxylic acid derivatives
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
DE3713672A1 (en) * 1987-04-24 1988-11-17 Bayer Ag METHOD FOR PRODUCING PARENTERALLY AVAILABLE CHINOLONIC CARBONIC ACIDS
JP2556330B2 (en) * 1987-07-09 1996-11-20 杏林製薬株式会社 Anisole derivative and method for producing the same
DE3724466A1 (en) * 1987-07-24 1989-02-02 Bayer Ag PROCESS FOR THE PREPARATION OF CHINOLON CARBOXYANESE
IL88003A (en) * 1987-10-16 1992-11-15 Dainippon Pharmaceutical Co Quinoline derivatives,their preparation and pharmaceutical compositions containing them
US5164392A (en) * 1987-10-16 1992-11-17 Dainippon Pharmaceutical Co., Ltd. Quinoline derivatives and antibacterial agent containing them
EP0342849A3 (en) * 1988-05-19 1990-03-14 Pfizer Inc. Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
KR910003630B1 (en) * 1988-06-17 1991-06-07 한국과학기술원 Benzoyl acetic ester derivatives and there of method
GR1000201B (en) * 1988-06-23 1992-03-20 Tsetis Kleon Method for the synthesis of 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-chloro-quinoline-3-carboxylic acid as basis for the preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-quinoline-3-carboxylic acids
FI95130C (en) * 1988-07-20 1995-12-27 Sankyo Co Process for the preparation of 4-oxoquinoline-3-carboxylic acid derivatives useful as a medicament
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US5219781A (en) * 1988-12-08 1993-06-15 Mitsubishi Denki Kabushiki Kaisha Method for manufacturing semiconductor memory device having a stacked type capacitor
FR2655545B1 (en) 1989-12-11 1994-06-10 Rhone Poulenc Sante NEW THERAPEUTIC APPLICATION OF FLUOROQUINOLONE DERIVATIVES.
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
ES2039301B1 (en) * 1991-11-20 1994-05-16 Genesis Para La Investigacion PROCEDURE FOR OBTAINING NEW USEFUL SYNTHESIS INTERMEDIATES FOR THE PREPARATION OF FLUOROQUINOLONS.
ES2050594B1 (en) * 1991-12-31 1994-12-16 Ind Quimica Agropecuaria S A PROCEDURE FOR OBTAINING 6-FLUORO-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYLIC ACIDS SUBSTITUTED IN 1-N.
ES2050613B1 (en) * 1992-10-16 1996-03-16 Iteve S A NEW PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF THE ACID 1-CICLOPROPIL-3-QUINOLINCARBOXILICO.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
ES2088742B1 (en) 1994-06-29 1997-03-16 Salvat Lab Sa ANTIBIOTIC COMPOSITION OF OTIC APPLICATION.
JP2944759B2 (en) * 1995-05-24 1999-09-06 アルコン ラボラトリーズ，インコーポレイテッド Antimicrobial composition
DE19547635A1 (en) 1995-12-20 1997-06-26 Bayer Ag Process for the preparation of cyclopropanecarboxamides
CA2353557A1 (en) 1998-12-04 2000-06-08 Influx, Inc. Inhibitors of multidrug transporters
CA2383759A1 (en) 1999-09-02 2001-03-15 Wakunaga Pharmaceutical Co., Ltd. Quinolinecarboxylic acid derivative or its salt
SE9904108D0 (en) 1999-11-15 1999-11-15 New Pharma Research Ab New compounds
DE10031043A1 (en) 2000-06-26 2002-02-14 Bayer Ag Retarded preparations of quinolone antibiotics and process for their preparation
EP1349853B1 (en) 2000-12-21 2006-03-08 Pharmacia & Upjohn Company LLC Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
DE102007004732A1 (en) 2007-01-31 2008-08-07 Bayer Healthcare Ag Enrofloxacin hexahydrate
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
CN113912539B (en) * 2021-12-13 2022-03-11 山东国邦药业有限公司 Synthesis method of cyclopropanecarboxylic acid

