PH12015500547B1 - Non-invasive determination of methylome of fetus or tumor from plasma - Google Patents
Non-invasive determination of methylome of fetus or tumor from plasmaInfo
- Publication number
- PH12015500547B1 PH12015500547B1 PH1/2015/500547A PH12015500547A PH12015500547B1 PH 12015500547 B1 PH12015500547 B1 PH 12015500547B1 PH 12015500547 A PH12015500547 A PH 12015500547A PH 12015500547 B1 PH12015500547 B1 PH 12015500547B1
- Authority
- PH
- Philippines
- Prior art keywords
- methylation
- fetus
- tumor
- dna
- profile
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 210000003754 fetus Anatomy 0.000 title abstract 4
- 230000011987 methylation Effects 0.000 abstract 10
- 238000007069 methylation reaction Methods 0.000 abstract 10
- 230000001605 fetal effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/125—Bisulfite(s)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703512P | 2012-09-20 | 2012-09-20 | |
| US13/842,209 US9732390B2 (en) | 2012-09-20 | 2013-03-15 | Non-invasive determination of methylome of fetus or tumor from plasma |
| US201361830571P | 2013-06-03 | 2013-06-03 | |
| PCT/AU2013/001088 WO2014043763A1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12015500547A1 PH12015500547A1 (en) | 2015-05-04 |
| PH12015500547B1 true PH12015500547B1 (en) | 2024-05-17 |
Family
ID=50340462
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2015/500547A PH12015500547B1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
| PH1/2022/552061A PH12022552061A1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2022/552061A PH12022552061A1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
Country Status (28)
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| ES2665273T5 (es) | 2012-09-20 | 2023-10-02 | Univ Hong Kong Chinese | Determinación no invasiva de metiloma del feto o tumor de plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| ES2685893T3 (es) * | 2013-07-30 | 2018-10-15 | Bgi Genomics Co., Limited | Método para determinar la composición de ácidos nucleicos de una mezcla de ácidos nucleicos |
| US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| WO2015126840A1 (en) * | 2014-02-18 | 2015-08-27 | Bionano Genomics, Inc. | Improved methods of determining nucleic acid structural information |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| CA2945962C (en) * | 2014-04-21 | 2023-08-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| MA39951A (fr) | 2014-05-09 | 2017-03-15 | Lifecodexx Ag | Détection de l'adn provenant d'un type spécifique de cellule et méthodes associées |
| TWI813141B (zh) * | 2014-07-18 | 2023-08-21 | 香港中文大學 | Ｄｎａ混合物中之組織甲基化模式分析 |
| WO2016010401A1 (ko) * | 2014-07-18 | 2016-01-21 | 에스케이텔레콘 주식회사 | 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법 |
| CN107002122B (zh) | 2014-07-25 | 2023-09-19 | 华盛顿大学 | 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法 |
| ES2828279T3 (es) | 2014-12-31 | 2021-05-25 | Guardant Health Inc | Detección y tratamiento de enfermedades que muestran heterogeneidad celular de enfermedad y sistemas y métodos para comunicar los resultados de las pruebas |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| CA2976303A1 (en) | 2015-02-10 | 2016-08-18 | The Chinese University Of Hong Kong | Detecting mutations for cancer screening and fetal analysis |
