NO158018C - ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYL ACID. - Google Patents
ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYL ACID.Info
- Publication number
- NO158018C NO158018C NO822346A NO822346A NO158018C NO 158018 C NO158018 C NO 158018C NO 822346 A NO822346 A NO 822346A NO 822346 A NO822346 A NO 822346A NO 158018 C NO158018 C NO 158018C
- Authority
- NO
- Norway
- Prior art keywords
- cyclopropyl
- dihydro
- oxo
- piperazino
- quinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Fodder In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1. Claims (for the Contracting States : AT, BE, CH, DE, FR, GB, IT, LI, NL, SE) Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acids of the formula I see diagramm : EP0078362,P10,F3 in which R denotes hydrogen, methyl, ethyl or beta-hydroxyethyl, and their pharmaceutically usable acid addition salts, alkali metal salts and hydrates, except 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acid and its hydrochloride, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (4-methylpiperazino)-quinoline-3-carboxylic acid and 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7- (4-ethylpiperazino)-quinoline-3-carboxylic acid hydroiodide. 1. Claims (for the Contracting State LU) 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acids of the formula I see diagramm : EP0078362,P11,F3 in which R denotes hydrogen, methyl, ethyl or beta-hydroxyethyl, and their pharmaceutically usable acid addition salts and hydrates.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO871195A NO167800C (en) | 1981-10-29 | 1987-03-23 | INTERMEDIATE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYLIC ACID. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19813142854 DE3142854A1 (en) | 1981-10-29 | 1981-10-29 | 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-CHINOLINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
Publications (3)
Publication Number | Publication Date |
---|---|
NO822346L NO822346L (en) | 1983-05-02 |
NO158018B NO158018B (en) | 1988-03-21 |
NO158018C true NO158018C (en) | 1988-06-29 |
Family
ID=6145081
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO822346A NO158018C (en) | 1981-10-29 | 1982-07-05 | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYL ACID. |
NO1994030C NO1994030I1 (en) | 1981-10-29 | 1994-12-30 | Enrofloxacin / 1-cyclopropyl-7- (4-ethyl-1-piperazinyl) -6-fluoro-1,4-dihydro-1-oxo-3-3-quinolinecarboxylic acid |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO1994030C NO1994030I1 (en) | 1981-10-29 | 1994-12-30 | Enrofloxacin / 1-cyclopropyl-7- (4-ethyl-1-piperazinyl) -6-fluoro-1,4-dihydro-1-oxo-3-3-quinolinecarboxylic acid |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0078362B1 (en) |
JP (5) | JPS5874667A (en) |
KR (1) | KR870000895B1 (en) |
AT (1) | ATE23040T1 (en) |
AU (3) | AU561103B2 (en) |
CA (1) | CA1218067A (en) |
DD (1) | DD202560A5 (en) |
DE (2) | DE3142854A1 (en) |
DK (2) | DK160491C (en) |
ES (1) | ES516921A0 (en) |
FI (1) | FI78689C (en) |
GR (1) | GR77707B (en) |
HU (1) | HU187580B (en) |
IE (1) | IE53709B1 (en) |
IL (1) | IL66243A (en) |
LU (1) | LU88325I2 (en) |
NO (2) | NO158018C (en) |
NZ (1) | NZ202278A (en) |
PH (1) | PH18803A (en) |
ZA (1) | ZA824829B (en) |
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DE3306772A1 (en) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | CHINOLONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE ANTIBACTERIAL AGENTS CONTAINING THEM |
DE3318145A1 (en) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-AMINO-1-CYCLOPROPYL-6,8-DIFLUOR-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS |
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US4528285A (en) * | 1984-04-26 | 1985-07-09 | Abbott Laboratories | Methylenedioxy quino-benzothiazine derivatives |
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WO2013157018A1 (en) | 2012-04-18 | 2013-10-24 | Indian Institute Of Technology Madras | A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics |
CN113912539B (en) * | 2021-12-13 | 2022-03-11 | 山东国邦药业有限公司 | Synthesis method of cyclopropanecarboxylic acid |
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JPS5188973A (en) * | 1975-01-29 | 1976-08-04 | SHINKINAKINORONKARUBONSAN JUDOTAINOSEIHO | |
JPS53141286A (en) * | 1977-05-16 | 1978-12-08 | Kyorin Seiyaku Kk | Novel substituted quinolinecarboxylic acid |
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-
1981
- 1981-10-29 DE DE19813142854 patent/DE3142854A1/en not_active Withdrawn
-
1982
- 1982-07-01 IE IE1606/82A patent/IE53709B1/en not_active IP Right Cessation
- 1982-07-05 NO NO822346A patent/NO158018C/en not_active IP Right Cessation
- 1982-07-06 IL IL66243A patent/IL66243A/en not_active IP Right Cessation
- 1982-07-07 DK DK306082A patent/DK160491C/en not_active IP Right Cessation
- 1982-07-07 ZA ZA824829A patent/ZA824829B/en unknown
- 1982-07-08 FI FI822442A patent/FI78689C/en not_active IP Right Cessation
- 1982-07-09 AU AU85768/82A patent/AU561103B2/en not_active Expired
- 1982-07-16 DD DD82241728A patent/DD202560A5/en unknown
- 1982-07-19 KR KR8203203A patent/KR870000895B1/en active IP Right Grant
- 1982-07-19 EP EP82106472A patent/EP0078362B1/en not_active Expired
- 1982-07-19 AT AT82106472T patent/ATE23040T1/en not_active IP Right Cessation
- 1982-07-19 DE DE8282106472T patent/DE3273892D1/en not_active Expired
- 1982-07-29 JP JP57131346A patent/JPS5874667A/en active Granted
- 1982-08-13 CA CA000409435A patent/CA1218067A/en not_active Expired
- 1982-10-25 GR GR69612A patent/GR77707B/el unknown
- 1982-10-26 NZ NZ202278A patent/NZ202278A/en unknown
- 1982-10-28 PH PH28052A patent/PH18803A/en unknown
- 1982-10-28 ES ES516921A patent/ES516921A0/en active Granted
- 1982-10-28 HU HU823457A patent/HU187580B/en unknown
-
1987
- 1987-04-09 AU AU71405/87A patent/AU573125B2/en not_active Expired
- 1987-04-09 AU AU71406/87A patent/AU573126B2/en not_active Expired
- 1987-05-25 JP JP62127876A patent/JPS6322075A/en active Granted
- 1987-05-25 JP JP62127877A patent/JPS6322076A/en active Granted
- 1987-05-25 JP JP62127878A patent/JPS6322057A/en active Granted
-
1990
- 1990-08-10 DK DK190890A patent/DK162637C/en not_active IP Right Cessation
-
1991
- 1991-05-27 JP JP3151073A patent/JPH0824536B2/en not_active Expired - Lifetime
-
1993
- 1993-06-24 LU LU88325C patent/LU88325I2/en unknown
-
1994
- 1994-12-30 NO NO1994030C patent/NO1994030I1/en unknown
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MK1K | Patent expired |
Free format text: EXPIRED IN JULY 2002 |