ES2050594B1 - PROCEDURE FOR OBTAINING 6-FLUORO-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYLIC ACIDS SUBSTITUTED IN 1-N. - Google Patents

PROCEDURE FOR OBTAINING 6-FLUORO-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYLIC ACIDS SUBSTITUTED IN 1-N.

Info

Publication number
ES2050594B1
ES2050594B1 ES9102909A ES9102909A ES2050594B1 ES 2050594 B1 ES2050594 B1 ES 2050594B1 ES 9102909 A ES9102909 A ES 9102909A ES 9102909 A ES9102909 A ES 9102909A ES 2050594 B1 ES2050594 B1 ES 2050594B1
Authority
ES
Spain
Prior art keywords
fluoro
piperazino
quinolin
oxo
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9102909A
Other languages
Spanish (es)
Other versions
ES2050594A1 (en
Inventor
Martin M Elena Maymo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ind Quimica Agropecuaria S A
Original Assignee
Ind Quimica Agropecuaria S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Quimica Agropecuaria S A filed Critical Ind Quimica Agropecuaria S A
Priority to ES9102909A priority Critical patent/ES2050594B1/en
Publication of ES2050594A1 publication Critical patent/ES2050594A1/en
Application granted granted Critical
Publication of ES2050594B1 publication Critical patent/ES2050594B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE LOS ACIDOS 6-FLUORO-1,4DIHIDRO- 4-OXO-7-PIPERAZINO-QUINOLIN-CARBOXILICOS SUSTITUIDOS EN 1-N. SE HACEN REACCIONAR ACIDOS 7-CLORO-6-FLUORO-1, 4-DIHIDRO-4OXIQUINOLIN-3-CARBOXILICOS, CON POR LO MENOS DOS MOLES DE MONOETANOLAMINA Y SE REALIZA UNA CICLACION EN PRESENCIA DE UN CATALIZADOR. EN UNA PRIMERA FASE DE LA REACCION CON MONOETANOLAMINA, SE UTILIZA UN EXCESO SOBRE DOS MOLES DE MONOETANOLAMINA POR CADA MOL DE ACIDO, ACTUANDO ENTONCES LA MONOETANOLAMINA A LA VEZ COMO REACTIVO Y COMO DISOLVENTE. LOS PRODUCTOS OBTENIDOS SON PRINCIPALMENTE UTILIZADOS PARA INFECCIONES DEL TRACTO URINARIO Y EN INFECCIONES SISTEMICAS.PROCEDURE FOR THE OBTAINING OF ACIDS 6-FLUORO-1,4DIHIDRO- 4-OXO-7-PIPERAZINO-QUINOLIN-CARBOXILICOS SUBSTITUTED IN 1-N. ACIDES 7-CHLORO-6-FLUORO-1, 4-DIHIDRO-4OXIQUINOLIN-3-CARBOXILICOS ARE REACTED, WITH AT LEAST TWO MONOLES OF MONOETHANOLAMINE AND A CYCLATION IS PERFORMED IN THE PRESENCE OF A CATALYST. IN A FIRST PHASE OF THE REACTION WITH MONOETHANOLAMINE, AN EXCESS ON TWO MONOLES OF MONOETHANOLAMINE IS USED FOR EACH MOL OF ACID, THEN THE MONOETHANOLAMINE ACTING AS A REAGENT AND AS A SOLVENT. THE PRODUCTS OBTAINED ARE MAINLY USED FOR URINARY TRACT INFECTIONS AND IN SYSTEMIC INFECTIONS.

ES9102909A 1991-12-31 1991-12-31 PROCEDURE FOR OBTAINING 6-FLUORO-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYLIC ACIDS SUBSTITUTED IN 1-N. Expired - Lifetime ES2050594B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9102909A ES2050594B1 (en) 1991-12-31 1991-12-31 PROCEDURE FOR OBTAINING 6-FLUORO-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYLIC ACIDS SUBSTITUTED IN 1-N.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9102909A ES2050594B1 (en) 1991-12-31 1991-12-31 PROCEDURE FOR OBTAINING 6-FLUORO-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYLIC ACIDS SUBSTITUTED IN 1-N.

Publications (2)

Publication Number Publication Date
ES2050594A1 ES2050594A1 (en) 1994-05-16
ES2050594B1 true ES2050594B1 (en) 1994-12-16

Family

ID=8274654

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9102909A Expired - Lifetime ES2050594B1 (en) 1991-12-31 1991-12-31 PROCEDURE FOR OBTAINING 6-FLUORO-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-QUINOLIN-3-CARBOXYLIC ACIDS SUBSTITUTED IN 1-N.

Country Status (1)

Country Link
ES (1) ES2050594B1 (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5845426B2 (en) * 1978-09-29 1983-10-08 杏林製薬株式会社 Substituted quinoline carboxylic acid derivatives
US4620007A (en) * 1980-09-03 1986-10-28 Bayer Aktiengesellschaft 6-fluoro-7-chloro-1-cyclopropyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid
DE3142854A1 (en) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-CHINOLINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
IT1213173B (en) * 1984-06-04 1989-12-14 Chiesi Farma Spa ANTIBACTERIAL ACTIVITY COMPOUNDS, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS.
ES2010948A6 (en) * 1989-04-27 1989-12-01 Cenavisa S A Bactericidal quinoline carboxylic acid deriv. prepn.

Also Published As

Publication number Publication date
ES2050594A1 (en) 1994-05-16

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