| EP3325663B1 (en) | 2015-07-20 | 2020-08-19 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| EP3325664B1 (en) | 2015-07-23 | 2021-12-29 | The Chinese University Of Hong Kong | Analysis of fragmentation patterns of cell-free dna |
| HK1248286A1 (zh) | 2015-08-12 | 2018-10-12 | The Chinese University Of Hong Kong | 血浆dna的单分子测序 |
| IL293187B2 (en) | 2015-09-22 | 2024-03-01 | Univ Hong Kong Chinese | Accurate quantification of fetal dna fraction by shallow-depth sequencing of maternal plasma dna |
| US10260088B2 (en) * | 2015-10-30 | 2019-04-16 | New England Biolabs, Inc. | Compositions and methods for analyzing modified nucleotides |
| EP4180532A1 (en) * | 2015-11-09 | 2023-05-17 | Roche Molecular Systems, Inc. | Methods for determining the origin of dna molecules |
| HUE050491T2 (hu) | 2015-11-10 | 2020-12-28 | Eurofins Lifecodexx Gmbh | Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között |
| AU2016370835B2 (en) | 2015-12-17 | 2020-02-13 | Illumina, Inc. | Distinguishing methylation levels in complex biological samples |
| CN109072309B (zh) * | 2016-02-02 | 2023-05-16 | 夸登特健康公司 | 癌症进化检测和诊断 |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| US11078475B2 (en) * | 2016-05-03 | 2021-08-03 | Sinai Health System | Methods of capturing cell-free methylated DNA and uses of same |
| US12300356B2 (en) | 2016-05-04 | 2025-05-13 | Queen's University At Kingston | Cell-free detection of methylated tumour DNA |
| CN115161390B (zh) | 2016-05-30 | 2025-12-05 | 香港中文大学 | 使用血液中的无细胞dna检测血液病症 |
| AU2017285496B2 (en) * | 2016-06-16 | 2023-02-23 | The Johns Hopkins University | Methods and system for epigenetic analysis |
| US11999998B2 (en) | 2016-08-24 | 2024-06-04 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Modification of 5-methylcytosine catalyzed by Cmd1 enzyme and application thereof |
| MY205940A (en) * | 2016-10-19 | 2024-11-21 | Univ Hong Kong Chinese | Gestational age assessment by methylation and size profiling of maternal plasma dna |
| SG11201903509QA (en) | 2016-10-24 | 2019-05-30 | Univ Hong Kong Chinese | Methods and systems for tumor detection |
| IL315032A (en) * | 2016-11-30 | 2024-10-01 | Univ Hong Kong Chinese | Analysis of cell-free dna in urine and other samples |
| WO2018112100A2 (en) * | 2016-12-13 | 2018-06-21 | Bellwether Bio, Inc. | Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample |
| CA3049442A1 (en) * | 2017-01-11 | 2018-07-19 | Quest Diagnostics Investments Llc | Method for non-invasive prenatal screening for aneuploidy |
| CN110191964B (zh) * | 2017-01-24 | 2023-12-05 | 深圳华大基因股份有限公司 | 确定生物样本中预定来源的游离核酸比例的方法及装置 |
| MY197535A (en) | 2017-01-25 | 2023-06-21 | Univ Hong Kong Chinese | Diagnostic applications using nucleic acid fragments |
| CN107247873B (zh) * | 2017-03-29 | 2020-04-14 | 电子科技大学 | 一种差异甲基化位点识别方法 |
| CA3063405A1 (en) * | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Universal early cancer diagnostics |
| CA3069668A1 (en) * | 2017-07-12 | 2019-01-17 | Ande Corporation | Pattern recognition system |
| BR112020000681A2 (pt) * | 2017-07-12 | 2020-07-14 | University Health Network | detecção e classificação de cancro utilizando análise de metilome |
| US12227737B2 (en) | 2017-07-12 | 2025-02-18 | University Health Network | Cancer detection and classification using methylome analysis |
