PH12015501100B1 - Novel compounds - Google Patents
Novel compoundsInfo
- Publication number
- PH12015501100B1 PH12015501100B1 PH12015501100A PH12015501100A PH12015501100B1 PH 12015501100 B1 PH12015501100 B1 PH 12015501100B1 PH 12015501100 A PH12015501100 A PH 12015501100A PH 12015501100 A PH12015501100 A PH 12015501100A PH 12015501100 B1 PH12015501100 B1 PH 12015501100B1
- Authority
- PH
- Philippines
- Prior art keywords
- integer
- value
- compounds
- useful
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000014150 Interferons Human genes 0.000 abstract 2
- 108010050904 Interferons Proteins 0.000 abstract 2
- 229940079322 interferon Drugs 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012646 vaccine adjuvant Substances 0.000 abstract 1
- 229940124931 vaccine adjuvant Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728390P | 2012-11-20 | 2012-11-20 | |
| US201361774087P | 2013-03-07 | 2013-03-07 | |
| PCT/US2013/070472 WO2014081645A1 (en) | 2012-11-20 | 2013-11-18 | Novel compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12015501100A1 PH12015501100A1 (en) | 2015-07-27 |
| PH12015501100B1 true PH12015501100B1 (en) | 2017-10-06 |
Family
ID=50776485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12015501100A PH12015501100B1 (en) | 2012-11-20 | 2015-05-18 | Novel compounds |
Country Status (32)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| SI2734186T1 (sl) | 2011-07-22 | 2018-11-30 | Glaxosmithkline Llc | Sestavek |
| UY34987A (es) | 2012-08-24 | 2014-03-31 | Glaxosmithkline Llc | ?nuevos compuestos inductores del interferón humano para el tratamiento de diversos trastornos? |
| JP6216386B2 (ja) | 2012-11-20 | 2017-10-18 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | 新規化合物 |
| SG11201503282RA (en) | 2012-11-20 | 2015-06-29 | Glaxosmithkline Llc | Novel compounds |
| AU2013348217B2 (en) | 2012-11-20 | 2016-10-06 | Glaxosmithkline Llc | Novel compounds |
| RU2676684C2 (ru) * | 2014-02-20 | 2019-01-10 | ГлаксоСмитКлайн Интеллекчуал Проперти (No.2) Лимитед | ПРОИЗВОДНЫЕ ПИРРОЛО[3,2-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНДУКТОРОВ ЧЕЛОВЕЧЕСКОГО ИНТЕРФЕРОНА |
| MX386981B (es) * | 2014-08-15 | 2025-03-19 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Compuestos de pirrolopirimidina usados como agonistas del receptor de tipo toll 7 (tlr7). |
| CN105732635A (zh) * | 2014-12-29 | 2016-07-06 | 南京明德新药研发股份有限公司 | 一类Toll样受体7激动剂 |
| TWI558709B (zh) * | 2015-10-07 | 2016-11-21 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Pyrrolopyrimidine ring compounds, their use and pharmaceutical compositions |
| ES2833927T3 (es) * | 2015-11-05 | 2021-06-16 | Chai Tai Tianqing Pharmaceutical Group Co Ltd | Compuesto de 7-(tiazol-5-il)pirrolopirimidina como agonista de TLR7 |
| CN107043380A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| CN107043378A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
| CN107043379A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的晶型a、其制备方法和医药用途 |
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| SG11201503282RA (en) | 2012-11-20 | 2015-06-29 | Glaxosmithkline Llc | Novel compounds |
| JP6216386B2 (ja) | 2012-11-20 | 2017-10-18 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | 新規化合物 |
| AU2013348217B2 (en) | 2012-11-20 | 2016-10-06 | Glaxosmithkline Llc | Novel compounds |
| RU2676684C2 (ru) | 2014-02-20 | 2019-01-10 | ГлаксоСмитКлайн Интеллекчуал Проперти (No.2) Лимитед | ПРОИЗВОДНЫЕ ПИРРОЛО[3,2-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНДУКТОРОВ ЧЕЛОВЕЧЕСКОГО ИНТЕРФЕРОНА |
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2013
- 2013-11-18 SG SG11201503282RA patent/SG11201503282RA/en unknown
- 2013-11-18 JP JP2015542860A patent/JP6228223B2/ja not_active Expired - Fee Related
- 2013-11-18 KR KR1020157015893A patent/KR20150085055A/ko not_active Withdrawn
- 2013-11-18 PE PE2015000637A patent/PE20151086A1/es active IP Right Grant
- 2013-11-18 EP EP13857477.7A patent/EP2922549B1/en active Active
- 2013-11-18 LT LTEP13857477.7T patent/LT2922549T/lt unknown
- 2013-11-18 UA UAA201504354A patent/UA114645C2/uk unknown
- 2013-11-18 PL PL13857477T patent/PL2922549T3/pl unknown
- 2013-11-18 SM SM20170378T patent/SMT201700378T1/it unknown
- 2013-11-18 HR HRP20171150TT patent/HRP20171150T1/hr unknown
- 2013-11-18 NZ NZ70731913A patent/NZ707319A/en unknown
- 2013-11-18 HU HUE13857477A patent/HUE13857477T2/hu unknown
- 2013-11-18 ES ES13857477.7T patent/ES2639789T3/es active Active
- 2013-11-18 US US14/443,932 patent/US9540383B2/en active Active
- 2013-11-18 SI SI201330751T patent/SI2922549T1/sl unknown
- 2013-11-18 BR BR112015011400A patent/BR112015011400A8/pt not_active Application Discontinuation
- 2013-11-18 EA EA201590684A patent/EA028480B1/ru not_active IP Right Cessation
- 2013-11-18 WO PCT/US2013/070472 patent/WO2014081645A1/en not_active Ceased
- 2013-11-18 CN CN201380060067.8A patent/CN104780922B/zh not_active Expired - Fee Related
- 2013-11-18 RS RS20170841A patent/RS56233B1/sr unknown
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- 2013-11-18 ME MEP-2017-188A patent/ME02867B/me unknown
- 2013-11-18 CA CA2892218A patent/CA2892218A1/en not_active Abandoned
- 2013-11-18 AU AU2013348218A patent/AU2013348218B2/en not_active Ceased
- 2013-11-18 PT PT138574777T patent/PT2922549T/pt unknown
- 2013-11-18 DK DK13857477.7T patent/DK2922549T3/en active
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2015
- 2015-05-13 IL IL238800A patent/IL238800B/en not_active IP Right Cessation
- 2015-05-18 PH PH12015501100A patent/PH12015501100B1/en unknown
- 2015-05-18 CL CL2015001342A patent/CL2015001342A1/es unknown
- 2015-05-20 DO DO2015000121A patent/DOP2015000121A/es unknown
- 2015-05-20 CR CR20150268A patent/CR20150268A/es unknown
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2016
- 2016-12-06 US US15/370,211 patent/US9907847B2/en active Active
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2017
- 2017-08-24 CY CY20171100898T patent/CY1119557T1/el unknown
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2018
- 2018-01-18 US US15/873,996 patent/US20180140695A1/en not_active Abandoned
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