EA201500327A1 - Неинвазивное определение метилома плода или опухоли по плазме - Google Patents
Неинвазивное определение метилома плода или опухоли по плазмеInfo
- Publication number
- EA201500327A1 EA201500327A1 EA201500327A EA201500327A EA201500327A1 EA 201500327 A1 EA201500327 A1 EA 201500327A1 EA 201500327 A EA201500327 A EA 201500327A EA 201500327 A EA201500327 A EA 201500327A EA 201500327 A1 EA201500327 A1 EA 201500327A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methylation
- fetal
- tumor
- dna
- determined
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 230000001605 fetal effect Effects 0.000 title abstract 6
- 230000011987 methylation Effects 0.000 abstract 10
- 238000007069 methylation reaction Methods 0.000 abstract 10
- 238000000034 method Methods 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/125—Bisulfite(s)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
- C12Q2535/122—Massive parallel sequencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703512P | 2012-09-20 | 2012-09-20 | |
| US13/842,209 US9732390B2 (en) | 2012-09-20 | 2013-03-15 | Non-invasive determination of methylome of fetus or tumor from plasma |
| US201361830571P | 2013-06-03 | 2013-06-03 | |
| PCT/AU2013/001088 WO2014043763A1 (en) | 2012-09-20 | 2013-09-20 | Non-invasive determination of methylome of fetus or tumor from plasma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201500327A1 true EA201500327A1 (ru) | 2015-07-30 |
Family
ID=50340462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201500327A EA201500327A1 (ru) | 2012-09-20 | 2013-09-20 | Неинвазивное определение метилома плода или опухоли по плазме |
Country Status (28)
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101153336B (zh) | 2006-09-27 | 2011-09-07 | 香港中文大学 | 检测dna甲基化程度的方法和试剂盒 |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| EP2898100B9 (en) | 2012-09-20 | 2023-08-02 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3029148B1 (en) * | 2013-07-30 | 2018-06-27 | BGI Genomics Co., Limited | Method for determining nucleic acid composition of nucleic acid mixture |
| US10174375B2 (en) * | 2013-09-20 | 2019-01-08 | The Chinese University Of Hong Kong | Sequencing analysis of circulating DNA to detect and monitor autoimmune diseases |
| WO2015126840A1 (en) * | 2014-02-18 | 2015-08-27 | Bionano Genomics, Inc. | Improved methods of determining nucleic acid structural information |
| US12492429B2 (en) | 2014-04-21 | 2025-12-09 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| JP6659575B2 (ja) * | 2014-04-21 | 2020-03-04 | ナテラ， インコーポレイテッド | 変異の検出および染色体分節の倍数性 |
| EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| WO2015169947A1 (en) | 2014-05-09 | 2015-11-12 | Lifecodexx Ag | Detection of dna that originates from a specific cell-type and related methods |
| WO2016010401A1 (ko) * | 2014-07-18 | 2016-01-21 | 에스케이텔레콘 주식회사 | 산모의 혈청 dna를 이용한 태아의 단일유전자 유전변이의 예측방법 |
| HUE056267T2 (hu) | 2014-07-18 | 2022-02-28 | Univ Hong Kong Chinese | DNS-keverékek szöveteinek metilációs mintázatelemzése |
| JP2017522908A (ja) | 2014-07-25 | 2017-08-17 | ユニヴァーシティ オブ ワシントン | セルフリーｄｎａを生じる組織及び／又は細胞タイプを決定する方法、並びにそれを用いて疾患又は異常を識別する方法 |