| ES2959360T3 (es) * | 2017-07-26 | 2024-02-23 | Univ Hong Kong Chinese | Mejora del cribado del cáncer mediante ácidos nucleicos víricos acelulares |
| US20200263170A1 (en) | 2017-09-14 | 2020-08-20 | Grail, Inc. | Methods for preparing a sequencing library from single-stranded dna |
| EP4026915B1 (en) | 2017-09-28 | 2023-10-25 | Grail, LLC | Enrichment of short nucleic acid fragments in sequencing library preparation |
| US11168356B2 (en) * | 2017-11-02 | 2021-11-09 | The Chinese University Of Hong Kong | Using nucleic acid size range for noninvasive cancer detection |
| CN111989407B (zh) | 2018-03-13 | 2024-10-29 | 格里尔公司 | 异常的片段检测及分类 |
| SG11202008957VA (en) * | 2018-03-15 | 2020-10-29 | Grail Inc | Tissue-specific methylation marker |
| CN112236520B (zh) | 2018-04-02 | 2025-01-24 | 格里尔公司 | 甲基化标记和标靶甲基化探针板 |
| US11681953B2 (en) * | 2018-04-13 | 2023-06-20 | Freenome Holdings, Inc. | Machine learning implementation for multi-analyte assay development and testing |
| EP3781709A4 (en) * | 2018-04-16 | 2022-11-30 | Grail, LLC | Systems and methods for determining tumor fraction in cell-free nucleic acid |
| WO2019209884A1 (en) | 2018-04-23 | 2019-10-31 | Grail, Inc. | Methods and systems for screening for conditions |
| US11932899B2 (en) * | 2018-06-07 | 2024-03-19 | 10X Genomics, Inc. | Methods and systems for characterizing nucleic acid molecules |
| CN109448789A (zh) * | 2018-09-17 | 2019-03-08 | 上海派森诺生物科技股份有限公司 | 一种基于perl语言的种群特异SNP位点的自动化分析方法 |
| CA3111887A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
| CN109295230A (zh) * | 2018-10-24 | 2019-02-01 | 福建翊善生物科技有限公司 | 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法 |
| GB2615955B (en) | 2018-11-21 | 2023-11-22 | Agilent Technologies Inc | Methods for targeted nucleic acid library formation |
| DK3899018T3 (da) * | 2018-12-19 | 2024-01-08 | Univ Hong Kong Chinese | Cellefri DNA-endeegenskaber |
| WO2020132572A1 (en) | 2018-12-21 | 2020-06-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free-dna samples |
| ES2994567T3 (en) | 2019-02-05 | 2025-01-27 | Grail Inc | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| WO2020163410A1 (en) | 2019-02-05 | 2020-08-13 | Grail, Inc. | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| CN114072527B (zh) | 2019-03-25 | 2025-03-04 | 香港中文大学 | 确定循环核酸的线性和环状形式 |
| US11773450B2 (en) | 2019-04-03 | 2023-10-03 | Grail, Llc | Methylation-based false positive duplicate marking reduction |
| US20220243263A1 (en) * | 2019-05-03 | 2022-08-04 | Cornell University | Markers for identifying and quantifying of nucleic acid sequence mutation, expression, splice variant, translocation, copy number, or methylation changes |
| KR102452413B1 (ko) * | 2019-08-19 | 2022-10-11 | 주식회사 지씨지놈 | 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법 |
| EP4020484A4 (en) * | 2019-08-19 | 2023-08-30 | Green Cross Genome Corporation | METHOD FOR DETECTING A CHROMOSOME ABNORMALITY USING INFORMATION CONCERNING THE DISTANCE BETWEEN NUCLEIC ACID FRAGMENTS |
| GB201915469D0 (en) | 2019-10-24 | 2019-12-11 | Univ London | Cancer detection methods |
| CN115836349A (zh) * | 2019-11-27 | 2023-03-21 | 格里尔公司 | 用于评估纵向生物特征数据的系统和方法 |
| JP7732991B2 (ja) | 2020-01-31 | 2025-09-02 | アジレント・テクノロジーズ・インク | 標的化された核酸捕捉のためのシステムおよび方法 |