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5188973A (en) * 1975-01-29 1976-08-04 SHINKINAKINORONKARUBONSAN JUDOTAINOSEIHO
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS5466686A (en) * 1977-09-20 1979-05-29 Dainippon Pharmaceut Co Ltd Quinoline-3-carboxylic acid derivative, its preparation, and pharmaceutical composition containig the same
US4292317A (en) * 1977-09-20 1981-09-29 Laboratorie Roger Bellon 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them
DE2808070A1 (en) * 1978-02-24 1979-08-30 Bayer Ag PROCESS FOR THE PRODUCTION OF 4-PYRIDONE-3-CARBONIC ACIDS AND / OR DERIVATIVES
DE3033157A1 (en) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-4-OXO-1,4-DIHYDRO-NAPHTHYRIDINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM
JPS5762259A (en) * 1980-09-05 1982-04-15 Kyorin Pharmaceut Co Ltd Preparation of substituted quinolinecarboxylic acid derivative
IE52125B1 (en) * 1980-10-02 1987-06-24 Fox Charles L Jun 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quino-line carboxylic acid and metal salts thereof useful in burn therapy
US4788320A (en) * 1986-01-20 1988-11-29 Kyorin Pharmaceutical Co., Ltd. Benzoylacetic acid ester derivatives and process for their preparations
US4689423A (en) * 1986-04-01 1987-08-25 Warner-Lambert Company Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates
JPS6356224A (en) * 1986-08-27 1988-03-10 株式会社クボタ Soil covering apparatus of mulching work machine
CA2017090A1 (en) * 1990-05-17 1991-11-17 Stephen Dunn Coating composition

Also Published As

Publication number Publication date
JPS6322057A (en) 1988-01-29
NO822346L (en) 1983-05-02
DK162637B (en) 1991-11-25
ES8307787A1 (en) 1983-07-16
AU573125B2 (en) 1988-05-26
NO158018C (en) 1988-06-29
FI78689C (en) 1989-09-11
JPH0824536B2 (en) 1996-03-13
JPH04253963A (en) 1992-09-09
JPS5874667A (en) 1983-05-06
JPH0244827B2 (en) 1990-10-05
ATE23040T1 (en) 1986-11-15
JPH0463067B2 (en) 1992-10-08
CA1218067A (en) 1987-02-17
KR870000895B1 (en) 1987-05-02
DK190890A (en) 1990-08-10
AU8576882A (en) 1983-05-05
KR840000525A (en) 1984-02-25
DE3273892D1 (en) 1986-11-27
IL66243A (en) 1987-10-20
AU7140687A (en) 1987-07-30
IE821606L (en) 1983-04-29
DE3142854A1 (en) 1983-05-11
NO158018B (en) 1988-03-21
DD202560A5 (en) 1983-09-21
DK160491C (en) 1991-08-26
ZA824829B (en) 1983-05-25
AU7140587A (en) 1987-08-06
DK306082A (en) 1983-04-30
DK160491B (en) 1991-03-18
FI822442A0 (en) 1982-07-08
EP0078362A2 (en) 1983-05-11
NZ202278A (en) 1985-02-28
NO1994030I1 (en) 1994-12-30
AU561103B2 (en) 1987-04-30
LU88325I2 (en) 1994-05-04
ES516921A0 (en) 1983-07-16
JPH0457674B2 (en) 1992-09-14
PH18803A (en) 1985-09-27
JPS6322075A (en) 1988-01-29
GR77707B (en) 1984-09-25
JPS6322076A (en) 1988-01-29
DK162637C (en) 1992-04-13
IE53709B1 (en) 1989-01-18
FI78689B (en) 1989-05-31
EP0078362B1 (en) 1986-10-22
IL66243A0 (en) 1982-11-30
AU573126B2 (en) 1988-05-26
JPS6362510B2 (en) 1988-12-02
FI822442L (en) 1983-04-30
EP0078362A3 (en) 1984-08-22
HU187580B (en) 1986-01-28

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