| EP3240911B1 (en) * | 2014-12-31 | 2020-08-26 | Guardant Health, Inc. | Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| DK3256605T3 (da) | 2015-02-10 | 2022-03-14 | Univ Hong Kong Chinese | Påvisning af mutationer til cancerscreening og føtal analyse |
| EP3739061B1 (en) | 2015-07-20 | 2022-03-23 | The Chinese University Of Hong Kong | Methylation pattern analysis of haplotypes in tissues in dna mixture |
| ES2960201T3 (es) * | 2015-07-23 | 2024-03-01 | Univ Hong Kong Chinese | Análisis de los patrones de fragmentación del ADN acelular |
| MY188348A (en) | 2015-08-12 | 2021-12-02 | Univ Hong Kong Chinese | Single-molecule sequencing of plasma dna |
| TWI858334B (zh) | 2015-09-22 | 2024-10-11 | 香港中文大學 | 藉由母體血漿ｄｎａ之淺深度測序以準確定量胎兒dna含量 |
| US10260088B2 (en) * | 2015-10-30 | 2019-04-16 | New England Biolabs, Inc. | Compositions and methods for analyzing modified nucleotides |
| CA3004527A1 (en) * | 2015-11-09 | 2017-05-18 | Progenity, Inc. | Methods for determining the origin of dna molecules |
| HUE050491T2 (hu) | 2015-11-10 | 2020-12-28 | Eurofins Lifecodexx Gmbh | Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között |
| EP4648053A2 (en) * | 2015-12-17 | 2025-11-12 | Illumina, Inc. | Distinguishing methylation levels in complex biological samples |
| SG11201806609TA (en) * | 2016-02-02 | 2018-09-27 | Guardant Health Inc | Cancer evolution detection and diagnostic |
| US11514289B1 (en) | 2016-03-09 | 2022-11-29 | Freenome Holdings, Inc. | Generating machine learning models using genetic data |
| EP4425178A3 (en) * | 2016-05-03 | 2024-12-18 | University Health Network | Methods of capturing cell-free methylated dna and uses of same |
| WO2017201606A1 (en) * | 2016-05-04 | 2017-11-30 | Queen's University At Kingston | Cell-free detection of methylated tumour dna |
| IL303115B2 (en) * | 2016-05-30 | 2025-09-01 | Univ Hong Kong Chinese | Detection of hematological disorders using cell-free DNA in blood |
| EP3472358B1 (en) * | 2016-06-16 | 2021-08-18 | The Johns Hopkins University | Methods and system for epigenetic analysis |
| CN107779485B (zh) | 2016-08-24 | 2022-03-18 | 中国科学院分子细胞科学卓越创新中心 | Cmd1酶催化的5-甲基胞嘧啶核酸的新修饰及其应用 |
| MY205940A (en) * | 2016-10-19 | 2024-11-21 | Univ Hong Kong Chinese | Gestational age assessment by methylation and size profiling of maternal plasma dna |
| CA3041647A1 (en) | 2016-10-24 | 2018-05-03 | The Chinese University Of Hong Kong | Methods and systems for tumor detection |
| JP2020503003A (ja) | 2016-11-30 | 2020-01-30 | ザ チャイニーズ ユニバーシティ オブ ホンコン | 尿および他のサンプルにおける無細胞ｄｎａの分析 |
| EP4450648A3 (en) * | 2016-12-13 | 2025-01-15 | Bellwether Bio, Inc. | Determining a physiological condition in an individual by analyzing cell-free dna fragment endpoints in a biological sample |
| US20200255896A1 (en) * | 2017-01-11 | 2020-08-13 | Quest Diagnostics Investments Llc | Method for non-invasive prenatal screening for aneuploidy |
| HRP20240709T1 (hr) * | 2017-01-24 | 2024-08-16 | Bgi Genomics Co., Ltd. | Postupak za određivanje udjela nukleinskih kiselina bez stanica iz unaprijed određenog izvora u biološkom uzorku |
| US10633713B2 (en) | 2017-01-25 | 2020-04-28 | The Chinese University Of Hong Kong | Diagnostic applications using nucleic acid fragments |