| KR20220148196A (ko) * | 2020-02-10 | 2022-11-04 | 팔로젠 인코포레이티드 | 나노포어 디바이스 및 이를 사용하여 하전된 입자들을 검출하고 분류하는 방법 |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| WO2021174072A1 (en) * | 2020-02-28 | 2021-09-02 | Grail, Inc. | Identifying methylation patterns that discriminate or indicate a cancer condition |
| CN112662764A (zh) * | 2020-03-17 | 2021-04-16 | 博尔诚（北京）科技有限公司 | 一种检测11种癌症的探针组合物 |
| RU2738675C1 (ru) * | 2020-07-28 | 2020-12-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов |
| EP4247973A4 (en) * | 2020-11-19 | 2024-09-11 | Nucleix Ltd. | DETECTION OF METHYLATION CHANGES IN DNA SAMPLES USING RESTRICTION ENZYMES AND HIGH-THROUGHPUT SEQUENCING |
| AU2021401813A1 (en) * | 2020-12-17 | 2023-07-06 | Dana-Farber Cancer Institute, Inc. | Methods of cancer detection using extraembryonically methylated cpg islands |
| CN112813148A (zh) * | 2021-02-02 | 2021-05-18 | 博淼生物科技（北京）有限公司 | 飞行时间质谱检测5-羟甲基胞嘧啶的方法 |
| US20240371467A1 (en) * | 2021-09-28 | 2024-11-07 | Act Genomics (ip) Limited | Methylation biomarker selection apparatuses and methods |
| KR20230059423A (ko) * | 2021-10-26 | 2023-05-03 | 주식회사 지씨지놈 | 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법 |
| EP4384633A1 (en) * | 2021-11-04 | 2024-06-19 | Universal Diagnostics, S.A. | Systems and methods for preparing biological samples for genetic sequencing |
| IL314466A (en) | 2022-02-07 | 2024-09-01 | Centre For Novostics | Fragmentation for measuring methylation and disease |
| EP4482985A2 (en) * | 2022-02-22 | 2025-01-01 | Flagship Pioneering Innovations VI, LLC | Intra-individual analysis for presence of health conditions |
| CN115064211B (zh) * | 2022-08-15 | 2023-01-24 | 臻和(北京)生物科技有限公司 | 一种基于全基因组甲基化测序的ctDNA预测方法及装置 |
| CN115612723B (zh) * | 2022-09-26 | 2023-07-14 | 广州女娲生命科技有限公司 | 植入前胚胎的筛选方法 |
| WO2024203348A1 (ja) * | 2023-03-31 | 2024-10-03 | ソニーグループ株式会社 | 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法 |
| CN116555426B (zh) * | 2023-05-04 | 2024-07-12 | 杭州圣庭医疗科技有限公司 | 一种鉴定肿瘤组织来源的试剂盒及数据分析方法 |
| CN117025753A (zh) * | 2023-08-15 | 2023-11-10 | 广州女娲生命科技有限公司 | 检测染色体变异的方法和装置 |
| CN117079822B (zh) * | 2023-10-17 | 2024-01-02 | 北京大学第三医院（北京大学第三临床医学院） | 一种妊娠早中期四因子预测胎儿脑损伤的系统 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| DE60207979T2 (de) † | 2002-03-05 | 2006-09-28 | Epigenomics Ag | Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten |
| CA2506243A1 (en) † | 2002-11-19 | 2004-06-03 | Amgen Inc. | Amplified genes involved in cancer |
| US20060183128A1 (en) † | 2003-08-12 | 2006-08-17 | Epigenomics Ag | Methods and compositions for differentiating tissues for cell types using epigenetic markers |
| DE10348407A1 (de) | 2003-10-17 | 2005-05-19 | Widschwendter, Martin, Prof. | Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben |
| CA2559209C (en) * | 2004-03-08 | 2016-06-07 | Rubicon Genomics, Inc. | Methods and compositions for generating and amplifying dna libraries for sensitive detection and analysis of dna methylation |
| WO2006128192A2 (en) | 2005-05-27 | 2006-11-30 | John Wayne Cancer Institute | Use of free circulating dna for diagnosis, prognosis, and treatment of cancer |
| US7901884B2 (en) * | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
| US7754428B2 (en) | 2006-05-03 | 2010-07-13 | The Chinese University Of Hong Kong | Fetal methylation markers |
| TWI335354B (en) * | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| EP2173897A2 (en) | 2007-06-19 | 2010-04-14 | Oncomethylome Sciences SA | Improved urine sample collecting and processing |
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| JP4347372B2 (ja) | 2007-08-10 | 2009-10-21 | トヨタ自動車株式会社 | 静電塗装装置 |
| US20110028333A1 (en) * | 2009-05-01 | 2011-02-03 | Brown University | Diagnosing, prognosing, and early detection of cancers by dna methylation profiling |
| US8563242B2 (en) * | 2009-08-11 | 2013-10-22 | The Chinese University Of Hong Kong | Method for detecting chromosomal aneuploidy |
| US20120208711A1 (en) | 2009-10-02 | 2012-08-16 | Centre For Addiction And Mental Health | Method for Analysis of DNA Methylation Profiles of Cell-Free Circulating DNA in Bodily Fluids |
| CN102770558B (zh) * | 2009-11-05 | 2016-04-06 | 香港中文大学 | 由母本生物样品进行胎儿基因组的分析 |
| CA2780016C (en) | 2009-11-06 | 2017-09-19 | The Chinese University Of Hong Kong | Size-based genomic analysis |
| CA2786564A1 (en) † | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
| JP2013517789A (ja) * | 2010-01-26 | 2013-05-20 | ニプド ジェネティクス リミテッド | 胎児異数性の非侵襲性出生前診断の方法および組成物 |
| KR101903547B1 (ko) † | 2010-04-29 | 2018-10-04 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 게놈 모델에 대한 데이터 통합을 이용하는 경로 인지 알고리즘 （ｐａｒａｄｉｇｍ） |
| GB201007944D0 (en) * | 2010-05-12 | 2010-06-30 | Univ Aberystwyth | Methods |
| US10167513B2 (en) | 2010-05-25 | 2019-01-01 | The Johns Hopkins University | Compositions and methods for detecting a neoplasia |
| MX361944B (es) * | 2010-07-23 | 2018-12-19 | President And Fellows Of Harvard College Star | Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales. |
| US20120021919A1 (en) * | 2010-07-23 | 2012-01-26 | Thomas Scholl | Identification of Differentially Represented Fetal or Maternal Genomic Regions and Uses Thereof |
| WO2012031329A1 (en) * | 2010-09-10 | 2012-03-15 | Murdoch Childrens Research Institute | Assay for detection and monitoring of cancer |
| KR102040307B1 (ko) † | 2010-11-30 | 2019-11-27 | 더 차이니즈 유니버시티 오브 홍콩 | 암과 연관된 유전적 또는 분자적 이상들의 검출 |
| ES2665273T5 (es) * | 2012-09-20 | 2023-10-02 | Univ Hong Kong Chinese | Determinación no invasiva de metiloma del feto o tumor de plasma |
-
2013
- 2013-09-20 ES ES13838770T patent/ES2665273T5/es active Active
- 2013-09-20 JP JP2015532250A patent/JP6317354B2/ja active Active
- 2013-09-20 PT PT138387709T patent/PT2898100T/pt unknown
- 2013-09-20 SG SG10201705198UA patent/SG10201705198UA/en unknown
- 2013-09-20 MY MYPI2015000628A patent/MY173356A/en unknown
- 2013-09-20 CA CA3122779A patent/CA3122779A1/en active Pending
- 2013-09-20 ES ES17202149T patent/ES2862726T3/es active Active
- 2013-09-20 HR HRP20240210TT patent/HRP20240210T1/hr unknown
- 2013-09-20 LT LTEP22171427.2T patent/LT4056712T/lt unknown
- 2013-09-20 PT PT191716307T patent/PT3536807T/pt unknown
- 2013-09-20 DK DK19171630.7T patent/DK3536807T3/da active
- 2013-09-20 EP EP13838770.9A patent/EP2898100B9/en active Active
- 2013-09-20 CN CN201380058654.3A patent/CN104781422B/zh active Active
- 2013-09-20 FI FIEP19171630.7T patent/FI3536807T3/fi active
- 2013-09-20 EP EP17202149.5A patent/EP3354747B1/en not_active Revoked
- 2013-09-20 PL PL22171427.2T patent/PL4056712T3/pl unknown
- 2013-09-20 PT PT221714272T patent/PT4056712T/pt unknown