| CN107247873B (zh) * | 2017-03-29 | 2020-04-14 | 电子科技大学 | 一种差异甲基化位点识别方法 |
| JP7368235B2 (ja) * | 2017-05-12 | 2023-10-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ユニバーサル早期がん診断 |
| CN118782138A (zh) * | 2017-07-12 | 2024-10-15 | 安德股份有限公司 | 模式识别系统 |
| US12227737B2 (en) | 2017-07-12 | 2025-02-18 | University Health Network | Cancer detection and classification using methylome analysis |
| WO2019010564A1 (en) * | 2017-07-12 | 2019-01-17 | University Health Network | DETECTION AND CLASSIFICATION OF CANCER USING METHYLOME ANALYSIS |
| DK3658684T3 (da) | 2017-07-26 | 2023-10-09 | Univ Hong Kong Chinese | Forbedring af cancerscreening ved hjælp af cellefrie, virale nukleinsyrer |
| US20200263170A1 (en) | 2017-09-14 | 2020-08-20 | Grail, Inc. | Methods for preparing a sequencing library from single-stranded dna |
| EP4269583B1 (en) | 2017-09-28 | 2025-12-31 | Grail, Inc. | ENRICHEMENT OF SHORT NUCLEIC ACID FRAGMENTS IN SEQUENCING BANK PREPARATION |
| US11168356B2 (en) * | 2017-11-02 | 2021-11-09 | The Chinese University Of Hong Kong | Using nucleic acid size range for noninvasive cancer detection |
| TW202434742A (zh) | 2018-03-13 | 2024-09-01 | 美商格瑞爾有限責任公司 | 異常片段偵測及分類 |
| CA3093971A1 (en) * | 2018-03-15 | 2019-09-19 | Grail, Inc. | Tissue-specific methylation marker |
| GB2587939B (en) | 2018-04-02 | 2023-06-14 | Grail Llc | Methylation markers and targeted methylation probe panels |
| EP3776381A4 (en) * | 2018-04-13 | 2022-01-05 | Freenome Holdings, Inc. | IMPLEMENTATION OF MACHINE LEARNING FOR MULTI-ANALYTE TESTS OF BIOLOGICAL SAMPLES |
| EP3781709A4 (en) * | 2018-04-16 | 2022-11-30 | Grail, LLC | Systems and methods for determining tumor fraction in cell-free nucleic acid |
| WO2019209884A1 (en) | 2018-04-23 | 2019-10-31 | Grail, Inc. | Methods and systems for screening for conditions |
| US11932899B2 (en) * | 2018-06-07 | 2024-03-19 | 10X Genomics, Inc. | Methods and systems for characterizing nucleic acid molecules |
| CN109448789A (zh) * | 2018-09-17 | 2019-03-08 | 上海派森诺生物科技股份有限公司 | 一种基于perl语言的种群特异SNP位点的自动化分析方法 |
| CN113286881A (zh) | 2018-09-27 | 2021-08-20 | 格里尔公司 | 甲基化标记和标靶甲基化探针板 |
| CN109295230A (zh) * | 2018-10-24 | 2019-02-01 | 福建翊善生物科技有限公司 | 一种基于ctDNA的多基因联合突变检测评估肿瘤动态变化的方法 |
| AU2019384154B2 (en) | 2018-11-21 | 2025-11-20 | Agilent Technologies, Inc. | Methods for targeted nucleic acid library formation |
| KR20210113237A (ko) * | 2018-12-19 | 2021-09-15 | 더 차이니즈 유니버시티 오브 홍콩 | 무 세포 dna 말단 특성 |
| US12234514B2 (en) | 2018-12-21 | 2025-02-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free DNA samples |
| WO2020163410A1 (en) | 2019-02-05 | 2020-08-13 | Grail, Inc. | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| EP3921445B1 (en) | 2019-02-05 | 2024-09-04 | Grail, Inc. | Detecting cancer, cancer tissue of origin, and/or a cancer cell type |
| US12098429B2 (en) | 2019-03-25 | 2024-09-24 | The Chinese University Of Hong Kong | Determining linear and circular forms of circulating nucleic acids |
| US11773450B2 (en) | 2019-04-03 | 2023-10-03 | Grail, Llc | Methylation-based false positive duplicate marking reduction |