- 2013-09-20 CN CN202311671688.1A patent/CN117757932A/zh active Pending
- 2013-09-20 DK DK13838770.9T patent/DK2898100T4/da active
- 2013-09-20 PL PL17202149T patent/PL3354747T3/pl unknown
- 2013-09-20 PH PH1/2015/500547A patent/PH12015500547B1/en unknown
- 2013-09-20 PL PL19171630.7T patent/PL3536807T3/pl unknown
- 2013-09-20 HU HUE19171630A patent/HUE066054T2/hu unknown
- 2013-09-20 ES ES22171427T patent/ES2994426T3/es active Active
- 2013-09-20 PT PT172021495T patent/PT3354747T/pt unknown
- 2013-09-20 EP EP19171630.7A patent/EP3536807B1/en active Active
- 2013-09-20 NZ NZ717423A patent/NZ717423A/en unknown
- 2013-09-20 HR HRP20241142TT patent/HRP20241142T1/hr unknown
- 2013-09-20 LT LTEP17202149.5T patent/LT3354747T/lt unknown
- 2013-09-20 WO PCT/AU2013/001088 patent/WO2014043763A1/en not_active Ceased
- 2013-09-20 SG SG11201501927VA patent/SG11201501927VA/en unknown
- 2013-09-20 KR KR1020157010184A patent/KR102148547B1/ko active Active
- 2013-09-20 SM SM20210256T patent/SMT202100256T1/it unknown
- 2013-09-20 EA EA201500327A patent/EA201500327A1/ru unknown
- 2013-09-20 MY MYPI2018000607A patent/MY187444A/en unknown
- 2013-09-20 CA CA2884066A patent/CA2884066C/en active Active
- 2013-09-20 PH PH1/2022/552061A patent/PH12022552061A1/en unknown
- 2013-09-20 AU AU2013317708A patent/AU2013317708C1/en active Active
- 2013-09-20 HU HUE17202149A patent/HUE053822T2/hu unknown
- 2013-09-20 ES ES19171630T patent/ES2969567T3/es active Active
- 2013-09-20 KR KR1020217030373A patent/KR102390711B1/ko active Active
- 2013-09-20 BR BR122021021825-0A patent/BR122021021825B1/pt active IP Right Grant
- 2013-09-20 IL IL313451A patent/IL313451A/en unknown
- 2013-09-20 KR KR1020207019527A patent/KR102307424B1/ko active Active
- 2013-09-20 DK DK22171427.2T patent/DK4056712T3/da active
- 2013-09-20 NZ NZ706269A patent/NZ706269A/en unknown
- 2013-09-20 HU HUE22171427A patent/HUE068129T2/hu unknown
- 2013-09-20 EP EP22171427.2A patent/EP4056712B1/en active Active
- 2013-09-20 MX MX2015003571A patent/MX360034B/es active IP Right Grant
- 2013-09-20 KR KR1020227013227A patent/KR102587176B1/ko active Active
- 2013-09-20 FI FIEP22171427.2T patent/FI4056712T3/fi active
- 2013-09-20 DK DK17202149.5T patent/DK3354747T3/da active
- 2013-09-20 EP EP24153604.4A patent/EP4335929A3/en active Pending
- 2013-09-20 PL PL13838770.9T patent/PL2898100T5/pl unknown
- 2013-09-20 KR KR1020237033920A patent/KR20230145530A/ko not_active Ceased
- 2013-09-20 BR BR122021021823-4A patent/BR122021021823B1/pt active IP Right Grant
- 2013-09-20 IL IL299444A patent/IL299444B2/en unknown
- 2013-09-20 SI SI201332088T patent/SI4056712T1/sl unknown
- 2013-09-20 BR BR112015006183-4A patent/BR112015006183B1/pt active IP Right Grant
- 2013-09-20 EP EP21151739.6A patent/EP3839065A1/en active Pending
- 2013-09-23 TW TW111119079A patent/TWI806621B/zh active
- 2013-09-23 TW TW102134227A patent/TWI640634B/zh active
- 2013-09-23 TW TW109112451A patent/TWI784258B/zh active
- 2013-09-23 TW TW107123815A patent/TWI707953B/zh active
-
2015
- 2015-03-02 IL IL237495A patent/IL237495B/en active IP Right Grant
- 2015-03-16 ZA ZA2015/01772A patent/ZA201501772B/en unknown
-
2017
- 2017-10-27 AU AU2017251832A patent/AU2017251832B2/en active Active
-
2018