| US20220243263A1 (en) * | 2019-05-03 | 2022-08-04 | Cornell University | Markers for identifying and quantifying of nucleic acid sequence mutation, expression, splice variant, translocation, copy number, or methylation changes |
| CA3147613A1 (en) * | 2019-08-19 | 2021-02-25 | Chang-Seok Ki | Method for detecting chromosomal abnormality by using information about distance between nucleic acid fragments |
| KR102452413B1 (ko) * | 2019-08-19 | 2022-10-11 | 주식회사 지씨지놈 | 핵산 단편간 거리 정보를 이용한 염색체 이상 검출 방법 |
| GB201915469D0 (en) | 2019-10-24 | 2019-12-11 | Univ London | Cancer detection methods |
| CA3158101A1 (en) * | 2019-11-27 | 2021-06-03 | M. Cyrus MAHER | Systems and methods for evaluating longitudinal biological feature data |
| EP4097231B1 (en) | 2020-01-31 | 2025-03-19 | Agilent Technologies, Inc. | Systems and methods for targeted nucleic acid capture |
| EP4103740A1 (en) * | 2020-02-10 | 2022-12-21 | Palogen, Inc. | Nanopore device and methods of detecting and classifying charged particles using same |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| CN115443507A (zh) * | 2020-02-28 | 2022-12-06 | 格里尔公司 | 鉴定可鉴别或指示癌症病状的甲基化模式 |
| CN112662764A (zh) * | 2020-03-17 | 2021-04-16 | 博尔诚（北京）科技有限公司 | 一种检测11种癌症的探针组合物 |
| RU2738675C1 (ru) * | 2020-07-28 | 2020-12-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Способ прогнозирования риска развития преэклампсии у женщин без отягощенного семейного анамнеза с учетом генетических факторов |
| CN116848262A (zh) * | 2020-11-19 | 2023-10-03 | 纽克莱克斯有限公司 | 使用限制性酶和高通量测序检测dna样品中的甲基化改变 |
| AU2021401813A1 (en) * | 2020-12-17 | 2023-07-06 | Dana-Farber Cancer Institute, Inc. | Methods of cancer detection using extraembryonically methylated cpg islands |
| CN112813148A (zh) * | 2021-02-02 | 2021-05-18 | 博淼生物科技（北京）有限公司 | 飞行时间质谱检测5-羟甲基胞嘧啶的方法 |
| EP4409468A4 (en) * | 2021-09-28 | 2025-08-13 | Act Genomics Ip Ltd | APPARATUS AND METHODS FOR SELECTING METHYLATION BIOMARKERS |
| KR20230059423A (ko) | 2021-10-26 | 2023-05-03 | 주식회사 지씨지놈 | 메틸화된 무세포 핵산을 이용한 암 진단 및 암 종 예측방법 |
| WO2023079047A1 (en) * | 2021-11-04 | 2023-05-11 | Universal Diagnostics S.A | Systems and methods for preparing biological samples for genetic sequencing |
| JP2025506435A (ja) | 2022-02-07 | 2025-03-11 | センター フォー ノヴォスティクス | メチル化及び疾患を測定するための断片化 |
| EP4482985A2 (en) * | 2022-02-22 | 2025-01-01 | Flagship Pioneering Innovations VI, LLC | Intra-individual analysis for presence of health conditions |
| CN115064211B (zh) * | 2022-08-15 | 2023-01-24 | 臻和(北京)生物科技有限公司 | 一种基于全基因组甲基化测序的ctDNA预测方法及装置 |
| CN115612723B (zh) * | 2022-09-26 | 2023-07-14 | 广州女娲生命科技有限公司 | 植入前胚胎的筛选方法 |
| WO2024203348A1 (ja) * | 2023-03-31 | 2024-10-03 | ソニーグループ株式会社 | 腫瘍の解析方法、腫瘍の解析システム、及び腫瘍の解析データ生成方法 |
| CN118737268A (zh) * | 2023-05-04 | 2024-10-01 | 杭州圣庭医疗科技有限公司 | 一种鉴定肿瘤组织来源的试剂盒的数据分析方法 |
| CN117025753A (zh) * | 2023-08-15 | 2023-11-10 | 广州女娲生命科技有限公司 | 检测染色体变异的方法和装置 |
| CN117079822B (zh) * | 2023-10-17 | 2024-01-02 | 北京大学第三医院（北京大学第三临床医学院） | 一种妊娠早中期四因子预测胎儿脑损伤的系统 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927028B2 (en) * | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| DE60207979T2 (de) | 2002-03-05 | 2006-09-28 | Epigenomics Ag | Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten |
| AU2003294315A1 (en) * | 2002-11-19 | 2004-06-15 | Amgen Inc. | Amplified genes involved in cancer |
| US20060183128A1 (en) | 2003-08-12 | 2006-08-17 | Epigenomics Ag | Methods and compositions for differentiating tissues for cell types using epigenetic markers |
| DE10348407A1 (de) | 2003-10-17 | 2005-05-19 | Widschwendter, Martin, Prof. | Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben |
| US8440404B2 (en) * | 2004-03-08 | 2013-05-14 | Rubicon Genomics | Methods and compositions for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation |
| WO2006128192A2 (en) | 2005-05-27 | 2006-11-30 | John Wayne Cancer Institute | Use of free circulating dna for diagnosis, prognosis, and treatment of cancer |
| US7901884B2 (en) * | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
| US7754428B2 (en) * | 2006-05-03 | 2010-07-13 | The Chinese University Of Hong Kong | Fetal methylation markers |
| CN101153336B (zh) * | 2006-09-27 | 2011-09-07 | 香港中文大学 | 检测dna甲基化程度的方法和试剂盒 |
| EP2173897A2 (en) | 2007-06-19 | 2010-04-14 | Oncomethylome Sciences SA | Improved urine sample collecting and processing |
| KR102561664B1 (ko) | 2007-07-23 | 2023-07-28 | 더 차이니즈 유니버시티 오브 홍콩 | 대규모 병렬 게놈 서열분석을 이용한 태아 염색체 이수성의 진단 방법 |
| JP4347372B2 (ja) | 2007-08-10 | 2009-10-21 | トヨタ自動車株式会社 | 静電塗装装置 |
| US20110028333A1 (en) * | 2009-05-01 | 2011-02-03 | Brown University | Diagnosing, prognosing, and early detection of cancers by dna methylation profiling |
| US8563242B2 (en) * | 2009-08-11 | 2013-10-22 | The Chinese University Of Hong Kong | Method for detecting chromosomal aneuploidy |
| US20120208711A1 (en) | 2009-10-02 | 2012-08-16 | Centre For Addiction And Mental Health | Method for Analysis of DNA Methylation Profiles of Cell-Free Circulating DNA in Bodily Fluids |
| LT3783110T (lt) * | 2009-11-05 | 2023-01-25 | The Chinese University Of Hong Kong | Vaisiaus genomo analizė iš motinos biologinio mėginio |
| US8620593B2 (en) | 2009-11-06 | 2013-12-31 | The Chinese University Of Hong Kong | Size-based genomic analysis |
| CA2786564A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
| US9249462B2 (en) * | 2010-01-26 | 2016-02-02 | Nipd Genetics Ltd | Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies |
| EP2564340B1 (en) | 2010-04-29 | 2020-01-08 | The Regents of The University of California | Pathway recognition algorithm using data integration on genomic models (paradigm) |
| GB201007944D0 (en) * | 2010-05-12 | 2010-06-30 | Univ Aberystwyth | Methods |
| ES2581594T3 (es) | 2010-05-25 | 2016-09-06 | The Johns Hopkins University | Composiciones y métodos para detectar una neoplasia |
| MX382244B (es) * | 2010-07-23 | 2025-03-13 | Harvard College | Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales |
| CN103069006A (zh) * | 2010-07-23 | 2013-04-24 | 艾索特里克斯遗传实验室有限责任公司 | 区别表达的胚胎或母源基因组区的鉴定及其用途 |
| WO2012031329A1 (en) * | 2010-09-10 | 2012-03-15 | Murdoch Childrens Research Institute | Assay for detection and monitoring of cancer |
| EP2646579B1 (en) | 2010-11-30 | 2017-06-14 | The Chinese University Of Hong Kong | Detection of genetic or molecular aberrations associated with cancer |
| EP2898100B9 (en) * | 2012-09-20 | 2023-08-02 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
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