- 2018-03-28 JP JP2018061744A patent/JP6683752B2/ja active Active
-
2019
- 2019-08-05 IL IL268512A patent/IL268512B2/en unknown
-
2020
- 2020-01-08 AU AU2020200128A patent/AU2020200128B2/en active Active
- 2020-03-26 JP JP2020055387A patent/JP6985753B2/ja active Active
-
2021
- 2021-05-07 HR HRP20210716TT patent/HRP20210716T1/hr unknown
- 2021-05-14 CY CY20211100417T patent/CY1124139T1/el unknown
- 2021-11-18 JP JP2021188060A patent/JP2022031753A/ja active Pending
-
2022
- 2022-02-16 AU AU2022201026A patent/AU2022201026B2/en active Active
-
2023
- 2023-09-28 JP JP2023167714A patent/JP7594817B2/ja active Active
-
2024
- 2024-11-18 JP JP2024200780A patent/JP2025026936A/ja active Pending
-
2025
- 2025-07-03 AU AU2025205087A patent/AU2025205087A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12015500547B1 (en) | Non-invasive determination of methylome of fetus or tumor from plasma | |
| Vachon et al. | Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk | |
| MY205940A (en) | Gestational age assessment by methylation and size profiling of maternal plasma dna | |
| WO2013132305A8 (en) | Size-based analysis of fetal dna fraction in maternal plasma | |
| AU2019229353A1 (en) | Mutant calreticulin for the diagnosis of myeloid malignancies | |
| MX2014000116A (es) | Metodos y acidos nucleicos para determinar el pronostico de un sujeto con cancer. | |
| EP4484572A3 (en) | Identification and use of circulating nucleic acid tumor markers | |
| WO2013025952A3 (en) | Methods and compositions for the treatment and diagnosis of breast cancer | |
| BR112012022802A2 (pt) | uso de um inibidor de erbb3, e, método de supressão de crescimento de uma célula e de um tumor de câncer de mama | |
| BR112012018458A2 (pt) | métodos e composições para diagnóstico pré-natal não invasivo de aneuploidias fetais | |
| EP3683320A3 (en) | Mirna fingerprint in the diagnosis of lung cancer | |
| WO2012174256A3 (en) | Dna methylation profiles in cancer | |
| AU2014205038A8 (en) | Noninvasive prenatal molecular karyotyping from maternal plasma | |
| WO2014201092A8 (en) | Non-invasive blood based monitoring of genomic alterations in cancer | |
| MX2019012260A (es) | Metodos de analisis mutacional y de metilacion del adn para vigilancia del cancer de vejiga. | |
| MX2017015210A (es) | Composiciones y metodos para el cribado de tumores solidos. | |
| BR112013006683A2 (pt) | diagnóstico de câncer de mama | |
| EP4246144A3 (en) | Compositions and methods for screening mutations in thyroid cancer | |
| MX369028B (es) | Anti-progestinas para ser usadas en un metodo para inhibir el crecimiento de un tumor susceptible a inhibición del crecimiento por anti-progestinas. | |
| NZ748624A (en) | Methods of selecting an individual who will benefit from treatment with a telomerase inhibitor using a formalin fixed paraffin embedded (ffpe) biological sample of solid tumor cancer cells | |
| WO2013169771A3 (en) | Methods and compositions for the prognosis and treatment of relapsed leukemia | |
| MX382589B (es) | Determinación no invasiva del metiloma fetal o de tumor de plasma. | |
| WO2016018524A8 (en) | E2f4 signature for use in diagnosing and treating breast and bladder cancer | |
| WO2019103421A3 (ko) | 유전자의 cpg 메틸화 변화를 이용한 간암의 예후 또는 위험도를 평가하는 방법 | |
| PH12012502578A1 (en) | Quinazoline compounds |